CIMOXATONE (BioDeep_00000859155)

   


代谢物信息卡片


CIMOXATONE

化学式: C19H18N2O4 (338.1267)
中文名称: 西莫沙酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COCC1CN(C(=O)O1)C2=CC=C(C=C2)OCC3=CC(=CC=C3)C#N
InChI: InChI=1S/C19H18N2O4/c1-23-13-18-11-21(19(22)25-18)16-5-7-17(8-6-16)24-12-15-4-2-3-14(9-15)10-20/h2-9,18H,11-13H2,1H3

描述信息

D004791 - Enzyme Inhibitors > D008996 - Monoamine Oxidase Inhibitors
C471 - Enzyme Inhibitor > C667 - Monoamine Oxidase Inhibitor
D000890 - Anti-Infective Agents > D023303 - Oxazolidinones

同义名列表

1 个代谢物同义名

CIMOXATONE



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • N A Garrick, T Seppala, M Linnoila, D L Murphy. Rhesus monkey cerebrospinal fluid amine metabolite changes following treatment with the reversible monoamine oxidase type-A inhibitor cimoxatone. Psychopharmacology. 1985; 86(3):265-9. doi: 10.1007/bf00432211. [PMID: 2412251]
  • R C Causon, M J Brown. Measurement of tyramine in human plasma, utilising ion-pair extraction and high-performance liquid chromatography with amperometric detection. Journal of chromatography. 1984 Sep; 310(1):11-7. doi: 10.1016/0378-4347(84)80063-8. [PMID: 6501508]
  • M Strolin Benedetti, A Eschalier, A Lesage, G Dordain, V Rovei, E Zarifian, P Dostert. Effect of a reversible and selective MAO-A inhibitor (cimoxatone) on diurnal variation in plasma prolactin level in man. European journal of clinical pharmacology. 1984; 26(1):71-7. doi: 10.1007/bf00546712. [PMID: 6538844]
  • V Rovei, M Mitchard, M Strolin Benedetti, M J Kendall. Pharmacokinetic and relative bioavailability studies of cimoxatone in humans. International journal of clinical pharmacology, therapy, and toxicology. 1984 Jan; 22(1):56-62. doi: NULL. [PMID: 6698662]
  • C T Dollery, M J Brown, D S Davies, P J Lewis, M Strolin-Benedetti. Oral absorption and concentration-effect relationship of tyramine with and without cimoxatone, a type-A specific inhibitor of monoamine oxidase. Clinical pharmacology and therapeutics. 1983 Nov; 34(5):651-62. doi: 10.1038/clpt.1983.228. [PMID: 6627826]
  • V Rovei, M Rigal, M Sanjuan, A Thiola. High-performance liquid chromatographic determination of cimoxatone and its O-demethyl metabolite in plasma. Journal of chromatography. 1983 Oct; 277(?):391-5. doi: 10.1016/s0378-4347(00)84864-1. [PMID: 6643627]
  • C J Fowler, M Strolin Benedetti, V Rovei. Estimation of the elimination half-life of the monoamine oxidase inhibitor cimoxatone in rat brain on the basis of ex vivo inhibition data. European journal of drug metabolism and pharmacokinetics. 1983 Oct; 8(4):389-93. doi: 10.1007/bf03188771. [PMID: 6673976]
  • V Rovei, F Chanoine, M Strolin Benedetti, R Zini, J P Tillement. Plasma protein binding of the reversible type A MAO inhibitor cimoxatone (MD 780515). Biochemical pharmacology. 1983 Aug; 32(15):2303-8. doi: 10.1016/0006-2952(83)90177-6. [PMID: 6192825]
  • C J Fowler, M S Benedetti. The metabolism of dopamine by both forms of monoamine oxidase in the rat brain and its inhibition by cimoxatone. Journal of neurochemistry. 1983 Jun; 40(6):1534-41. doi: 10.1111/j.1471-4159.1983.tb08123.x. [PMID: 6406646]
  • M F Poirier, J P Olié, H Lôo, P Deniker, M Strolin Benedetti, V Rovei, A Lesage. [Antidepressive action, pharmacokinetic characteristics and biochemical properties of cimoxatone, a new reversible MAO-A inhibitor]. L'Encephale. 1983; 9(4):331-43. doi: NULL. [PMID: 6368197]