Lifibrol (BioDeep_00000859171)

   


代谢物信息卡片


4-[4-(4-tert-butylphenyl)-2-hydroxybutoxy]benzoic acid

化学式: C21H26O4 (342.18309960000005)
中文名称: 利非贝罗
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)(C)C1=CC=C(C=C1)CCC(COC2=CC=C(C=C2)C(=O)O)O
InChI: InChI=1S/C21H26O4/c1-21(2,3)17-9-4-15(5-10-17)6-11-18(22)14-25-19-12-7-16(8-13-19)20(23)24/h4-5,7-10,12-13,18,22H,6,11,14H2,1-3H3,(H,23,24)

描述信息

C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent

同义名列表

2 个代谢物同义名

4-[4-(4-tert-butylphenyl)-2-hydroxybutoxy]benzoic acid; Lifibrol



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Heiner K Berthold, Thomas Sudhop, Klaus von Bergmann, Ioanna Gouni-Berthold. Lifibrol as a model compound for a novel lipid-lowering mechanism of action. Journal of cardiovascular pharmacology and therapeutics. 2010 Dec; 15(4):364-72. doi: 10.1177/1074248410371100. [PMID: 20693157]
  • G L Vega, K von Bergmann, S M Grundy, S Blumenschein, N B Carter, P Laeis, B Lindenthal, J von Bergmann, A Simatupang, D Lutjohann, B Adams-Huet. Effect of lifibrol on the metabolism of low density lipoproteins and cholesterol. Journal of internal medicine. 1999 Jul; 246(1):1-9. doi: 10.1046/j.1365-2796.1999.00536.x. [PMID: 10447220]
  • E L Sun, K L Feenstra, F P Bell, P E Sanders, J G Slatter, R G Ulrich. Biotransformation of lifibrol (U-83860) to mixed glyceride metabolites by rat and human hepatocytes in primary culture. Drug metabolism and disposition: the biological fate of chemicals. 1996 Feb; 24(2):221-31. doi: ". [PMID: 8742235]
  • H Scharnagl, W März, M Schliack, R Löser, W Gross. A novel assay for cytosolic 3-hydroxy-3-methylglutaryl-coenzyme A synthase activity using reversed-phase ion-pair chromatography: demonstration that Lifibrol (K12.148) modulates the enzyme activity. Journal of lipid research. 1995 Mar; 36(3):622-7. doi: 10.1016/s0022-2275(20)39896-5. [PMID: 7775873]
  • P K Locker, G L Jungbluth, S F Francom, G S Hughes. Lifibrol: a novel lipid-lowering drug for the therapy of hypercholesterolemia. Lifibrol Study Group. Clinical pharmacology and therapeutics. 1995 Jan; 57(1):73-88. doi: 10.1016/0009-9236(95)90269-4. [PMID: 7828385]
  • B R Krause, R Bousley, K Kieft, D Robertson, R Stanfield, E Urda, R S Newton. Comparison of lifibrol to other lipid-regulating agents in experimental animals. Pharmacological research. 1994 May; 29(4):345-57. doi: 10.1016/1043-6618(94)80056-1. [PMID: 7971686]
  • R R Walters, C Y Hsu. Chiral assay methods for lifibrol and metabolites in plasma and the observation of unidirectional chiral inversion following administration of the enantiomers to dogs. Chirality. 1994; 6(2):105-15. doi: 10.1002/chir.530060211. [PMID: 8204414]
  • F P Bell, L C St John. Action of the new hypolipidemic agent lifibrol (K12.148) on lipid homeostasis in normal rats: plasma lipids, hepatic sterologenesis, and the fate of injected [14C]acetate. Lipids. 1993 Dec; 28(12):1079-85. doi: 10.1007/bf02537074. [PMID: 8121250]
  • F P Bell. Effect of the lipid-lowering drug lifibrol on lipid metabolism in rat macrophages and in atherosclerotic arteries from swine and WHHL rabbits, in vitro. Implications in atherogenesis. Biochemical pharmacology. 1993 Oct; 46(8):1475-80. doi: 10.1016/0006-2952(93)90114-c. [PMID: 8240398]
  • H Hasibeder, H J Staab, K Seibel, B Heibel, G Schmidle, W März. Clinical pharmacology of the hypocholesterolemic agent K 12.148 (lifibrol) in healthy volunteers. European journal of clinical pharmacology. 1991; 40 Suppl 1(?):S91-4. doi: NULL. [PMID: 2044652]
  • M Schliack, R Löser, K Seibel, B Rattel, G Lang. The hypolipidemic effect of lifibrol during a long term treatment of pigs. Artery. 1990; 18(1):1-15. doi: NULL. [PMID: 2085283]
  • M Schliack, R Löser, K Seibel, K H Blay. Hypolipemic activity of K12.148 in rats, marmosets and pigs. Artery. 1989; 16(2):90-104. doi: NULL. [PMID: 2712711]