Angiotensin amide (BioDeep_00000859224)
代谢物信息卡片
(Asn1,Val5)-Angiotensin II
化学式: C49H70N14O11 (1030.534823)
中文名称: 血管紧张素胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)C(C(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(C(C)C)C(=O)NC(CC2=CN=CN2)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)N)N
InChI: InChI=1S/C49H70N14O11/c1-26(2)39(61-42(67)33(12-8-18-55-49(52)53)57-41(66)32(50)23-38(51)65)45(70)58-34(20-29-14-16-31(64)17-15-29)43(68)62-40(27(3)4)46(71)59-35(22-30-24-54-25-56-30)47(72)63-19-9-13-37(63)44(69)60-36(48(73)74)21-28-10-6-5-7-11-28/h5-7,10-11,14-17,24-27,32-37,39-40,64H,8-9,12-13,18-23,50H2,1-4H3,(H2,51,65)(H,54,56)(H,57,66)(H,58,70)(H,59,71)(H,60,69)(H,61,67)(H,62,68)(H,73,74)(H4,52,53,55)
描述信息
D002317 - Cardiovascular Agents > D014662 - Vasoconstrictor Agents
同义名列表
2 个代谢物同义名
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Guanjie Chen, Daniel Shriner, Ayo P Doumatey, Jie Zhou, Amy R Bentley, Lin Lei, Adebowale Adeyemo, Charles N Rotimi. Refining genome-wide associated loci for serum uric acid in individuals with African ancestry.
Human molecular genetics.
2020 02; 29(3):506-514. doi:
10.1093/hmg/ddz272. [PMID: 31841133] - Hye W Lee, Hyun-Ja Lim, Ji H Jun, Jiae Choi, Myeong S Lee. Ginseng for Treating Hypertension: A Systematic Review and Meta-Analysis of Double Blind, Randomized, Placebo-Controlled Trials.
Current vascular pharmacology.
2017; 15(6):549-556. doi:
10.2174/1570161115666170713092701. [PMID: 28707603] - Tarah Fatani, Asma Binjab, Hope Weiler, Atul Sharma, Celia Rodd. Persistent elevation of fibroblast growth factor 23 concentrations in healthy appropriate-for-gestational-age preterm infants.
Journal of pediatric endocrinology & metabolism : JPEM.
2015 Jul; 28(7-8):825-32. doi:
10.1515/jpem-2014-0186. [PMID: 25968436] - Andrew D Blann, Gregory Y H Lip. Renal, endothelial function, warfarin management, and the CHADS2, CHA2DS2VASc and HAS-BLED scores inpredicting MACE in AF.
Thrombosis and haemostasis.
2015 May; 113(5):1155-7. doi:
10.1160/th14-11-0932. [PMID: 25716989] - Shur-Jen Wang, Stanley J F Laulederkind, G Thomas Hayman, Victoria Petri, Weisong Liu, Jennifer R Smith, Rajni Nigam, Melinda R Dwinell, Mary Shimoyama. PhenoMiner: a quantitative phenotype database for the laboratory rat, Rattus norvegicus. Application in hypertension and renal disease.
Database : the journal of biological databases and curation.
2015; 2015(?):. doi:
10.1093/database/bau128. [PMID: 25632109] - Samira Fargali, Angelo L Garcia, Masato Sadahiro, Cheng Jiang, William G Janssen, Wei-Jye Lin, Valeria Cogliani, Alice Elste, Steven Mortillo, Cheryl Cero, Britta Veitenheimer, Gallia Graiani, Giulio M Pasinetti, Sushil K Mahata, John W Osborn, George W Huntley, Greg R Phillips, Deanna L Benson, Alessandro Bartolomucci, Stephen R Salton. The granin VGF promotes genesis of secretory vesicles, and regulates circulating catecholamine levels and blood pressure.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2014 May; 28(5):2120-33. doi:
10.1096/fj.13-239509. [PMID: 24497580] - I Heuch, I Heuch, K Hagen, J A Zwart. Does high blood pressure reduce the risk of chronic low back pain? The Nord-Trøndelag Health Study.
European journal of pain (London, England).
2014 Apr; 18(4):590-8. doi:
10.1002/j.1532-2149.2013.00398.x. [PMID: 24019262] - Patrick Lacolley, Véronique Regnault, Antonino Nicoletti, Zhenlin Li, Jean-Baptiste Michel. The vascular smooth muscle cell in arterial pathology: a cell that can take on multiple roles.
Cardiovascular research.
2012 Jul; 95(2):194-204. doi:
10.1093/cvr/cvs135. [PMID: 22467316] - Laura A Bienvenu, James Morgan, Amanda J Rickard, Greg H Tesch, Greg A Cranston, Elizabeth K Fletcher, Lea M D Delbridge, Morag J Young. Macrophage mineralocorticoid receptor signaling plays a key role in aldosterone-independent cardiac fibrosis.
Endocrinology.
2012 Jul; 153(7):3416-25. doi:
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Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2011 May; 43(5):312-8. doi:
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Neurobiology of aging.
2011 Jan; 32(1):31-41. doi:
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Biological psychology.
2009 Feb; 80(2):240-5. doi:
10.1016/j.biopsycho.2008.10.003. [PMID: 19013496] - Ettore Guidi, Mariagrazia Cozzi, Silvano Milani, Elena Spada. Nephrectomy modifies renal angiotensin II effects in kidney donors.
American journal of hypertension.
2008 May; 21(5):592-8. doi:
10.1038/ajh.2008.35. [PMID: 18437153] - M Dharmani, M R Mustafa, F I Achike, M K Sim. Effect of des-aspartate-angiotensin I on the actions of angiotensin II in the isolated renal and mesenteric vasculature of hypertensive and STZ-induced diabetic rats.
Regulatory peptides.
2005 Jul; 129(1-3):213-9. doi:
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Clinical therapeutics.
2001 Sep; 23(9):1478-91. doi:
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Hypertension in pregnancy.
2000; 19(3):289-98. doi:
10.1081/prg-100101990. [PMID: 11118402] - N J Bernier, S F Perry. Cardiovascular effects of angiotensin-II-mediated adrenaline release in rainbow trout Oncorhynchus mykiss.
The Journal of experimental biology.
1999 Jan; 202(Pt 1):55-66. doi:
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The American journal of physiology.
1997 Sep; 273(3 Pt 1):G571-85. doi:
10.1152/ajpgi.1997.273.3.g571. [PMID: 9316461] - R P McKinnon, C J Sinclair. Angiotensinamide in the treatment of probable anaphylaxis to succinylated gelatin (Gelofusine).
Anaesthesia.
1994 Apr; 49(4):309-11. doi:
10.1111/j.1365-2044.1994.tb14180.x. [PMID: 8179137] - J Duggan, J Nussberger, S Kilfeather, K O'Malley. Aging and human hormonal and pressor responsiveness to angiotensin II infusion with simultaneous measurement of exogenous and endogenous angiotensin II.
American journal of hypertension.
1993 Aug; 6(8):641-7. doi:
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The Journal of endocrinology.
1989 Jun; 121(3):579-83. doi:
10.1677/joe.0.1210579. [PMID: 2547012] - V Eisen, M R Munday, J D Slater. Effects of angiotensin I converting enzyme inhibition and calcium channel blockade on plasma levels of active and inactive renin in conscious rabbits.
Biochemical pharmacology.
1987 Jul; 36(14):2331-5. doi:
10.1016/0006-2952(87)90599-5. [PMID: 2440439] - T Yoshimura, K Matsui, M Ito, T Yunohara, N Kawasaki, T Nakamura, H Okamura. Effects of highly purified eicosapentaenoic acid on plasma beta thromboglobulin level and vascular reactivity to angiotensin II.
Artery.
1987; 14(5):295-303. doi:
NULL. [PMID: 2821970] - T Kono, A Taniguchi, H Imura, F Oseko, M C Khosla. Relative biological activities of Asn1-,Val5-angiotensin II, Ile5-angiotensin II and Sar1-angiotensin II in man.
Life sciences.
1985 Jul; 37(4):365-9. doi:
10.1016/0024-3205(85)90507-7. [PMID: 3892218] - S Nag. Cerebral endothelial surface charge in hypertension.
Acta neuropathologica.
1984; 63(4):276-81. doi:
10.1007/bf00687333. [PMID: 6475487] - J A Millar. Plasma active and inactive renin in man during infusion of angiotensin II with and without prior administration of nifedipine.
Clinical and experimental hypertension. Part A, Theory and practice.
1982; 4(11-12):2415-24. doi:
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Padiatrie und Padologie.
1981; 16(1):81-92. doi:
NULL. [PMID: 7017552] - J R Blair-West, J P Coghlan, D A Denton, D T Fei, K J Hardy, B A Scoggins, R D Wright. A dose-response comparison of the actions of angiotensin II and angiotensin III in sheep.
The Journal of endocrinology.
1980 Dec; 87(3):409-17. doi:
10.1677/joe.0.0870409. [PMID: 7452126] - S Kaufman, G Peters. Regulatory drinking in the pigeon Columba livia.
The American journal of physiology.
1980 Sep; 239(3):R219-25. doi:
10.1152/ajpregu.1980.239.3.r219. [PMID: 7435592] - F A Mendelsohn. Different potencies of [Asp1, Ile5]- and [Asn1, Val5]-angiotensin II in stimulating aldosterone production from rat adrenal zona glomerulosa cells in vitro.
Clinical and experimental pharmacology & physiology.
1980 Mar; 7(2):199-203. doi:
10.1111/j.1440-1681.1980.tb00061.x. [PMID: 7379348] - S A Al-Merani, D P Brooks, B J Chapman, K A Munday. The half-lives of angiotensin II, angiotensin II-amide, angiotensin III, Sar1-Ala8-angiotensin II and renin in the circulatory system of the rat.
The Journal of physiology.
1978 May; 278(?):471-90. doi:
10.1113/jphysiol.1978.sp012318. [PMID: 671333] - B J Chapman, A J Riley, A Taton. Renal effects of angiotensin II in conscious rabbits [proceedings].
The Journal of physiology.
1977 Dec; 273(2):86P-87P. doi:
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Klinische Wochenschrift.
1975 Jul; 53(13):623-8. doi:
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Klinische Wochenschrift.
1965 Jun; 43(?):614-7. doi:
10.1007/bf01879185. [PMID: 14308402] - F PRUEGGER, H CESNIK. [RESULTS OF HYPERTENSIN DETERMINATION IN MAN].
Wiener klinische Wochenschrift.
1965 Feb; 77(?):84-7. doi:
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Minerva medica.
1964 Apr; 55(?):1054-9. doi:
NULL. [PMID: 14144860] - K MERTSOU, K MOUSOURAKE, S KOUREMENOS. [PERSONAL EXPERIENCE IN THE USE OF HYPERTENSIN II IN THE TREATMENT OF SHOCK].
Hellenike cheirourgike. Acta chirurgica Hellenica.
1963 Sep; 10(?):618-36. doi:
NULL. [PMID: 14092769] - L F MILLS, P M HAMILTON. [REGULATION OF ALDOSTERONE SECRETION. ROLE OF THE KIDNEY AND THE RENIN-ANGIOTENSIN SYSTEM (HYPERTENSIN)].
L'Annee endocrinologique.
1963; 15(?):21-6. doi:
NULL. [PMID: 14333522] - J Y GILLENWATER, J B SCOTT, E D FROHLICH. Effect of chlorothiazide on response of renal vascular bed to vasoactive substances.
Circulation research.
1962 Aug; 11(?):283-6. doi:
10.1161/01.res.11.2.283. [PMID: 13898617] - P H BARNETT, A SCHIRGER, S G SHEPS. Renin-angiotensin machanisms and renoprival hypertension.
Proceedings of the staff meetings. Mayo Clinic.
1962 Aug; 37(?):418-26. doi:
NULL. [PMID: 13865118] - R SCHROEDER. [Research on the relation between angiotensin infusion and aldosterone secretion].
Klinische Wochenschrift.
1962 Jul; 40(?):752-4. doi:
10.1007/bf01482419. [PMID: 13909329] - H E SCHMID. Renin, a physiologic regulator of renal hemodynamics?.
Circulation research.
1962 Jul; 11(?):185-93. doi:
10.1161/01.res.11.1.185. [PMID: 14039025] - E GLAZ, K SUGAR. The effect of synthetic angiotensin II on synthesis of aldosterone by the adrenals.
The Journal of endocrinology.
1962 Jun; 24(?):299-302. doi:
10.1677/joe.0.0240299. [PMID: 13899163] - J H LARAGH. Hormones and the pathogenesis of congestive heart failure: vasopressin, aldosterone, and angiotensin II. Further evidence for renal-adrenal interaction from studies in hypertension and in cirrhosis.
Circulation.
1962 Jun; 25(?):1015-23. doi:
10.1161/01.cir.25.6.1015. [PMID: 14462379] - G M MASSON. Juxtaglomerular cells, renal pressor substances and nephrosclerosis.
Experientia.
1962 May; 18(?):243-7. doi:
10.1007/bf02148325. [PMID: 14470951] - W E JUDSON. Pressor activity of dialyzed plasma of patients with primary and secondary (renal) hypertension.
The American journal of cardiology.
1962 May; 9(?):710-6. doi:
10.1016/0002-9149(62)90131-5. [PMID: 14452715] - J D ROMANI, A KELLER. [The role of the kidney and angiotensin in stimulating the mineral function of the adrenal gland].
Annales d'endocrinologie.
1962 May; 23(?):344-8. doi:
NULL. [PMID: 14493540] - H E SCHMID, L GRAHAM, B B BRENNAN, G E WAKERLIN. Renin concentration of normotensive and hypertensive dog kidney: its relation to serum antirenin titer.
Circulation research.
1962 Apr; 10(?):696-703. doi:
10.1161/01.res.10.4.696. [PMID: 14498645] - A M BLAIR. Pharmacological actions of pepsitensin.
British journal of pharmacology and chemotherapy.
1962 Apr; 18(?):255-74. doi:
10.1111/j.1476-5381.1962.tb01406.x. [PMID: 13869728] - H BRUNNER, P A DESAULLES, D REGOLI, F GROSS. Renin content and excretory function of the kidney in rats with experimental hypertension.
The American journal of physiology.
1962 Apr; 202(?):795-9. doi:
10.1152/ajplegacy.1962.202.4.795. [PMID: 13874039] - N F JONES, M A BARRACLOUGH. Response of the kidneys in unilateral renal-artery stenosis.
Lancet (London, England).
1962 Mar; 1(7227):454-7. doi:
10.1016/s0140-6736(62)91419-8. [PMID: 14452309] - A F LEVER, W S PEART. Renin and angiotensin-like activity in renal lymph.
The Journal of physiology.
1962 Mar; 160(?):548-63. doi:
10.1113/jphysiol.1962.sp006865. [PMID: 14464509] - P J MULROW, W F GANONG, G CERA, A KULJIAN. The nature of the aldosterone-stimulating factor in dog kidneys.
The Journal of clinical investigation.
1962 Mar; 41(?):505-18. doi:
10.1172/jci104504. [PMID: 14477160] - J O DAVIS, P M HARTROFT, E O TITUS, C C CARPENTER, C R AYERS, H E SPIEGEL. The role of the renin-angiotensin system in the control of aldosterone secretion.
The Journal of clinical investigation.
1962 Feb; 41(?):378-89. doi:
10.1172/jci104492. [PMID: 13883925] - J J BROWN, W S PEART. The effect of angiotension on urine flow and electrolyte excretion in hypertensive patients.
Clinical science.
1962 Feb; 22(?):1-17. doi:
NULL. [PMID: 13873671] - R L WOLF, M MENDLOWITZ, J PICK, S E GITLOW, N NAFTCHI. In vitro degradation of I-131 labeled angiotensin II by normotensive and hypertensive human serum.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
1962 Feb; 109(?):308-13. doi:
10.3181/00379727-109-27187. [PMID: 14007958] - L TOBIAN. Relationship of juxtaglomerular apparatus to renin and angiotensin.
Circulation.
1962 Jan; 25(?):189-92. doi:
10.1161/01.cir.25.1.189. [PMID: 14039739] - O M HELMER. Presence of renin in plasma of patients with arterial hypertension.
Circulation.
1962 Jan; 25(?):169-73. doi:
10.1161/01.cir.25.1.169. [PMID: 13906339] - D REGOLI, H BRUNNER, G PETERS, F GROSS. Changes in renin content in kidneys of renal hypertensive rats.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
1962 Jan; 109(?):142-5. doi:
10.3181/00379727-109-27129. [PMID: 14491100] - F DEL GRECO. Comparative effects of valine-5 angiotensin II amide and pitressin on renal excretory function in diabetes insipidus.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
1962 Jan; 109(?):105-10. doi:
10.3181/00379727-109-27117. [PMID: 13884973] - P J MULROW, W F GANONG. Role of the kidney and the renin-angiotensin system in the response of aldosterone secretion to hemorrhage.
Circulation.
1962 Jan; 25(?):213-20. doi:
10.1161/01.cir.25.1.213. [PMID: 14477161] - P BLAQUIER, D F BOHR, A C TAQUINI, S W HOOBLER. Renin and angiotensinase content of the kidney of normal and renal hypertensive rats.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
1961 Dec; 108(?):711-5. doi:
10.3181/00379727-108-27044. [PMID: 13869857] - J Y GILLENWATER, J B SCOTT, E D FROHLICH. Chlorothiazide attenuation of the pressor responses to epinephrine, levarterenol, and angiotensin in the perfused renal vascular bed.
Report. Army Medical Research Laboratory (U.S.).
1961 Nov; ?(?):10p. doi:
NULL. [PMID: 13898616] - A C TAQUINI, A C TAQUINI. The renin-angiotensin system in hypertension.
American heart journal.
1961 Oct; 62(?):558-64. doi:
10.1016/0002-8703(61)90265-4. [PMID: 14039648] - H DEMOPOULOS, G KALEY, B W ZWEIFACH. Response of granular juxtaglomerular cells and tissue mast cells in various experimental states.
Circulation research.
1961 Jul; 9(?):845-50. doi:
10.1161/01.res.9.4.845. [PMID: 13721802] - J GENEST, P BIRON, E KOIW, W NOWACZYNSKI, R BOUCHER, M CHRETIEN. Studies of the pathogenesis of human hypertension. The adrenal cortex and renal pressor mechanism.
Annals of internal medicine.
1961 Jul; 55(?):12-28. doi:
10.7326/0003-4819-55-1-12. [PMID: 13704359] - P BLAQUIER. The role of renin in experimental renal hypertension.
Medical bulletin (Ann Arbor, Mich.).
1961 Jul; 27(?):176-82. doi:
NULL. [PMID: 13869859] - E R FISHER, G M MASSON. Renal lesions in renin proteinuria.
Archives of pathology.
1961 May; 71(?):480-4. doi:
NULL. [PMID: 13699952] - P P LEYSSAC, U V LASSEN, J H THAYSEN. Inhibition of sodium transport in isolated renal tissue by angiotensin.
Biochimica et biophysica acta.
1961 Apr; 48(?):602-3. doi:
10.1016/0006-3002(61)90063-4. [PMID: 13761795] - P J MULROW, W F GANONG. Stimulation of aldosterone secretion by angiotensisn. II. A preliminary report.
The Yale journal of biology and medicine.
1961 Apr; 33(?):386-95. doi:
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Circulation research.
1961 Mar; 9(?):256-63. doi:
10.1161/01.res.9.2.256. [PMID: 13699665] - J GENEST. Angiotensin, aldosterone and human arterial hypertension.
Canadian Medical Association journal.
1961 Feb; 84(?):403-19. doi:
NULL. [PMID: 13704363] - W S PEART, J J BROWN. Effect of angiotensin (hypertensin or angiotonin) on urine flow and electrolyte excretion in hypertensive patients.
Lancet (London, England).
1961 Jan; 1(7167):28-9. doi:
10.1016/s0140-6736(61)92191-2. [PMID: 13733801] - F NERI, A MAESTRI, M MARCATO, F RASCHI. [Arteriographical research on renal circulation in the dog after administration of synthetic hypertensin].
Archivio per le scienze mediche.
1960 Dec; 110(?):622-56. doi:
NULL. [PMID: 13728378] - C A SCHAFFENBURG, HAASE, H GOLDBLATT. Concentration of renin in kidneys and angiotensinogen in serum of various species.
The American journal of physiology.
1960 Nov; 199(?):788-92. doi:
10.1152/ajplegacy.1960.199.5.788. [PMID: 13747214] - H DEMOPOULOS, G KALEY, B W ZWEIFACH. The histologic distribution of renin in the kidneys of the rat and rabbit.
The American journal of pathology.
1960 Oct; 37(?):443-55. doi:
NULL. [PMID: 13721803] - F S FERUGLIO, B MIGHELI, S CAMPUS, G PANDOLFO. [Studies on the circulation of an organ; action of hypertensin on cardiac output and renal circulation].
Bollettino della Societa italiana di biologia sperimentale.
1960 Sep; 36(?):955-6. doi:
NULL. [PMID: 13699202] - F GROSS, O BUSCHOR, P ZEUGIN. Renin in the kidneys of rats with aminonucleoside nephrosis.
The American journal of physiology.
1960 Jul; 199(?):1-4. doi:
10.1152/ajplegacy.1960.199.1.1. [PMID: 13829626] - S D DEODHAR. Immunologic production of antiangiotensin. II. Production and detection of antiangiotensin.
The Journal of experimental medicine.
1960 Mar; 111(?):429-39. doi:
10.1084/jem.111.3.429. [PMID: 13721954] - F E ALONSO, M M PUEBLA, J C FASCIOLO. [Indirecttitration of renin of the kidney].
Comptes rendus des seances de la Societe de biologie et de ses filiales.
1960 Feb; 153(?):1603-4. doi:
NULL. [PMID: 13792885] - H DENGLER, G REICHEL. [Studies on the intracellular localization of renin and hypertensinase activity].
Experientia.
1960 Jan; 16(?):36-8. doi:
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1959 Nov; 197(?):1103-6. doi:
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1959 Oct; 197(?):869-72. doi:
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1958 Sep; 36(17):808-14. doi:
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The Journal of experimental medicine.
1956 Aug; 104(2):183-91. doi:
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The Journal of experimental medicine.
1956 Mar; 103(3):295-9. doi:
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The Journal of experimental medicine.
1954 Mar; 99(3):275-82. doi:
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