diammine[cyclobutane-1,1-dicarboxylato(2-)-k2O1,O1]platinum (BioDeep_00000859135)
代谢物信息卡片
diammine[cyclobutane-1,1-dicarboxylato(2-)-k2O1,O1]platinum
化学式: C6H14N2O4Pt (373.0601)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC(C1)(C(=O)O)C(=O)O.N.N.[Pt]
InChI: 2*1H3
描述信息
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D003432 - Cross-Linking Reagents
D000970 - Antineoplastic Agents
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Lian Wang, Bing Xiong, Wei Lu, Yujie Cheng, Jihui Zhu, Guihai Ai, Xiaojie Zhang, Xiuni Liu, Zhongping Cheng. Senolytic drugs dasatinib and quercetin combined with Carboplatin or Olaparib reduced the peritoneal and adipose tissue metastasis of ovarian cancer.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2024 May; 174(?):116474. doi:
10.1016/j.biopha.2024.116474. [PMID: 38518604] - Eman Jaradat, Adam Meziane, Dimitrios A Lamprou. Conventional vs PEGylated loaded liposomal formulations by microfluidics for delivering hydrophilic chemotherapy.
International journal of pharmaceutics.
2024 Apr; 655(?):124077. doi:
10.1016/j.ijpharm.2024.124077. [PMID: 38569975] - Kunxiang Gong, Yinger Huang, Yanqin Zheng, Wenbo Hao, Kun Shi. ZSWIM4 inhibition improves chemosensitivity in epithelial ovarian cancer cells by suppressing intracellular glycine biosynthesis.
Journal of translational medicine.
2024 Feb; 22(1):192. doi:
10.1186/s12967-024-04980-8. [PMID: 38383406] - Xiangying Li, Guan Wang, Xiuye Sun, Yue Feng, Lei Wang, Gangyuan Sun, Hong Qiao. Effect of AGEs-RAGE system on the efficacy of PD-1 inhibitors in the treatment of driver-gene mutation negative advanced non-squamous non-small cell lung cancer.
Cellular and molecular biology (Noisy-le-Grand, France).
2023 Dec; 69(14):155-160. doi:
10.14715/cmb/2023.69.14.25. [PMID: 38279452] - Xinyu Hao, Ming Zu, Jing Ning, Xin Zhou, Yueqing Gong, Xiurui Han, Qiao Meng, Dong Li, Shigang Ding. Antitumor effect of luteolin proven by patient-derived organoids of gastric cancer.
Phytotherapy research : PTR.
2023 Jul; ?(?):. doi:
10.1002/ptr.7963. [PMID: 37469042] - K Cetinkaya, M Atasever, Z Erisgin, C Sonmez, C Ozer, B Coskun, M Alisik. The role of oxidative stress in chemotherapy-induced gonadotoxicity in a rat model, and the protective effects of Nigella Sativa oil on oxidative stress, the anti-Müllerian hormone level, and apoptosis.
European review for medical and pharmacological sciences.
2023 07; 27(13):6343-6350. doi:
10.26355/eurrev_202307_32994. [PMID: 37458651] - Xue Hou, Chengzhi Zhou, Guowu Wu, Wen Lin, Zhanhong Xie, Haibo Zhang, Jiqun Yi, Zheng Peng, Lifeng Yin, Chi Ma, Likun Chen. Efficacy, Safety, and Health-Related Quality of Life With Camrelizumab Plus Pemetrexed and Carboplatin as First-Line Treatment for Advanced Nonsquamous NSCLC With Brain Metastases (CAP-BRAIN): A Multicenter, Open-Label, Single-Arm, Phase 2 Study.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
2023 06; 18(6):769-779. doi:
10.1016/j.jtho.2023.01.083. [PMID: 36738928] - Margaret Ndinguri, Lisa Middleton, Jason Unrine, Shu Lui, Joseph Rollins, Emma Nienaber, Cassidy Spease, Aggie Williams, Lindsay Cormier. Therapeutic dosing and targeting efficacy of Pt-Mal-LHRH towards triple negative breast cancer.
PloS one.
2023; 18(10):e0287151. doi:
10.1371/journal.pone.0287151. [PMID: 37816015] - Zhiyang Zhou, Li Jin, Jian Shen, Weihui Shi, Yue Xu, Longyun Ye, Junxi Liu, Jiexue Pan. COM33 suppresses carboplatin-induced epithelial-mesenchymal transition via inhibition of Twist1 in ovarian cancer.
Acta biochimica et biophysica Sinica.
2022 Dec; ?(?):. doi:
10.3724/abbs.2022195. [PMID: 36647720] - Zhang Tao, Xingwang Kuai, Guangwei Wang, Sanfeng Liu, Kai Liu, Heng Zhang, Shujing Xia, Hua Zhu. Combination of chemotherapy and immune checkpoint therapy by the immunoconjugates-based nanocomplexes synergistically improves therapeutic efficacy in SCLC.
Drug delivery.
2022 Dec; 29(1):1571-1581. doi:
10.1080/10717544.2022.2039803. [PMID: 35612299] - Pierre Idlas, Abdallah Ladaycia, Fariba Némati, Elise Lepeltier, Pascal Pigeon, Gerard Jaouen, Didier Decaudin, Catherine Passirani. Ferrocifen stealth LNCs and conventional chemotherapy: A promising combination against multidrug-resistant ovarian adenocarcinoma.
International journal of pharmaceutics.
2022 Oct; 626(?):122164. doi:
10.1016/j.ijpharm.2022.122164. [PMID: 36089209] - Zi-Heng Qi, Xiao-Jun Yan, Yang-Yang Liu, Xia Hou, Zhu Zhao, Yan-Yan Zhu, Ying-Jie He, Zhao-Jie Wang, Hong-Jun Yang, Zhong-Yuan Na, Yun-Li Zhao, Xiao-Dong Luo. The Protective Effect of Sweet Potato Root Tuber on Chemotherapy-Induced Thrombocytopenia.
Molecular nutrition & food research.
2022 08; 66(16):e2200126. doi:
10.1002/mnfr.202200126. [PMID: 35712860] - Ze Yang He, Hai Ying Li, Jiao Yan, Si Jin Li, Dao Cheng Li, Zhong Zhe Liang. A prospective trial to evaluate the clinical efficacy and safety of neoadjuvant chemotherapy with arsenic trioxide and carboplatin in locally advanced cervical cancer: a study protocol for randomized controlled clinical.
Trials.
2022 Jul; 23(1):556. doi:
10.1186/s13063-022-06489-1. [PMID: 35804452] - Qing Yang, Enhong Han, Shanshan Xu, Yongxing Xu, Jianjun Gao. Treatment of advanced ovarian cancer with carboplatin and paclitaxel in a patient undergoing hemodialysis: Case report and literature review.
Hemodialysis international. International Symposium on Home Hemodialysis.
2022 07; 26(3):E31-E36. doi:
10.1111/hdi.13020. [PMID: 35583084] - Diogo J Silva, Alexandra Mesquita. Complete and long-lasting response to immunotherapy: A case report of urothelial cancer.
Medicine.
2022 Jun; 101(24):e28940. doi:
10.1097/md.0000000000028940. [PMID: 35713423] - Yi-Hong Wu, Hsing-Yu Chen, Wei-Chin Hong, Chen-Ying Wei, Jong-Hwei Su Pang. Carboplatin-Induced Thrombocytopenia through JAK2 Downregulation, S-Phase Cell Cycle Arrest and Apoptosis in Megakaryocytes.
International journal of molecular sciences.
2022 Jun; 23(11):. doi:
10.3390/ijms23116290. [PMID: 35682967] - Sabeen Irshad, Arham Shabbir, Hina Aslam, Tasleem Akhtar, Muhammad Shahzad. Carica papaya ameliorates thrombocytopenia through upregulation of Interleukin-11 and modulation of thrombopoietin in mouse model of carboplatin-induced myelosuppression.
Molecular biology reports.
2022 Jun; 49(6):4633-4641. doi:
10.1007/s11033-022-07311-6. [PMID: 35301648] - Kazuho Nakanishi, Yuri Maeoka, Takashi Yamada, Shunji Suzuki. Maintenance therapy for long-term control of high-grade endometrial stromal sarcoma.
BMJ case reports.
2022 May; 15(5):. doi:
10.1136/bcr-2022-248971. [PMID: 35550323] - Weitao Qiu, Yu Fu, Yun Dang, Bingxin Cai, Shumei Tuo, Baohong Mao, Ru Lin, Qing Liu, Yilin Li. Effectiveness and safety of weekly therapy versus 3-weekly therapy of paclitaxel plus carboplatin in women with ovarian cancer: a protocol of systematic review and meta-analysis.
BMJ open.
2022 03; 12(3):e053182. doi:
10.1136/bmjopen-2021-053182. [PMID: 35296476] - Zena Wilson, Rajesh Odedra, Yann Wallez, Paul W G Wijnhoven, Adina M Hughes, Joe Gerrard, Gemma N Jones, Hannah Bargh-Dawson, Elaine Brown, Lucy A Young, Mark J O'Connor, Alan Lau. ATR Inhibitor AZD6738 (Ceralasertib) Exerts Antitumor Activity as a Monotherapy and in Combination with Chemotherapy and the PARP Inhibitor Olaparib.
Cancer research.
2022 03; 82(6):1140-1152. doi:
10.1158/0008-5472.can-21-2997. [PMID: 35078817] - Jingchen Liu, Chunli Zhang, Baoyun Jia, Kaiye Dong, Mingjun Li, Dong Qiu, Lei Li, Bing Xu, Shuguang Sun, Cairui Li. Panax notoginseng saponins induce apoptosis in retinoblastoma Y79 cells via the PI3K/AKT signalling pathway.
Experimental eye research.
2022 03; 216(?):108954. doi:
10.1016/j.exer.2022.108954. [PMID: 35074343] - Alissa Groenendijk, Harm van Tinteren, Yilin Jiang, Ronald R de Krijger, Gordan M Vujanic, Jan Godzinski, Christian Rübe, Jens-Peter Schenk, Carlo Morosi, Kathy Pritchard-Jones, Reem Al-Saadi, Sucheta J Vaidya, Arnauld C Verschuur, Gema L Ramírez-Villar, Norbert Graf, Beatriz de Camargo, Jarno Drost, Daniela Perotti, Marry M van den Heuvel-Eibrink, Jesper Brok, Filippo Spreafico, Annelies M C Mavinkurve-Groothuis. Outcome of SIOP patients with low- or intermediate-risk Wilms tumour relapsing after initial vincristine and actinomycin-D therapy only - the SIOP 93-01 and 2001 protocols.
European journal of cancer (Oxford, England : 1990).
2022 03; 163(?):88-97. doi:
10.1016/j.ejca.2021.12.014. [PMID: 35042071] - Matilda Xinwei Lee, Andrea L A Wong, Samuel Ow, Raghav Sundar, David S P Tan, Ross A Soo, Cheng Ean Chee, Joline S J Lim, Wei Peng Yong, Siew Eng Lim, Boon Cher Goh, Lingzhi Wang, Soo Chin Lee. Phase Ib Dose-Finding Study of Varlitinib Combined with Weekly Paclitaxel With or Without Carboplatin ± Trastuzumab in Advanced Solid Tumors.
Targeted oncology.
2022 03; 17(2):141-151. doi:
10.1007/s11523-022-00867-0. [PMID: 35195837] - Chengheng Liao, Cherise Ryan Glodowski, Cheng Fan, Juan Liu, Kevin R Mott, Akash Kaushik, Hieu Vu, Jason W Locasale, Samuel K McBrayer, Ralph J DeBerardinis, Charles M Perou, Qing Zhang. Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers.
Cancer research.
2022 02; 82(4):665-680. doi:
10.1158/0008-5472.can-21-2745. [PMID: 34911787] - M Illiano, M Colinard, S Taque, B Mallon, C Larue, V Laithier, C Vérité-Goulard, H Sudour-Bonnange, C Faure-Conter, C Coze, I Aerts, C Dumesnil De Maricourt, C Paillard, S Branchereau, L Brugières, B Fresneau. Long-term morbidity and mortality in 2-year hepatoblastoma survivors treated with SIOPEL risk-adapted strategies.
Hepatology international.
2022 Feb; 16(1):125-134. doi:
10.1007/s12072-021-10251-1. [PMID: 34506008] - Shota Omori, Hideyuki Harada, Keita Mori, Yasushi Hisamatsu, Yuko Tsuboguchi, Hiroshige Yoshioka, Ryotaro Morinaga, Haruko Daga, Takayasu Kurata, Toshiaki Takahashi. Phase I study of weekly nab-paclitaxel plus carboplatin and concurrent thoracic radiotherapy in elderly patients with unresectable locally advanced non-small cell lung cancer.
Investigational new drugs.
2022 02; 40(1):106-114. doi:
10.1007/s10637-021-01155-w. [PMID: 34495421] - Ari J Rosenberg, Evgeny Izumchenko, Alexander Pearson, Zhen Gooi, Elizabeth Blair, Theodore Karrison, Aditya Juloori, Daniel Ginat, Nicole Cipriani, Mark Lingen, Hillary Sloane, Daniel L Edelstein, Kirsten Keyser, Johannes Fredebohm, Frank Holtrup, Frederick S Jones, Daniel Haraf, Nishant Agrawal, Everett E Vokes. Prospective study evaluating dynamic changes of cell-free HPV DNA in locoregional viral-associated oropharyngeal cancer treated with induction chemotherapy and response-adaptive treatment.
BMC cancer.
2022 Jan; 22(1):17. doi:
10.1186/s12885-021-09146-z. [PMID: 34980038] - Matthew J Murray, Rafael Moleron, Jennifer Adamski, Martin English, G A Amos Burke, Justin Cross, Thankamma Ajithkumar, Sara Stoneham, James C Nicholson. Vinblastine monotherapy induction prior to radiotherapy for patients with intracranial germinoma during the COVID-19 pandemic.
Pediatric blood & cancer.
2022 01; 69(1):e29359. doi:
10.1002/pbc.29359. [PMID: 34520101] - Corinne A Calo, Brentley Q Smith, Kalpana Deepa Priya Dorayappan, Uksha Saini, Michelle Lightfoot, Vincent Wagner, Deepika Kalaiyarasan, Casey Cosgrove, Qi-En Wang, G Larry Maxwell, Tamás Kálai, Periannan Kuppusamy, David E Cohn, Karuppaiyah Selvendiran. Aberrant expression of TMEM205 signaling promotes platinum resistance in ovarian cancer: An implication for the antitumor potential of DAP compound.
Gynecologic oncology.
2022 01; 164(1):136-145. doi:
10.1016/j.ygyno.2021.10.076. [PMID: 34756749] - Olena Bilyk, Bahareh Hamedi, Indrani Dutta, Marnie Newell, Amirali B Bukhari, Armin M Gamper, Rojine C McVea, Jiahui Liu, Julia Schueler, Gabrielle M Siegers, Catherine J Field, Lynne-Marie Postovit. Docosahexaenoic Acid in the Inhibition of Tumor Cell Growth in Preclinical Models of Ovarian Cancer.
Nutrition and cancer.
2022; 74(4):1431-1445. doi:
10.1080/01635581.2021.1952453. [PMID: 34286635] - Beatriz Belda, José Ramos-Vara, Kristen M Messenger, Marije Risselada. Pharmacokinetic and safety assessment of carboplatin-impregnated calcium sulfate hemihydrate beads in eight rats.
Veterinary surgery : VS.
2021 Nov; 50(8):1650-1661. doi:
10.1111/vsu.13712. [PMID: 34375028] - Paulo D'Amora, Ismael Dale C G Silva, Krishnansu S Tewari, Robert E Bristow, Fabio Cappuccini, Steven S Evans, Marcia B Salzgeber, Paula J Addis-Bernard, Anton M Palma, Dirce M L Marchioni, Antonio A F Carioca, Kristine R Penner, Jill Alldredge, Teresa Longoria, Robert A Nagourney. Platinum resistance in gynecologic malignancies: Response, disease free and overall survival are predicted by biochemical signature: A metabolomic analysis.
Gynecologic oncology.
2021 10; 163(1):162-170. doi:
10.1016/j.ygyno.2021.08.001. [PMID: 34446269] - Timothy A Yap, Matthew G Krebs, Sophie Postel-Vinay, Anthony El-Khouiery, Jean-Charles Soria, Juanita Lopez, Alienor Berges, S Y Amy Cheung, Itziar Irurzun-Arana, Andrew Goldwin, Brunella Felicetti, Gemma N Jones, Alan Lau, Paul Frewer, Andrew J Pierce, Glen Clack, Christine Stephens, Simon A Smith, Emma Dean, Simon J Hollingsworth. Ceralasertib (AZD6738), an Oral ATR Kinase Inhibitor, in Combination with Carboplatin in Patients with Advanced Solid Tumors: A Phase I Study.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2021 10; 27(19):5213-5224. doi:
10.1158/1078-0432.ccr-21-1032. [PMID: 34301752] - Hyung-Don Kim, Hyeon-Su Im, Jwa Hoon Kim, Hyehyun Jeong, Shin Kyo Yoon, Inkeun Park, Jae Lyun Lee. Use of Gemcitabine plus Carboplatin is Associated with Poor Outcomes in Urothelial Carcinoma Patients with Chronic Kidney Disease Stage 4-5.
Cancer research and treatment.
2021 Oct; 53(4):1166-1173. doi:
10.4143/crt.2021.091. [PMID: 33677847] - Shannon L Puhalla, Véronique Diéras, Banu K Arun, Bella Kaufman, Hans Wildiers, Hyo S Han, Jean-Pierre Ayoub, Vered Stearns, Yuan Yuan, Teresa Helsten, Bridget Riley-Gillis, Erin Murphy, Madan G Kundu, Meijing Wu, David Maag, Christine K Ratajczak, Cyril Y Ramathal, Michael Friedlander. Relevance of Platinum-free Interval and BRCA Reversion Mutations for Veliparib Monotherapy after Progression on Carboplatin/Paclitaxel for gBRCA Advanced Breast Cancer (BROCADE3 Crossover).
Clinical cancer research : an official journal of the American Association for Cancer Research.
2021 09; 27(18):4983-4993. doi:
10.1158/1078-0432.ccr-21-0748. [PMID: 34131001] - Hitomi Fujishiro, Hiroki Taguchi, Satoko Hamao, Daigo Sumi, Seiichiro Himeno. Comparisons of segment-specific toxicity of platinum-based agents and cadmium using S1, S2, and S3 cells derived from mouse kidney proximal tubules.
Toxicology in vitro : an international journal published in association with BIBRA.
2021 Sep; 75(?):105179. doi:
10.1016/j.tiv.2021.105179. [PMID: 33905841] - Akihiro Hamada, Takeshi Sano, Keiyu Matsumoto, Toru Sakatani, Kenji Nakamura, Atsuro Sawada, Shusuke Akamatsu, Yoshiyuki Matsui, Osamu Ogawa, Takashi Kobayashi. Modification of Platinum-based Systemic Chemotherapy for Advanced Urothelial Carcinoma in Patients With Suboptimal Renal Function.
In vivo (Athens, Greece).
2021 Sep; 35(5):2821-2829. doi:
10.21873/invivo.12569. [PMID: 34410974] - Shruti Gupta, Ignacio Portales-Castillo, Amir Daher, Abhijat Kitchlu. Conventional Chemotherapy Nephrotoxicity.
Advances in chronic kidney disease.
2021 09; 28(5):402-414.e1. doi:
10.1053/j.ackd.2021.08.001. [PMID: 35190107] - Lijuan Jiang, Zunguang Bai, Shoulun Zhu, Tingting Zhao, Yining Yang, Zhiyong Li, Dong Chen, Zhiming Wu, Yanjun Wang, Fangjian Zhou, Yonghong Li. A novel germline BRCA2 mutation in a Chinese patient with prostate cancer sensitive to platinum chemotherapy: a case report.
BMC urology.
2021 Aug; 21(1):114. doi:
10.1186/s12894-021-00879-4. [PMID: 34425813] - G C Bai, Y Song, J Jin, W Yu, Z S He. [Clinical efficacy of docetaxel combined with carboplatin in patients with metastatic castration-resistant prostate cancer].
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences.
2021 Aug; 53(4):686-691. doi:
NULL. [PMID: 34393229] - Y M Shen, L Q Jin, S S Tang, Y Wang, W G Lyu, Z B Chen, X Xie. [Factors affecting long-term survival of advanced high-grade serous ovarian cancer].
Zhonghua fu chan ke za zhi.
2021 Jun; 56(6):393-400. doi:
10.3760/cma.j.cn112141-20201212-00877. [PMID: 34154314] - Farasat Kazmi, Shibani Nicum, Rene L Roux, Laura Spiers, Chat Gnanaranjan, Ajithkumar Sukumaran, Hani Gabra, Essam Ghazaly, Nigel W McCracken, David J Harrison, Sarah P Blagden. A Phase Ib Open-Label, Dose-Escalation Study of NUC-1031 in Combination with Carboplatin for Recurrent Ovarian Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2021 06; 27(11):3028-3038. doi:
10.1158/1078-0432.ccr-20-4403. [PMID: 33741651] - Jairo Galot-Linaldi, Karla M Hernández-Sánchez, Elizabet Estrada-Muñiz, Libia Vega. Anacardic Acids from Amphipterygium adstringens Confer Cytoprotection against 5-Fluorouracil and Carboplatin Induced Blood Cell Toxicity While Increasing Antitumoral Activity and Survival in an Animal Model of Breast Cancer.
Molecules (Basel, Switzerland).
2021 May; 26(11):. doi:
10.3390/molecules26113241. [PMID: 34071241] - Toshiki Morimoto, Takeshi Orihashi, Kei Yamasaki, Masahiro Tahara, Kaori Kato, Kazuhiro Yatera. Paraneoplastic Sensory Polyneuropathy Related to Anti-PD-L1-including Anticancer Treatment in a Patient with Lung Cancer.
Internal medicine (Tokyo, Japan).
2021 May; 60(10):1577-1581. doi:
10.2169/internalmedicine.5629-20. [PMID: 33328400] - Masataka Iwano, Kohei Sadahiro, Takuya Maruo, Shinpei Kawarai, Hideki Kayanuma, Kensuke Orito. Serum concentration and safety of intravenous drip versus subcutaneous administration of carboplatin in dogs.
The Journal of veterinary medical science.
2021 May; 83(5):775-779. doi:
10.1292/jvms.20-0653. [PMID: 33716231] - Satya Prakash Yadav, Teena Wadhwa, Dhwanee Thakkar, Rohit Kapoor, Neha Rastogi, Smita Sarma. COVID-19 reinfection in two children with cancer.
Pediatric hematology and oncology.
2021 05; 38(4):403-405. doi:
10.1080/08880018.2020.1855276. [PMID: 33625290] - Vance G Nielsen. Modulation of Diverse Procoagulant Venom Activities by Combinations of Platinoid Compounds.
International journal of molecular sciences.
2021 Apr; 22(9):. doi:
10.3390/ijms22094612. [PMID: 33924780] - G Vilà-Nadal, A Fiandor Román, R Heredia Revuelto, D Hernández-Maraver, A E Kerguelen Fuentes, E Ramírez García, R Cabañas Moreno. Efficacy of Therapeutic Plasma Exchange in Severe Immune Hemolytic Anemia Induced by a Carboplatin Desensitization Procedure.
Journal of investigational allergology & clinical immunology.
2021 Apr; 31(2):178-179. doi:
10.18176/jiaci.0634. [PMID: 32732185] - Christine Chevreau, Christophe Massard, Aude Flechon, Rémy Delva, Gwenaëlle Gravis, Jean-Pierre Lotz, Jacques-Olivier Bay, Marine Gross-Goupil, Karim Fizazi, Loïc Mourey, Angelo Paci, Jérôme Guitton, Fabienne Thomas, Bénédicte Lelièvre, Joseph Ciccolini, Sotheara Moeung, Yohan Gallois, Pascale Olivier, Stéphane Culine, Thomas Filleron, Etienne Chatelut. Multicentric phase II trial of TI-CE high-dose chemotherapy with therapeutic drug monitoring of carboplatin in patients with relapsed advanced germ cell tumors.
Cancer medicine.
2021 04; 10(7):2250-2258. doi:
10.1002/cam4.3687. [PMID: 33675184] - Vance G Nielsen. Platinoid effects on human plasmatic coagulation kinetics: a viscoelastic analysis.
Journal of thrombosis and thrombolysis.
2021 Apr; 51(3):577-583. doi:
10.1007/s11239-020-02373-4. [PMID: 33389608] - Paul Cressey, Maral Amrahli, Po-Wah So, Wladyslaw Gedroyc, Michael Wright, Maya Thanou. Image-guided thermosensitive liposomes for focused ultrasound enhanced co-delivery of carboplatin and SN-38 against triple negative breast cancer in mice.
Biomaterials.
2021 04; 271(?):120758. doi:
10.1016/j.biomaterials.2021.120758. [PMID: 33774525] - Mark P Ward, Feras Abu Saadeh, Sharon A O'Toole, John J O'Leary, Noreen Gleeson, Lucy A Norris. Procoagulant activity in high grade serous ovarian cancer patients following neoadjuvant chemotherapy-The role of the activated protein C pathway.
Thrombosis research.
2021 04; 200(?):91-98. doi:
10.1016/j.thromres.2021.01.012. [PMID: 33571724] - Tingyan Shi, Jianqing Zhu, Yanling Feng, Dongsheng Tu, Yuqin Zhang, Ping Zhang, Huixun Jia, Xiao Huang, Yunlang Cai, Sheng Yin, Rong Jiang, Wenjuan Tian, Wen Gao, Jihong Liu, Huijuan Yang, Xi Cheng, Rongyu Zang. Secondary cytoreduction followed by chemotherapy versus chemotherapy alone in platinum-sensitive relapsed ovarian cancer (SOC-1): a multicentre, open-label, randomised, phase 3 trial.
The Lancet. Oncology.
2021 04; 22(4):439-449. doi:
10.1016/s1470-2045(21)00006-1. [PMID: 33705695] - May Myat Mon, Chantragan Srisomsap, Daranee Chokchaichamnankit, Kamolwan Watcharatanyatip, Churat Weeraphan, Jisnuson Svasti, Kajornkiat Maneechai, Paramee Thongsuksai, Pritsana Raungrut. Serum Proteomic Profiling Reveals Differentially Expressed IGHG3 and A1AG1 as Potential Predictors of Chemotherapeutic Response in Advanced Non-small Cell Lung Cancer.
Anticancer research.
2021 Apr; 41(4):1871-1882. doi:
10.21873/anticanres.14953. [PMID: 33813392] - Kathryn Taikowski, Adam J Rudinsky, Darian S Louke, Emma Warry, Joelle M Fenger. Plasma Cytokeratin 18 and fecal Alpha-1 Antitrypsin concentrations in dogs with osteosarcoma receiving carboplatin chemotherapy.
Veterinary medicine and science.
2021 03; 7(2):385-392. doi:
10.1002/vms3.392. [PMID: 33222415] - Corey Tsang, Ayub Akbari, Dominque Frechette, Pierre Antoine Brown. Accurate determination of glomerular filtration rate in adults for carboplatin dosing: Moving beyond Cockcroft and Gault.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.
2021 Mar; 27(2):368-375. doi:
10.1177/1078155220978446. [PMID: 33297846] - Kenji Zennami, Makoto Sumitomo, Kiyoshi Takahara, Takuhisa Nukaya, Masashi Takenaka, Kosuke Fukaya, Manabu Ichino, Naohiko Fukami, Hitomi Sasaki, Mamoru Kusaka, Ryoichi Shiroki. Two cycles of neoadjuvant chemotherapy improves survival in patients with high-risk upper tract urothelial carcinoma.
BJU international.
2021 03; 127(3):332-339. doi:
10.1111/bju.15230. [PMID: 32896105] - Ye-Hua Shen, Shou-Yin Jiang. Primary yolk sac tumor of pterygopalatine fossa with loss of vision: A case report.
Medicine.
2021 Feb; 100(8):e24916. doi:
10.1097/md.0000000000024916. [PMID: 33663127] - Wei Wang, Ming Liu, Boyong Ding. Comparison of the short-term efficacy and serum markers between lobaplatin/paclitaxel- And carboplatin/paclitaxel-based adjuvant chemotherapy in patient with ovarian cancer.
Journal of clinical pharmacy and therapeutics.
2021 Feb; 46(1):166-172. doi:
10.1111/jcpt.13276. [PMID: 33098169] - Yi Hu, Chun Yang, Tania Amorim, Mohsin Maqbool, Jenny Lin, Chen Li, Chuanfeng Fang, Li Xue, Ariel Kwart, Hua Fang, Mei Yin, Allison J Janocha, Daisuke Tsuchimoto, Yusaku Nakabeppu, Xiaofeng Jiang, Alex Mejia-Garcia, Faiz Anwer, Jack Khouri, Xin Qi, Qing Y Zheng, Jennifer S Yu, Shan Yan, Thomas LaFramboise, Kenneth C Anderson, Leal C Herlitz, Nikhil C Munshi, Jianhong Lin, Jianjun Zhao. Cisplatin-Mediated Upregulation of APE2 Binding to MYH9 Provokes Mitochondrial Fragmentation and Acute Kidney Injury.
Cancer research.
2021 02; 81(3):713-723. doi:
10.1158/0008-5472.can-20-1010. [PMID: 33288657] - Duygu Alpaslan, Tuba Erşen Dudu, Nahit Aktaş. Synthesis and characterization of novel organo-hydrogel based agar, glycerol and peppermint oil as a natural drug carrier/release material.
Materials science & engineering. C, Materials for biological applications.
2021 Jan; 118(?):111534. doi:
10.1016/j.msec.2020.111534. [PMID: 33255087] - Rui Yang, You-Yang Shi, Xiang-Hui Han, Sheng Liu. The Impact of Platinum-Containing Chemotherapies in Advanced Triple-Negative Breast Cancer: Meta-Analytical Approach to Evaluating Its Efficacy and Safety.
Oncology research and treatment.
2021; 44(6):333-343. doi:
10.1159/000515353. [PMID: 33975311] - Youngjoo Lee, Jungnam Joo, You Jin Lee, Eun Kyung Lee, Sohyun Park, Tae-Sung Kim, Soo-Hyun Lee, So Young Kim, Gyung-Ah Wie, Minjoung Park, Mi-Jung Kim, Jin Soo Lee, Ji-Youn Han. Randomized phase II study of platinum-based chemotherapy plus controlled diet with or without metformin in patients with advanced non-small cell lung cancer.
Lung cancer (Amsterdam, Netherlands).
2021 01; 151(?):8-15. doi:
10.1016/j.lungcan.2020.11.011. [PMID: 33278671] - Theresa Vilsmaier, Helene Hildegard Heidegger, Lennard Schröder, Elisabeth Trapp, Alaleh Zati Zehni, Brigitte Rack, Wolfgang Janni, Sven Mahner, Tobias Weissenbacher, Udo Jeschke, Jan-Niclas Mumm. Interleukin 15 and Eotaxin correlate with the outcome of breast cancer patients vice versa independent of CTC status.
Archives of gynecology and obstetrics.
2021 01; 303(1):217-230. doi:
10.1007/s00404-020-05793-y. [PMID: 32929618] - Shivani Tendulkar, Suneel Dodamani. Chemoresistance in Ovarian Cancer: Prospects for New Drugs.
Anti-cancer agents in medicinal chemistry.
2021; 21(6):668-678. doi:
10.2174/1871520620666200908104835. [PMID: 32900355] - Mads Kingo Guldberg Hansen, Maja Patricia Smerdel, Marianne Waldstrøm, Rikke Fredslund Andersen, Parvin Adimi, Anders Jakobsen, Karina Dahl Steffensen. Carboplatin re-treatment in platinum-resistant epithelial ovarian cancer patients.
Cancer chemotherapy and pharmacology.
2020 12; 86(6):751-759. doi:
10.1007/s00280-020-04162-5. [PMID: 33067703] - Victor Passos Gibson, Rabeb Mouna Derbali, Huu Trong Phan, Houda Tahiri, Christine Allen, Pierre Hardy, Jeanne Leblond Chain. Survivin silencing improved the cytotoxicity of carboplatin and melphalan in Y79 and primary retinoblastoma cells.
International journal of pharmaceutics.
2020 Nov; 589(?):119824. doi:
10.1016/j.ijpharm.2020.119824. [PMID: 32861768] - Jelena S Katanic Stankovic, Dragica Selakovic, Vladimir Mihailovic, Gvozden Rosic. Antioxidant Supplementation in the Treatment of Neurotoxicity Induced by Platinum-Based Chemotherapeutics-A Review.
International journal of molecular sciences.
2020 Oct; 21(20):. doi:
10.3390/ijms21207753. [PMID: 33092125] - Luiz Carlos da Costa Junior, Clarissa Lourenço de Castro, Daniely Regina Freitas-Alves, Rosane Vianna-Jorge, Paulo Caleb Júnior Lima Santos. ABCB1 and ERCC1 gene polymorphisms are associated with nephro- and hepatotoxicity to carboplatin/paclitaxel-based chemotherapy in patients with gynecologic cancers.
European journal of clinical pharmacology.
2020 Oct; 76(10):1401-1408. doi:
10.1007/s00228-020-02934-9. [PMID: 32564116] - Anand Joshi, Jianxia Guo, Julianne L Holleran, Brian Kiesel, Sarah Taylor, Susan Christner, Robert A Parise, Brian M Miller, S Percy Ivy, Edward Chu, Raman Venkataramanan, Jan H Beumer. Evaluation of the pharmacokinetic drug-drug interaction potential of iohexol, a renal filtration marker.
Cancer chemotherapy and pharmacology.
2020 10; 86(4):535-545. doi:
10.1007/s00280-020-04145-6. [PMID: 32948918] - K Esther Broekman, Marieke A J Hof, Daan J Touw, Jourik A Gietema, Hans W Nijman, Joop D Lefrandt, An K L Reyners, Mathilde Jalving. Phase I study of metformin in combination with carboplatin/paclitaxel chemotherapy in patients with advanced epithelial ovarian cancer.
Investigational new drugs.
2020 10; 38(5):1454-1462. doi:
10.1007/s10637-020-00920-7. [PMID: 32146550] - Valentina Ranzuglia, Ilaria Lorenzon, Ilenia Pellarin, Maura Sonego, Alessandra Dall'Acqua, Sara D'Andrea, Sara Lovisa, Ilenia Segatto, Michela Coan, Jerry Polesel, Diego Serraino, Patrizia Sabatelli, Paola Spessotto, Barbara Belletti, Gustavo Baldassarre, Monica Schiappacassi. Serum- and glucocorticoid- inducible kinase 2, SGK2, is a novel autophagy regulator and modulates platinum drugs response in cancer cells.
Oncogene.
2020 10; 39(40):6370-6386. doi:
10.1038/s41388-020-01433-6. [PMID: 32848212] - Sarah Schoch, Sabine Gajewski, Jana Rothfuß, Andrea Hartwig, Beate Köberle. Comparative Study of the Mode of Action of Clinically Approved Platinum-Based Chemotherapeutics.
International journal of molecular sciences.
2020 Sep; 21(18):. doi:
10.3390/ijms21186928. [PMID: 32967255] - Andrey Soares, Fabio A Schutz, Diogo Assed Bastos, Denis Jardim, Fernando Sabino Marques Montiero. Use of Immunotherapy in Patients With Cancer During the COVID-19 Pandemic.
Oncology (Williston Park, N.Y.).
2020 09; 34(9):370-376. doi:
10.46883/onc.2020.3409.0370. [PMID: 32965669] - Huihan Ma, Qian Qin, Jiaqing Mi, Qinmei Feng. 1-MT inhibits the invasion of CBP-resistant ovarian cancer cells via down-regulating IDO expression and re-activating immune cells function.
BMC pharmacology & toxicology.
2020 09; 21(1):67. doi:
10.1186/s40360-020-00439-w. [PMID: 32912307] - A Laura Nijstad, Natasha K A van Eijkelenburg, Kathelijne C J M Kraal, Marieke J M Meijs, Clara T M M de Kanter, Marc R Lilien, Alwin D R Huitema. Cisplatin and carboplatin pharmacokinetics in a pediatric patient with hepatoblastoma receiving peritoneal dialysis.
Cancer chemotherapy and pharmacology.
2020 09; 86(3):445-449. doi:
10.1007/s00280-020-04130-z. [PMID: 32816154] - Corine de Jong, Vera H M Deneer, Johannes C Kelder, Henk Ruven, Toine C G Egberts, Gerarda J M Herder. Association between serum biomarkers CEA and LDH and response in advanced non-small cell lung cancer patients treated with platinum-based chemotherapy.
Thoracic cancer.
2020 07; 11(7):1790-1800. doi:
10.1111/1759-7714.13449. [PMID: 32383328] - Iman Al Dybiat, Alibi Baitukha, Cynthia Pimpie, Rachid Kaci, Marc Pocard, Farzaneh Arefi Khonsari, Massoud Mirshahi. Multi-nanolayer drug delivery using radiofrequency plasma technology.
BMC cancer.
2020 Jun; 20(1):565. doi:
10.1186/s12885-020-06989-w. [PMID: 32552705] - Luke McLean, James R Whittle, Jonathan Graham, Huda Ismail, Meir Lichtenstein, Rodney J Hicks, Orla McNally, Alan Herschtal, Mark Rosenthal, Danny Rischin, Anne Hamilton. Carboplatin dosing in the era of IDMS-creatinine; the Cockroft-Gault formula no longer provides a sufficiently accurate estimate of glomerular filtration rate for routine use in clinical care.
Gynecologic oncology.
2020 06; 157(3):793-798. doi:
10.1016/j.ygyno.2020.03.017. [PMID: 32220419] - Ruo-Xi Wang, Peng Ji, Yue Gong, Zhi-Ming Shao, Sheng Chen. Value of CXCL8-CXCR1/2 axis in neoadjuvant chemotherapy for triple-negative breast cancer patients: a retrospective pilot study.
Breast cancer research and treatment.
2020 Jun; 181(3):561-570. doi:
10.1007/s10549-020-05660-z. [PMID: 32361849] - Samineh Dehghanpour, Hamid Reza Pourzamani, Mohammad Mehdi Amin, Karim Ebrahimpour. Evaluation of toxic effects of platinum-based antineoplastic drugs (cisplatin, carboplatin and oxaliplatin) on green alga Chlorella vulgaris.
Aquatic toxicology (Amsterdam, Netherlands).
2020 Jun; 223(?):105495. doi:
10.1016/j.aquatox.2020.105495. [PMID: 32371336] - Akimasa Asai, Takayuki Katsuno, Makoto Yamaguchi, Shiho Iwagaitsu, Hironobu Nobata, Hiroshi Kinashi, Hiroshi Kitamura, Shogo Banno, Yasuhiko Ito. Carboplatin-related acute interstitial nephritis in a patient with pancreatic neuroendocrine tumor.
CEN case reports.
2020 05; 9(2):114-121. doi:
10.1007/s13730-019-00437-w. [PMID: 31834568] - Yuji Shibata, Nobuaki Kobayashi, Takashi Sato, Kentaro Nakashima, Takeshi Kaneko. The clinical significance of CXCL16 in the treatment of advanced non-small cell lung cancer.
Thoracic cancer.
2020 05; 11(5):1258-1264. doi:
10.1111/1759-7714.13387. [PMID: 32163231] - Daiki Mori, Hiroo Ishida, Tadahaya Mizuno, Sojiro Kusumoto, Yusuke Kondo, Saki Izumi, Genki Nakata, Yoshitane Nozaki, Kazuya Maeda, Yasutsuna Sasaki, Ken-Ichi Fujita, Hiroyuki Kusuhara. Alteration in the Plasma Concentrations of Endogenous Organic Anion-Transporting Polypeptide 1B Biomarkers in Patients with Non-Small Cell Lung Cancer Treated with Paclitaxel.
Drug metabolism and disposition: the biological fate of chemicals.
2020 05; 48(5):387-394. doi:
10.1124/dmd.119.089474. [PMID: 32114508] - K Suzuki, Y Sato, R Nakahara, R Tatsuta, R Tanaka, H Itoh. Venous thromboembolisms and rheology in ovarian cancer patients after postoperative adjuvant paclitaxel and carboplatin therapy.
Die Pharmazie.
2020 05; 75(5):205-207. doi:
10.1691/ph.2020.9908. [PMID: 32393430] - Elizabeth A Maxwell, Heidi Phillips, Stuart C Clark-Price, Miranda D Vieson, Laura E Selmic, David J Schaeffer, Timothy M Fan. Pharmacokinetics of platinum and safety evaluation of carboplatin-impregnated calcium sulfate hemihydrate beads after implantation in healthy cats.
Veterinary surgery : VS.
2020 May; 49(4):748-757. doi:
10.1111/vsu.13372. [PMID: 31944331] - Ping Cheng, Huan Liu, Yinchuan Li, Peiling Pi, Yu Jiang, Shaozhen Zang, Xiaorong Li, Ailing Fu, Xiaoyuan Ren, Jianqiang Xu, Arne Holmgren, Jun Lu. Inhibition of thioredoxin reductase 1 correlates with platinum-based chemotherapeutic induced tissue injury.
Biochemical pharmacology.
2020 05; 175(?):113873. doi:
10.1016/j.bcp.2020.113873. [PMID: 32092292] - Abir Mukherjee, Chun-Yi Chiang, Helen A Daifotis, Kristin M Nieman, Johannes F Fahrmann, Ricardo R Lastra, Iris L Romero, Oliver Fiehn, Ernst Lengyel. Adipocyte-Induced FABP4 Expression in Ovarian Cancer Cells Promotes Metastasis and Mediates Carboplatin Resistance.
Cancer research.
2020 04; 80(8):1748-1761. doi:
10.1158/0008-5472.can-19-1999. [PMID: 32054768] - Eve Roberts, Jasper A W Mogg, Mark Barnfield, Gareth J Veal. Investigating current practices in renal function measurement and carboplatin dosing in children with cancer - a UK perspective.
Pediatric hematology and oncology.
2020 Apr; 37(3):235-244. doi:
10.1080/08880018.2020.1713939. [PMID: 31941404] - Angeles Alvarez Secord, Kirsten Bell Burdett, Kouros Owzar, David Tritchler, Alexander B Sibley, Yingmiao Liu, Mark D Starr, J Chris Brady, Heather A Lankes, Herbert I Hurwitz, Robert S Mannel, Krishnansu S Tewari, David M O'Malley, Heidi Gray, Jamie N Bakkum-Gamez, Keiichi Fujiwara, Matthew Boente, Wei Deng, Robert A Burger, Michael J Birrer, Andrew B Nixon. Predictive Blood-Based Biomarkers in Patients with Epithelial Ovarian Cancer Treated with Carboplatin and Paclitaxel with or without Bevacizumab: Results from GOG-0218.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2020 03; 26(6):1288-1296. doi:
10.1158/1078-0432.ccr-19-0226. [PMID: 31919136] - Hailing Xu, Dongqing Lv, Yinnan Meng, Miao Wang, Wei Wang, Chao Zhou, Suna Zhou, Xiaofeng Chen, Haihua Yang. Endostar improved efficacy of concurrent chemoradiotherapy with vinorelbine plus carboplatin in locally advanced lung squamous cell carcinoma patients with high serum Lp(a) concentration.
Annals of palliative medicine.
2020 Mar; 9(2):298-307. doi:
10.21037/apm.2020.01.16. [PMID: 32075401] - Melanie White-Koning, Marie Noëlle Paludetto, Félicien Le Louedec, Laurence Gladieff, Christine Chevreau, Etienne Chatelut, Florent Puisset. Formulae recently proposed to estimate renal glomerular filtration rate improve the prediction of carboplatin clearance.
Cancer chemotherapy and pharmacology.
2020 03; 85(3):585-592. doi:
10.1007/s00280-019-04020-z. [PMID: 31915969] - Tomohiro Enokida, Takenori Ogawa, Akihiro Homma, Kenji Okami, Shujiro Minami, Ayako Nakanome, Yasushi Shimizu, Daisuke Maki, Yuri Ueda, Takao Fujisawa, Atsushi Motegi, Akira Ohkoshi, Jun Taguchi, Koji Ebisumoto, Shogo Nomura, Susumu Okano, Makoto Tahara. A multicenter phase II trial of paclitaxel, carboplatin, and cetuximab followed by chemoradiotherapy in patients with unresectable locally advanced squamous cell carcinoma of the head and neck.
Cancer medicine.
2020 03; 9(5):1671-1682. doi:
10.1002/cam4.2852. [PMID: 31943834] - Kuifeng Xu, Junqi Liu, Chaojun Zhang. Intra-arterial chemotherapy combined with VEC intravenous chemotherapy in the treatment of advanced retinoblastoma.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology.
2020 Mar; 25(2):1199-1205. doi:
NULL. [PMID: 32521926] - Yasser Elborai, Mohammad Almutereen, Ossama M Maher, Hanafy Hafez, Michelle A Lee, Leslie Lehmann. Changes in glomerular filtration rate and clinical course after sequential doses of carboplatin in children with embryonal brain tumors undergoing autologous stem cell transplantation.
Journal of the Egyptian National Cancer Institute.
2020 Feb; 32(1):9. doi:
10.1186/s43046-020-00024-6. [PMID: 32372349] - Vassiliki A Papadimitrakopoulou, Ji-Youn Han, Myung-Ju Ahn, Suresh S Ramalingam, Angelo Delmonte, Te-Chun Hsia, Janessa Laskin, Sang-We Kim, Yong He, Chun-Ming Tsai, Toyoaki Hida, Makoto Maemondo, Terufumi Kato, Suzanne Jenkins, Sabina Patel, Xiangning Huang, Gianluca Laus, Aleksandra Markovets, Kenneth S Thress, Yi-Long Wu, Tony Mok. Epidermal growth factor receptor mutation analysis in tissue and plasma from the AURA3 trial: Osimertinib versus platinum-pemetrexed for T790M mutation-positive advanced non-small cell lung cancer.
Cancer.
2020 01; 126(2):373-380. doi:
10.1002/cncr.32503. [PMID: 31769875] - Junliang Li, Jianxia Ma, Xuxia Zhang, Xiaohui Tai, Le Liu, Lingfang Zhang. Long Non-Coding RNA (lncRNA) BMP/OP-Responsive Gene (BORG) Promotes Development of Chemoresistance of Colorectal Cancer Cells to Carboplatin.
Medical science monitor : international medical journal of experimental and clinical research.
2020 Jan; 26(?):e919103. doi:
10.12659/msm.919103. [PMID: 31937750] - Raffaele Longo, Camille Jaud, William Gehin, Laurent Hennequin, Claire Bastien, Marco Campitiello, Antonio Rozzi, Francesca Plastino. Renal Metastases from a Nasal Cavity Mixed Squamous Cell and Adenoid Cystic Carcinoma: A Case Report.
The American journal of case reports.
2020 Jan; 21(?):e919781. doi:
10.12659/ajcr.919781. [PMID: 31911575] - Junjian Wang. Combination Treatment of Cervical Cancer Using Folate-Decorated, pH-Sensitive, Carboplatin and Paclitaxel Co-Loaded Lipid-Polymer Hybrid Nanoparticles.
Drug design, development and therapy.
2020; 14(?):823-832. doi:
10.2147/dddt.s235098. [PMID: 32161442]
