5-[Bis(carboxymethyl)amino]-3-(carboxymethyl)-4-cyano-2-thiophenecarboxylic acid; strontium (BioDeep_00000859139)
代谢物信息卡片
5-[Bis(carboxymethyl)amino]-3-(carboxymethyl)-4-cyano-2-thiophenecarboxylic acid; strontium
化学式: C12H10N2O8SSr2 (517.827036)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(C1=C(SC(=C1C#N)N(CC(=O)O)CC(=O)O)C(=O)O)C(=O)O.[Sr].[Sr]
InChI: /h1,3-4H2,(H,15,16)(H,17,18)(H,19,20)(H,21,22)
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- S Khalid, S Calderon-Larranaga, A Sami, S Hawley, A Judge, N Arden, T P Van Staa, C Cooper, B Abrahamsen, M Kassim Javaid, D Prieto-Alhambra. Comparative risk of acute myocardial infarction for anti-osteoporosis drugs in primary care: a meta-analysis of propensity-matched cohort findings from the UK Clinical Practice Research Database and the Catalan SIDIAP Database.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
2022 Jul; 33(7):1579-1589. doi:
10.1007/s00198-021-06262-1. [PMID: 35138412] - Takashi Hara, Yasukazu Hijikata, Yukiko Matsubara, Norio Watanabe. Pharmacological interventions versus placebo, no treatment or usual care for osteoporosis in people with chronic kidney disease stages 3-5D.
The Cochrane database of systematic reviews.
2021 Jul; 7(?):CD013424. doi:
10.1002/14651858.cd013424.pub2. [PMID: 34231877] - Dan Zhang, Aihua Du, Xiaolin Wang, Lina Zhang, Man Yang, Jingyi Ma, Ming Deng, Huichen Liu. Pharmacokinetics and bioequivalence of two strontium ranelate formulations after single oral administration in healthy Chinese subjects.
Xenobiotica; the fate of foreign compounds in biological systems.
2019 Apr; 49(4):457-462. doi:
10.1080/00498254.2018.1465210. [PMID: 29676197] - Yi Pei, Ke Zheng, GuanNing Shang, YuMing Wang, Wei Wang, EnDuo Qiu, ShenLong Li, XiaoJing Zhang. Therapeutic Effect of Strontium Ranelate on Bone in Chemotherapy-Induced Osteopenic Rats via Increased Bone Volume and Reduced Bone Loss.
Biological trace element research.
2019 Feb; 187(2):472-481. doi:
10.1007/s12011-018-1401-3. [PMID: 29882118] - Pedro Álvarez-Lloret, Juan Manuel Fernández, María Silvina Molinuevo, Agustina Berenice Lino, José Luis Ferretti, Ricardo Francisco Capozza, Ana María Cortizo, Antonio Desmond McCarthy. Multi-Scale Approach for the Evaluation of Bone Mineralization in Strontium Ranelate-Treated Diabetic Rats.
Biological trace element research.
2018 Dec; 186(2):457-466. doi:
10.1007/s12011-018-1322-1. [PMID: 29623650] - Sheila Moreira Alves, Susana Capistrano Abreu, Jonas Cavalcante Lemos, Francisco Isaac Fernandes Gomes, Shirley Moreira Alves, Danielle Rocha do Val, Raul Sousa Freitas, Karuza Maria Alves Pereira, Vicente de Paulo Teixeira Pinto, Gerly Anne de Castro Brito, Mirna Marques Bezerra, Gerardo Cristino-Filho, Hellíada Vasconcelos Chaves. Anti-inflammatory and anti-nociceptive effects of strontium ranelate on the zymosan-induced temporomandibular joint inflammatory hypernociception in rats depend on TNF-α inhibition.
Pharmacological reports : PR.
2017 Aug; 69(4):764-772. doi:
10.1016/j.pharep.2017.03.007. [PMID: 28587937] - Nebi Cansın Karakan, Aysun Akpınar, Fahrettin Göze, Ömer Poyraz. Investigating the Effects of Systemically Administered Strontium Ranelate on Alveolar Bone Loss Histomorphometrically and Histopathologically on Experimental Periodontitis in Rats.
Journal of periodontology.
2017 02; 88(2):e24-e31. doi:
10.1902/jop.2016.160227. [PMID: 27615270] - Nunziata Morabito, Antonino Catalano, Agostino Gaudio, Elisabetta Morini, Lucia Maria Bruno, Giorgio Basile, Eleni Tsiantouli, Federica Bellone, Rita Maria Agostino, Basilia Piraino, Maria Angela La Rosa, Carmelo Salpietro, Antonino Lasco. Effects of strontium ranelate on bone mass and bone turnover in women with thalassemia major-related osteoporosis.
Journal of bone and mineral metabolism.
2016 Sep; 34(5):540-6. doi:
10.1007/s00774-015-0689-8. [PMID: 26204844] - Marco Atteritano, Antonino Catalano, Domenico Santoro, Antonino Lasco, Salvatore Benvenga. Effects of strontium ranelate on markers of cardiovascular risk in postmenopausal osteoporotic women.
Endocrine.
2016 Jul; 53(1):305-12. doi:
10.1007/s12020-015-0721-8. [PMID: 26304851] - Mohd Rafiq Mohd Ibrahim, Simmrat Singh, Azhar Mahmood Merican, Hanumantha Rao Balaji Raghavendran, Malliga Raman Murali, Sangeetha Vasudevaraj Naveen, Tunku Kamarul. The effect of strontium ranelate on the healing of a fractured ulna with bone gap in rabbit.
BMC veterinary research.
2016 Jun; 12(1):112. doi:
10.1186/s12917-016-0724-6. [PMID: 27307015] - Michał Stuss, Ewa Sewerynek, Iwona Król, Wioletta Stępień-Kłos, Sławomir Jędrzejczyk. Assessment of OPG, RANKL, bone turnover markers serum levels and BMD after treatment with strontium ranelate and ibandronate in patients with postmenopausal osteoporosis.
Endokrynologia Polska.
2016; 67(2):174-84. doi:
10.5603/ep.a2016.0014. [PMID: 26884284] - Marina Komrakova, Anna Weidemann, Christian Dullin, Joachim Ebert, Mohammad Tezval, Klaus Michael Stuermer, Stephan Sehmisch. The Impact of Strontium Ranelate on Metaphyseal Bone Healing in Ovariectomized Rats.
Calcified tissue international.
2015 Oct; 97(4):391-401. doi:
10.1007/s00223-015-0019-0. [PMID: 26084691] - Dan Zhang, Xiaolin Wang, Man Liu, Lina Zhang, Ming Deng, Huichen Liu. Quantification of strontium in human serum by ICP-MS using alternate analyte-free matrix and its application to a pilot bioequivalence study of two strontium ranelate oral formulations in healthy Chinese subjects.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS).
2015 Jan; 29(?):69-74. doi:
10.1016/j.jtemb.2014.06.008. [PMID: 25023847] - Lola S Abboskhujaeva, Saydiganikhodja I Ismailov, Nodira M Alikhanova. Efficacy of strontium ranelate in combination with a D-hormone analog for the treatment of postmenopausal osteoporosis.
Drugs in R&D.
2014 Dec; 14(4):315-24. doi:
10.1007/s40268-014-0069-1. [PMID: 25480348] - Ai Tian, Jun-jiang Zhai, Yan Peng, Li Zhang, Min-hua Teng, Jian Liao, Xu Sun, Xing Liang. Osteoblast response to titanium surfaces coated with strontium ranelate-loaded chitosan film.
The International journal of oral & maxillofacial implants.
2014 Nov; 29(6):1446-53. doi:
10.11607/jomi.3806. [PMID: 25397808] - M Gosch, C Kammerlander, J A Nicholas. Treatment of osteoporosis in older adults.
Panminerva medica.
2014 Jun; 56(2):133-43. doi:
NULL. [PMID: 24820095] - R Rizzoli, B Dawson-Hughes, J-M Kaufman, P Fardellone, M L Brandi, B Vellas, J Collette, J-Y Reginster. Correction of vitamin D insufficiency with combined strontium ranelate and vitamin D3 in osteoporotic patients.
European journal of endocrinology.
2014 Mar; 170(3):441-50. doi:
10.1530/eje-13-0775. [PMID: 24322182] - Ilhan Bayhan, Nasuh U Dogan, Gulnur Ozaksit, Dilek Uygur, Nil Ugurlu, Mustafa Ugur. Effect of strontium ranelate on serum leptin and bone turnover markers in women with established postmenopausal osteoporosis.
The Journal of reproductive medicine.
2013 Jul; 58(7-8):319-23. doi:
NULL. [PMID: 23947082] - Michal Stuss, Piotr Rieske, Agnieszka Cegłowska, Wioletta Stêpień-Kłos, Paweł P Liberski, Ewa Brzeziańska, Ewa Sewerynek. Assessment of OPG/RANK/RANKL gene expression levels in peripheral blood mononuclear cells (PBMC) after treatment with strontium ranelate and ibandronate in patients with postmenopausal osteoporosis.
The Journal of clinical endocrinology and metabolism.
2013 May; 98(5):E1007-11. doi:
10.1210/jc.2012-3885. [PMID: 23543663] - Elizabeth Smelter, Marc C Hochberg. New treatments for osteoarthritis.
Current opinion in rheumatology.
2013 May; 25(3):310-6. doi:
10.1097/bor.0b013e32835f69b4. [PMID: 23425965] - Juan Manuel Fernández, María Silvina Molinuevo, Claudia Sedlinsky, León Schurman, Ana María Cortizo, Antonio Desmond McCarthy. Strontium ranelate prevents the deleterious action of advanced glycation endproducts on osteoblastic cells via calcium channel activation.
European journal of pharmacology.
2013 Apr; 706(1-3):41-7. doi:
10.1016/j.ejphar.2013.02.042. [PMID: 23499695] - Jean-Pierre Pelletier, Mohit Kapoor, Hassan Fahmi, Daniel Lajeunesse, Alexia Blesius, Juliette Maillet, Johanne Martel-Pelletier. Strontium ranelate reduces the progression of experimental dog osteoarthritis by inhibiting the expression of key proteases in cartilage and of IL-1β in the synovium.
Annals of the rheumatic diseases.
2013 Feb; 72(2):250-7. doi:
10.1136/annrheumdis-2012-201710. [PMID: 23065732] - Vincenzo Carnevale, Romano Del Fiacco, Elisabetta Romagnoli, Andrea Fontana, Cristiana Cipriani, Jessica Pepe, Salvatore Minisola. Effects of strontium ranelate administration on calcium metabolism in female patients with postmenopausal osteoporosis and primary hyperparathyroidism.
Calcified tissue international.
2013 Jan; 92(1):15-22. doi:
10.1007/s00223-012-9659-5. [PMID: 23080188] - Yunfeng Li, Xudong Li, Guodong Song, Kan Chen, Guozhu Yin, Jing Hu. Effects of strontium ranelate on osseointegration of titanium implant in osteoporotic rats.
Clinical oral implants research.
2012 Sep; 23(9):1038-44. doi:
10.1111/j.1600-0501.2011.02252.x. [PMID: 22117625] - Serap Yalin, Ozgun Sagír, Ulku Comelekoglu, Mehmet Berköz, Pelin Eroglu. Strontium ranelate treatment improves oxidative damage in osteoporotic rat model.
Pharmacological reports : PR.
2012; 64(2):396-402. doi:
10.1016/s1734-1140(12)70780-6. [PMID: 22661191] - Zekeriya Ulger, Esin Ileri Gurel, Meltem Halil, Gulsen Oozen, Isilay Kalan, Nurten Seringec, Burcu Balam Yavuz, Yusuf Yesil, Mustafa Cankurtaran, Neslihan Dikmenoglu, Servet Ariogul. Hemorheological changes with strontium ranelate treatment do not seem to be related to its claimed prothrombotic effects.
Archives of gerontology and geriatrics.
2012 Jan; 54(1):218-21. doi:
10.1016/j.archger.2010.11.024. [PMID: 21167612] - R Rizzoli, R D Chapurlat, J-M Laroche, M A Krieg, T Thomas, I Frieling, S Boutroy, A Laib, O Bock, D Felsenberg. Effects of strontium ranelate and alendronate on bone microstructure in women with osteoporosis. Results of a 2-year study.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
2012 Jan; 23(1):305-15. doi:
10.1007/s00198-011-1758-z. [PMID: 21909729] - Kristyna Brabnikova Maresova, Tomas Franek, Tomas Vondracek, Jan J Stepan. A comparison of the acute effects of calcium and strontium ranelate on the serum marker of bone resorption.
Clinical chemistry and laboratory medicine.
2011 Nov; 50(2):333-5. doi:
10.1515/cclm.2011.781. [PMID: 22080821] - Bernhard Pemmer, Jochen G Hofstaetter, Florian Meirer, Stephan Smolek, Peter Wobrauschek, Rolf Simon, Robyn K Fuchs, Matthew R Allen, Keith W Condon, Susan Reinwald, Roger J Phipps, David B Burr, Eleftherios P Paschalis, Klaus Klaushofer, Christina Streli, Paul Roschger. Increased strontium uptake in trabecular bone of ovariectomized calcium-deficient rats treated with strontium ranelate or strontium chloride.
Journal of synchrotron radiation.
2011 Nov; 18(Pt 6):835-41. doi:
10.1107/s090904951103038x. [PMID: 21997907] - Wei Qi, Pu-jie Wang, Wen-jun Guo, Ya-bo Yan, Yang Zhang, Wei Lei. The mechanism of Cordyceps sinensis and strontium in prevention of osteoporosis in rats.
Biological trace element research.
2011 Oct; 143(1):302-9. doi:
10.1007/s12011-010-8829-4. [PMID: 20803174] - N N C Carvalho, L A Voss, M O P Almeida, C L Salgado, F Bandeira. Atypical femoral fractures during prolonged use of bisphosphonates: short-term responses to strontium ranelate and teriparatide.
The Journal of clinical endocrinology and metabolism.
2011 Sep; 96(9):2675-80. doi:
10.1210/jc.2011-0593. [PMID: 21752890] - P Alexandersen, M A Karsdal, I Byrjalsen, C Christiansen. Strontium ranelate effect in postmenopausal women with different clinical levels of osteoarthritis.
Climacteric : the journal of the International Menopause Society.
2011 Apr; 14(2):236-43. doi:
10.3109/13697137.2010.507887. [PMID: 20726814] - Annemarie Brüel, Jakob Olsen, Henrik Birkedal, Malene Risager, Troels Torp Andreassen, Anders Christer Raffalt, Jens Enevold Thaulov Andersen, Jesper Skovhus Thomsen. Strontium is incorporated into the fracture callus but does not influence the mechanical strength of healing rat fractures.
Calcified tissue international.
2011 Feb; 88(2):142-52. doi:
10.1007/s00223-010-9439-z. [PMID: 21153023] - Björn Jobke, Andrew J Burghardt, Burkhard Muche, Michael Hahn, Jutta Semler, Michael Amling, Sharmila Majumdar, Björn Busse. Trabecular reorganization in consecutive iliac crest biopsies when switching from bisphosphonate to strontium ranelate treatment.
PloS one.
2011; 6(8):e23638. doi:
10.1371/journal.pone.0023638. [PMID: 21858188] - V Geoffroy, D Chappard, C Marty, H Libouban, A Ostertag, A Lalande, M-C de Vernejoul. Strontium ranelate decreases the incidence of new caudal vertebral fractures in a growing mouse model with spontaneous fractures by improving bone microarchitecture.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
2011 Jan; 22(1):289-97. doi:
10.1007/s00198-010-1193-6. [PMID: 20204596] - S Takaoka, T Yamaguchi, S Yano, M Yamauchi, T Sugimoto. The Calcium-sensing Receptor (CaR) is involved in strontium ranelate-induced osteoblast differentiation and mineralization.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2010 Aug; 42(9):627-31. doi:
10.1055/s-0030-1255091. [PMID: 20560105] - O Bruyère, J Collette, R Rizzoli, C Decock, S Ortolani, C Cormier, J Detilleux, J-Y Reginster. Relationship between 3-month changes in biochemical markers of bone remodelling and changes in bone mineral density and fracture incidence in patients treated with strontium ranelate for 3 years.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
2010 Jun; 21(6):1031-6. doi:
10.1007/s00198-009-1078-8. [PMID: 19813043] - Rui Yang, Zhen Huang, De-hong Cai, Hua Zhang, A-na Lai, Zhen Zhang, Ping Sun, Hong Chen. [Preventive and therapeutic effect of strontium ranelate on osteoporosis in rats subjected to simulated weightlessness].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2010 Apr; 30(4):834-7. doi:
NULL. [PMID: 20423860] - Isabel Oliveira de Sousa, Erik Trovão Diniz, Thyciara Fontenele Marques, Luiz Griz, Mário de Almeida Pereira Coutinho, Francisco Bandeira. Short-term bone marker responses to teriparatide and strontium ranelate in patients with osteoporosis previously treated with bisphosphonates.
Arquivos brasileiros de endocrinologia e metabologia.
2010 Mar; 54(2):244-9. doi:
10.1590/s0004-27302010000200023. [PMID: 20485916] - Deepa Iyer, Yvonne Buggy, Katherine O'Reilly, Martin Searle. Strontium ranelate as a cause of acute renal failure and dress syndrome.
Nephrology (Carlton, Vic.).
2009 Sep; 14(6):624. doi:
10.1111/j.1440-1797.2009.01125.x. [PMID: 19712264] - Robert R Recker, Fernando Marin, Sophia Ish-Shalom, Rüdiger Möricke, Federico Hawkins, Georgios Kapetanos, María P de la Peña, Jörn Kekow, Jordi Farrerons, Beatriz Sanz, Heide Oertel, Jan Stepan. Comparative effects of teriparatide and strontium ranelate on bone biopsies and biochemical markers of bone turnover in postmenopausal women with osteoporosis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
2009 Aug; 24(8):1358-68. doi:
10.1359/jbmr.090315. [PMID: 19338452] - S D Bain, C Jerome, V Shen, I Dupin-Roger, P Ammann. Strontium ranelate improves bone strength in ovariectomized rat by positively influencing bone resistance determinants.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
2009 Aug; 20(8):1417-28. doi:
10.1007/s00198-008-0815-8. [PMID: 19096745] - Athanasios D Anastasilakis, Dimirtios G Goulis, Stergios A Polyzos, Spiridon Gerou, Iris Ballaouri, Zoe Efstathiadou, Marina Kita, Avraam Avramidis. No difference between strontium ranelate (SR) and calcium/vitamin D on bone turnover markers in women with established osteoporosis previously treated with teriparatide: a randomized controlled trial.
Clinical endocrinology.
2009 Apr; 70(4):522-6. doi:
10.1111/j.1365-2265.2008.03342.x. [PMID: 18625000] - Ilhan Bayhan, Dilek Uygur, Nil Ugurlu, Gulnur Ozaksit. Strontium ranelate decreases plasma homocysteine levels in postmenopausal osteoporotic women.
Rheumatology international.
2009 Jan; 29(3):263-6. doi:
10.1007/s00296-008-0693-6. [PMID: 18818926] - J S Hwang, J F Chen, T S Yang, D J Wu, K S Tsai, C Ho, C H Wu, S L Su, C J Wang, S T Tu. The effects of strontium ranelate in Asian women with postmenopausal osteoporosis.
Calcified tissue international.
2008 Nov; 83(5):308-14. doi:
10.1007/s00223-008-9180-z. [PMID: 18843436] - Ibrahim Gulhan, Sibel Bilgili, Rezzan Gunaydin, Sibel Gulhan, Cemal Posaci. The effect of strontium ranelate on serum insulin like growth factor-1 and leptin levels in osteoporotic post-menopausal women: a prospective study.
Archives of gynecology and obstetrics.
2008 Nov; 278(5):437-41. doi:
10.1007/s00404-008-0611-x. [PMID: 18322691] - R K Fuchs, M R Allen, K W Condon, S Reinwald, L M Miller, D McClenathan, B Keck, R J Phipps, D B Burr. Strontium ranelate does not stimulate bone formation in ovariectomized rats.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
2008 Sep; 19(9):1331-41. doi:
10.1007/s00198-008-0602-6. [PMID: 18385919] - Meltem Halil, Mustafa Cankurtaran, Burcu Balam Yavuz, Zekeriya Ulger, Serhan Piskinpasa, Arzu Gedik, Ibrahim Celalettin Haznedaroglu, Serafettin Kirazli, Servet Ariogul. Short-term hemostatic safety of strontium ranelate treatment in elderly women with osteoporosis.
The Annals of pharmacotherapy.
2007 Jan; 41(1):41-5. doi:
10.1345/aph.1h506. [PMID: 17179188] - Peter Alexandersen, M A Karsdal, Per Qvist, J-Y Reginster, Claus Christiansen. Strontium ranelate reduces the urinary level of cartilage degradation biomarker CTX-II in postmenopausal women.
Bone.
2007 Jan; 40(1):218-22. doi:
10.1016/j.bone.2006.07.028. [PMID: 17010685] - Pierre J Marie. Strontium ranelate: a dual mode of action rebalancing bone turnover in favour of bone formation.
Current opinion in rheumatology.
2006 Jun; 18 Suppl 1(?):S11-5. doi:
10.1097/01.bor.0000229522.89546.7b. [PMID: 16735840] - Christian Fottner, Matthias M Weber. [The latest developments in endocrinology 2004/2005].
Medizinische Klinik (Munich, Germany : 1983).
2006 Jan; 101(1):29-36. doi:
10.1007/s00063-006-1005-0. [PMID: 16418812] - Serge Cremers, Patrick Garnero. Biochemical markers of bone turnover in the clinical development of drugs for osteoporosis and metastatic bone disease: potential uses and pitfalls.
Drugs.
2006; 66(16):2031-58. doi:
10.2165/00003495-200666160-00001. [PMID: 17112299] - Hans Peter Dimai. [Strontium ranelate: a novel concept for the treatment of osteoporosis].
Wiener klinische Wochenschrift.
2005 Nov; 117(21-22):728-38. doi:
10.1007/s00508-005-0471-3. [PMID: 16416353] - Lee S Simon. Osteoporosis.
Clinics in geriatric medicine.
2005 Aug; 21(3):603-29, viii. doi:
10.1016/j.cger.2005.02.002. [PMID: 15911210] - P J Marie. Strontium ranelate: a novel mode of action optimizing bone formation and resorption.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
2005 Jan; 16 Suppl 1(?):S7-10. doi:
10.1007/s00198-004-1753-8. [PMID: 15578159] - Patrick Ammann, Victor Shen, Bruno Robin, Yves Mauras, Jean-Philippe Bonjour, Rene Rizzoli. Strontium ranelate improves bone resistance by increasing bone mass and improving architecture in intact female rats.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
2004 Dec; 19(12):2012-20. doi:
10.1359/jbmr.040906. [PMID: 15537445] - J Y Reginster, J P Devogelaer. [Treatment of postmenopausal osteoporosis in 2004].
Revue medicale de Liege.
2004 Nov; 59(11):633-47. doi:
NULL. [PMID: 15646737] - P Delannoy, D Bazot, P J Marie. Long-term treatment with strontium ranelate increases vertebral bone mass without deleterious effect in mice.
Metabolism: clinical and experimental.
2002 Jul; 51(7):906-11. doi:
10.1053/meta.2002.33360. [PMID: 12077740] - P J Meunier, D O Slosman, P D Delmas, J L Sebert, M L Brandi, C Albanese, R Lorenc, S Pors-Nielsen, M C De Vernejoul, A Roces, J Y Reginster. Strontium ranelate: dose-dependent effects in established postmenopausal vertebral osteoporosis--a 2-year randomized placebo controlled trial.
The Journal of clinical endocrinology and metabolism.
2002 May; 87(5):2060-6. doi:
10.1210/jcem.87.5.8507. [PMID: 11994341] - J Buehler, P Chappuis, J L Saffar, Y Tsouderos, A Vignery. Strontium ranelate inhibits bone resorption while maintaining bone formation in alveolar bone in monkeys (Macaca fascicularis).
Bone.
2001 Aug; 29(2):176-9. doi:
10.1016/s8756-3282(01)00484-7. [PMID: 11502480] - P J Marie, M Hott, D Modrowski, C De Pollak, J Guillemain, P Deloffre, Y Tsouderos. An uncoupling agent containing strontium prevents bone loss by depressing bone resorption and maintaining bone formation in estrogen-deficient rats.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
1993 May; 8(5):607-15. doi:
10.1002/jbmr.5650080512. [PMID: 8511988]