Foradil (TN) (BioDeep_00000859229)
代谢物信息卡片
Foradil (TN)
化学式: C42H52N4O12 (804.3581552)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(CC1=CC=C(C=C1)OC)NCC(C2=CC(=C(C=C2)O)NC=O)O.CC(CC1=CC=C(C=C1)OC)NCC(C2=CC(=C(C=C2)O)NC=O)O.C(=CC(=O)O)C(=O)O
InChI: 2-1+
描述信息
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Piotr Kuna, Joanna Jerzynska, Matteo Martini, Andrea Vele, Irene Barneschi, Fabrizia Mariotti, George Georges, Giorgia Ciurlia. Pharmacokinetics of extrafine beclometasone dipropionate/formoterol fumarate/glycopyrronium bromide in adolescent and adult patients with asthma.
Pharmacology research & perspectives.
2022 08; 10(4):e980. doi:
10.1002/prp2.980. [PMID: 35733414] - Zhu Luo, Germano Lucci, Luigi Santoro, Eva Topole, Fabrizia Mariotti. Pharmacokinetic profile of beclometasone dipropionate/formoterol fumarate administered through a novel dry-powder inhaler in Chinese healthy volunteers.
Pulmonary pharmacology & therapeutics.
2022 06; 73-74(?):102129. doi:
10.1016/j.pupt.2022.102129. [PMID: 35525480] - Glenn A Jacobson, Morten Hostrup. The salmeterol anomaly and the need for a urine threshold.
Drug testing and analysis.
2022 Jun; 14(6):997-1003. doi:
10.1002/dta.2810. [PMID: 32314556] - Hong Zhang, Sami Z Daoud, Michael S Gillen, Natalia Calderon, Maria Heijer, Eduard Molins, Esther Garcia-Gil, Hong Chen, Qianqian Li, Chengjiao Liu, Yanhua Ding. An Evaluation of the Pharmacokinetics, Safety, and Tolerability of Aclidinium/Formoterol Fixed-Dose Combination Administered in Chinese Patients with Moderate-to-Severe Chronic Obstructive Pulmonary Disease.
Drugs in R&D.
2022 Mar; 22(1):35-42. doi:
10.1007/s40268-021-00374-z. [PMID: 35133636] - F D Richard Hobbs, Ly-Mee Yu, Benjamin R Saville, Mona Bafadhel, Christopher C Butler. High-dose budesonide for early COVID-19 - Authors' reply.
Lancet (London, England).
2021 12; 398(10317):2147-2148. doi:
10.1016/s0140-6736(21)02449-1. [PMID: 34895528] - Massimo Cella, Jörg Täubel, Irisz Delestre-Levai, Anne Tulard, Andrea Vele, George Georges. Ethnic Sensitivity Study of the Extrafine, Single-Inhaler, Triple Therapy Beclomethasone Dipropionate, Formoterol Fumarate, and Glycopyrronium Bromide Pressurized Metered Dose Inhaler in Japanese and Caucasian Healthy Individuals: A Randomized, Double-Blind, Single-Dose Crossover Study.
Clinical therapeutics.
2021 11; 43(11):1934-1947.e4. doi:
10.1016/j.clinthera.2021.09.001. [PMID: 34600734] - Sanjay Ramakrishnan, Mona Bafadhel. Inhaled budesonide for early treatment of COVID-19 - Authors' reply.
The Lancet. Respiratory medicine.
2021 07; 9(7):e61. doi:
10.1016/s2213-2600(21)00212-5. [PMID: 33991509] - Ernest L Vallorz, Karen Blohm-Mangone, Rick G Schnellmann, Heidi M Mansour. Formoterol PLGA-PEG Nanoparticles Induce Mitochondrial Biogenesis in Renal Proximal Tubules.
The AAPS journal.
2021 06; 23(4):88. doi:
10.1208/s12248-021-00619-4. [PMID: 34169439] - Dietrich Reinhardt. Title Not Available.
MMW Fortschritte der Medizin.
2021 04; 163(8):27-28. doi:
10.1007/s15006-021-9864-0. [PMID: 33904080] - Kristan H Cleveland, Frank C Brosius, Rick G Schnellmann. Regulation of mitochondrial dynamics and energetics in the diabetic renal proximal tubule by the β2-adrenergic receptor agonist formoterol.
American journal of physiology. Renal physiology.
2020 11; 319(5):F773-F779. doi:
10.1152/ajprenal.00427.2020. [PMID: 32954853] - Ying Huang, Pryseley Nkouibert Assam, Cong Feng, Rong Su, Paul Dorinsky, Michael Gillen. Ethnic pharmacokinetic comparison of budesonide/glycopyrrolate/formoterol fumarate metered dose inhaler (BGF MDI) between Asian and Western healthy subjects.
Pulmonary pharmacology & therapeutics.
2020 10; 64(?):101976. doi:
10.1016/j.pupt.2020.101976. [PMID: 33152467] - Lisa Joy Juergens, Heinrich Worth, Uwe R Juergens. New Perspectives for Mucolytic, Anti-inflammatory and Adjunctive Therapy with 1,8-Cineole in COPD and Asthma: Review on the New Therapeutic Approach.
Advances in therapy.
2020 05; 37(5):1737-1753. doi:
10.1007/s12325-020-01279-0. [PMID: 32200535] - Chao Hu, Jia Miao, Shiqing Shu, Ying Wang, Xiaohong Zhu, Zhu Luo. Pharmacokinetics, pharmacodynamics and safety of a novel extrafine BDP/FF/GB combination delivered via metered-dose inhaler in healthy Chinese subjects.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2020 Mar; 144(?):105198. doi:
10.1016/j.ejps.2019.105198. [PMID: 31862312] - Pallavi Bhargava, Jaroslav Janda, Rick G Schnellmann. Elucidation of cGMP-dependent induction of mitochondrial biogenesis through PKG and p38 MAPK in the kidney.
American journal of physiology. Renal physiology.
2020 02; 318(2):F322-F328. doi:
10.1152/ajprenal.00533.2019. [PMID: 31841384] - Leonard J Dunn, Edward M Kerwin, Kiernan DeAngelis, Patrick Darken, Michael Gillen, Paul Dorinsky. Pharmacokinetics of budesonide/glycopyrrolate/formoterol fumarate metered dose inhaler formulated using co-suspension delivery technology after single and chronic dosing in patients with COPD.
Pulmonary pharmacology & therapeutics.
2020 02; 60(?):101873. doi:
10.1016/j.pupt.2019.101873. [PMID: 31841699] - Alessia Vignoli, Giuseppe Santini, Leonardo Tenori, Giuseppe Macis, Nadia Mores, Francesco Macagno, Francesco Pagano, Tim Higenbottam, Claudio Luchinat, Paolo Montuschi. NMR-Based Metabolomics for the Assessment of Inhaled Pharmacotherapy in Chronic Obstructive Pulmonary Disease Patients.
Journal of proteome research.
2020 01; 19(1):64-74. doi:
10.1021/acs.jproteome.9b00345. [PMID: 31621329] - Donald P Tashkin. Formoterol for the Treatment of Chronic Obstructive Pulmonary Disease.
International journal of chronic obstructive pulmonary disease.
2020; 15(?):3105-3122. doi:
10.2147/copd.s273497. [PMID: 33273813] - Omar Usmani, Nicolas Roche, Jonathan Marshall, Helen Danagher, David Price. An innovative corticosteroid/long-acting β2-agonist breath-triggered inhaler: facilitating lung delivery of fluticasone propionate/formoterol fumarate for the treatment of asthma.
Expert opinion on drug delivery.
2019 12; 16(12):1367-1380. doi:
10.1080/17425247.2019.1689957. [PMID: 31752560] - Ehtesham Arif, Ashish K Solanki, Pankaj Srivastava, Bushra Rahman, Wayne R Fitzgibbon, Peifeng Deng, Milos N Budisavljevic, Catalin F Baicu, Michael R Zile, Judit Megyesi, Michael G Janech, Sang-Ho Kwon, Justin Collier, Rick G Schnellmann, Deepak Nihalani. Mitochondrial biogenesis induced by the β2-adrenergic receptor agonist formoterol accelerates podocyte recovery from glomerular injury.
Kidney international.
2019 09; 96(3):656-673. doi:
10.1016/j.kint.2019.03.023. [PMID: 31262488] - Morten Hostrup, Christian K Narkowicz, Sajad Habib, David S Nichols, Glenn A Jacobson. Beta2 -adrenergic ligand racemic formoterol exhibits enantioselective disposition in blood and skeletal muscle of humans, and elicits myocellular PKA signaling at therapeutic inhaled doses.
Drug testing and analysis.
2019 Jul; 11(7):1048-1056. doi:
10.1002/dta.2580. [PMID: 30836453] - Glenn A Jacobson, Morten Hostrup, Christian K Narkowicz, David S Nichols, E Haydn Walters. Enantioselective disposition of (R,R)-formoterol, (S,S)-formoterol and their respective glucuronides in urine following single inhaled dosing and application to doping control.
Drug testing and analysis.
2019 Jul; 11(7):950-956. doi:
10.1002/dta.2587. [PMID: 30865387] - Robert B Cameron, Whitney S Gibbs, Siennah R Miller, Tess V Dupre, Judit Megyesi, Craig C Beeson, Rick G Schnellmann. Proximal Tubule β 2-Adrenergic Receptor Mediates Formoterol-Induced Recovery of Mitochondrial and Renal Function after Ischemia-Reperfusion Injury.
The Journal of pharmacology and experimental therapeutics.
2019 04; 369(1):173-180. doi:
10.1124/jpet.118.252833. [PMID: 30709866] - Andrea Maes, Paolo DePetrillo, Shahid Siddiqui, Colin Reisner, Paul Dorinsky. Pharmacokinetics of Co-Suspension Delivery Technology Budesonide/Glycopyrronium/Formoterol Fumarate Dihydrate (BGF MDI) and Budesonide/Formoterol Fumarate Dihydrate (BFF MDI) Fixed-Dose Combinations Compared With an Active Control: A Phase 1, Randomized, Single-Dose, Crossover Study in Healthy Adults.
Clinical pharmacology in drug development.
2019 02; 8(2):223-233. doi:
10.1002/cpdd.585. [PMID: 29901860] - Colin Reisner, Joel Miller, Paolo DePetrillo, Andrea Maes, Shahid Siddiqui, Ubaldo J Martin. Pharmacokinetics and safety of a single dose of the novel LAMA/LABA fixed-dose combination of glycopyrronium/formoterol fumarate dihydrate metered dose inhaler, formulated using co-suspension delivery technology, in Japanese healthy subjects.
Pulmonary pharmacology & therapeutics.
2018 12; 53(?):33-38. doi:
10.1016/j.pupt.2018.09.005. [PMID: 30218695] - Warisara Parichatikanond, Akiyuki Nishimura, Motohiro Nishida, Supachoke Mangmool. Prolonged stimulation of β2-adrenergic receptor with β2-agonists impairs insulin actions in H9c2 cells.
Journal of pharmacological sciences.
2018 Nov; 138(3):184-191. doi:
10.1016/j.jphs.2018.09.007. [PMID: 30322801] - Ana Isabel Martín, Ana Belén Gómez-SanMiguel, Teresa Priego, Asunción López-Calderón. Formoterol treatment prevents the effects of endotoxin on muscle TNF/NF-kB, Akt/mTOR, and proteolytic pathways in a rat model. Role of IGF-I and miRNA 29b.
American journal of physiology. Endocrinology and metabolism.
2018 10; 315(4):E705-E714. doi:
10.1152/ajpendo.00043.2018. [PMID: 29969314] - Paul Dorinsky, Paolo DePetrillo, Shahid Siddiqui, Andrea Maes, Colin Reisner. Safety and pharmacokinetics of budesonide/glycopyrronium/formoterol fumarate dihydrate metered dose inhaler (BGF MDI) in healthy adult subjects of Japanese descent.
Pulmonary pharmacology & therapeutics.
2018 08; 51(?):18-25. doi:
10.1016/j.pupt.2018.05.001. [PMID: 29763659] - Patrick Darken, Paolo DePetrillo, Colin Reisner, Earl St Rose, Paul Dorinsky. The pharmacokinetics of three doses of budesonide/glycopyrronium/formoterol fumarate dihydrate metered dose inhaler compared with active controls: A Phase I randomized, single-dose, crossover study in healthy adults.
Pulmonary pharmacology & therapeutics.
2018 06; 50(?):11-18. doi:
10.1016/j.pupt.2018.03.001. [PMID: 29544728] - Faisal Fakih, Selwyn Spangenthal, Barry Sigal, Patrick Darken, Andrea Maes, Shahid Siddiqui, Michael Gillen, Colin Reisner, Ubaldo J Martin. Randomized study of the effects of Aerochamber Plus® Flow-Vu® on the efficacy, pharmacokinetics and safety of glycopyrronium/formoterol fumarate dihydrate metered dose inhaler in patients with chronic obstructive pulmonary disease.
Respiratory medicine.
2018 05; 138(?):74-80. doi:
10.1016/j.rmed.2018.03.033. [PMID: 29724397] - Ole D Wolthers, Sabine Mersmann, Sanjeeva Dissanayake. A Pilot Study of the Normative Range of Overnight Urinary Free Cortisol Corrected for Creatinine in Children.
Clinical drug investigation.
2018 Apr; 38(4):313-318. doi:
10.1007/s40261-017-0609-x. [PMID: 29256049] - Gary T Ferguson, Roberto Rodriguez-Roisin, Colin Reisner, Andrea Maes, Shahid Siddiqui, Ubaldo J Martin. Pharmacokinetics of glycopyrronium/formoterol fumarate dihydrate delivered via metered dose inhaler using co-suspension delivery technology in patients with moderate-to-very severe COPD.
International journal of chronic obstructive pulmonary disease.
2018; 13(?):945-953. doi:
10.2147/copd.s154988. [PMID: 29606861] - Robert B Cameron, Yuri K Peterson, Craig C Beeson, Rick G Schnellmann. Structural and pharmacological basis for the induction of mitochondrial biogenesis by formoterol but not clenbuterol.
Scientific reports.
2017 09; 7(1):10578. doi:
10.1038/s41598-017-11030-5. [PMID: 28874749] - Johan Onslev, Glenn Jacobson, Christian Narkowicz, Vibeke Backer, Anders Kalsen, Michael Kreiberg, Søren Jessen, Jens Bangsbo, Morten Hostrup. Beta2-adrenergic stimulation increases energy expenditure at rest, but not during submaximal exercise in active overweight men.
European journal of applied physiology.
2017 Sep; 117(9):1907-1915. doi:
10.1007/s00421-017-3679-9. [PMID: 28702809] - Fabrizia Mariotti, Giorgia Ciurlia, Luca Spaccapelo, Annamaria Muraro, Daniela Acerbi. A Two-Period Open-Label, Single-Dose Crossover Study in Healthy Volunteers to Evaluate the Drug-Drug Interaction Between Cimetidine and Inhaled Extrafine CHF 5993.
European journal of drug metabolism and pharmacokinetics.
2017 Apr; 42(2):269-279. doi:
10.1007/s13318-016-0345-2. [PMID: 27209586] - H A Inal, Z H Ozturk Inal, N Yilmaz, H Timur, A S Oruc, M N Kalem, O Han. The effects of formoterol on the serum, peritoneal VEGF, MDA, and VEGF levels in the ovaries and endometrium of rats with OHSS.
Clinical and experimental obstetrics & gynecology.
2017; 44(1):122-128. doi:
. [PMID: 29714880] - Glenn A Jacobson, J Paul Fawcett. Beta2-Agonist Doping Control and Optical Isomer Challenges.
Sports medicine (Auckland, N.Z.).
2016 Dec; 46(12):1787-1795. doi:
10.1007/s40279-016-0547-4. [PMID: 27164986] - Andrzej Emeryk, Rabih Klink, Tammy McIver, Prashant Dalvi. A 12-week open-label, randomized, controlled trial and 24-week extension to assess the efficacy and safety of fluticasone propionate/formoterol in children with asthma.
Therapeutic advances in respiratory disease.
2016 08; 10(4):324-37. doi:
10.1177/1753465816646320. [PMID: 27185164] - Renata D Belfort-DeAguiar, Sarita Naik, Janice Hwang, Barbara Szepietowska, Robert S Sherwin. Inhaled Formoterol Diminishes Insulin-Induced Hypoglycemia in Type 1 Diabetes.
Diabetes care.
2015 Sep; 38(9):1736-41. doi:
10.2337/dc14-2472. [PMID: 26153273] - Piotr Kuna, Mirco Govoni, Germano Lucci, Mario Scuri, Daniela Acerbi, Iwona Stelmach. Pharmacokinetics and pharmacodynamics of an extrafine fixed pMDI combination of beclometasone dipropionate/formoterol fumarate in adolescent asthma.
British journal of clinical pharmacology.
2015 Sep; 80(3):569-80. doi:
10.1111/bcp.12640. [PMID: 25808292] - Lori Weisfeld, Youyi Shu, Tushar P Shah. Bioequivalence of budesonide plus formoterol (BF) Spiromax® and BF Turbohaler® (with and without charcoal block) in healthy volunteers.
International journal of clinical pharmacology and therapeutics.
2015 Jul; 53(7):593-602. doi:
10.5414/cp202238. [PMID: 26042485] - Nikolaos Grekas, Katerina Athanassiou, Katerina Papataxiarchou, Simona Rizea Savu, Luigi Silvestro. Pharmacokinetic study for the establishment of bioequivalence of two inhalation treatments containing budesonide plus formoterol.
The Journal of pharmacy and pharmacology.
2014 Dec; 66(12):1677-85. doi:
10.1111/jphp.12303. [PMID: 25109416] - Marti Antilla, Fábio Castro, Álvaro Cruz, Adalberto Rubin, Nelson Rosário, Rafael Stelmach. Efficacy and safety of the single-capsule combination of fluticasone/formoterol in patients with persistent asthma: a non-inferiority trial.
Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia.
2014 Nov; 40(6):599-608. doi:
10.1590/s1806-37132014000600003. [PMID: 25610500] - A Kalsen, M Hostrup, J Bangsbo, V Backer. Combined inhalation of beta2 -agonists improves swim ergometer sprint performance but not high-intensity swim performance.
Scandinavian journal of medicine & science in sports.
2014 Oct; 24(5):814-22. doi:
10.1111/sms.12096. [PMID: 23834392] - Saba Arshi, Morteza Fallahpour, Mohammad Nabavi, Mohammad Hasan Bemanian, Seyed Ali Javad-Mousavi, Marzieh Nojomi, Hossein Esmaeilzadeh, Rasool Molatefi, Mahsa Rekabi, Farhad Jalali, Nadieh Akbarpour. The effects of vitamin D supplementation on airway functions in mild to moderate persistent asthma.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2014 Oct; 113(4):404-9. doi:
10.1016/j.anai.2014.07.005. [PMID: 25091714] - Kang Mi Lee, Ho Jun Kim, Junghyun Son, Ju-Hyung Park, Oh-Seung Kwon, Jaeick Lee. Simple quantitation of formoterol and 11-nor-Δ(9)-tetrahydrocannabinol-9-carboxylic acid in human urine by liquid chromatography-tandem mass spectrometry in doping control.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Sep; 967(?):8-12. doi:
10.1016/j.jchromb.2014.07.009. [PMID: 25063922] - Genye He, Jianghai Lu, Xiaobing Wang, Youxuan Xu, Yun Wu, Ying Dong, Li Shen, Zhenwen He, Jian Zhao, Hong Yuan. An improved liquid chromatography-tandem mass spectrometric method to quantify formoterol in human urine.
Journal of chromatographic science.
2014 Sep; 52(8):848-51. doi:
10.1093/chromsci/bmt127. [PMID: 24029618] - Sean R Jesinkey, Jason A Funk, L Jay Stallons, Lauren P Wills, Judit K Megyesi, Craig C Beeson, Rick G Schnellmann. Formoterol restores mitochondrial and renal function after ischemia-reperfusion injury.
Journal of the American Society of Nephrology : JASN.
2014 Jun; 25(6):1157-62. doi:
10.1681/asn.2013090952. [PMID: 24511124] - Teddy Kosoglou, James Hubbell, David L Cutler, Amy O Johnson-Levonas, Danlin Xu, Bhavna S Kantesaria, Kenneth Kim, S David Miller. Hypothalamic-pituitary-adrenal axis effects of mometasone furoate/formoterol fumarate vs fluticasone propionate/salmeterol administered through metered-dose inhaler.
Chest.
2013 Dec; 144(6):1795-1802. doi:
10.1378/chest.13-0505. [PMID: 24077095] - Yang Quanjun, Yang Genjin, Wan Lili, Li Bin, Lu Jin, Yu Qi, Li Yan, Han Yonglong, Guo Cheng, Zhang Junping. Serum metabolic profiles reveal the effect of formoterol on cachexia in tumor-bearing mice.
Molecular bioSystems.
2013 Dec; 9(12):3015-25. doi:
10.1039/c3mb70134d. [PMID: 24056883] - Leif Bjermer, Johan Rosenborg, Thomas Bengtsson, Jan Lötvall. Comparison of the bronchodilator and systemic effects of AZD3199, an inhaled ultra-long-acting β₂-adrenoceptor agonist, with formoterol in patients with asthma.
Therapeutic advances in respiratory disease.
2013 Oct; 7(5):264-71. doi:
10.1177/1753465813497527. [PMID: 23907810] - Monica Mazzarino, Xavier de la Torre, Ilaria Fiacco, Chiara Pompei, Fabiana Calabrese, Francesco Botrè. A simplified procedure for the analysis of formoterol in human urine by liquid chromatography-electrospray tandem mass spectrometry: application to the characterization of the metabolic profile and stability of formoterol in urine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2013 Jul; 931(?):75-83. doi:
10.1016/j.jchromb.2013.05.021. [PMID: 23777613] - P Lee, R O Day, J R Greenfield, K K Y Ho. Formoterol, a highly β2-selective agonist, increases energy expenditure and fat utilisation in men.
International journal of obesity (2005).
2013 Apr; 37(4):593-7. doi:
10.1038/ijo.2012.90. [PMID: 22641064] - Bo L K Chawes, Annalisa Piccinno, Eskil Kreiner-Møller, Nadja H Vissing, Porntiva Poorisrisak, Li Mortensen, Erik Nilson, Amalie Bisgaard, Anna Dossing, Maja Deleuran, Nanna L Skytt, Nasim Samandari, Francesco Sergio, Giorgia Ciurlia, Gianluigi Poli, Daniela Acerbi, Hans Bisgaard. Pharmacokinetic comparison of inhaled fixed combination vs. the free combination of beclomethasone and formoterol pMDIs in asthmatic children.
British journal of clinical pharmacology.
2013 Apr; 75(4):1081-8. doi:
10.1111/j.1365-2125.2012.04459.x. [PMID: 22978252] - Rosa Ventura, Lucia M P Damasceno, Rosalía Ramírez, Magí Farré, Rosa Bergés, Jordi Segura. Evaluation of the urinary threshold concentration of formoterol in sports drug testing.
Drug testing and analysis.
2013 Apr; 5(4):266-9. doi:
10.1002/dta.1450. [PMID: 23355217] - Christian Grabow Westergaard, Celeste Porsbjerg, Vibeke Backer. A review of mometasone furoate / formoterol in the treatment of asthma.
Expert opinion on pharmacotherapy.
2013 Feb; 14(3):339-46. doi:
10.1517/14656566.2013.761976. [PMID: 23363416] - Nikol Sullo, Fiorentina Roviezzo, Maria Matteis, Giuseppe Spaziano, Stefania Del Gaudio, Assunta Lombardi, Monica Lucattelli, Francesca Polverino, Giuseppe Lungarella, Giuseppe Cirino, Francesco Rossi, Bruno D'Agostino. Skeletal muscle oxidative metabolism in an animal model of pulmonary emphysema: formoterol and skeletal muscle dysfunction.
American journal of respiratory cell and molecular biology.
2013 Feb; 48(2):198-203. doi:
10.1165/rcmb.2012-0167oc. [PMID: 23144332] - Soo Jung Um, Stephen Lam, Harvey Coxson, Shu Fan Paul Man, Don D Sin. Budesonide/formoterol enhances the expression of pro Surfactant Protein-B in lungs of COPD patients.
PloS one.
2013; 8(12):e83881. doi:
10.1371/journal.pone.0083881. [PMID: 24386300] - Teddy Kosoglou, James Hubbell, Fengjuan Xuan, David L Cutler, Alan G Meehan, Bhavna Kantesaria, Bret A Wittmer. Comparison of the systemic bioavailability of mometasone furoate after oral inhalation from a mometasone furoate/formoterol fumarate metered-dose inhaler versus a mometasone furoate dry-powder inhaler in patients with chronic obstructive pulmonary disease.
International journal of chronic obstructive pulmonary disease.
2013; 8(?):107-16. doi:
10.2147/copd.s36592. [PMID: 23525511] - Giusy Daniela Albano, Caterina Di Sano, Anna Bonanno, Loredana Riccobono, Rosalia Gagliardo, Pascal Chanez, Mark Gjomarkaj, Angela Marina Montalbano, Giulia Anzalone, Stefania La Grutta, Fabio Luigi Massimo Ricciardolo, Mirella Profita. Th17 immunity in children with allergic asthma and rhinitis: a pharmacological approach.
PloS one.
2013; 8(4):e58892. doi:
10.1371/journal.pone.0058892. [PMID: 23573194] - Kasper Eibye, Jimmi Elers, Lars Pedersen, John Henninge, Peter Hemmersbach, Kim Dalhoff, Vibeke Backer. Formoterol concentrations in blood and urine: the World Anti-Doping Agency 2012 regulations.
Medicine and science in sports and exercise.
2013 Jan; 45(1):16-22. doi:
10.1249/mss.0b013e318269fba2. [PMID: 22843108] - V F Sardela, K Deventer, H M G Pereira, F R de Aquino Neto, P Van Eenoo. Development and validation of a ultra high performance liquid chromatography-tandem mass spectrometric method for the direct detection of formoterol in human urine.
Journal of pharmaceutical and biomedical analysis.
2012 Nov; 70(?):471-5. doi:
10.1016/j.jpba.2012.06.042. [PMID: 22841556] - D J Nicholls, S Jordan, E Cadogan, M Lawson, R P Austin, S W Paine, P Gardiner, R Bonnert, S Connolly, A Young. Characteristics of AZD9708, a novel, selective β2-adrenoceptor agonist with rapid onset and long duration of action.
Pulmonary pharmacology & therapeutics.
2012 Aug; 25(4):293-302. doi:
10.1016/j.pupt.2012.05.008. [PMID: 22659538] - Shashi Bhushan, Kazuhisa Kondo, Benjamin L Predmore, Maxim Zlatopolsky, Adrienne L King, Claire Pearce, Hui Huang, Ya-Xiong Tao, Marah E Condit, David J Lefer. Selective β2-adrenoreceptor stimulation attenuates myocardial cell death and preserves cardiac function after ischemia-reperfusion injury.
Arteriosclerosis, thrombosis, and vascular biology.
2012 Aug; 32(8):1865-74. doi:
10.1161/atvbaha.112.251769. [PMID: 22652602] - Lauren P Wills, Richard E Trager, Gyda C Beeson, Christopher C Lindsey, Yuri K Peterson, Craig C Beeson, Rick G Schnellmann. The β2-adrenoceptor agonist formoterol stimulates mitochondrial biogenesis.
The Journal of pharmacology and experimental therapeutics.
2012 Jul; 342(1):106-18. doi:
10.1124/jpet.112.191528. [PMID: 22490378] - K Deventer, O J Pozo, F T Delbeke, P Van Eenoo. Quantitative detection of inhaled formoterol in human urine and relevance to doping control analysis.
Drug testing and analysis.
2012 Jun; 4(6):449-54. doi:
10.1002/dta.418. [PMID: 22447497] - Zongbao Chen, Yan Cai, Lin Zhang, Lan Zhang. Capillary electrochromatography of three β2-agonists in human urine using a lauryl methacrylate-based monolithic column.
Journal of separation science.
2012 May; 35(9):1138-45. doi:
10.1002/jssc.201101005. [PMID: 22689490] - Takefumi Saito, Tomoko Hasunuma. Safety and Tolerability of High-Dose Budesonide/Formoterol via Turbuhaler® in Japanese Patients with Asthma : A Randomized, Double-Blind, Crossover, Active Comparator-Controlled, Phase III Study.
Clinical drug investigation.
2012 Jan; 32(1):51-61. doi:
10.2165/11595440-000000000-00000. [PMID: 27933599] - Rhys M Jones, Anthony Harrison. A new methodology for predicting human pharmacokinetics for inhaled drugs from oratracheal pharmacokinetic data in rats.
Xenobiotica; the fate of foreign compounds in biological systems.
2012 Jan; 42(1):75-85. doi:
10.3109/00498254.2011.626465. [PMID: 22077102] - Rebecca N Burns, Nader H Moniri. Agonist- and hydrogen peroxide-mediated oxidation of the β2 adrenergic receptor: evidence of receptor s-sulfenation as detected by a modified biotin-switch assay.
The Journal of pharmacology and experimental therapeutics.
2011 Dec; 339(3):914-21. doi:
10.1124/jpet.111.185975. [PMID: 21917560] - Dave Singh, Sara Collarini, Gianluigi Poli, Daniela Acerbi, Alessio Amadasi, Antonio Rusca. Effect of AeroChamber Plus™ on the lung and systemic bioavailability of beclometasone dipropionate/formoterol pMDI.
British journal of clinical pharmacology.
2011 Dec; 72(6):932-9. doi:
10.1111/j.1365-2125.2011.04024.x. [PMID: 21615456] - Lizbet Todorova, Leif Bjermer, Gunilla Westergren-Thorsson, Anna Miller-Larsson. TGFβ-induced matrix production by bronchial fibroblasts in asthma: budesonide and formoterol effects.
Respiratory medicine.
2011 Sep; 105(9):1296-307. doi:
10.1016/j.rmed.2011.03.020. [PMID: 21514131] - Koichi Suda, Masashi Tsuruta, Jihyoun Eom, Chris Or, Tammy Mui, Jen-Erh Jaw, Yuexin Li, Ni Bai, Joseph Kim, Julie Man, David Ngan, Jee Lee, Søren Hansen, Seung-Won Lee, Sheena Tam, S Paul Man, Stephan Van Eeden, Don D Sin. Acute lung injury induces cardiovascular dysfunction: effects of IL-6 and budesonide/formoterol.
American journal of respiratory cell and molecular biology.
2011 Sep; 45(3):510-6. doi:
10.1165/rcmb.2010-0169oc. [PMID: 21169556] - J Hinkle, J Hinson, E Kerwin, E Goodwin, K Sciarappa, L Curry, J P Hanrahan. A cumulative dose, safety and tolerability study of arformoterol in pediatric subjects with stable asthma.
Pediatric pulmonology.
2011 Aug; 46(8):761-9. doi:
10.1002/ppul.21446. [PMID: 21584948] - P R Cooper, R C Kurten, J Zhang, D J Nicholls, I A Dainty, R A Panettieri. Formoterol and salmeterol induce a similar degree of β2-adrenoceptor tolerance in human small airways but via different mechanisms.
British journal of pharmacology.
2011 Jun; 163(3):521-32. doi:
10.1111/j.1476-5381.2011.01257.x. [PMID: 21306583] - Christian de Mey, Nassr Nassr, Gezim Lahu. No relevant cardiac, pharmacokinetic or safety interactions between roflumilast and inhaled formoterol in healthy subjects: an open-label, randomised, actively controlled study.
BMC clinical pharmacology.
2011 Jun; 11(?):7. doi:
10.1186/1472-6904-11-7. [PMID: 21631929] - Jorge F Maspero, Hendrik Nolte, Iván Chérrez-Ojeda. Long-term safety of mometasone furoate/formoterol combination for treatment of patients with persistent asthma.
The Journal of asthma : official journal of the Association for the Care of Asthma.
2010 Dec; 47(10):1106-15. doi:
10.3109/02770903.2010.514634. [PMID: 20874458] - Volker Strauss, Thomas Wöhrmann, Ilona Frank, Ulrich Hübel, Jörg Luft, Gerd Bode, Paul-Georg Germann. Short-term increase of serum troponin I and serum heart-type fatty acid-binding protein (H-FABP) in dogs following administration of formoterol.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.
2010 Jul; 62(4):343-52. doi:
10.1016/j.etp.2009.05.006. [PMID: 19581074] - Wilfried De Backer, Annick Devolder, Gianluigi Poli, Daniela Acerbi, Raffaella Monno, Christiane Herpich, Knut Sommerer, Thomas Meyer, Fabrizia Mariotti. Lung deposition of BDP/formoterol HFA pMDI in healthy volunteers, asthmatic, and COPD patients.
Journal of aerosol medicine and pulmonary drug delivery.
2010 Jun; 23(3):137-48. doi:
10.1089/jamp.2009.0772. [PMID: 20109122] - Gustavo J Rodrigo, Hugo Neffen, Federico D Colodenco, José A Castro-Rodriguez. Formoterol for acute asthma in the emergency department: a systematic review with meta-analysis.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2010 Mar; 104(3):247-52. doi:
10.1016/j.anai.2009.11.064. [PMID: 20377114] - Celestine Juliet Po, Saumya Subhash Chandran, Nazma Syed, K Raghu Naidu, Manoj Rathod, Ameet Sule, Amar Lulla, Shrinivas Purandare. Comparative bioavailability of two hydrofluoroalkane formulations of formoterol fumarate both delivered by pressurised metered dose inhaler.
Arzneimittel-Forschung.
2010; 60(2):81-6. doi:
10.1055/s-0031-1296253. [PMID: 20329656] - William E Berger, Jeffrey G Leflein, David E Geller, Bhash Parasuraman, Christopher J Miller, Christopher D O'Brien, Liza O'Dowd. The safety and clinical benefit of budesonide/formoterol pressurized metered-dose inhaler versus budesonide alone in children.
Allergy and asthma proceedings.
2010 Jan; 31(1):26-39. doi:
10.2500/aap.2010.31.3301. [PMID: 20167143] - Chris Dalby, Tomasz Polanowski, Thomas Larsson, Lars Borgström, Staffan Edsbäcker, Tim W Harrison. The bioavailability and airway clearance of the steroid component of budesonide/formoterol and salmeterol/fluticasone after inhaled administration in patients with COPD and healthy subjects: a randomized controlled trial.
Respiratory research.
2009 Oct; 10(?):104. doi:
10.1186/1465-9921-10-104. [PMID: 19878590] - Craig LaForce, Phillip Korenblat, Pamela Osborne, Fang Dong, Mark Higgins. 24-hour bronchodilator efficacy of single doses of indacaterol in patients with persistent asthma: comparison with placebo and formoterol.
Current medical research and opinion.
2009 Oct; 25(10):2353-9. doi:
10.1185/03007990903143143. [PMID: 19650753] - Jörgen Syk, Anna-Lena Undén, Kjell Alving. Relationship between exhaled nitric oxide and IgE sensitisation in patients with asthma: influence of steroid treatment.
The clinical respiratory journal.
2009 Jul; 3(3):143-51. doi:
10.1111/j.1752-699x.2008.00124.x. [PMID: 20298397] - Marie E Gibbs, Candice L Rodricks, Dana S Hutchinson, Roger J Summers, Suzanne L Miller. Importance of adrenergic receptors in prenatally induced cognitive impairment in the domestic chick.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience.
2009 Feb; 27(1):27-35. doi:
10.1016/j.ijdevneu.2008.10.005. [PMID: 19027843] - Olivier Bauwens, Vincent Ninane, Boudewijn Van de Maele, Roz Firth, Fang Dong, Roger Owen, Mark Higgins. 24-hour bronchodilator efficacy of single doses of indacaterol in subjects with COPD: comparison with placebo and formoterol.
Current medical research and opinion.
2009 Feb; 25(2):463-70. doi:
10.1185/03007990802675096. [PMID: 19192991] - Jean Bousquet, Gianluigi Poli, Daniela Acerbi, Raffaella Monno, Steven Ramael, Fabrice Nollevaux. Systemic exposure and implications for lung deposition with an extra-fine hydrofluoroalkane beclometasone dipropionate/formoterol fixed combination.
Clinical pharmacokinetics.
2009; 48(6):347-58. doi:
10.2165/00003088-200948060-00001. [PMID: 19650674] - Nicholas J Gross, Edward Kerwin, Bernard Levine, Kenneth T Kim, Kimberly Denis-Mize, Mohammad Hamzavi, Michelle Carpenter, Mike Rinehart. Nebulized formoterol fumarate: Dose selection and pharmacokinetics.
Pulmonary pharmacology & therapeutics.
2008 Oct; 21(5):818-23. doi:
10.1016/j.pupt.2008.07.002. [PMID: 18655841] - Erik Bathoorn, Jeroen J W Liesker, Dirkje S Postma, Martin Boorsma, Eva Bondesson, Gerard H Koëter, Henk F Kauffman, Antoon J M van Oosterhout, Huib A M Kerstjens. Anti-inflammatory effects of combined budesonide/formoterol in COPD exacerbations.
COPD.
2008 Oct; 5(5):282-90. doi:
10.1080/15412550802363360. [PMID: 18972276] - Lihui Zheng, Ping Tong, Xinyu Zheng, Yuwu Chi, Guonan Chen, Lan Zhang. Electrostacking online sample pre-concentration capillary electrophoresis with amperometric detection for beta2-agonists in human urine.
Journal of separation science.
2008 Oct; 31(20):3556-64. doi:
10.1002/jssc.200800359. [PMID: 18844207] - Ursula Petzold, Hans-Joachim Kremer, Duc Tung Nguyen, Ullrich Munzel, Hartmut Dietrich, Joachim Maus. Single-dose pharmacokinetics and safety pharmacodynamics of formoterol delivered by two different dry powder inhalers.
Journal of aerosol medicine and pulmonary drug delivery.
2008 Sep; 21(3):309-19. doi:
10.1089/jamp.2008.0690. [PMID: 18598160] - J Kharidia, C M Fogarty, C F Laforce, G Maier, R Hsu, K M Dunnington, L Curry, R A Baumgartner, J P Hanrahan. A pharmacokinetic/pharmacodynamic study comparing arformoterol tartrate inhalation solution and racemic formoterol dry powder inhaler in subjects with chronic obstructive pulmonary disease.
Pulmonary pharmacology & therapeutics.
2008 Aug; 21(4):657-62. doi:
10.1016/j.pupt.2008.03.003. [PMID: 18501650] - James F Donohue, N A Hanania, C Fogarty, S C Campbell, M Rinehart, K Denis-Mize. Long-term safety of nebulized formoterol: results of a twelve-month open-label clinical trial.
Therapeutic advances in respiratory disease.
2008 Aug; 2(4):199-208. doi:
10.1177/1753465808093934. [PMID: 19124372] - Jan Lötvall, Jaro Ankerst. Long duration of airway but not systemic effects of inhaled formoterol in asthmatic patients.
Respiratory medicine.
2008 Mar; 102(3):449-56. doi:
10.1016/j.rmed.2007.10.003. [PMID: 18023335] - Dave Singh, Annalisa Piccinno, Zoe Borrill, Gianluigi Poli, Daniela Acerbi, Luc Meuleners, Ashley Woodcock. Tolerability of high cumulative doses of the HFA modulite beclomethasone dipropionate/formoterol combination inhaler in asthmatic patients.
Pulmonary pharmacology & therapeutics.
2008; 21(3):551-7. doi:
10.1016/j.pupt.2008.01.001. [PMID: 18321744] - Sabine Pestel, Volker Krzykalla, Gerhard Weckesser. Measurement of glomerular filtration rate in the conscious rat.
Journal of pharmacological and toxicological methods.
2007 Nov; 56(3):277-89. doi:
10.1016/j.vascn.2007.03.001. [PMID: 17582786] - Cecilia Ahlström Emanuelsson, Morgan Andersson, Carl G A Persson, Lars Thorsson, Lennart Greiff. Effects of topical formoterol alone and in combination with budesonide in a pollen season model of allergic rhinitis.
Respiratory medicine.
2007 Jun; 101(6):1106-12. doi:
10.1016/j.rmed.2006.11.017. [PMID: 17215115] - Mohammed A Alzoghaibi, Ahmed S Bahammam. Lipid peroxides in stable asthmatics receiving inhaled steroids and long-acting beta2 -agonists.
Respirology (Carlton, Vic.).
2007 May; 12(3):439-42. doi:
10.1111/j.1440-1843.2007.01034.x. [PMID: 17539852] - D K Nadarassan, H Chrystyn, B J Clark, K H Assi. Validation of high-performance liquid chromatography assay for quantification of formoterol in urine samples after inhalation using UV detection technique.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 May; 850(1-2):31-7. doi:
10.1016/j.jchromb.2006.10.059. [PMID: 17126087]