Fosfluconazole (BioDeep_00000859148)

   


代谢物信息卡片


Fosfluconazole

化学式: C13H13F2N6O4P (386.07039320000007)
中文名称: 福司氟康唑
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)OP(=O)(O)O
InChI: InChI=1S/C13H13F2N6O4P/c14-10-1-2-11(12(15)3-10)13(25-26(22,23)24,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9H,4-5H2,(H2,22,23,24)

描述信息

D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D065088 - Steroid Synthesis Inhibitors
D004791 - Enzyme Inhibitors > D065088 - Steroid Synthesis Inhibitors > D058888 - 14-alpha Demethylase Inhibitors
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors
C254 - Anti-Infective Agent > C514 - Antifungal Agent

同义名列表

1 个代谢物同义名

Fosfluconazole



数据库引用编号

5 个数据库交叉引用编号

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相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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PlantCyc(0)

COVID-19 Disease Map(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • T Saito, N Shime, K Itoh, N Fujita, Y Saito, M Shinozaki, K Shibuya, K Makimura, S Hashimoto. Disseminated aspergillosis following resolution of Pneumocystis pneumonia with sustained elevation of beta-glucan in an Intensive Care Unit: a case report. Infection. 2009 Dec; 37(6):547-50. doi: 10.1007/s15010-009-8108-5. [PMID: 19730788]
  • Haodan Yuan, Na Li, Yurong Lai. Evaluation of in vitro models for screening alkaline phosphatase-mediated bioconversion of phosphate ester prodrugs. Drug metabolism and disposition: the biological fate of chemicals. 2009 Jul; 37(7):1443-7. doi: 10.1124/dmd.108.026245. [PMID: 19372225]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • Takahiko Aoyama, Kazuhiro Ogata, Makiko Shimizu, Shigeo Hatta, Keiso Masuhara, Yoshinori Shima, Kenjirou Kimura, Yoshiaki Matsumoto. Pharmacokinetics of fluconazole and fosfluconazole after intraperitoneal administration to peritoneal dialysis rats. Drug metabolism and pharmacokinetics. 2005 Dec; 20(6):485-90. doi: 10.2133/dmpk.20.485. [PMID: 16415533]
  • Satoshi Sobue, Keith Tan, Gertraud Haug-Pihale. The effects of hepatic impairment on the pharmacokinetics of fosfluconazole and fluconazole following a single intravenous bolus injection of fosfluconazole. British journal of clinical pharmacology. 2005 Feb; 59(2):160-6. doi: 10.1111/j.1365-2125.2004.02234.x. [PMID: 15676037]
  • Satoshi Sobue, Keith Tan, Gary Layton, Malcolm Eve, J Brian Sanderson. Pharmacokinetics of fosfluconazole and fluconazole following multiple intravenous administration of fosfluconazole in healthy male volunteers. British journal of clinical pharmacology. 2004 Jul; 58(1):20-5. doi: 10.1111/j.1365-2125.2004.02107.x. [PMID: 15206988]
  • Yutaka Kawakami, Kenji Nagino, Keisuke Shinkai, Satoshi Sobue, Masaaki Abe, Junichi Ishiko. [Nonclinical studies and clinical studies on fosfluconazole, a triazole antifungal agent (Prodif)]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 2004 Jul; 124(1):41-51. doi: 10.1254/fpj.124.41. [PMID: 15226621]
  • Satoshi Sobue, Keith Tan, Gary Layton, Violette Leclerc, Angelika Weil. The effects of renal impairment on the pharmacokinetics and safety of fosfluconazole and fluconazole following a single intravenous bolus injection of fosfluconazole. British journal of clinical pharmacology. 2004 Jun; 57(6):773-84. doi: 10.1111/j.1365-2125.2004.02073.x. [PMID: 15151523]
  • Satoshi Sobue, Keith Tan, Linda Shaw, Gary Layton, Rita Hust. Comparison of the pharmacokinetics of fosfluconazole and fluconazole after single intravenous administration of fosfluconazole in healthy Japanese and Caucasian volunteers. European journal of clinical pharmacology. 2004 Jun; 60(4):247-53. doi: 10.1007/s00228-004-0764-x. [PMID: 15103438]
  • Satoshi Sobue, Kaneo Sekiguchi, Katsuyoshi Shimatani, Keith Tan. Pharmacokinetics and safety of Fosfluconazole after single intravenous bolus injection in healthy male Japanese volunteers. Journal of clinical pharmacology. 2004 Mar; 44(3):284-92. doi: 10.1177/0091270003262799. [PMID: 14973307]
  • J H Holmes, I Kanfer, H Zwarenstein. Effect of benzodiazepine derivatives on human blood cholinesterase in vitro. Research communications in chemical pathology and pharmacology. 1978 Aug; 21(2):367-70. doi: . [PMID: 29327]