Omeprazole sodium hydrate (BioDeep_00000859190)
代谢物信息卡片
Omeprazole sodium monohydrate
化学式: C17H20N3NaO4S (385.1072160000001)
中文名称: 奥美拉唑钠
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC.O.[Na+]
InChI: +1
描述信息
D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents
D004791 - Enzyme Inhibitors > D054328 - Proton Pump Inhibitors
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ghazal Nabil, Yasmine H Ahmed, Omaima Ahmed, Selvia S Milad, Mohamed Hisham, Mohamed Rafat, Mohamed Atia, Aya A Shokry. Argel's stemmoside C as a novel natural remedy for mice with alcohol-induced gastric ulcer based on its molecular mechanistic pathways.
Journal of ethnopharmacology.
2024 Jun; 327(?):117970. doi:
10.1016/j.jep.2024.117970. [PMID: 38428660] - N J Menzies-Gow, T Shurlock. The effect of feeding a commercial feedstuff on gastric squamous gastric disease (ESGD) healing and prevention of recurrence.
Journal of equine veterinary science.
2024 Feb; 133(?):105015. doi:
10.1016/j.jevs.2024.105015. [PMID: 38281606] - Salah Tofik Jalal Balaky. Anti H. pylori, anti-secretory and gastroprotective effects of Thymus vulgaris on ethanol-induced gastric ulcer in Sprague Dawley rats.
PloS one.
2024; 19(1):e0287569. doi:
10.1371/journal.pone.0287569. [PMID: 38271407] - Monika Singh, Shreshtha Singh, Dinesh Puri, Shalini Kapoor Sawhney, Nitin Kumar, Mohd Yasir, Pankaj Nainwal. The Anti-ulcer Potential of Weissella cibaria Assisted Bio-fermented Product of Citrus limetta Waste Peel in Wistar Albino Rats.
Recent patents on biotechnology.
2024; 18(4):344-357. doi:
10.2174/0118722083278152231121173605. [PMID: 38566382] - Ruiqi Zhao, Sen Lin, Mengyao Han, Zhimei Lin, Mengjiao Yu, Lisheng Peng. Does proton pump inhibitors use increase risk of digestive tumors?: A 2-sample Mendelian randomization study.
Medicine.
2023 Nov; 102(45):e36085. doi:
10.1097/md.0000000000036085. [PMID: 37960715] - Doaa R I Abdel-Gawad, Marwa A Ibrahim, Usama K Moawad, Shaimaa Kamel, Hossny A El-Banna, Ahmed H El-Banna, Walid Hamdy Hassan, Fatma I Abo El-Ela. Effectiveness of natural biomaterials in the protection and healing of experimentally induced gastric mucosa Ulcer in rats.
Molecular biology reports.
2023 Sep; ?(?):. doi:
10.1007/s11033-023-08776-9. [PMID: 37741810] - Sumit Bansal, C Austin Zamarripa, Tory R Spindle, Elise M Weerts, Kenneth E Thummel, Ryan Vandrey, Mary F Paine, Jashvant D Unadkat. Evaluation of Cytochrome P450-Mediated Cannabinoid-Drug Interactions in Healthy Adult Participants.
Clinical pharmacology and therapeutics.
2023 Jun; ?(?):. doi:
10.1002/cpt.2973. [PMID: 37313955] - Faryal Rubab, Hira Ijaz, Shah Hussain, Ans Munir, Stefan Stuppner, Thomas Jakschitz, Günther K Bonn, Saiqa Ishtiaq. Gastroprotective effects of Caragana ambigua stocks on ethanol-induced gastric ulcer in rats supported by LC-MS/MS characterization of formononetin and biochanin A.
Journal of the science of food and agriculture.
2022 Dec; 102(15):7030-7038. doi:
10.1002/jsfa.12064. [PMID: 35689485] - Hui-Lin Yang, Ying Li, Yi Chen, Si-Ying Chen, Yue-Ting Li, Yong Huang, Lin Zheng, Jing Huang, Yong-Lin Wang, Zi-Peng Gong. [Effect of Laportea bulbifera extract on CYP450 enzyme activities in rats by Cocktail probe drug method].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Dec; 47(23):6320-6332. doi:
10.19540/j.cnki.cjcmm.20220623.204. [PMID: 36604876] - Guoxin Bai, Junyu Yi, Yuanyuan Yu, Hongxing Du. Clinical effect of Anwei Qingyou recipe on peptic ulcer and its effect on the levels of EGF and PGE2: A retrospective study.
Medicine.
2022 Oct; 101(40):e30898. doi:
10.1097/md.0000000000030898. [PMID: 36221352] - Yue Ma, Shu Li, Hongxi Yang, Yuan Zhang, Huiping Li, Lihui Zhou, Jing Lin, Yanchun Chen, Yabing Hou, Xinyu Zhang, Tong Liu, Xin Zhou, Yaogang Wang. Acid suppressants use and risk of atherosclerotic cardiovascular disease in middle-aged and older adults.
Atherosclerosis.
2022 10; 358(?):47-54. doi:
10.1016/j.atherosclerosis.2022.09.001. [PMID: 36113328] - Seok Hwee Koo, Gaik Hong Soon, Alain Pruvost, Henri Benech, Tiing Leong Ang, Edmund Jon Deoon Lee, Daphne Shih Wen Ang. Evaluation of a six-probe cocktail (caffeine, tolbutamide, omeprazole, dextromethorphan, midazolam, and digoxin) approach to estimate hepatic drug detoxification capability and dosage requirements after a single oral dosing in healthy Chinese volunteers.
Naunyn-Schmiedeberg's archives of pharmacology.
2022 07; 395(7):815-826. doi:
10.1007/s00210-022-02235-1. [PMID: 35394133] - Urs Duthaler, Fabio Bachmann, Claudia Suenderhauf, Tanja Grandinetti, Florian Pfefferkorn, Manuel Haschke, Petr Hruz, Jamal Bouitbir, Stephan Krähenbühl. Liver Cirrhosis Affects the Pharmacokinetics of the Six Substrates of the Basel Phenotyping Cocktail Differently.
Clinical pharmacokinetics.
2022 07; 61(7):1039-1055. doi:
10.1007/s40262-022-01119-0. [PMID: 35570253] - Yiming Cheng, Liangang Liu, Yongjun Xue, Simon Zhou, Yan Li. An Open Label, Phase 1, Randomized, Seven-treatment, Seven-period, Crossover Study to Assess the Relative Bioavailability, pH Effect, Food Effect, and Dose Proportionality of CC-292, a Potent and Orally Available Bruton's Tyrosine Kinase Inhibitor.
European journal of drug metabolism and pharmacokinetics.
2022 Jul; 47(4):579-592. doi:
10.1007/s13318-022-00776-7. [PMID: 35657581] - Roland Heinig, Johannes Nagelschmitz, Stephanie Loewen. Results From Phase I Studies Investigating the Dose Linearity of Finerenone Tablets and the Influence of Food or pH-Modifying Comedications on its Pharmacokinetics in Healthy Male Volunteers.
European journal of drug metabolism and pharmacokinetics.
2022 Jul; 47(4):549-559. doi:
10.1007/s13318-022-00770-z. [PMID: 35612708] - Huan Gao, Yanqing Song, Jie Ma, Jinghui Zhai, Yueming Zhang, Xiaoyu Qu. Untargeted metabolomics analysis of omeprazole-enhanced chemosensitivity to cisplatin in mice with non-small cell lung cancer.
Chemico-biological interactions.
2022 Jun; 360(?):109933. doi:
10.1016/j.cbi.2022.109933. [PMID: 35447140] - Shuang Zhou, Ran Xie, Xiaodan Zhang, Xu He, Jie Huang, Yin Jungang, Man Liao, Ying Ding, Dandan Yang, Ying Liu, Qian Zhang, Guoping Yang, Fang Liu, Shengjiang Guan, Qing He, Honggang Lou, Fengyun Gong, Xianmin Meng, Qian Xiang, Xia Zhao, Yimin Cui. Evaluation of the relationship between polymorphisms in CYP2C19 and the single-dose pharmacokinetics of omeprazole in healthy Chinese volunteers: A multicenter study.
Clinical and translational science.
2022 Jun; 15(6):1439-1448. doi:
10.1111/cts.13255. [PMID: 35235711] - Xiaoyu Li, Ying Wang, Xiaohong Zhu, Li Zheng. Clinical study of drug-drug interaction between omeprazole and pyrotinib after meal.
British journal of clinical pharmacology.
2022 05; 88(5):2349-2358. doi:
10.1111/bcp.15169. [PMID: 34873745] - Slimen Selmi, Dhouha Alimi, Kais Rtibi, Saber Jedidi, Dhekra Grami, Lamjed Marzouki, Karim Hosni, Hichem Sebai. Gastroprotective and Antioxidant Properties of Trigonella foenum graecum Seeds Aqueous Extract (Fenugreek) and Omeprazole Against Ethanol-Induced Peptic Ulcer.
Journal of medicinal food.
2022 May; 25(5):513-522. doi:
10.1089/jmf.2020.0217. [PMID: 35561273] - Larissa Selbach Dries, Rochelli Haefliger, Bruna Sherer Seibert, Angélica Gewehr de Lima, Caroline de Oliveira Cardoso, Magda Susana Perassolo. Cognition, oxidative stress and vitamin B12 levels evaluation on patients under long-term omeprazole use.
The Journal of pharmacy and pharmacology.
2022 Apr; 74(4):547-555. doi:
10.1093/jpp/rgab001. [PMID: 33793790] - C Zeng, T Neogi, A T Chan, J Wei, D Misra, N Lu, H K Choi, G Lei, Y Zhang. Proton pump inhibitor therapy and risk of knee replacement surgery: a general population-based cohort study.
Osteoarthritis and cartilage.
2022 04; 30(4):559-569. doi:
10.1016/j.joca.2021.12.010. [PMID: 35031493] - Amira Hussain, Declan P Naughton, James Barker. Potential Effects of Ibuprofen, Remdesivir and Omeprazole on Dexamethasone Metabolism in Control Sprague Dawley Male Rat Liver Microsomes (Drugs Often Used Together Alongside COVID-19 Treatment).
Molecules (Basel, Switzerland).
2022 Mar; 27(7):. doi:
10.3390/molecules27072238. [PMID: 35408639] - Choki Dorji, Farruk Ahammed Robin, Kesara Na-Bangchang. Omeprazole-induced galactorrhea in kidney transplant patients-a case report.
Journal of medical case reports.
2022 Mar; 16(1):121. doi:
10.1186/s13256-022-03337-3. [PMID: 35339194] - Yan Zhang, Yiping Yu, Hong Li, Wenge Huang, Ping Wang. Effects of Citri Reticulatae Pericarpium and grapefruit juice on the pharmacokinetics of omeprazole in rats.
Journal of food biochemistry.
2022 03; 46(3):e13804. doi:
10.1111/jfbc.13804. [PMID: 34080214] - Lujing Wang, Yang Chen, Wangda Zhou, Xin Miao, Honghui Zhou. Utilization of physiologically-based pharmacokinetic model to assess disease-mediated therapeutic protein-disease-drug interaction in immune-mediated inflammatory diseases.
Clinical and translational science.
2022 02; 15(2):464-476. doi:
10.1111/cts.13164. [PMID: 34581012] - Stephan Schaller, Frederico S Martins, Pavel Balazki, Sonja Böhm, Joachim Baumgart, Ralf A Hilger, Dietrich W Beelen, Claudia Hemmelmann, Arne Ring. Evaluation of the drug-drug interaction potential of treosulfan using a physiologically-based pharmacokinetic modelling approach.
British journal of clinical pharmacology.
2022 02; 88(4):1722-1734. doi:
10.1111/bcp.15081. [PMID: 34519068] - Zhelong Liu, Jian Xiong, Song Gao, Michael X Zhu, Kai Sun, Min Li, Guohua Zhang, Yi-Ping Li. Ameliorating cancer cachexia by inhibiting cancer cell release of Hsp70 and Hsp90 with omeprazole.
Journal of cachexia, sarcopenia and muscle.
2022 02; 13(1):636-647. doi:
10.1002/jcsm.12851. [PMID: 34729960] - Ashit Trivedi, Winnie Sohn, Pegah Jafarinasabian, Hanze Zhang, Bianca Terminello, Stephen Flach, Siddique Abbasi, Sandeep Dutta, Edward Lee. Pharmacokinetic Drug-Drug Interaction Study of Omecamtiv Mecarbil With Omeprazole, a Proton Pump Inhibitor, in Healthy Subjects.
Clinical pharmacology in drug development.
2022 01; 11(1):129-133. doi:
10.1002/cpdd.997. [PMID: 34272833] - Camille Lenoir, Amine Niederer, Victoria Rollason, Jules Alexandre Desmeules, Youssef Daali, Caroline Flora Samer. Prediction of cytochromes P450 3A and 2C19 modulation by both inflammation and drug interactions using physiologically based pharmacokinetics.
CPT: pharmacometrics & systems pharmacology.
2022 01; 11(1):30-43. doi:
10.1002/psp4.12730. [PMID: 34791831] - Wenying Hao, Longfan Piao, Maojie Sun, Fanzhuo Zeng. Clinical effect of combination of octreotide and omeprazole in children with acute upper gastrointestinal bleeding and the levels of serum creatinine and serum urea nitrogen.
Pakistan journal of pharmaceutical sciences.
2022 Jan; 35(1(Special)):343-347. doi:
NULL. [PMID: 35236645] - Antonio Portolés-Pérez, Ana Belén Rivas Paterna, Andrés Sánchez Pernaute, Antonio José Torres García, Carmen Moreno Lopera, Luis M Chicharro, Fernando Bandrés, Amanda López-Picado, Miguel A Rubio, Emilio Vargas Castrillón. Effect of Obesity and Roux-En-Y Gastric Surgery on Omeprazole Pharmacokinetics.
Obesity facts.
2022; 15(2):271-280. doi:
10.1159/000521570. [PMID: 34979510] - Serafino Fazio, Paolo Bellavite, Elisabetta Zanolin, Peter A McCullough, Sergio Pandolfi, Flora Affuso. Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis of Early COVID-19 and Treated at Home Within 3 Days or After 3 Days of Symptom Onset with Prescribed and Non-Prescribed Treatments Between November 2020 and August 2021.
Medical science monitor : international medical journal of experimental and clinical research.
2021 Dec; 27(?):e935379. doi:
10.12659/msm.935379. [PMID: 34966165] - Ahmed El-Olemy, Ahmed H Abdelazim, Sherif Ramzy, Mohamed A Hasan, Ahmed W Madkour, Ahmed A Almrasy, Mohamed Shahin. Application of different spectrofluorimetric approaches for quantitative determination of acetylsalicylic acid and omeprazole in recently approved pharmaceutical preparation and human plasma.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2021 Dec; 262(?):120116. doi:
10.1016/j.saa.2021.120116. [PMID: 34217146] - Fabio Bachmann, Urs Duthaler, Stephan Krähenbühl. Effect of deglucuronidation on the results of the Basel phenotyping cocktail.
British journal of clinical pharmacology.
2021 12; 87(12):4608-4618. doi:
10.1111/bcp.14874. [PMID: 33890704] - Joo Young Na, Inseung Jeon, Jangsoo Yoon, Yewon Choi, Seo Hyun Yoon, Kyung-Sang Yu, Jae-Yong Chung. Influence of CYP2C19 Polymorphisms on the Pharmacokinetics of Omeprazole in Elderly Subjects.
Clinical pharmacology in drug development.
2021 12; 10(12):1469-1477. doi:
10.1002/cpdd.966. [PMID: 34337876] - Ashley Spencer, Jessica M Quimby, Josh M Price, Sally MacLane, Shanna Hillsman, Patty Secoura, Jörg M Steiner, M Katherine Tolbert. Appetite-stimulating effects of once-daily omeprazole in cats with chronic kidney disease: Double-blind, placebo-controlled, randomized, crossover trial.
Journal of veterinary internal medicine.
2021 Nov; 35(6):2705-2712. doi:
10.1111/jvim.16268. [PMID: 34590746] - Bruna Barbosa da Luz, Daniele Maria-Ferreira, Jorge Luiz Dallazen, Ana Flávia de Oliveira, José Ederaldo Queiroz Telles, Olair Carlos Beltrame, Thales Ricardo Cipriani, Maria Fernanda de Paula Werner. Effectiveness of the polyphenols-rich Sedum dendroideum infusion on gastric ulcer healing in rats: Roles of protective endogenous factors and antioxidant and anti-inflammatory mechanisms.
Journal of ethnopharmacology.
2021 Oct; 278(?):114260. doi:
10.1016/j.jep.2021.114260. [PMID: 34062247] - Smit S Deliwala, Grigoriy E Gurvits. Acute Esophageal Necrosis in a Patient With COVID-19.
The American journal of gastroenterology.
2021 10; 116(10):1977. doi:
10.14309/ajg.0000000000001207. [PMID: 33661144] - Mohamed I Zanaty, Adel Abdel-Moneim, Yoichiro Kitani, Toshio Sekiguchi, Nobuo Suzuki. Effect of Omeprazole on Osteoblasts and Osteoclasts in vivo and in the in vitro Model Using Fish Scales.
Biochemistry. Biokhimiia.
2021 Oct; 86(10):1192-1200. doi:
10.1134/s0006297921100035. [PMID: 34903151] - Koki Kato, Tomohiro Mizuno, Takenao Koseki, Yoshimasa Ito, Masakazu Hatano, Kazuo Takahashi, Shigeki Yamada, Naotake Tsuboi. Concomitant Proton Pump Inhibitors and Immune Checkpoint Inhibitors Increase Nephritis Frequency.
In vivo (Athens, Greece).
2021 Sep; 35(5):2831-2840. doi:
10.21873/invivo.12570. [PMID: 34410975] - Keiji Tanimoto, Kiichi Hirota, Takahiro Fukazawa, Yoshiyuki Matsuo, Toshihito Nomura, Nazmul Tanuza, Nobuyuki Hirohashi, Hidemasa Bono, Takemasa Sakaguchi. Inhibiting SARS-CoV-2 infection in vitro by suppressing its receptor, angiotensin-converting enzyme 2, via aryl-hydrocarbon receptor signal.
Scientific reports.
2021 08; 11(1):16629. doi:
10.1038/s41598-021-96109-w. [PMID: 34404832] - Srinivasan Damodharan, Gerard Marshall Raj, M Sakthibalan, Karthikeyan Dakshinamoorthy, P Muraliswaran. Effect of long-term acid suppression therapy with proton pump inhibitors or H2 receptor blockers on serum vitamin B12 levels in elderly population.
Irish journal of medical science.
2021 Aug; 190(3):1213-1217. doi:
10.1007/s11845-020-02399-w. [PMID: 33085017] - Xiaoshu Dai, Michael D Karol, Matthew Hitron, Marjie L Hard, Matthew T Goulet, Colleen F McLaughlin, Scott J Brantley. Napabucasin Drug-Drug Interaction Potential, Safety, Tolerability, and Pharmacokinetics Following Oral Dosing in Healthy Adult Volunteers.
Clinical pharmacology in drug development.
2021 08; 10(8):824-839. doi:
10.1002/cpdd.961. [PMID: 34107166] - Theodore W Perry. Abrupt-onset, profound erectile dysfunction in a healthy young man after initiating over-the-counter omeprazole: a case report.
Journal of medical case reports.
2021 Jul; 15(1):360. doi:
10.1186/s13256-021-02981-5. [PMID: 34301322] - Jiaqi Zhang, Hui Che, Beihua Zhang, Chang Zhang, Bin Zhou, Haijie Ji, Jingyi Xie, Xiaoshuang Shi, Xia Li, Fengyun Wang, Xudong Tang. JianpiQinghua granule reduced PPI dosage in patients with nonerosive reflux disease: A multicenter, randomized, double-blind, double-dummy, noninferiority study.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 Jul; 88(?):153584. doi:
10.1016/j.phymed.2021.153584. [PMID: 34119741] - Luis Francisco Calleja, Belem Yoval-Sánchez, Luz Hernández-Esquivel, Juan Carlos Gallardo-Pérez, Marcela Sosa-Garrocho, Álvaro Marín-Hernández, Ricardo Jasso-Chávez, Marina Macías-Silva, José Salud Rodríguez-Zavala. Activation of ALDH1A1 by omeprazole reduces cell oxidative stress damage.
The FEBS journal.
2021 07; 288(13):4064-4080. doi:
10.1111/febs.15698. [PMID: 33400378] - Lei Li, Yu-Xia Xiang, Guo-Ping Yang, Xing-Fei Zhang, Xiao-Yan Yang, Shuang Yang, Jie Huang. Pharmacokinetic effects of proton pump inhibitors on the novel PARP inhibitor fluzoparib: a single-arm, fixed-sequence trial in male healthy volunteers.
Investigational new drugs.
2021 06; 39(3):796-802. doi:
10.1007/s10637-020-01034-w. [PMID: 33420642] - Porfirio Alonso Ruiz-Hurtado, Leticia Garduño-Siciliano, Pilar Dominguez-Verano, Elizdath Martinez-Galero, Maria Margarita Canales-Martinez, Marco Aurelio Rodriguez-Monroy. Evaluation of the gastroprotective effects of Chihuahua propolis on indomethacin- induced gastric ulcers in mouse.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 May; 137(?):111345. doi:
10.1016/j.biopha.2021.111345. [PMID: 33556873] - Cheng Xie, Langhui Liu, Suyou Zhu, Mingquan Wei. Effectiveness and safety of Chinese medicine combined with omeprazole in the treatment of gastric ulcer: A protocol for systematic review and meta-analysis.
Medicine.
2021 Apr; 100(17):e25744. doi:
10.1097/md.0000000000025744. [PMID: 33907169] - Daniela Lopes-de-Campos, Catarina Pereira-Leite, Philippe Fontaine, Ana Coutinho, Manuel Prieto, Bruno Sarmento, Sven Jakobtorweihen, Cláudia Nunes, Salette Reis. Interface-Mediated Mechanism of Action-The Root of the Cytoprotective Effect of Immediate-Release Omeprazole.
Journal of medicinal chemistry.
2021 04; 64(8):5171-5184. doi:
10.1021/acs.jmedchem.1c00251. [PMID: 33847502] - Samet Tekin, Serkan Dundar, Fatih Demirci, Alihan Bozoglan, Tuba Talo Yildirim, Nedim Gunes, Izzet Acikan, Erhan Cahit Ozcan. Biomechanical and biochemical evaluation of the effect of systemic application of omeprazole on the osseointegration of titanium implants.
International journal of implant dentistry.
2021 04; 7(1):27. doi:
10.1186/s40729-021-00310-5. [PMID: 33843027] - Jing Zhang, Panya Diao, Lin Zhang. Intravenous versus oral omeprazole on patients with high risk bleeding peptic ulcers: A prospective randomized clinical trial protocol.
Medicine.
2021 Apr; 100(14):e25136. doi:
10.1097/md.0000000000025136. [PMID: 33832076] - John Mach, XiaoSuo Wang, Sarah N Hilmer. Quantification of serum levels in mice of seven drugs (and six metabolites) commonly taken by older people with polypharmacy.
Fundamental & clinical pharmacology.
2021 Apr; 35(2):410-422. doi:
10.1111/fcp.12602. [PMID: 32813878] - Naghmeh Ghasemkhani, Aidin Shojaee Tabrizi, Fatemeh Namazi, Saeed Nazifi. Treatment effects of Shilajit on aspirin-induced gastric lesions in rats.
Physiological reports.
2021 04; 9(7):e14822. doi:
10.14814/phy2.14822. [PMID: 33818003] - Shogo Matsumoto, Shotaro Uehara, Hidetaka Kamimura, Hiroshi Ikeda, Satoshi Maeda, Machiko Hattori, Megumi Nishiwaki, Kazuhiko Kato, Hiroshi Yamazaki. Human total clearance values and volumes of distribution of typical human cytochrome P450 2C9/19 substrates predicted by single-species allometric scaling using pharmacokinetic data sets from common marmosets genotyped for P450 2C19.
Xenobiotica; the fate of foreign compounds in biological systems.
2021 Apr; 51(4):479-493. doi:
10.1080/00498254.2020.1871113. [PMID: 33455494] - Domagoj Segregur, James Mann, Andrea Moir, Eva M Karlsson, Jennifer Dressman. Prediction of plasma profiles of a weakly basic drug after administration of omeprazole using PBPK modeling.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2021 Mar; 158(?):105656. doi:
10.1016/j.ejps.2020.105656. [PMID: 33253885] - Cengiz Güney, Kübra Açıkalın Coşkun, Yusuf Tutar. ATPase inhibition by omeprazole reveals role of heat shock proteins on testicular torsion.
Andrologia.
2021 Mar; 53(2):e13929. doi:
10.1111/and.13929. [PMID: 33368442] - Megan Ricord, Frank M Andrews, Francisco J M Yñiguez, Michael Keowen, Frank Garza, Linda Paul, Ann Chapman, Heidi E Banse. Impact of concurrent treatment with omeprazole on phenylbutazone-induced equine gastric ulcer syndrome (EGUS).
Equine veterinary journal.
2021 Mar; 53(2):356-363. doi:
10.1111/evj.13323. [PMID: 32697849] - Ewa Wronska, Marcin Polkowski, Janina Orlowska, Andrzej Mroz, Paulina Wieszczy, Jaroslaw Regula. Argon plasma coagulation for Barrett's esophagus with low-grade dysplasia: a randomized trial with long-term follow-up on the impact of power setting and proton pump inhibitor dose.
Endoscopy.
2021 Feb; 53(2):123-132. doi:
10.1055/a-1203-5930. [PMID: 32650347] - Jessica C Wise, Kristopher J Hughes, Scott Edwards, Glenn A Jacobson, Christian K Narkowicz, Sharanne L Raidal. Pharmacokinetic and pharmacodynamic effects of 2 registered omeprazole preparations and varying dose rates in horses.
Journal of veterinary internal medicine.
2021 Jan; 35(1):620-631. doi:
10.1111/jvim.15971. [PMID: 33340169] - Motoyasu Miura, Shimako Tanaka, Shinya Uchida, Chiaki Kamiya, Naoki Katayama, Akio Hakamata, Keiichi Odagiri, Naoki Inui, Junichi Kawakami, Hiroshi Watanabe, Noriyuki Namiki. Prediction of the Area under the Curve Using Limited-Point Blood Sampling in a Cocktail Study to Assess Multiple CYP Activities.
Biological & pharmaceutical bulletin.
2021; 44(6):762-770. doi:
10.1248/bpb.b20-00691. [PMID: 34078808] - Yu Zhang, Jiaming Zhang, Qiuchi Xu, Yimeng Wang, Wenying Wu, Weiping Wang, Xiaoting Li, Tianhong Zhang. Simultaneous Determination of Loratadine and Its Metabolite Desloratadine in Beagle Plasma by LC-MS/MS and Application for Pharmacokinetics Study of Loratadine Tablets and Omeprazole‑Induced Drug-Drug Interaction.
Drug design, development and therapy.
2021; 15(?):5109-5122. doi:
10.2147/dddt.s328106. [PMID: 34992347] - Aditya A Joshi, Pankaj P Nerkar. Determination of Proton Pump Inhibitors by Spectrophotometric, Chromatographic and by Hyphenated Techniques: A Review.
Critical reviews in analytical chemistry.
2021; 51(6):527-548. doi:
10.1080/10408347.2020.1750339. [PMID: 32312104] - Siriporn Chamniansawat, Nattida Kampuang, Nasisorn Suksridechacin, Narongrit Thongon. Ultrastructural intestinal mucosa change after prolonged inhibition of gastric acid secretion by omeprazole in male rats.
Anatomical science international.
2021 Jan; 96(1):142-156. doi:
10.1007/s12565-020-00572-w. [PMID: 32931001] - Qin Tan, Yanding Gao, Pin Zhang, Yan Huo, Yihan Lu, Weifeng Huang. Comparison of Outcomes in Patients with Obesity Between Two Administration Routes of Omeprazole After Laparoscopic Sleeve Gastrectomy: An Open-Label Randomized Clinical Trial.
Drug design, development and therapy.
2021; 15(?):1569-1576. doi:
10.2147/dddt.s297360. [PMID: 33883880] - Magdalena Gómez-Mateos, Francisco Arrebola, María Concepción Navarro, María Carmen Romero, José María González, Adela Valero. Acute Anisakiasis: Pharmacological Evaluation of Various Drugs in an Animal Model.
Digestive diseases and sciences.
2021 01; 66(1):105-113. doi:
10.1007/s10620-020-06144-2. [PMID: 32107679] - Oday T Ali, Wafaa S Hassan, Ahdab N Khayyat, Ahmad J Almalki, Mahmoud M Sebaiy. HPLC Determination of Imidazoles with Variant Anti-Infective Activity in Their Dosage Forms and Human Plasma.
Molecules (Basel, Switzerland).
2020 Dec; 26(1):. doi:
10.3390/molecules26010129. [PMID: 33396585] - Tsutomu Shimada, Mai Okano, Momoko Yamada, Yuki Ogawa, Arimi Ueda, Katsuhiko Nagase, Yoshimichi Sai. Administration of erlotinib in apple juice overcomes decreased absorption in a rat model of gastric acid suppression.
Drug metabolism and pharmacokinetics.
2020 Dec; 35(6):534-538. doi:
10.1016/j.dmpk.2020.08.003. [PMID: 33028492] - Noha A El-Boghdady, Maher A Kamel, Rouaina M El-Shamy. Omeprazole and Spirulina Platensis Ameliorate Steatohepatitis in Experimental Nonalcoholic Fatty Liver Disease.
Metabolic syndrome and related disorders.
2020 11; 18(9):426-434. doi:
10.1089/met.2019.0129. [PMID: 32795119] - Kiran Mashaal, Rehana Perveen, Zubia Zia, Syed Muhammad Mahmood, Khurram Minhas, Sadaf Ibrahim, Syed Naim Ul Hasan Naqvi, Hira Naeem. Histopathological effects on stomach, liver and kidney associated with Cedrus deodara root oil in ulcer induced rats (Wistar strain).
Pakistan journal of pharmaceutical sciences.
2020 Nov; 33(6):2483-2488. doi:
NULL. [PMID: 33867320] - Simona Cerri, Bernard Taminiau, Alexandra Hache-Carré de Lusancay, Laureline Lecoq, Hélène Amory, Georges Daube, Carla Cesarini. Effect of oral administration of omeprazole on the microbiota of the gastric glandular mucosa and feces of healthy horses.
Journal of veterinary internal medicine.
2020 Nov; 34(6):2727-2737. doi:
10.1111/jvim.15937. [PMID: 33063923] - Yaowei Zhu, Yan Xu, Yanli Zhuang, Alexa Piantone, Cathye Shu, Dion Chen, Honghui Zhou, Zhenhua Xu, Amarnath Sharma. Evaluating Potential Disease-Mediated Protein-Drug Interactions in Patients With Moderate-to-Severe Plaque Psoriasis Receiving Subcutaneous Guselkumab.
Clinical and translational science.
2020 11; 13(6):1217-1226. doi:
10.1111/cts.12807. [PMID: 32407591] - J J Mai, H Zhang, Y Y Peng, X Yang, L Mao, L Luo, H M Xie, Y J Zhang, X J Li, Y H Ding. [Evaluation of drug-drug interactions between yimitasvir phosphate capsules with sofosbuvir tablets, omeprazole magnesium enteric-coated tablets, and rosuvastatin calcium tablets].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.
2020 Oct; 28(10):838-843. doi:
10.3760/cma.j.cn501113-20200907-00503. [PMID: 33105928] - Qien He, Guanghui Ying, Xiapei Fei, Chenqin Zha, Zhaogui Chen, Yishu Bao, Jiaorong Long, Zhujun Wang, Xuelin He, Min Xia. Drug rash with eosinophilia and systemic symptoms and severe renal injury induced by proton pump inhibitor therapy: A case report.
Medicine.
2020 Oct; 99(42):e22509. doi:
10.1097/md.0000000000022509. [PMID: 33080685] - Peiyu Chen, Linkai Li, Hongli Wang, Junhong Zhao, Yang Cheng, Jing Xie, Meiwan Cao, Ling Huang, Fangying Yang, Huan Chen, Jiayu Chen, Mingmin Su, Yuxin Xu, Fengfeng Zheng, Lanlan Geng, Wanfu Xu, Sitang Gong. Omeprazole, an inhibitor of proton pump, suppresses De novo lipogenesis in gastric epithelial cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Oct; 130(?):110472. doi:
10.1016/j.biopha.2020.110472. [PMID: 32738635] - Khaled A Shibany, Stefanie L Pratt, Mohammed Aldurdunji, Sabine Totemeyer, Stuart W Paine. Prediction of pharmacokinetic clearance and potential Drug-Drug interactions for omeprazole in the horse using in vitro systems.
Xenobiotica; the fate of foreign compounds in biological systems.
2020 Oct; 50(10):1220-1227. doi:
10.1080/00498254.2020.1764131. [PMID: 32369392] - Petra Bestebreurtje, Barbara A E de Koning, Nel Roeleveld, Catherijne A J Knibbe, Dick Tibboel, Bianca van Groen, Cees P van de Ven, Frans B Plötz, Saskia N de Wildt. Rectal Omeprazole in Infants With Gastroesophageal Reflux Disease: A Randomized Pilot Trial.
European journal of drug metabolism and pharmacokinetics.
2020 Oct; 45(5):635-643. doi:
10.1007/s13318-020-00630-8. [PMID: 32594305] - Susan M Jones, Ann Gaier, Hiroko Enomoto, Patricia Ishii, Rachel Pilla, Josh Price, Jan Suchodolski, Joerg M Steiner, Mark G Papich, Kristen Messenger, M Katherine Tolbert. The effect of combined carprofen and omeprazole administration on gastrointestinal permeability and inflammation in dogs.
Journal of veterinary internal medicine.
2020 Sep; 34(5):1886-1893. doi:
10.1111/jvim.15897. [PMID: 32893926] - Alan K Jarmusch, Alison Vrbanac, Jeremiah D Momper, Joseph D Ma, Maher Alhaja, Marlon Liyanage, Rob Knight, Pieter C Dorrestein, Shirley M Tsunoda. Enhanced Characterization of Drug Metabolism and the Influence of the Intestinal Microbiome: A Pharmacokinetic, Microbiome, and Untargeted Metabolomics Study.
Clinical and translational science.
2020 09; 13(5):972-984. doi:
10.1111/cts.12785. [PMID: 32216086] - Sophie Jang, Benjamin Lebwohl, Julian A Abrams, Peter H R Green, Daniel E Freedberg, Armin Alaedini. Celiac disease serology and gut microbiome following proton pump inhibitor treatment.
Medicine.
2020 08; 99(35):e21488. doi:
10.1097/md.0000000000021488. [PMID: 32871870] - Lu Xie, Yi-Lin Guo, Yu-Rou Chen, Li-Ying Zhang, Zhi-Cheng Wang, Tong Zhang, Bing Wang. A potential drug combination of omeprazole and patchouli alcohol significantly normalizes oxidative stress and inflammatory responses against gastric ulcer in ethanol-induced rat model.
International immunopharmacology.
2020 Aug; 85(?):106660. doi:
10.1016/j.intimp.2020.106660. [PMID: 32559721] - Sara Blanco Dorado, Olalla Maroñas Amigo, Ana Latorre-Pellicer, María Teresa Rodríguez Jato, Ana López-Vizcaíno, Aurea Gómez Márquez, Belén Bardán García, Dolores Belles Medall, Gema Barbeito Castiñeiras, María Luisa Pérez Del Molino Bernal, Manuel Campos-Toimil, Francisco Otero Espinar, Andrés Blanco Hortas, Irene Zarra Ferro, Ángel Carracedo, María Jesús Lamas, Anxo Fernández-Ferreiro. A multicentre prospective study evaluating the impact of proton-pump inhibitors omeprazole and pantoprazole on voriconazole plasma concentrations.
British journal of clinical pharmacology.
2020 08; 86(8):1661-1666. doi:
10.1111/bcp.14267. [PMID: 32110830] - Lu-Ning Sun, Ye Zhang, Yu-Qing Yang, Ye Shen, Yu-Wen Ying, Yu-Wen Su, Xue-Hui Zhang, Yun Liu, Xu Huang, Yong-Qing Wang. Simultaneous enantioselective determination of omeprazole, rabeprazole, lansoprazole, and pantoprazole enantiomers in human plasma by chiral liquid chromatography-tandem mass spectrometry.
Journal of separation science.
2020 Aug; 43(16):3183-3196. doi:
10.1002/jssc.202000226. [PMID: 32495501] - Dolores Ochoa, Manuel Román, Teresa Cabaleiro, Miriam Saiz-Rodríguez, Gina Mejía, Francisco Abad-Santos. Effect of food on the pharmacokinetics of omeprazole, pantoprazole and rabeprazole.
BMC pharmacology & toxicology.
2020 07; 21(1):54. doi:
10.1186/s40360-020-00433-2. [PMID: 32711578] - Naohi Isse, Masashi Hashimoto. Omeprazole-induced hypomagnesaemia, causing renal tubular acidosis with hypokalaemia, hypocalcaemia, hyperlactacidaemia and hyperammonaemia.
BMJ case reports.
2020 Jul; 13(7):. doi:
10.1136/bcr-2020-235385. [PMID: 32641306] - Jessica M Sanches-Lopes, Graziele C Ferreira, Lucas C Pinheiro, Rafael Kemp, Jose E Tanus-Santos. Consistent gastric pH-dependent effects of suppressors of gastric acid secretion on the antihypertensive responses to oral nitrite.
Biochemical pharmacology.
2020 07; 177(?):113940. doi:
10.1016/j.bcp.2020.113940. [PMID: 32224135] - Huan Gao, Xiangfeng Wang, Xiaoyu Qu, Jinghui Zhai, Lina Tao, Yueming Zhang, Yanqing Song, Wenrui Zhang. Omeprazole attenuates cisplatin-induced kidney injury through suppression of the TLR4/NF-κB/NLRP3 signaling pathway.
Toxicology.
2020 07; 440(?):152487. doi:
10.1016/j.tox.2020.152487. [PMID: 32418911] - Ken Ogasawara, Patricia M LoRusso, Anthony J Olszanski, Olivier Rixe, Christine Xu, Jian Yin, Maria Palmisano, Gopal Krishna. Assessment of effects of repeated oral doses of fedratinib on inhibition of cytochrome P450 activities in patients with solid tumors using a cocktail approach.
Cancer chemotherapy and pharmacology.
2020 07; 86(1):87-95. doi:
10.1007/s00280-020-04102-3. [PMID: 32537715] - Isabel J B van der Zalm, Tom J M Tobé, Susan J J Logtenberg. Omeprazole-induced and pantoprazole-induced asymptomatic hyponatremia: a case report.
Journal of medical case reports.
2020 Jun; 14(1):83. doi:
10.1186/s13256-020-02423-8. [PMID: 32594911] - Se-Eun Kim, Azra Memon, Bae Yong Kim, Hyelin Jeon, Woon Kyu Lee, Se Chan Kang. Gastroprotective effect of phytoncide extract from Pinus koraiensis pinecone in Helicobacter pylori infection.
Scientific reports.
2020 06; 10(1):9547. doi:
10.1038/s41598-020-66603-8. [PMID: 32533032] - Qi Huang, Qiong Liu, Tao Yin, Lin Hu, Hanjun Ding, Shao Liu, Yueping Jiang. Effect of proton pump inhibitors on voriconazole concentrations in Chinese patients with malignant hematological diseases.
European journal of clinical pharmacology.
2020 Jun; 76(6):833-842. doi:
10.1007/s00228-020-02841-z. [PMID: 32157329] - Nan Hu, Jing Ling, Lulu Dong, Yan Jiang, Qi Zhou, Sulan Zou. Pharmacokinetics of omeprazole in rats with dextran sulfate sodium-induced ulcerative colitis.
Drug metabolism and pharmacokinetics.
2020 Jun; 35(3):297-303. doi:
10.1016/j.dmpk.2020.02.002. [PMID: 32354532] - Miguel Fontecha-Barriuso, Diego Martín-Sanchez, Julio M Martinez-Moreno, Daniela Cardenas-Villacres, Susana Carrasco, Maria D Sanchez-Niño, Marta Ruiz-Ortega, Alberto Ortiz, Ana B Sanz. Molecular pathways driving omeprazole nephrotoxicity.
Redox biology.
2020 05; 32(?):101464. doi:
10.1016/j.redox.2020.101464. [PMID: 32092686] - Martin Schnierer, Matej Samoš, Tomáš Bolek, Ingrid Škorňová, Lenka Nosáková, Peter Bánovčin, Peter Galajda, Ján Stasko, Peter Kubisz, Rudolf Hyrdel, Marián Mokáň. The Effect of Proton Pump Inhibitor Withdrawal on Dabigatran Etexilate Plasma Levels in Patients With Atrial Fibrillation: A Washout Study.
Journal of cardiovascular pharmacology.
2020 04; 75(4):333-335. doi:
10.1097/fjc.0000000000000791. [PMID: 31895873] - Nasisorn Suksridechacin, Punnisa Kulwong, Siriporn Chamniansawat, Narongrit Thongon. Effect of prolonged omeprazole administration on segmental intestinal Mg2+ absorption in male Sprague-Dawley rats.
World journal of gastroenterology.
2020 Mar; 26(11):1142-1155. doi:
10.3748/wjg.v26.i11.1142. [PMID: 32231419] - Eman Mostafa Hamed, Mohamed Hussein Meabed, Raghda R S Hussein, Usama Farghaly Aly. Recent insight on improving the iron chelation efficacy of deferasirox by adjuvant therapy in transfusion dependent beta thalassemia children with sluggish response.
Expert opinion on drug metabolism & toxicology.
2020 Mar; 16(3):179-193. doi:
10.1080/17425255.2020.1729353. [PMID: 32067512] - Shane K Eagles, Xiaosuo Wang, Annette S Gross, Andrew J McLachlan. An improved cytochrome P450 phenotyping cocktail with a simplified and highly sensitive UHPLC-MS/MS assay in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 Mar; 1140(?):122013. doi:
10.1016/j.jchromb.2020.122013. [PMID: 32050158] - Joe D Pagan, Laura Petroski-Rose, Alana Mann, Ashlee Hauss. Omeprazole Reduces Calcium Digestibility in Thoroughbred Horses.
Journal of equine veterinary science.
2020 03; 86(?):102851. doi:
10.1016/j.jevs.2019.102851. [PMID: 32067660] - Fernanda A Goncalves, Jessica Santos de Jesus, Lilian Cordeiro, Maria Clara T Piraciaba, Luiza K R P de Araujo, Carolina Steller Wagner Martins, Maria Aparecida Dalboni, Benedito J Pereira, Bruno C Silva, Rosa Maria A Moysés, Hugo Abensur, Rosilene M Elias. Hypokalemia and hyperkalemia in patients on peritoneal dialysis: incidence and associated factors.
International urology and nephrology.
2020 Feb; 52(2):393-398. doi:
10.1007/s11255-020-02385-2. [PMID: 32016907]