Lysine acetylsalicylate (BioDeep_00000859188)
代谢物信息卡片
Lysine acetylsalicylate
化学式: C15H22N2O6 (326.1478)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)OC1=CC=CC=C1C(=O)[O-].C(CC[NH3+])CC(C(=O)O)N
InChI: 5H,1-4,7-8H2,(H,9,10)
描述信息
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
D000893 - Anti-Inflammatory Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D012459 - Salicylates
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78275 - Agent Affecting Blood or Body Fluid > C263 - Anticoagulant Agent
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
D002491 - Central Nervous System Agents > D000700 - Analgesics
D004791 - Enzyme Inhibitors
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Lucyna Mastalerz, Rafał Januszek, Marek Kaszuba, Krzysztof Wójcik, Natalia Celejewska-Wójcik, Anna Gielicz, Hanna Plutecka, Krzysztof Oleś, Paweł Stręk, Marek Sanak. Aspirin provocation increases 8-iso-PGE2 in exhaled breath condensate of aspirin-hypersensitive asthmatics.
Prostaglandins & other lipid mediators.
2015 Sep; 121(Pt B):163-9. doi:
10.1016/j.prostaglandins.2015.07.001. [PMID: 26209241] - Eyram Yoan Amekoudi, Kossi Akomola Sabi, Befa Noto Kadou Kaza. [Profound anemia, hemoglobinuria ... where to stop in the etiological investigation?].
Nephrologie & therapeutique.
2014 Feb; 10(1):58-9. doi:
10.1016/j.nephro.2013.07.001. [PMID: 23978630] - Wei-Dong Huang, Jie-Zan Wang, Yuan-Qiang Lu, Ya-Min DI, Jiu-Kun Jiang, Qin Zhang. Lysine acetylsalicylate ameliorates lung injury in rats acutely exposed to paraquat.
Chinese medical journal.
2011 Aug; 124(16):2496-501. doi:
NULL. [PMID: 21933594] - R J Dinis-Oliveira, H Pontes, M L Bastos, F Remião, J A Duarte, F Carvalho. An effective antidote for paraquat poisonings: the treatment with lysine acetylsalicylate.
Toxicology.
2009 Jan; 255(3):187-93. doi:
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Transplantation proceedings.
2008 May; 40(4):971-3. doi:
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The Journal of allergy and clinical immunology.
2008 Feb; 121(2):348-54. doi:
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European annals of allergy and clinical immunology.
2007 May; 39(5):162-6. doi:
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The Journal of pharmacology and experimental therapeutics.
2003 May; 305(2):755-64. doi:
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European journal of drug metabolism and pharmacokinetics.
2003 Apr; 28(2):125-8. doi:
10.1007/bf03190500. [PMID: 12877570] - C Raschka, H J Koch. [Pharmacokinetics after oral and intravenous administration of d,l-monolysine acetylsalicylate and an oral dose of acetylsalicylic acid in healthy volunteers].
Therapie.
2001 Nov; 56(6):669-74. doi:
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Clinical cardiology.
2000 Sep; 23(9):697-700. doi:
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The European respiratory journal.
2000 May; 15(5):863-9. doi:
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Journal of veterinary pharmacology and therapeutics.
2000 Apr; 23(2):73-9. doi:
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1998 Jul; 23(3):383-9. doi:
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The Journal of pharmacy and pharmacology.
1998 May; 50(5):565-6. doi:
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Hypertension research : official journal of the Japanese Society of Hypertension.
1997 Mar; 20(1):29-34. doi:
10.1291/hypres.20.29. [PMID: 9101310] - K S al-Sahlawi, O M Tawfik. Comparative study of the efficacy of lysine acetylsalicylate, indomethacin and pethidine in acute renal colic.
European journal of emergency medicine : official journal of the European Society for Emergency Medicine.
1996 Sep; 3(3):183-6. doi:
10.1097/00063110-199609000-00008. [PMID: 9023498] - S O'Sullivan, B Dahlén, S E Dahlén, M Kumlin. Increased urinary excretion of the prostaglandin D2 metabolite 9 alpha, 11 beta-prostaglandin F2 after aspirin challenge supports mast cell activation in aspirin-induced airway obstruction.
The Journal of allergy and clinical immunology.
1996 Aug; 98(2):421-32. doi:
10.1016/s0091-6749(96)70167-7. [PMID: 8757220] - P Sestini, L Armetti, G Gambaro, M G Pieroni, R M Refini, A Sala, A Vaghi, G C Folco, S Bianco, M Robuschi. Inhaled PGE2 prevents aspirin-induced bronchoconstriction and urinary LTE4 excretion in aspirin-sensitive asthma.
American journal of respiratory and critical care medicine.
1996 Feb; 153(2):572-5. doi:
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Transplantation proceedings.
1996 Feb; 28(1):312-3. doi:
NULL. [PMID: 8644237] - G D'Abrigeon, P Blanc, L Durand, D Larrey, H Michel. [Liver cirrhosis and granulomatous hepatitis after prolonged ingestion of lysine acetylsalicylate].
Gastroenterologie clinique et biologique.
1995 Nov; 19(11):944-7. doi:
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Hepatology (Baltimore, Md.).
1995 Sep; 22(3):915-20. doi:
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Japanese journal of pharmacology.
1994 Dec; 66(4):457-64. doi:
10.1254/jjp.66.457. [PMID: 7723223] - K Sladek, R Dworski, J Soja, J R Sheller, E Nizankowska, J A Oates, A Szczeklik. Eicosanoids in bronchoalveolar lavage fluid of aspirin-intolerant patients with asthma after aspirin challenge.
American journal of respiratory and critical care medicine.
1994 Apr; 149(4 Pt 1):940-6. doi:
10.1164/ajrccm.149.4.8143059. [PMID: 8143059] - J Bernhardt, K Rogalla, T F Lüscher, F R Bühler, T J Resink. Acetylsalicylic acid, at high concentrations, inhibits vascular smooth muscle cell proliferation.
Journal of cardiovascular pharmacology.
1993 Jun; 21(6):973-6. doi:
10.1097/00005344-199306000-00019. [PMID: 7687725] - T Yasu, S Oshima, M Imanishi, H Nonogi, K Haze, M Kuramochi, T Omae, Y Hayashi, S Yamamoto. Effects of aspirin DL-lysine on thrombin generation in unstable angina pectoris.
The American journal of cardiology.
1993 May; 71(13):1164-8. doi:
10.1016/0002-9149(93)90640-x. [PMID: 8480641] - J M Stassen, H J Rapold, I Vanlinthout, D Collen. Comparative effects of enoxaparin and heparin on arterial and venous clot lysis with alteplase in dogs.
Thrombosis and haemostasis.
1993 May; 69(5):454-9. doi:
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Canadian journal of veterinary research = Revue canadienne de recherche veterinaire.
1993 Apr; 57(2):95-8. doi:
NULL. [PMID: 8490813] - P E Christie, P Tagari, A W Ford-Hutchinson, C Black, A Markendorf, M Schmitz-Schumann, T H Lee. Urinary leukotriene E4 after lysine-aspirin inhalation in asthmatic subjects.
The American review of respiratory disease.
1992 Dec; 146(6):1531-4. doi:
10.1164/ajrccm/146.6.1531. [PMID: 1333741] - M Imanishi, M Ohta, S Akabane, M Kawamura, Y Matsushima, S Kojima, M Kuramochi, K Kimura, M Takamiya, K Ito. Aspirin injection test to predict angioplasty outcome in unilateral renovascular hypertension: preliminary report.
Clinical and investigative medicine. Medecine clinique et experimentale.
1991 Dec; 14(6):566-73. doi:
NULL. [PMID: 1838974] - T W van Haeften, T F Veneman, E A van der Veen. Influence of lysine acetyl-salicylate on glucose and arginine stimulated insulin release in man.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
1991 Apr; 23(4):168-70. doi:
10.1055/s-2007-1003643. [PMID: 1908430] - S Akabane, H Yoshimi, K Yoshida, Y Kawano, T Ashida, O Kinoshita, Y Matsushima, M Kawamura, M Imanishi, M Kuramochi. Differential effects of endothelin-1 and big endothelin on canine kidneys.
Journal of cardiovascular pharmacology.
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Blood.
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Anesthesiology.
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The American journal of physiology.
1989 Sep; 257(3 Pt 1):E361-6. doi:
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International journal of clinical pharmacology research.
1989; 9(6):385-9. doi:
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International urology and nephrology.
1989; 21(3):245-9. doi:
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Biotherapy (Dordrecht, Netherlands).
1989; 1(4):361-7. doi:
10.1007/bf02171012. [PMID: 2518282] - M Viara, A M Amato, V Menicanti, S Longatti. [Comparative clinical study of tiaprofenic acid and lysine acetylsalicylate in aged osteoarthrosis patients].
Minerva medica.
1987 Jun; 78(12):865-70. doi:
NULL. [PMID: 3110654] - M Naguib, H Farag, J A Magbagbeola. Effect of pre-treatment with lysine acetyl salicylate on suxamethonium-induced myalgia.
British journal of anaesthesia.
1987 May; 59(5):606-10. doi:
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International journal of clinical pharmacology research.
1987; 7(6):455-61. doi:
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Experimental and clinical endocrinology.
1986 Nov; 88(1):119-22. doi:
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Scandinavian journal of gastroenterology. Supplement.
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The Journal of clinical endocrinology and metabolism.
1985 Jul; 61(1):160-6. doi:
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Kidney international.
1984 Jul; 26(1):72-80. doi:
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Clinical therapeutics.
1984; 6(4):483-7. doi:
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Cardiovascular research.
1983 Nov; 17(11):662-70. doi:
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Archives internationales de pharmacodynamie et de therapie.
1983 Sep; 265(1):138-49. doi:
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Bollettino della Societa italiana di biologia sperimentale.
1983 Aug; 59(8):1130-3. doi:
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European journal of clinical investigation.
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Gastroenterology.
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Diabete & metabolisme.
1982 Dec; 8(4):279-82. doi:
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Bollettino della Societa italiana di biologia sperimentale.
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Diabetes.
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Acta cardiologica.
1980; 35(6):419-27. doi:
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Clinical science and molecular medicine.
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