Esomeprazole magnesium hydrate (BioDeep_00000859223)
代谢物信息卡片
化学式: C34H42MgN6O9S2 (766.2305062000001)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC.CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC.O.O.O.[Mg+2]
InChI: +2
描述信息
C78276 - Agent Affecting Digestive System or Metabolism > C29701 - Anti-ulcer Agent > C29723 - Proton Pump Inhibitor
D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents
D004791 - Enzyme Inhibitors > D054328 - Proton Pump Inhibitors
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Qianjun Zhuang, Aijun Liao, Qingling He, Chengxia Liu, Changqing Zheng, Xing Li, Youli Liu, Bangmao Wang, Side Liu, Yan Zhang, Rong Lin, Huixin Chen, Min Deng, Yanping Tang, Chiyi He, Weijie Dai, Haitao Tang, Lei Gong, Liangping Li, Baohong Xu, Changqing Yang, Bingxi Zhou, Dongxing Su, Qinghong Guo, Bin Li, Yongjian Zhou, Xiaoyang Wang, Sujuan Fei, Huili Wu, Sichen Wei, Zhihong Peng, Jianning Wang, Yanqing Li, Hong Wang, Tianwei Deng, Shigang Ding, Fangfang Li, Minhu Chen, Yinglian Xiao. The efficacy and safety of fexuprazan in treating erosive esophagitis: a phase III, randomized, double-blind, multicenter study.
Journal of gastroenterology and hepatology.
2024 Apr; 39(4):658-666. doi:
10.1111/jgh.16471
. [PMID: 38251791] - Rozh Q Ameen, Zahra A Amin, Hiwa O Ahmad, Diler D Ghafur, Melodya G Toma, Nyan Sabah, Muhammad Fakhir, Gardoon Abdulla. Gastroprotective effect of rhodanine and 2,4-thiazolidinediones scaffolds in rat stomachs by contribution of anti-apoptotic (BCL-2) and tumor suppressor (P53) proteins.
Scientific reports.
2024 01; 14(1):1699. doi:
10.1038/s41598-024-51446-4
. [PMID: 38242960] - Dan-Ni Liu, Qiu-Yan Wang, Pei-Yuan Li, Dong-Han Wu, Jing Pan, Zheng-Yi Chen, Yan-Qiang Li, Xiang-Yang Han, Cheng Lan, Jing Tang, Yan Tan, Cui-Yi Mo, Wei-Zhong Yang, Jun-Ling Han, Xiao-Xi Huang. Comparing high-dose dual therapy with bismuth-containing quadruple therapy for the initial eradication of Helicobacter pylori infection on Hainan Island: A randomized, multicenter clinical trial.
Clinics and research in hepatology and gastroenterology.
2023 05; 47(5):102125. doi:
10.1016/j.clinre.2023.102125
. [PMID: 37062356] - Ying-Ying Han, Hui Long, Ya Lin, Qiong He, Wei-Gang Chen, Xiang-Wu Ding, Lin Zhou, Ping An, Fen Wang, Zhen-Yu Zhang, Yun-Lian Hu, Pei-Yuan Li. Optimized dual therapy for treatment-naive patients of Helicobacter pylori infection: A large-scale prospective, multicenter, open-label, randomized controlled study.
Helicobacter.
2022 Oct; 27(5):e12922. doi:
10.1111/hel.12922
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Biophysical chemistry.
2022 06; 285(?):106809. doi:
10.1016/j.bpc.2022.106809
. [PMID: 35367785] - Leyla Karadurmus, M Emin Corman, Lokman Uzun, Sibel A Ozkan. Enantioselective recognition of esomeprazole with a molecularly imprinted sol-gel-based electrochemical sensor.
Mikrochimica acta.
2022 05; 189(6):225. doi:
10.1007/s00604-022-05321-6
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Biomedical chromatography : BMC.
2022 May; 36(5):e5343. doi:
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Clinical and translational science.
2022 05; 15(5):1281-1290. doi:
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Osteoarthritis and cartilage.
2022 04; 30(4):559-569. doi:
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. [PMID: 35031493] - Nehal F Farid, Maimana A Magdy, Basma H Anwar, Nessreen S Abdelhamid. Multivariate Model Update Chemometric Methods for Determination of Prednisolone and Esomeprazole in Spiked Human Plasma: A Comparative Study.
Journal of AOAC International.
2022 Feb; 105(1):317-322. doi:
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. [PMID: 34478551] - Ramesh Boinpally, Kaifeng Lu. Evaluation of the Pharmacokinetic Interaction and Safety of Ubrogepant Coadministered With Esomeprazole Magnesium.
Clinical pharmacology in drug development.
2022 02; 11(2):270-277. doi:
10.1002/cpdd.1034
. [PMID: 34811955] - Leni van Doorn, Niels Heersche, Femke M de Man, Peter de Bruijn, Ivo Bijl, Esther Oomen-de Hoop, Ferry A L M Eskens, Ate van der Gaast, Ron H J Mathijssen, Sander Bins. Effect of the Proton Pump Inhibitor Esomeprazole on the Systemic Exposure of Capecitabine: Results of A Randomized Crossover Trial.
Clinical pharmacology and therapeutics.
2022 02; 111(2):455-460. doi:
10.1002/cpt.2444
. [PMID: 34656072] - Huiping Xu, Melissa O'Gorman, Kyle Matschke, Tanya Boutros, Nicoletta Brega, Weiwei Tan, Akintunde Bello. Evaluation of Proton Pump Inhibitor Esomeprazole on Crizotinib Pharmacokinetics in Healthy Participants.
Clinical pharmacology in drug development.
2022 01; 11(1):34-42. doi:
10.1002/cpdd.1032
. [PMID: 34825782] - Camille Lenoir, Amine Niederer, Victoria Rollason, Jules Alexandre Desmeules, Youssef Daali, Caroline Flora Samer. Prediction of cytochromes P450 3A and 2C19 modulation by both inflammation and drug interactions using physiologically based pharmacokinetics.
CPT: pharmacometrics & systems pharmacology.
2022 01; 11(1):30-43. doi:
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Drug design, development and therapy.
2022; 16(?):619-634. doi:
10.2147/dddt.s338131
. [PMID: 35281316] - Bahia Abbas Moussa, Hanaa M A Hashem, Marianne Alphonse Mahrouse, Sally Tarek Mahmoud. Synchronized determination of sacubitril and valsartan with some co-administered drugs in human plasma via UPLC-MS/MS method using solid-phase extraction.
Biomedical chromatography : BMC.
2021 Nov; 35(11):e5203. doi:
10.1002/bmc.5203
. [PMID: 34145610] - Marouf Alhalabi, Mohammed Waleed Alassi, Kamal Alaa Eddin, Khaled Cheha. Efficacy of two-week therapy with doxycycline-based quadruple regimen versus levofloxacin concomitant regimen for helicobacter pylori infection: a prospective single-center randomized controlled trial.
BMC infectious diseases.
2021 Jul; 21(1):642. doi:
10.1186/s12879-021-06356-5
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Scandinavian journal of gastroenterology.
2021 02; 56(2):128-136. doi:
10.1080/00365521.2020.1859610
. [PMID: 33327801] - Yuanhang Yang, Xiaoting Li, Qi Zhou, Lingling Sun, Tianhong Zhang. Simultaneous determination of naproxen and esomeprazole in beagle dog plasma by supercritical fluid chromatography-tandem mass spectrometry coupled with evaporation-free liquid-liquid extraction.
Journal of pharmaceutical and biomedical analysis.
2021 Jan; 193(?):113668. doi:
10.1016/j.jpba.2020.113668
. [PMID: 33176242] - Yao Chen, Hongxun Yuan, Hui Ye, Zongming Shi, Xin Deng, Xuezhi Zhang, Xikang Hou. Application of a semi-automatic, intensive follow-up for improving efficacy and adherence of Helicobacter pylori eradication therapy: A randomized controlled trial.
MicrobiologyOpen.
2021 01; 10(1):e1172. doi:
10.1002/mbo3.1172
. [PMID: 33650799] - Gang Chen, Li-Juan Ning, Yan Qin, Bin Zhao, Dan Mei, Xue-Mei Li. Acute kidney injury following the use of different proton pump inhibitor regimens: A real-world analysis of post-marketing surveillance data.
Journal of gastroenterology and hepatology.
2021 Jan; 36(1):156-162. doi:
10.1111/jgh.15151
. [PMID: 32542684] - Taavi J K Kaartinen, Aleksi Tornio, Tuija Tapaninen, Terhi Launiainen, Nina Isoherranen, Mikko Niemi, Janne T Backman. Effect of High-Dose Esomeprazole on CYP1A2, CYP2C19, and CYP3A4 Activities in Humans: Evidence for Substantial and Long-lasting Inhibition of CYP2C19.
Clinical pharmacology and therapeutics.
2020 12; 108(6):1254-1264. doi:
10.1002/cpt.1949
. [PMID: 32558923] - Mario Nagase, Hitoshi Shimada, Masahiro Nii, Shinya Ueda, Mitsuo Higashimori, Katsuomi Ichikawa, Li Zhang, Li Zhou, Yingxue Chen, Diansong Zhou, James Dunyak, Nidal Al-Huniti. Population pharmacokinetic analysis of esomeprazole in Japanese subjects with various CYP2C19 phenotypes.
Journal of clinical pharmacy and therapeutics.
2020 Oct; 45(5):1030-1038. doi:
10.1111/jcpt.13129
. [PMID: 32227647] - Doaa El-Bohy, Magdy El Sharkawy, Soheir Abo-Elazm, Sara Shahin, Waleed Bchari, Azza Mancy, Manal El Hamamsy. Esomeprazole vs pantoprazole effects on cyclosporine levels in kidney transplantation: A randomized clinical trial.
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy.
2020 Oct; 24(5):591-598. doi:
10.1111/1744-9987.13464
. [PMID: 31856374] - Jumpei Saito, Naho Yakuwa, Noriko Sandaiji, Hiroyo Kawasaki, Kayoko Kaneko, Tomo Suzuki, Akimasa Yamatani, Haruhiko Sago, Atsuko Murashima. Esomeprazole During Pregnancy and Lactation: Esomeprazole Levels in Maternal Serum, Cord Blood, Breast Milk, and the Infant's Serum.
Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine.
2020 09; 15(9):598-601. doi:
10.1089/bfm.2020.0175
. [PMID: 32635742] - Sara Blanco Dorado, Olalla Maroñas Amigo, Ana Latorre-Pellicer, María Teresa Rodríguez Jato, Ana López-Vizcaíno, Aurea Gómez Márquez, Belén Bardán García, Dolores Belles Medall, Gema Barbeito Castiñeiras, María Luisa Pérez Del Molino Bernal, Manuel Campos-Toimil, Francisco Otero Espinar, Andrés Blanco Hortas, Irene Zarra Ferro, Ángel Carracedo, María Jesús Lamas, Anxo Fernández-Ferreiro. A multicentre prospective study evaluating the impact of proton-pump inhibitors omeprazole and pantoprazole on voriconazole plasma concentrations.
British journal of clinical pharmacology.
2020 08; 86(8):1661-1666. doi:
10.1111/bcp.14267
. [PMID: 32110830] - Jie Pan, Zhengchao Shi, Dingsai Lin, Ningmin Yang, Fei Meng, Lang Lin, Zhencheng Jin, Qingjie Zhou, Jiansheng Wu, Jianzhong Zhang, Youming Li. Is tailored therapy based on antibiotic susceptibility effective ? a multicenter, open-label, randomized trial.
Frontiers of medicine.
2020 Feb; 14(1):43-50. doi:
10.1007/s11684-019-0706-8
. [PMID: 31907860] - Bhuvanachandra Pasupuleti, Vamshikrishna Gone, Ravali Baddam, Raj Kumar Venisetty, Om Prakash Prasad. Clinical Impact of Co-medication of Levetiracetam and Clobazam with Proton Pump Inhibitors: A Drug Interaction Study.
Current drug metabolism.
2020; 21(2):126-131. doi:
10.2174/1389200221666200218121050
. [PMID: 32067615] - Zakia Belhadj, Bing He, Jijun Fu, Hua Zhang, Xueqing Wang, Wenbing Dai, Qiang Zhang. Regulating Interactions Between Targeted Nanocarriers and Mononuclear Phagocyte System via an Esomeprazole-Based Preconditioning Strategy.
International journal of nanomedicine.
2020; 15(?):6385-6399. doi:
10.2147/ijn.s258054
. [PMID: 32922007] - Manal A Abbas, Yasser I Kandil, Ahmad M Disi, Sahar M Jaffal. Gastroprotective activity of Loranthus acaciae flower extract in a rodent model of ethanol-induced ulcer.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.
2019 Dec; 44(12):1283-1288. doi:
10.1139/apnm-2019-0166
. [PMID: 31009579] - Hongyun Wang, Feng Shao, Xuemei Liu, Wen Xu, Ning Ou, Xianghong Qin, Fang Liu, Xuemei Hou, Haitang Hu, Ji Jiang. Efficacy, safety and pharmacokinetics of ilaprazole infusion in healthy subjects and patients with esomeprazole as positive control.
British journal of clinical pharmacology.
2019 11; 85(11):2547-2558. doi:
10.1111/bcp.14076
. [PMID: 31332820] - Amy Fakhry Boushra, Asmaa Mohammed Elsayed, Noha Abdellatif Ibrahim, Maha Khaled Abdelwahed, Eman Ibrahim Ahmed. A comparative study on the possible protective effect of esomeprazole, spirulina, wheatgrass on indomethacin-induced gastric ulcer in male albino rats.
Molecular biology reports.
2019 Oct; 46(5):4843-4860. doi:
10.1007/s11033-019-04933-1
. [PMID: 31297714] - Cüneyt Türkeş. A potential risk factor for paraoxonase 1: in silico and in-vitro analysis of the biological activity of proton-pump inhibitors.
The Journal of pharmacy and pharmacology.
2019 Oct; 71(10):1553-1564. doi:
10.1111/jphp.13141
. [PMID: 31353473] - Jie Ying, Liu-Cheng Li, Cui-Yun Wu, Zhen-Wei Yu, Lian-Di Kan. The status of proton pump inhibitor use: a prescription survey of 45 hospitals in China.
Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva.
2019 Oct; 111(10):738-743. doi:
10.17235/reed.2019.6155/2019
. [PMID: 31373505] - Sungpil Han, Hee Youn Choi, Yo Han Kim, Ji Yeon Nam, Bongtae Kim, Geun Seog Song, Hyeong-Seok Lim, Kyun-Seop Bae. Randomised clinical trial: safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple oral doses of tegoprazan (CJ-12420), a novel potassium-competitive acid blocker, in healthy male subjects.
Alimentary pharmacology & therapeutics.
2019 10; 50(7):751-759. doi:
10.1111/apt.15438
. [PMID: 31437865] - Mahmoud M Sebaiy, Wafaa S Hassan, Mostafa E Elhennawy. Developing a High-Performance Liquid Chromatography (HPLC) Method for Simultaneous Determination of Oxytetracycline, Tinidazole and Esomeprazole in Human Plasma.
Journal of chromatographic science.
2019 Aug; 57(8):724-729. doi:
10.1093/chromsci/bmz046
. [PMID: 31251331] - Ryohkan Funakoshi, Yukana Tomoda, Toshiyuki Kudo, Kenichi Furihata, Hiroyuki Kusuhara, Kiyomi Ito. Effects of proton pump inhibitors, esomeprazole and vonoprazan, on the disposition of proguanil, a CYP2C19 substrate, in healthy volunteers.
British journal of clinical pharmacology.
2019 07; 85(7):1454-1463. doi:
10.1111/bcp.13914
. [PMID: 30845361] - Do-Hyun Seo, Jong-Bok Lee, Ji-Hye Hwang, Jong-Woo Jeong, Gun-Ho Song, Tae-Sung Koo, Kyoung-Won Seo. Pharmacokinetics and pharmacodynamics of intravenous esomeprazole at 2 different dosages in dogs.
Journal of veterinary internal medicine.
2019 Mar; 33(2):531-535. doi:
10.1111/jvim.15383
. [PMID: 30548689] - Karen E Hansen, Jeri W Nieves, Sai Nudurupati, David C Metz, Maria Claudia Perez. Dexlansoprazole and Esomeprazole Do Not Affect Bone Homeostasis in Healthy Postmenopausal Women.
Gastroenterology.
2019 03; 156(4):926-934.e6. doi:
10.1053/j.gastro.2018.11.023
. [PMID: 30445008] - Dong-Min Yi, Tao-Tao Yang, Shuai-Heng Chao, Ya-Xin Li, Ying-Lei Zhou, Hai-Hui Zhang, Ling Lan, Yu-Wei Zhang, Xue-Mei Wang, Yan-Rui Zhang, Jian Li, Song-Ze Ding. Comparison the cost-efficacy of furazolidone-based versus clarithromycin-based quadruple therapy in initial treatment of Helicobacter pylori infection in a variable clarithromycin drug-resistant region, a single-center, prospective, randomized, open-label study.
Medicine.
2019 Feb; 98(6):e14408. doi:
10.1097/md.0000000000014408
. [PMID: 30732192] - Toshiaki Shimizu, Yoshiko Nakayama, Eizaburo Ishii, Shinobu Ida, Tomoki Satou, Daisuke Tokuhara, Katsuhiro Arai, Masahiro Nii, Hans Rydholm, Toshitaka Yajima. Oral esomeprazole in Japanese pediatric patients with gastric acid-related disease: Safety, efficacy, and pharmacokinetics.
Pediatrics international : official journal of the Japan Pediatric Society.
2019 Jan; 61(1):87-95. doi:
10.1111/ped.13733
. [PMID: 30422368] - Dasohm Kim, Min Soo Park, Byung Won Yoo, Taegon Hong, Shin Jung Park, Choon Ok Kim. The safety, pharmacodynamics, and pharmacokinetics of immediate-release formulation containing esomeprazole 20 mg/sodium bicarbonate 800 mg in healthy adult male.
Drug design, development and therapy.
2019; 13(?):3151-3159. doi:
10.2147/dddt.s212491
. [PMID: 31564831] - Eunwoo Kim, Anhye Kim, Sojeong Yi, Yu Kyong Kim, Seong Bok Jang, Hae Mi Byun, Seo Hyun Yoon, Joo-Youn Cho, In-Jin Jang, Kyung-Sang Yu, SeungHwan Lee. Effect of food on the pharmacokinetics of YH4808, a potassium-competitive acid blocker, after single- and multiple-oral dosing in healthy subjects.
European journal of clinical pharmacology.
2018 Oct; 74(10):1261-1272. doi:
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Clinical pharmacology and therapeutics.
2018 07; 104(1):188-200. doi:
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Alimentary pharmacology & therapeutics.
2018 07; 48(2):206-218. doi:
10.1111/apt.14818
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Journal of the Chinese Medical Association : JCMA.
2018 Jul; 81(7):585-592. doi:
10.1016/j.jcma.2018.01.011
. [PMID: 29780000] - Amani N Shafik, Mahmoud A Khattab, Ahmed H Osman. Magnesium sulfate versus esomeprazole impact on the neonates of preeclamptic rats.
European journal of obstetrics, gynecology, and reproductive biology.
2018 Jun; 225(?):236-242. doi:
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International urology and nephrology.
2018 Feb; 50(2):217-223. doi:
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BioMed research international.
2018; 2018(?):6374374. doi:
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Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology.
2018 ; 115(3):299-304. doi:
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PloS one.
2018; 13(7):e0199160. doi:
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Jan; 97(?):1356-1365. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Nov; 1068-1069(?):352-357. doi:
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Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition.
2017 Nov; 48(6):933-936. doi:
NULL
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Alimentary pharmacology & therapeutics.
2017 08; 46(3):337-346. doi:
10.1111/apt.14148
. [PMID: 28543183] - Ward A Heggermont, Gregor Verhoef, Pieter Evenepoel, Ben Sprangers, Evelyn Lerut, Thomas Tousseyn, Kathleen Claes. Clinical case report: a rare cause of acute kidney failure - tissue is the issue.
Acta clinica Belgica.
2017 Jun; 72(3):201-204. doi:
10.1080/17843286.2016.1178967
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Biomedical chromatography : BMC.
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"
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