Lonazolac (BioDeep_00000859064)

   


代谢物信息卡片


1H-Pyrazole-4-aceticacid, 3-(4-chlorophenyl)-1-phenyl-

化学式: C17H13ClN2O2 (312.0665508)
中文名称: [3-(4-氯苯基)-1-苯基-1H-吡唑-4-基]乙酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C=C1)N2C=C(C(=N2)C3=CC=C(C=C3)Cl)CC(=O)O
InChI: InChI=1S/C17H13ClN2O2/c18-14-8-6-12(7-9-14)17-13(10-16(21)22)11-20(19-17)15-4-2-1-3-5-15/h1-9,11H,10H2,(H,21,22)

描述信息

M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AB - Acetic acid derivatives and related substances
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents

同义名列表

2 个代谢物同义名

1H-Pyrazole-4-aceticacid, 3-(4-chlorophenyl)-1-phenyl-; Lonazolac



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Nabil Mohie Abdel-Hamid, Sara Gamal Abd Allah, Mohamed K Hassan, Amal A M Ahmed, Nahla H Anber, Ibrahim Adel Faried. Possible Protective Potency of Argun Nut (Medemia argun - An Ancient Egyptian Palm) against Hepatocellular Carcinoma in Rats. Nutrition and cancer. 2022; 74(2):527-538. doi: 10.1080/01635581.2021.1883683. [PMID: 33570439]
  • H H Maurer, F X Tauvel, T Kraemer. Screening procedure for detection of non-steroidal anti-inflammatory drugs and their metabolites in urine as part of a systematic toxicological analysis procedure for acidic drugs and poisons by gas chromatography-mass spectrometry after extractive methylation. Journal of analytical toxicology. 2001 May; 25(4):237-44. doi: 10.1093/jat/25.4.237. [PMID: 11386636]
  • J Deneke, V Luckow, R Guserle, H H Pässler. Transsynovial kinetics of lonazolac and its hydroxy metabolite in synovitis patients. International journal of clinical pharmacology and therapeutics. 1998 Aug; 36(8):418-24. doi: NULL. [PMID: 9726694]
  • W Kullich, K Fromme, G Klein. [Gastroduodenal tolerance and clinical effectiveness of therapy with lonazolac-calcium in rheumatic diseases]. Wiener medizinische Wochenschrift (1946). 1996; 146(17):459-64. doi: NULL. [PMID: 9045528]
  • P Stehlík, J Hapala, H Cepeláková. [Determination of Lonazolac in blood using liquid chromatography with fluorescence detection and use of this method in a comparison of Lonazolac-Irritren preparations]. Ceskoslovenska farmacie. 1991 Mar; 40(1):37-9. doi: NULL. [PMID: 1878992]
  • R Huber, K Zech, E C Dittmann, R Lühmann, A Petitet. [Pharmacokinetics of the antirheumatic lonazolac-Ca in humans]. Arzneimittel-Forschung. 1990 Aug; 40(8):918-25. doi: NULL. [PMID: 2242085]
  • R Naeff, V Pliska, H G Weder. Pharmacokinetics of small unilamellar liposomes and incorporated lonazolac after i.m. administration. Journal of microencapsulation. 1990 Jan; 7(1):95-103. doi: 10.3109/02652049009028427. [PMID: 2308057]
  • E Vinge, S Björkman. Compared effects of the two antiinflammatory drugs indoprofen and lonazolac on thromboxane generation and on platelet aggregation, related to plasma concentrations after single oral doses. Acta pharmacologica et toxicologica. 1986 Sep; 59(3):165-74. doi: 10.1111/j.1600-0773.1986.tb00150.x. [PMID: 3799197]
  • F Mayrhofer, N Thumb. Concentrations of lonazolac in serum and synovial fluid of patients with inflammatory or degenerate joint disease. International journal of clinical pharmacology research. 1984; 4(6):415-7. doi: NULL. [PMID: 6533085]
  • G Lonauer, H Wagner, U Boerngen, K M Goebel. [Lonazolac-Ca-a non-steroidal antirheumatic agent. Long-term clinical study in chronic polyarthritis]. Zeitschrift fur Rheumatologie. 1981 Jul; 40(4):161-4. doi: NULL. [PMID: 7027681]