Bonefos (BioDeep_00000859182)
代谢物信息卡片
Bonefos
化学式: CH10Cl2Na2O10P2 (359.892168)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(P(=O)(O)[O-])(P(=O)(O)[O-])(Cl)Cl.O.O.O.O.[Na+].[Na+]
InChI: /p-2
描述信息
C78275 - Agent Affecting Blood or Body Fluid > C2136 - Malignancy-Associated Hypercalcemia Inhibitor
C78281 - Agent Affecting Musculoskeletal System > C67439 - Bone Resorption Inhibitor
D050071 - Bone Density Conservation Agents > D004164 - Diphosphonates
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:59587
- KEGGdrug: D90258
- KEGGdrug: D03544
- PubChem: 23724874
- MeSH: Clodronic Acid
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Dhaval Oza, Fernando Ivich, Joshua Pace, Mikyung Yu, Mark Niedre, Mansoor Amiji. Lipid nanoparticle encapsulated large peritoneal macrophages migrate to the lungs via the systemic circulation in a model of clodronate-mediated lung-resident macrophage depletion.
Theranostics.
2024; 14(6):2526-2543. doi:
10.7150/thno.91062. [PMID: 38646640] - Rudragouda Channappanavar, Muneeswaran Selvaraj, Sunil More, Stanley Perlman. Alveolar macrophages protect mice from MERS-CoV-induced pneumonia and severe disease.
Veterinary pathology.
2022 07; 59(4):627-638. doi:
10.1177/03009858221095270. [PMID: 35499307] - Daiki Goto, Soichiro Nagata, Yoshitaka Naito, Shinsuke Isobe, Takamasa Iwakura, Tomoyuki Fujikura, Naro Ohashi, Akihiko Kato, Hiroaki Miyajima, Ken Sugimoto, Hideo Yasuda. Nicotinic acetylcholine receptor agonist reduces acute lung injury after renal ischemia-reperfusion injury by acting on splenic macrophages in mice.
American journal of physiology. Renal physiology.
2022 05; 322(5):F540-F552. doi:
10.1152/ajprenal.00334.2021. [PMID: 35311383] - Alexander Jacob, Michael Phelps, Shane Fraher, Marcos Lopez, Anthony Chang, Richard J Quigg, Jessy J Alexander. Macrophage Depletion Reduces Disease Pathology in Factor H-Dependent Immune Complex-Mediated Glomerulonephritis.
Journal of immunology research.
2022; 2022(?):1737419. doi:
10.1155/2022/1737419. [PMID: 35097132] - Patrice Garcia, Isabelle Perot, Benoit Loup, Frederic Balssa, Murielle Jaubert, Vivian Delcourt, Chris Dujardin, Marie-Agnes Popot, Ludovic Bailly-Chouriberry. Long-term detection of clodronate in equine plasma by liquid chromatography-tandem mass spectrometry.
Drug testing and analysis.
2021 Aug; 13(8):1527-1534. doi:
10.1002/dta.3050. [PMID: 33870655] - Atsushi Miura, Takashi Hosono, Taiichiro Seki. Macrophage potentiates the recovery of liver zonation and metabolic function after acute liver injury.
Scientific reports.
2021 05; 11(1):9730. doi:
10.1038/s41598-021-88989-9. [PMID: 33958644] - Madoka Koyanagi, Satoshi Imai, Mayuna Matsumoto, Yoko Iguma, Nobuko Kawaguchi-Sakita, Takeshi Kotake, Yuki Iwamitsu, Mpumelelo Ntogwa, Ren Hiraiwa, Kazuki Nagayasu, Mamiko Saigo, Takashi Ogihara, Atsushi Yonezawa, Tomohiro Omura, Shunsaku Nakagawa, Takayuki Nakagawa, Kazuo Matsubara. Pronociceptive Roles of Schwann Cell-Derived Galectin-3 in Taxane-Induced Peripheral Neuropathy.
Cancer research.
2021 04; 81(8):2207-2219. doi:
10.1158/0008-5472.can-20-2799. [PMID: 33608316] - Shuang-Quan Yu, Shuangtao Ma, Donna H Wang. Ablation of TRPV1-positive nerves exacerbates salt-induced hypertension and tissue injury in rats after renal ischemia-reperfusion via infiltration of macrophages.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2021 Apr; 43(3):254-262. doi:
10.1080/10641963.2020.1860078. [PMID: 33327798] - Clarisa R Krueger, Colin F Mitchell, Britta S Leise, Heather K Knych. Pharmacokinetics and pharmacodynamics of clodronate disodium evaluated in plasma, synovial fluid and urine.
Equine veterinary journal.
2020 Sep; 52(5):725-732. doi:
10.1111/evj.13244. [PMID: 32003488] - Yang Ye, Hua-Wei Zhang, Hong-Xia Mei, Hao-Ran Xu, Shu-Yang Xiang, Qian Yang, Sheng-Xing Zheng, Fang Gao Smith, Sheng-Wei Jin, Qian Wang. PDX regulates inflammatory cell infiltration via resident macrophage in LPS-induced lung injury.
Journal of cellular and molecular medicine.
2020 09; 24(18):10604-10614. doi:
10.1111/jcmm.15679. [PMID: 32735065] - Claire Godbersen-Palmer, Tiffany A Coupet, Zakaria Grada, Samuel C Zhang, Charles L Sentman. Toxicity Induced by a Bispecific T Cell-Redirecting Protein Is Mediated by Both T Cells and Myeloid Cells in Immunocompetent Mice.
Journal of immunology (Baltimore, Md. : 1950).
2020 06; 204(11):2973-2983. doi:
10.4049/jimmunol.1901401. [PMID: 32295875] - Bibek Poudel, Corbin A Shields, Andrea K Brown, Ubong Ekperikpe, Tyler Johnson, Denise C Cornelius, Jan M Williams. Depletion of macrophages slows the early progression of renal injury in obese Dahl salt-sensitive leptin receptor mutant rats.
American journal of physiology. Renal physiology.
2020 06; 318(6):F1489-F1499. doi:
10.1152/ajprenal.00100.2020. [PMID: 32390513] - Satoshi Nishiwaki, Shigeki Saito, Kyosuke Takeshita, Hidefumi Kato, Ryuzo Ueda, Akiyoshi Takami, Tomoki Naoe, Mika Ogawa, Takayuki Nakayama. In vivo tracking of transplanted macrophages with near infrared fluorescent dye reveals temporal distribution and specific homing in the liver that can be perturbed by clodronate liposomes.
PloS one.
2020; 15(12):e0242488. doi:
10.1371/journal.pone.0242488. [PMID: 33301448] - Yoshinori Ozono, Kotaro Shide, Fumiyo Toyoshima, Yuuka Takaishi, Mai Tsuchimochi, Ayako Kamiunten, Takuro Kameda, Kenichi Nakamura, Tadashi Miike, Kazunori Kusumoto, Hisayoshi Iwakiri, Satoru Hasuike, Kenji Nagata, Akira Sawaguchi, Kazuya Shimoda. Monocyte-derived fibrocytes elimination had little contribution on liver fibrosis.
Hepatobiliary & pancreatic diseases international : HBPD INT.
2019 Aug; 18(4):348-353. doi:
10.1016/j.hbpd.2019.02.002. [PMID: 30826294] - Khatora S Opperman, Kate Vandyke, Kimberley C Clark, Elizabeth A Coulter, Duncan R Hewett, Krzysztof M Mrozik, Nisha Schwarz, Andreas Evdokiou, Peter I Croucher, Peter J Psaltis, Jacqueline E Noll, Andrew Cw Zannettino. Clodronate-Liposome Mediated Macrophage Depletion Abrogates Multiple Myeloma Tumor Establishment In Vivo.
Neoplasia (New York, N.Y.).
2019 08; 21(8):777-787. doi:
10.1016/j.neo.2019.05.006. [PMID: 31247457] - Daniel J Fehrenbach, Justine M Abais-Battad, John Henry Dasinger, Hayley Lund, David L Mattson. Salt-sensitive increase in macrophages in the kidneys of Dahl SS rats.
American journal of physiology. Renal physiology.
2019 08; 317(2):F361-F374. doi:
10.1152/ajprenal.00096.2019. [PMID: 31215801] - Gunnar Schley, Bernd Klanke, Joanna Kalucka, Valentin Schatz, Christoph Daniel, Marleen Mayer, Margarete Goppelt-Struebe, Martin Herrmann, Margret Thorsteinsdottir, Runolfur Palsson, Angelika Beneke, Dörthe M Katschinski, Nicolai Burzlaff, Kai-Uwe Eckardt, Alexander Weidemann, Jonathan Jantsch, Carsten Willam. Mononuclear phagocytes orchestrate prolyl hydroxylase inhibition-mediated renoprotection in chronic tubulointerstitial nephritis.
Kidney international.
2019 08; 96(2):378-396. doi:
10.1016/j.kint.2019.02.016. [PMID: 31146971] - Sivaramakrishnan Ramadurai, Nirod Kumar Sarangi, Sean Maher, Nicola MacConnell, Alan M Bond, Dennis McDaid, Damien Flynn, Tia E Keyes. Microcavity-Supported Lipid Bilayers; Evaluation of Drug-Lipid Membrane Interactions by Electrochemical Impedance and Fluorescence Correlation Spectroscopy.
Langmuir : the ACS journal of surfaces and colloids.
2019 06; 35(24):8095-8109. doi:
10.1021/acs.langmuir.9b01028. [PMID: 31120755] - Congcong Wu, Wenjun Chen, Jian Wu, Xi Zhang, Xuanzhang Huang, Ruifang Lin, Baoling Zhu, Hua Jiang. Effect of bisphosphonates on overall survival in subgroups of patients with prostate cancer.
Clinical & experimental metastasis.
2019 06; 36(3):199-209. doi:
10.1007/s10585-019-09963-4. [PMID: 30963355] - M N Michalski, L E Zweifler, B P Sinder, A J Koh, J Yamashita, H Roca, L K McCauley. Clodronate-Loaded Liposome Treatment Has Site-Specific Skeletal Effects.
Journal of dental research.
2019 04; 98(4):459-467. doi:
10.1177/0022034518821685. [PMID: 30626255] - Jackie E Bader, Reilly T Enos, Kandy T Velázquez, Meredith S Carson, Alex T Sougiannis, Owen P McGuinness, Cory M Robinson, E Angela Murphy. Repeated clodronate-liposome treatment results in neutrophilia and is not effective in limiting obesity-linked metabolic impairments.
American journal of physiology. Endocrinology and metabolism.
2019 03; 316(3):E358-E372. doi:
10.1152/ajpendo.00438.2018. [PMID: 30576244] - Eun Jeong Jeon, Dong Young Kim, Na Hyun Lee, Hye-Eun Choi, Hyae Gyeong Cheon. Telmisartan induces browning of fully differentiated white adipocytes via M2 macrophage polarization.
Scientific reports.
2019 02; 9(1):1236. doi:
10.1038/s41598-018-38399-1. [PMID: 30718686] - Yuhui Li, Hongda Lu, Xiaojuan Lv, Qiu Tang, Wangxia Li, Hongfei Zhu, Yuan Long. Blockade of Aquaporin 4 Inhibits Irradiation-Induced Pulmonary Inflammation and Modulates Macrophage Polarization in Mice.
Inflammation.
2018 Dec; 41(6):2196-2205. doi:
10.1007/s10753-018-0862-z. [PMID: 30091034] - Katja F Düsterdieck-Zellmer. [Use of bisphosphonates in horses - a review].
Tierarztliche Praxis. Ausgabe G, Grosstiere/Nutztiere.
2018 Oct; 46(5):323-333. doi:
10.15653/tpg-170804. [PMID: 30340242] - Amrutesh S Puranik, Irina A Leaf, Mark A Jensen, Ahmad F Hedayat, Ahmad Saad, Ki-Wook Kim, Abdulrahman M Saadalla, John R Woollard, Sonu Kashyap, Stephen C Textor, Joseph P Grande, Amir Lerman, Robert D Simari, Gwendalyn J Randolph, Jeremy S Duffield, Lilach O Lerman. Kidney-resident macrophages promote a proangiogenic environment in the normal and chronically ischemic mouse kidney.
Scientific reports.
2018 09; 8(1):13948. doi:
10.1038/s41598-018-31887-4. [PMID: 30224726] - Tine V Karlsen, Elham Nikpey, Jianhua Han, Tore Reikvam, Natalia Rakova, Jorge A Castorena-Gonzalez, Michael J Davis, Jens M Titze, Olav Tenstad, Helge Wiig. High-Salt Diet Causes Expansion of the Lymphatic Network and Increased Lymph Flow in Skin and Muscle of Rats.
Arteriosclerosis, thrombosis, and vascular biology.
2018 09; 38(9):2054-2064. doi:
10.1161/atvbaha.118.311149. [PMID: 30354256] - Gianantonio Saviola, Lul Abdi-Ali, Maria Rosaria Povino, Lorella Campostrini, Silvano Sacco, Luca Dalle Carbonare, Luca Dalle Carbonare. Intramuscular clodronate in erosive osteoarthritis of the hand is effective on pain and reduces serum COMP: a randomized pilot trial-The ER.O.D.E. study (ERosive Osteoarthritis and Disodium-clodronate Evaluation).
Clinical rheumatology.
2017 10; 36(10):2343-2350. doi:
10.1007/s10067-017-3681-y. [PMID: 28536825] - Young-Tae Lee, Eun-Ju Ko, Ki-Hye Kim, Hye Suk Hwang, Youri Lee, Young-Man Kwon, Min-Chul Kim, Yu-Na Lee, Yu-Jin Jung, Sang-Moo Kang. Cellular Immune Correlates Preventing Disease Against Respiratory Syncytial Virus by Vaccination with Virus-Like Nanoparticles Carrying Fusion Proteins.
Journal of biomedical nanotechnology.
2017 Jan; 13(1):84-98. doi:
10.1166/jbn.2017.2341. [PMID: 29302248] - M Žaloudíková, R Vytášek, O Vajnerová, O Hniličková, M Vízek, V Hampl, J Herget. Depletion of alveolar macrophages attenuates hypoxic pulmonary hypertension but not hypoxia-induced increase in serum concentration of MCP-1.
Physiological research.
2016 11; 65(5):763-768. doi:
10.33549/physiolres.933187. [PMID: 27429111] - David C Woodland, Wei Liu, Jacky Leong, Mallory L Sears, Ping Luo, Xiaojuan Chen. Short-term high-fat feeding induces islet macrophage infiltration and β-cell replication independently of insulin resistance in mice.
American journal of physiology. Endocrinology and metabolism.
2016 10; 311(4):E763-E771. doi:
10.1152/ajpendo.00092.2016. [PMID: 27577853] - David O Osei-Hwedieh, Tamir Kanias, Claudette St Croix, Morgan Jessup, Zeyu Xiong, Derek Sinchar, Jonathan Franks, Qinzi Xu, Enrico M Novelli, Jonas T Sertorio, Karin Potoka, Robert J Binder, Swati Basu, Andrea M Belanger, Daniel B Kim-Shapiro, Darrell Triulzi, Janet S Lee, Mark T Gladwin. Sickle Cell Trait Increases Red Blood Cell Storage Hemolysis and Post-Transfusion Clearance in Mice.
EBioMedicine.
2016 Sep; 11(?):239-248. doi:
10.1016/j.ebiom.2016.08.006. [PMID: 27523807] - Nicolas Darville, Marjolein van Heerden, Dirk Mariën, Marc De Meulder, Stefaan Rossenu, An Vermeulen, An Vynckier, Sandra De Jonghe, Patrick Sterkens, Pieter Annaert, Guy Van den Mooter. The effect of macrophage and angiogenesis inhibition on the drug release and absorption from an intramuscular sustained-release paliperidone palmitate suspension.
Journal of controlled release : official journal of the Controlled Release Society.
2016 05; 230(?):95-108. doi:
10.1016/j.jconrel.2016.03.041. [PMID: 27067365] - Young-Tae Lee, Ki-Hye Kim, Hye Suk Hwang, Youri Lee, Young-Man Kwon, Eun-Ju Ko, Yu-Jin Jung, Yu-Na Lee, Min-Chul Kim, Sang-Moo Kang. Innate and adaptive cellular phenotypes contributing to pulmonary disease in mice after respiratory syncytial virus immunization and infection.
Virology.
2015 Nov; 485(?):36-46. doi:
10.1016/j.virol.2015.07.001. [PMID: 26196232] - Yu Jin Jung, Ae Sin Lee, Tung Nguyen-Thanh, Kyung Pyo Kang, Sik Lee, Kyu Yun Jang, Myung Ki Kim, Sun Hee Kim, Sung Kwang Park, Won Kim. Hyaluronan-induced VEGF-C promotes fibrosis-induced lymphangiogenesis via Toll-like receptor 4-dependent signal pathway.
Biochemical and biophysical research communications.
2015 Oct; 466(3):339-45. doi:
10.1016/j.bbrc.2015.09.023. [PMID: 26362177] - Saleh Yazdani, Ryanne S Hijmans, Fariba Poosti, Wendy Dam, Gerjan Navis, Harry van Goor, Jacob van den Born. Targeting tubulointerstitial remodeling in proteinuric nephropathy in rats.
Disease models & mechanisms.
2015 Aug; 8(8):919-30. doi:
10.1242/dmm.018580. [PMID: 26035383] - Julie Belliere, Audrey Casemayou, Laure Ducasse, Alexia Zakaroff-Girard, Frédéric Martins, Jason S Iacovoni, Céline Guilbeau-Frugier, Bénédicte Buffin-Meyer, Bernard Pipy, Dominique Chauveau, Joost P Schanstra, Jean-Loup Bascands. Specific macrophage subtypes influence the progression of rhabdomyolysis-induced kidney injury.
Journal of the American Society of Nephrology : JASN.
2015 Jun; 26(6):1363-77. doi:
10.1681/asn.2014040320. [PMID: 25270069] - Andy J Fischer, Christopher Zelinka, Nima Milani-Nejad. Reactive retinal microglia, neuronal survival, and the formation of retinal folds and detachments.
Glia.
2015 Feb; 63(2):313-27. doi:
10.1002/glia.22752. [PMID: 25231952] - Munkyung Kim, Alessandro Piaia, Neeta Shenoy, David Kagan, Berangere Gapp, Benjamin Kueng, Delphine Weber, William Dietrich, Iwona Ksiazek. Progression of Alport Kidney Disease in Col4a3 Knock Out Mice Is Independent of Sex or Macrophage Depletion by Clodronate Treatment.
PloS one.
2015; 10(11):e0141231. doi:
10.1371/journal.pone.0141231. [PMID: 26555339] - Joo Young Kim, Jung-Ho Sohn, Jae-Hyun Lee, Jung-Won Park. Obesity increases airway hyperresponsiveness via the TNF-α pathway and treating obesity induces recovery.
PloS one.
2015; 10(2):e0116540. doi:
10.1371/journal.pone.0116540. [PMID: 25658739] - Feng Li, Yongsheng Yang, Xiaohua Zhu, Lan Huang, Jinhua Xu. Macrophage Polarization Modulates Development of Systemic Lupus Erythematosus.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2015; 37(4):1279-88. doi:
10.1159/000430251. [PMID: 26431544] - Jiong Chen, Qiang Chen, Xin-Jiang Lu, Chang-Hong Li. LECT2 improves the outcomes in ayu with Vibrio anguillarum infection via monocytes/macrophages.
Fish & shellfish immunology.
2014 Dec; 41(2):586-92. doi:
10.1016/j.fsi.2014.10.012. [PMID: 25462453] - Mahmoud Hasan, Gitta Schumacher, Anne Seekamp, Tobias Taedken, Werner Siegmund, Stefan Oswald. LC-MS/MS method for the determination of clodronate in human plasma.
Journal of pharmaceutical and biomedical analysis.
2014 Nov; 100(?):341-347. doi:
10.1016/j.jpba.2014.08.022. [PMID: 25194348] - Alton G Sutter, Arun P Palanisamy, Justin D Ellet, Michael G Schmidt, Rick G Schnellmann, Kenneth D Chavin. Intereukin-10 and Kupffer cells protect steatotic mice livers from ischemia-reperfusion injury.
European cytokine network.
2014 Oct; 25(4):69-76. doi:
10.1684/ecn.2015.0359. [PMID: 25679269] - Davide Gatti, Ombretta Viapiana, Luca Idolazzi, Elena Fracassi, Claudio Ionescu, Carmela Dartizio, Sonila Troplini, Vidya Kunnathully, Silvano Adami, Maurizio Rossini. Distinct effect of zoledronate and clodronate on circulating levels of DKK1 and sclerostin in women with postmenopausal osteoporosis.
Bone.
2014 Oct; 67(?):189-92. doi:
10.1016/j.bone.2014.06.037. [PMID: 25003812] - Graham H Jackson, Gareth J Morgan, Faith E Davies, Ping Wu, Walter M Gregory, Sue E Bell, Alexander J Szubert, Nuria Navarro Coy, Mark T Drayson, Roger G Owen, Sylvia Feyler, Andrew J Ashcroft, Fiona M Ross, Jennifer Byrne, Huw Roddie, Claudius Rudin, Kevin D Boyd, Wendy L Osborne, Gordon Cook, J Anthony Child. Osteonecrosis of the jaw and renal safety in patients with newly diagnosed multiple myeloma: Medical Research Council Myeloma IX Study results.
British journal of haematology.
2014 Jul; 166(1):109-17. doi:
10.1111/bjh.12861. [PMID: 24673708] - Sheng-chun Dang, Yan-hua Zeng, Ping-jiang Wang, Bao-ding Chen, Rong-fang Chen, Arun Kumar Singh, Pankaj Kumar, Shu Feng, Lei Cui, Hao Wang, Jian-xin Zhang. Clodronate-superparamagnetic iron oxide-containing liposomes attenuate renal injury in rats with severe acute pancreatitis.
Journal of Zhejiang University. Science. B.
2014 Jun; 15(6):556-65. doi:
10.1631/jzus.b1300244. [PMID: 24903993] - Kara J Filbey, John R Grainger, Katherine A Smith, Louis Boon, Nico van Rooijen, Yvonne Harcus, Stephen Jenkins, James P Hewitson, Rick M Maizels. Innate and adaptive type 2 immune cell responses in genetically controlled resistance to intestinal helminth infection.
Immunology and cell biology.
2014 May; 92(5):436-48. doi:
10.1038/icb.2013.109. [PMID: 24492801] - Yukio Tsushima, Jae-Hwi Jang, Yoshito Yamada, Reto Schwendener, Kenji Suzuki, Walter Weder, Wolfgang Jungraithmayr. The depletion of donor macrophages reduces ischaemia-reperfusion injury after mouse lung transplantation.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.
2014 Apr; 45(4):703-9. doi:
10.1093/ejcts/ezt489. [PMID: 24113322] - Ulrike Niesler, Annette Palmer, Janine S Fröba, Sonja T Braumüller, Shaoxia Zhou, Florian Gebhard, Markus W Knöferl, Daniel H Seitz. Role of alveolar macrophages in the regulation of local and systemic inflammation after lung contusion.
The journal of trauma and acute care surgery.
2014 Feb; 76(2):386-93. doi:
10.1097/ta.0b013e3182aaa499. [PMID: 24458045] - Jin H Kim, Dong-Won Lee, Myeong H Jung, Hyun-Seop Cho, Dae-Hong Jeon, Se-Ho Chang, Dong Jun Park. Macrophage depletion ameliorates glycerol-induced acute kidney injury in mice.
Nephron. Experimental nephrology.
2014; 128(1-2):21-9. doi:
10.1159/000365851. [PMID: 25376384] - Tufan Mert, Isıl Ocal, A Irfan Guzel, Ismail Gunay. Clodronate changes neurobiological effects of pulsed magnetic field on diabetic rats with peripheral neuropathy.
Electromagnetic biology and medicine.
2013 Sep; 32(3):342-54. doi:
10.3109/15368378.2012.721846. [PMID: 23323995] - Jae-Ho Lee, Geun Taek Lee, Seung Hyo Woo, Yun-Sok Ha, Seok Joo Kwon, Wun-Jae Kim, Isaac Yi Kim. BMP-6 in renal cell carcinoma promotes tumor proliferation through IL-10-dependent M2 polarization of tumor-associated macrophages.
Cancer research.
2013 Jun; 73(12):3604-14. doi:
10.1158/0008-5472.can-12-4563. [PMID: 23633487] - Michiko Itoh, Hideaki Kato, Takayoshi Suganami, Kuniha Konuma, Yoshio Marumoto, Shuji Terai, Hiroshi Sakugawa, Sayaka Kanai, Miho Hamaguchi, Takahiro Fukaishi, Seiichiro Aoe, Kazunari Akiyoshi, Yoshihiro Komohara, Motohiro Takeya, Isao Sakaida, Yoshihiro Ogawa. Hepatic crown-like structure: a unique histological feature in non-alcoholic steatohepatitis in mice and humans.
PloS one.
2013; 8(12):e82163. doi:
10.1371/journal.pone.0082163. [PMID: 24349208] - Ae S Lee, Jung E Lee, Yu J Jung, Duk H Kim, Kyung P Kang, Sik Lee, Sung K Park, Sang Y Lee, Myung J Kang, Woo S Moon, Hyung J Kim, Young B Jeong, Mi J Sung, Won Kim. Vascular endothelial growth factor-C and -D are involved in lymphangiogenesis in mouse unilateral ureteral obstruction.
Kidney international.
2013 Jan; 83(1):50-62. doi:
10.1038/ki.2012.312. [PMID: 22932121] - Xue Deng, Senri Oguri, Hiromi Funayama, Yuko Ohtaki, Masafumi Ohsako, Zhiqian Yu, Shunji Sugawara, Yasuo Endo. Prime role of bone IL-1 in mice may lie in emergency Ca(2+)-supply to soft tissues, not in bone-remodeling.
International immunopharmacology.
2012 Dec; 14(4):658-64. doi:
10.1016/j.intimp.2012.10.001. [PMID: 23072833] - Matthew D Griffin. Mononuclear phagocyte depletion strategies in models of acute kidney disease: what are they trying to tell us?.
Kidney international.
2012 Oct; 82(8):835-7. doi:
10.1038/ki.2012.164. [PMID: 23018825] - David A Ferenbach, Tara A Sheldrake, Kevin Dhaliwal, Tiina M J Kipari, Lorna P Marson, David C Kluth, Jeremy Hughes. Macrophage/monocyte depletion by clodronate, but not diphtheria toxin, improves renal ischemia/reperfusion injury in mice.
Kidney international.
2012 Oct; 82(8):928-33. doi:
10.1038/ki.2012.207. [PMID: 22673886] - Arun Prakash, Kailin R Mesa, Kevin Wilhelmsen, Fengyun Xu, Jeffrey M Dodd-o, Judith Hellman. Alveolar macrophages and Toll-like receptor 4 mediate ventilated lung ischemia reperfusion injury in mice.
Anesthesiology.
2012 Oct; 117(4):822-35. doi:
10.1097/aln.0b013e31826a4ae3. [PMID: 22890118] - Baomei Wang, Bernd H Zinselmeyer, Herbert A Runnels, Timothy P LaBranche, Phillip A Morton, Daniel Kreisel, Matthias Mack, Cheryl Nickerson-Nutter, Paul M Allen, Mark J Miller. In vivo imaging implicates CCR2(+) monocytes as regulators of neutrophil recruitment during arthritis.
Cellular immunology.
2012 Jul; 278(1-2):103-12. doi:
10.1016/j.cellimm.2012.07.005. [PMID: 23121982] - Eetu Heervä, Sirkku Peltonen, Erkki Svedström, Hannu T Aro, Kalervo Väänänen, Juha Peltonen. Osteoclasts derived from patients with neurofibromatosis 1 (NF1) display insensitivity to bisphosphonates in vitro.
Bone.
2012 Mar; 50(3):798-803. doi:
10.1016/j.bone.2011.12.011. [PMID: 22226973] - Lawrence Lu, Sarah Faubel, Zhibin He, Ana Andres Hernando, Alkesh Jani, Ross Kedl, Charles L Edelstein. Depletion of macrophages and dendritic cells in ischemic acute kidney injury.
American journal of nephrology.
2012; 35(2):181-90. doi:
10.1159/000335582. [PMID: 22286667] - Jian-Xin Zhang, Sheng-Chun Dang, Kai Yin, De-Li Jiang. Protective effect of clodronate-containing liposomes on intestinal mucosal injury in rats with severe acute pancreatitis.
Hepatobiliary & pancreatic diseases international : HBPD INT.
2011 Oct; 10(5):544-51. doi:
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The Journal of pharmacology and experimental therapeutics.
2011 Oct; 339(1):93-8. doi:
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The American journal of pathology.
2011 Jul; 179(1):240-7. doi:
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Talanta.
2011 Apr; 84(2):437-42. doi:
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International journal of clinical pharmacology and therapeutics.
2011 Feb; 49(2):128-36. doi:
10.5414/cpp49128. [PMID: 21255529] - Lynne A Murray, Qingsheng Chen, Michael S Kramer, David P Hesson, Rochelle L Argentieri, Xueyang Peng, Mridu Gulati, Robert J Homer, Thomas Russell, Nico van Rooijen, Jack A Elias, Cory M Hogaboam, Erica L Herzog. TGF-beta driven lung fibrosis is macrophage dependent and blocked by Serum amyloid P.
The international journal of biochemistry & cell biology.
2011 Jan; 43(1):154-62. doi:
10.1016/j.biocel.2010.10.013. [PMID: 21044893] - Won Yong Cho, Hye Min Choi, So Young Lee, Myung Gyu Kim, Hyoung-Kyu Kim, Sang-Kyung Jo. The role of Tregs and CD11c(+) macrophages/dendritic cells in ischemic preconditioning of the kidney.
Kidney international.
2010 Nov; 78(10):981-92. doi:
10.1038/ki.2010.266. [PMID: 20686446] - Andrew J Mitchell, Lydie C Pradel, Lionel Chasson, Nico Van Rooijen, Georges E Grau, Nicholas H Hunt, Giovanna Chimini. Technical advance: autofluorescence as a tool for myeloid cell analysis.
Journal of leukocyte biology.
2010 Sep; 88(3):597-603. doi:
10.1189/jlb.0310184. [PMID: 20534703] - Myung-Gyu Kim, Chang Su Boo, Yoon Sook Ko, Hee Young Lee, Won Yong Cho, Hyoung Kyu Kim, Sang-Kyung Jo. Depletion of kidney CD11c+ F4/80+ cells impairs the recovery process in ischaemia/reperfusion-induced acute kidney injury.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2010 Sep; 25(9):2908-21. doi:
10.1093/ndt/gfq183. [PMID: 20388633] - Tobias Traeger, Marlene Mikulcak, Christian Eipel, Kerstin Abshagen, Stephan Diedrich, Claus-Dieter Heidecke, Stefan Maier, Brigitte Vollmar. Kupffer cell depletion reduces hepatic inflammation and apoptosis but decreases survival in abdominal sepsis.
European journal of gastroenterology & hepatology.
2010 Sep; 22(9):1039-49. doi:
10.1097/meg.0b013e32833847db. [PMID: 20300005] - Charles Godbout, Rosalie Bilodeau, Nico Van Rooijen, Patrice Bouchard, Jérôme Frenette. Transient neutropenia increases macrophage accumulation and cell proliferation but does not improve repair following intratendinous rupture of Achilles tendon.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
2010 Aug; 28(8):1084-91. doi:
10.1002/jor.21092. [PMID: 20135679] - Wei Zhang, Xiao-Dong Zhu, Hui-Chuan Sun, Yu-Quan Xiong, Peng-Yuan Zhuang, Hua-Xiang Xu, Ling-Qun Kong, Lu Wang, Wei-Zhong Wu, Zhao-You Tang. Depletion of tumor-associated macrophages enhances the effect of sorafenib in metastatic liver cancer models by antimetastatic and antiangiogenic effects.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2010 Jul; 16(13):3420-30. doi:
10.1158/1078-0432.ccr-09-2904. [PMID: 20570927] - Carla P Carlos, Glória E F Mendes, André R Miquelin, Marcus A M Luz, Cleonice G A da Silva, Nico van Rooijen, Terezila M Coimbra, Emmanuel A Burdmann. Macrophage depletion attenuates chronic cyclosporine A nephrotoxicity.
Transplantation.
2010 Jun; 89(11):1362-70. doi:
10.1097/tp.0b013e3181da0587. [PMID: 20535850] - Jian-Xin Zhang, Sheng-Chun Dang, Yong Zhang, Xin Sha, Li-Rong Zhang, Chuan-She Wei, Min Chen, De-Li Jiang. MRI shows clodronate-liposomes attenuating liver injury in rats with severe acute pancreatitis.
Hepatobiliary & pancreatic diseases international : HBPD INT.
2010 Apr; 9(2):192-200. doi:
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Hypertension (Dallas, Tex. : 1979).
2010 Mar; 55(3):652-9. doi:
10.1161/hypertensionaha.109.142836. [PMID: 20142564] - Lene Sylvest, Christine Dam Bendiksen, Gunnar Houen. Phosphatase inhibitors with anti-angiogenic effect in vitro.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.
2010 Jan; 118(1):49-59. doi:
10.1111/j.1600-0463.2009.02561.x. [PMID: 20041871] - Koichiro Kitamoto, Yuichi Machida, Junji Uchida, Yasukatsu Izumi, Masayuki Shiota, Takafumi Nakao, Hiroshi Iwao, Tokihito Yukimura, Tatsuya Nakatani, Katsuyuki Miura. Effects of liposome clodronate on renal leukocyte populations and renal fibrosis in murine obstructive nephropathy.
Journal of pharmacological sciences.
2009 Nov; 111(3):285-92. doi:
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The journal of gene medicine.
2009 Aug; 11(8):708-17. doi:
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Experimental animals.
2009 Jul; 58(4):383-94. doi:
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Cell and tissue research.
2009 May; 336(2):237-48. doi:
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Toxicology and applied pharmacology.
2009 Apr; 236(1):49-58. doi:
10.1016/j.taap.2009.01.007. [PMID: 19371622] - Kiyoyasu Kurahashi, Teiji Sawa, Maria Ota, Osamu Kajikawa, Keelung Hong, Thomas R Martin, Jeanine P Wiener-Kronish. Depletion of phagocytes in the reticuloendothelial system causes increased inflammation and mortality in rabbits with Pseudomonas aeruginosa pneumonia.
American journal of physiology. Lung cellular and molecular physiology.
2009 Feb; 296(2):L198-209. doi:
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Clinical and experimental obstetrics & gynecology.
2009; 36(4):219-25. doi:
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2008 Dec; 23(12):4061-9. doi:
10.1093/ndt/gfn388. [PMID: 18622021] - Socorro Espuelas, Christine Thumann, Béatrice Heurtault, Francis Schuber, Benoît Frisch. Influence of ligand valency on the targeting of immature human dendritic cells by mannosylated liposomes.
Bioconjugate chemistry.
2008 Dec; 19(12):2385-93. doi:
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Calcified tissue international.
2008 Dec; 83(6):414-24. doi:
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The Journal of surgical research.
2008 Oct; 149(2):192-8. doi:
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American journal of physiology. Gastrointestinal and liver physiology.
2008 Aug; 295(2):G294-304. doi:
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The Korean journal of internal medicine.
2008 Jun; 23(2):64-71. doi:
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Toxicology in vitro : an international journal published in association with BIBRA.
2008 Jun; 22(4):899-909. doi:
10.1016/j.tiv.2008.01.006. [PMID: 18325729] - Daniela Fraccarollo, Paolo Galuppo, Susanne Schraut, Susanne Kneitz, Nico van Rooijen, Georg Ertl, Johann Bauersachs. Immediate mineralocorticoid receptor blockade improves myocardial infarct healing by modulation of the inflammatory response.
Hypertension (Dallas, Tex. : 1979).
2008 Apr; 51(4):905-14. doi:
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Anticancer research.
2008 Mar; 28(2A):933-41. doi:
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The Journal of pathology.
2008 Jan; 214(1):104-13. doi:
10.1002/path.2259. [PMID: 17973244] - Masayo Hatano, Soichiro Sasaki, Shinsuke Ohata, Yoshiko Shiratsuchi, Takahiro Yamazaki, Kisaburo Nagata, Yoshiro Kobayashi. Effects of Kupffer cell-depletion on Concanavalin A-induced hepatitis.
Cellular immunology.
2008 Jan; 251(1):25-30. doi:
10.1016/j.cellimm.2008.02.003. [PMID: 18374909] - Erem Kaan Basok, Adnan Basaran, Necmettin Atsu, Asif Yildirim, Resit Tokuc. Are new-generation bisphosphonates effective for the inhibition of calcium oxalate stone formation in a rat model?.
Urologia internationalis.
2008; 81(3):325-9. doi:
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Calcified tissue international.
2007 Nov; 81(5):341-51. doi:
10.1007/s00223-007-9061-x. [PMID: 17874331] - Norberto C Gonzalez, Julie Allen, V Gustavo Blanco, Eric J Schmidt, Nico van Rooijen, John G Wood. Alveolar macrophages are necessary for the systemic inflammation of acute alveolar hypoxia.
Journal of applied physiology (Bethesda, Md. : 1985).
2007 Oct; 103(4):1386-94. doi:
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The Journal of clinical investigation.
2007 Oct; 117(10):2952-61. doi:
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