Lemildipine (BioDeep_00000859066)
代谢物信息卡片
Lemildipine
化学式: C20H22Cl2N2O6 (456.0854852)
中文名称: 来米地平
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C(C(=C(N1)COC(=O)N)C(=O)OC(C)C)C2=C(C(=CC=C2)Cl)Cl)C(=O)OC
InChI: InChI=1S/C20H22Cl2N2O6/c1-9(2)30-19(26)16-13(8-29-20(23)27)24-10(3)14(18(25)28-4)15(16)11-6-5-7-12(21)17(11)22/h5-7,9,15,24H,8H2,1-4H3,(H2,23,27)
描述信息
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:31769
- KEGGdrug: D01151
- PubChem: 65953
- ChEMBL: CHEMBL2104876
- CAS: 125729-29-5
- CAS: 94739-29-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tamer Z Attia, Mahmoud A Abdelmajed, Mahmoud A Omar, Khalid M Badr El-Din. Selective Spectrofluorimetric Protocol for Determination of Commonly Used Gram-negative Bactericidal Drug in Combined Pharmaceutical Dosage Forms and Human Plasma.
Journal of fluorescence.
2022 Mar; 32(2):603-612. doi:
10.1007/s10895-021-02862-6. [PMID: 35013853] - Kristīne Dišlere, Evita Rostoka, Egils Bisenieks, Gunars Duburs, Natalia Paramonova, Nikolajs Sjakste. 1,4-dihydropyridine derivatives increase mRNA expression of Psma3, Psmb5, and Psmc6 in rats.
Arhiv za higijenu rada i toksikologiju.
2021 Jun; 72(3):148-156. doi:
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Cardiovascular toxicology.
2020 12; 20(6):627-640. doi:
10.1007/s12012-020-09587-1. [PMID: 32671560] - George A Mugendi, Florence M Mutua, Patrizia Natale, Tonya M Esterhuizen, Giovanni Fm Strippoli. Calcium channel blockers for people with chronic kidney disease requiring dialysis.
The Cochrane database of systematic reviews.
2020 Oct; 10(?):CD011064. doi:
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Molecular and cellular endocrinology.
2018 09; 472(?):97-106. doi:
10.1016/j.mce.2017.11.024. [PMID: 29208420] - Minghua Yang, Fang Zhang, Yuting Hou, Yue Su, Yinlong Guo. Screening of illegally adulterated 1,4-dihydropyridine calcium antagonists in traditional Chinese medicines by a high-performance liquid chromatography electrospray ionization in-source collision-induced dissociation triple quadrupole mass spectrometric method.
Rapid communications in mass spectrometry : RCM.
2018 04; 32(8):672-676. doi:
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Journal of pharmacological sciences.
2018 Apr; 136(4):196-202. doi:
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The European physical journal. E, Soft matter.
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2012 Aug; 162(1):167-75. doi:
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2012 Jan; 32(1):110-1. doi:
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Life sciences.
2011 May; 88(19-20):898-907. doi:
10.1016/j.lfs.2011.03.019. [PMID: 21466810] - Miguel A Piñeros, Mark Tester. Calcium inhibits dihydropyridine-stimulated increases in opening and unitary conductance of a plant Ca²+ channel.
The Journal of membrane biology.
2011 Mar; 240(1):13-20. doi:
10.1007/s00232-011-9338-x. [PMID: 21274523] - Tomislava Lovaković, Marija Poljak-Blazi, Gunars Duburs, Ana Cipak, Marina Cindrić, Brigita Vigante, Egils Bisenieks, Morana Jaganjac, Lidija Mrakovcić, Azra Dedić, Neven Zarković. Growth modulation of human cells in vitro by mild oxidative stress and 1,4-dihydropyridine derivative antioxidants.
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2011 Mar; 35(1):137-41. doi:
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2008 Oct; 16(20):9349-58. doi:
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2008 Jan; 128(1):117-22. doi:
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Journal of chromatographic science.
2008 Jan; 46(1):35-41. doi:
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2007 Sep; 16(5):422-6. doi:
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Mitochondrion.
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2005 Mar; 13(5):1725-38. doi:
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2004 Sep; 99(1):177-90. doi:
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European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
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2001 Aug; 21(16):5944-51. doi:
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Molecular endocrinology (Baltimore, Md.).
2001 Jul; 15(7):1211-21. doi:
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2001 May; 166(10):6126-33. doi:
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American journal of physiology. Cell physiology.
2001 May; 280(5):C1193-203. doi:
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2001 May; 37(5):1268-72. doi:
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Pharmaceutical research.
2000 Jul; 17(7):844-50. doi:
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Biological & pharmaceutical bulletin.
2000 May; 23(5):581-4. doi:
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Molecular human reproduction.
2000 May; 6(5):435-42. doi:
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Cell biochemistry and function.
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Cell biochemistry and biophysics.
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General pharmacology.
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The American journal of physiology.
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Molecular and cellular biochemistry.
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