Tiletamine Hydrochloride (BioDeep_00000859110)
代谢物信息卡片
Tiletamine Hydrochloride
化学式: C12H18ClNOS (259.0797568)
中文名称: 盐酸替来他明
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCNC1(CCCCC1=O)C2=CC=CS2.Cl
InChI: 1H
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent
同义名列表
1 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- P Kucharski, Z Kiełbowicz. Dissociative anaesthesia in dogs and cats with use of tiletamine and zolazepam combination. What we already know about it.
Polish journal of veterinary sciences.
2021 Sep; 24(3):451-459. doi:
10.24425/pjvs.2021.138738. [PMID: 34730303] - Magdalene H Y Tang, Terence C Li, C K Lai, Y K Chong, C K Ching, Tony W L Mak. Emergence of new psychoactive substance 2-fluorodeschloroketamine: Toxicology and urinary analysis in a cluster of patients exposed to ketamine and multiple analogues.
Forensic science international.
2020 Jul; 312(?):110327. doi:
10.1016/j.forsciint.2020.110327. [PMID: 32460225] - Wai Lam Yip, Lam Rex Pui Kin, Yin Tang Magdalene, Lau Nike Kwai Cheung, Hon Tsui Matthew Sik. Tiletamine detected in a ketamine abuser with altered mental status.
Clinical toxicology (Philadelphia, Pa.).
2020 05; 58(5):430-431. doi:
10.1080/15563650.2019.1650938. [PMID: 31407598] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - S Y He, F J Gong, R Lian, Z H Sheng, J L Xu, W J Sun, S Q Zheng. Identification of Tiletamine, Zolazepam and Their Metabolites in Drug Facilitated Sexual Assault by GC-QTOF-MS.
Fa yi xue za zhi.
2019 Oct; 35(5):581-585. doi:
10.12116/j.issn.1004-5619.2019.05.013. [PMID: 31833293] - Oksana N Khokhlova, Elena A Tukhovskaya, Irina N Kravchenko, Elena S Sadovnikova, Irina A Pakhomova, Elena A Kalabina, Alexander V Lobanov, Elvira R Shaykhutdinova, Alina M Ismailova, Arkady N Murashev. Using Tiletamine-Zolazepam-Xylazine Anesthesia Compared to CO2-inhalation for Terminal Clinical Chemistry, Hematology, and Coagulation Analysis in Mice.
Journal of pharmacological and toxicological methods.
2017 Mar; 84(?):11-19. doi:
10.1016/j.vascn.2016.10.005. [PMID: 27773843] - Jihyun Kim, Hyesun Yum, Moonhee Jang, Ilchung Shin, Wonkyung Yang, Seungkyung Baeck, Joon Hyuk Suh, Sooyeun Lee, Sang Beom Han. A comprehensive and sensitive method for hair analysis in drug-facilitated crimes and incorporation of zolazepam and tiletamine into hair after a single exposure.
Analytical and bioanalytical chemistry.
2016 Jan; 408(1):251-63. doi:
10.1007/s00216-015-9099-y. [PMID: 26454443] - J C M Lewis, P Teale, G Webber, J W Sear, P M Taylor. Comparison of tiletamine and zolazepam pharmacokinetics in tigers (Panthera tigris) and leopards (Panthera pardus): do species differences account for adverse effects in tigers?.
Veterinary journal (London, England : 1997).
2014 Sep; 201(3):302-6. doi:
10.1016/j.tvjl.2014.05.041. [PMID: 25011709] - Atul Kumar, Henry J Mann, Rory P Remmel, Greg J Beilman, Nitin Kaila. Pharmacokinetic study in pigs and in vitro metabolic characterization in pig- and human-liver microsomes reveal marked differences in disposition and metabolism of tiletamine and zolazepam (Telazol).
Xenobiotica; the fate of foreign compounds in biological systems.
2014 Apr; 44(4):379-90. doi:
10.3109/00498254.2013.833362. [PMID: 24020890] - Il-Woo Shin, Young-Sool Hah, Cheol Kim, Jungchul Park, Heewon Shin, Kyeong-Eon Park, Seong-Ho Ok, Heon-Keun Lee, Young-Kyun Chung, Haeng Seon Shim, Dong Hoon Lim, Ju-Tae Sohn. Systemic blockage of nitric oxide synthase by L-NAME increases left ventricular systolic pressure, which is not augmented further by Intralipid®.
International journal of biological sciences.
2014; 10(4):367-76. doi:
10.7150/ijbs.8048. [PMID: 24719554] - José Angel Barasona, Jorge Ramón López-Olvera, Beatriz Beltrán-Beck, Christian Gortázar, Joaquín Vicente. Trap-effectiveness and response to tiletamine-zolazepam and medetomidine anaesthesia in Eurasian wild boar captured with cage and corral traps.
BMC veterinary research.
2013 May; 9(?):107. doi:
10.1186/1746-6148-9-107. [PMID: 23702232] - Kyeumhan Noh, Kil-Soo Kim, Byoungki Ahn, Pillippe Archimbault, Tae-Ho Oh, Wonku Kang. Simultaneous determination of zolazepam and tiletamine in dog plasma by liquid chromatography coupled to a tandem mass spectrometry.
Biomedical chromatography : BMC.
2012 Oct; 26(10):1133-6. doi:
10.1002/bmc.2692. [PMID: 22259017] - Akari Kamine, Michito Shimozuru, Haruki Shibata, Toshio Tsubota. Effects of intramuscular administration of tiletamine-zolazepam with and without sedative pretreatment on plasma and serum biochemical values and glucose tolerance test results in Japanese black bears (Ursus thibetanus japonicus).
American journal of veterinary research.
2012 Aug; 73(8):1282-9. doi:
10.2460/ajvr.73.8.1282. [PMID: 22849689] - Susanna J Fenwick, James P Scarth. In vitro metabolism of tiletamine, zolazepam and nonbenzodiazepine sedatives: Identification of target metabolites for equine doping control.
Drug testing and analysis.
2011 Oct; 3(10):705-16. doi:
10.1002/dta.300. [PMID: 21916022] - Asa Fahlman, Jon M Arnemo, Jon E Swenson, John Pringle, Sven Brunberg, Görel Nyman. Physiologic evaluation of capture and anesthesia with medetomidine-zolazepam-tiletamine in brown bears (Ursus arctos).
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2011 Mar; 42(1):1-11. doi:
10.1638/2008-0117.1. [PMID: 22946363] - E F A Machado, A C R Normand, L A S Nunes, R Brenzikofer, D V Macedo. Effects of different general anesthetics on serum hemolysis and hepatic and muscular glycogenolysis in rats.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
2009 Nov; 42(11):1035-8. doi:
10.1590/s0100-879x2009005000030. [PMID: 19802466] - Ju-Hee Oh, Se-Eun Park, Chang-Koo Shim, Young-Joo Lee. Biliary clearance of bromosulfophthalein in anesthetized and freely moving conscious rat.
Biopharmaceutics & drug disposition.
2009 Mar; 30(2):94-8. doi:
10.1002/bdd.646. [PMID: 19226651] - S F Anestis. Urinary cortisol responses to unusual events in captive chimpanzees (Pan troglodytes).
Stress (Amsterdam, Netherlands).
2009 Jan; 12(1):49-57. doi:
10.1080/10253890802041308. [PMID: 18850493] - Jeffrey A Clapper. Effects of two different anaesthetics on serum concentrations of cortisol and luteinizing hormone in barrows and gilts.
Laboratory animals.
2008 Jan; 42(1):83-91. doi:
10.1258/la.2007.006001. [PMID: 18348769] - M-J Kim, C-S Park, M-H Jun, M-C Kim. Antagonistic effects of yohimbine in pigs anaesthetised with tiletamine/zolazepam and xylazine.
The Veterinary record.
2007 Nov; 161(18):620-4. doi:
10.1136/vr.161.18.620. [PMID: 17982141] - C Ceylan, N Aydilek, H Ipek. Effects of tiletamine-zolazepam anaesthesia on plasma antioxidative status and some haematological parameters in sheep.
Acta veterinaria Hungarica.
2007 Jun; 55(2):191-7. doi:
10.1556/avet.55.2007.2.4. [PMID: 17555283] - Atul Kumar, Henry J Mann, Rory P Remmel. Determination of constituents of Telazol--tiletamine and zolazepam by a gas chromatography/mass spectrometry-based method.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Oct; 842(2):131-5. doi:
10.1016/j.jchromb.2006.05.014. [PMID: 16769259] - Kathryn E Wheatley, Corey J A Bradshaw, Robert G Harcourt, Lloyd S Davis, Mark A Hindell. Chemical immobilization of adult female Weddell seals with tiletamine and zolazepam: effects of age, condition and stage of lactation.
BMC veterinary research.
2006 Feb; 2(?):8. doi:
10.1186/1746-6148-2-8. [PMID: 16469105] - Manabu Onuma. Immobilization of sun bears (Helarctos malayanus) with medetomidine-zolazepam-tiletamine.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2003 Jun; 34(2):202-5. doi:
10.1638/1042-7260(2003)034[0202:iosbhm]2.0.co;2. [PMID: 12885141] - M T Quail, P Weimersheimer, A D Woolf, B Magnani. Abuse of telazol: an animal tranquilizer.
Journal of toxicology. Clinical toxicology.
2001; 39(4):399-402. doi:
10.1081/clt-100105161. [PMID: 11527235] - H A Semple, D K Gorecki, S D Farley, M A Ramsay. Pharmacokinetics and tissue residues of Telazol in free-ranging polar bears.
Journal of wildlife diseases.
2000 Oct; 36(4):653-62. doi:
10.7589/0090-3558-36.4.653. [PMID: 11085426] - H Chung, H Choi, E Kim, W Jin, H Lee, Y Yoo. A fatality due to injection of tiletamine and zolazepam.
Journal of analytical toxicology.
2000 May; 24(4):305-8. doi:
10.1093/jat/24.4.305. [PMID: 10872580] - J Fernández-Morán, J Palomeque, V I Peinado. Medetomidine/tiletamine/zolazepam and xylazine/tiletamine/zolazepam combinations for immobilization of fallow deer (Cervus dama).
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2000 Mar; 31(1):62-4. doi:
10.1638/1042-7260(2000)031[0062:mtzaxt]2.0.co;2. [PMID: 10884126] - C J Cording, R DeLuca, T Camporese, E Spratt. A fatality related to the veterinary anesthetic telazol.
Journal of analytical toxicology.
1999 Oct; 23(6):552-5. doi:
10.1093/jat/23.6.552. [PMID: 10517567] - D C Rankin, S A Greene, R D Keegan, A B Weil, R K Schneider, W M Bayly. Anesthesia of horses with a combination of detomidine, zolazepam, tiletamine, and isoflurane immediately after strenuous treadmill exercise.
American journal of veterinary research.
1999 Jun; 60(6):743-8. doi:
NULL. [PMID: 10376905] - W B Karesh, M M Uhart, E S Dierenfeld, W E Braselton, A Torres, C House, H Puche, R A Cook. Health evaluation of free-ranging guanaco (Lama guanicoe).
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
1998 Jun; 29(2):134-41. doi:
NULL. [PMID: 9732026] - P L Whitten, R Stavisky, F Aureli, E Russell. Response of fecal cortisol to stress in captive chimpanzees (Pan troglodytes).
American journal of primatology.
1998; 44(1):57-69. doi:
10.1002/(sici)1098-2345(1998)44:1<57::aid-ajp5>3.0.co;2-w. [PMID: 9444323] - G L Carroll, S M Hartsfield, R Hambleton. Anesthetic effects of tiletamine-zolazepam, alone or in combination with butorphanol, in goats.
Journal of the American Veterinary Medical Association.
1997 Sep; 211(5):593-7. doi:
NULL. [PMID: 9290827] - K D Evans, D L Dillehay, M J Huerkamp, S K Webb. Diagnostic exercise: azotemia in a rabbit (Oryctolagus cuniculus).
Laboratory animal science.
1996 Aug; 46(4):442-3. doi:
NULL. [PMID: 8872998] - B J Doerning, D W Brammer, C E Chrisp, H G Rush. Nephrotoxicity of tiletamine in New Zealand white rabbits.
Laboratory animal science.
1992 Jun; 42(3):267-9. doi:
NULL. [PMID: 1320157] - D W Brammer, B J Doerning, C E Chrisp, H G Rush. Anesthetic and nephrotoxic effects of Telazol in New Zealand white rabbits.
Laboratory animal science.
1991 Oct; 41(5):432-5. doi:
NULL. [PMID: 1666143] - J Van Heerden, R E Burroughs, J Dauth, M J Dreyer. Immobilization of wild dogs (Lycaon pictus) with a tiletamine hydrochloride/zolazepam hydrochloride combination and subsequent evaluation of selected blood chemistry parameters.
Journal of wildlife diseases.
1991 Apr; 27(2):225-9. doi:
10.7589/0090-3558-27.2.225. [PMID: 2067044] - M Bush, R S Custer, E E Smith. Use of dissociative anesthetics for the immobilization of captive bears: blood gas, hematology and biochemistry values.
Journal of wildlife diseases.
1980 Oct; 16(4):481-9. doi:
10.7589/0090-3558-16.4.481. [PMID: 7463600]