Defactinib (BioDeep_00000859046)
代谢物信息卡片
化学式: C20H21F3N8O3S (510.1409)
中文名称: 地法替尼
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CNC(=O)C1=CC=C(C=C1)NC2=NC=C(C(=N2)NCC3=NC=CN=C3N(C)S(=O)(=O)C)C(F)(F)F
InChI: InChI=1S/C20H21F3N8O3S/c1-24-18(32)12-4-6-13(7-5-12)29-19-28-10-14(20(21,22)23)16(30-19)27-11-15-17(26-9-8-25-15)31(2)35(3,33)34/h4-10H,11H2,1-3H3,(H,24,32)(H2,27,28,29,30)
描述信息
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C1967 - Tyrosine Kinase Inhibitor
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor
C274 - Antineoplastic Agent > C1742 - Angiogenesis Inhibitor
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- KEGGdrug: D10618
- PubChem: 25117126
- DrugBank: DB12282
- ChEMBL: CHEMBL3137331
- CAS: 1073154-85-4
- CAS: 1345713-71-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Jinzhao He, Shun Zhang, Zhiwei Qiu, Xiaowei Li, Huihui Huang, William Jin, Yue Xu, Guangying Shao, Liang Wang, Jia Meng, Shuyuan Wang, Xiaoqiang Geng, Yingli Jia, Min Li, Baoxue Yang, Hua A Jenny Lu, Hong Zhou. Inhibiting Focal Adhesion Kinase Ameliorates Cyst Development in Polycystin-1-Deficient Polycystic Kidney Disease in Animal Model.
Journal of the American Society of Nephrology : JASN.
2021 09; 32(9):2159-2174. doi:
10.1681/asn.2020111560. [PMID: 34465607] - Gurulingappa Hallur, Natarajan Tamizharasan, Suresh P Sulochana, Neeraj Kumar Saini, Mohd Zainuddin, Ramesh Mullangi. LC-ESI-MS/MS determination of defactinib, a novel FAK inhibitor in mice plasma and its application to a pharmacokinetic study in mice.
Journal of pharmaceutical and biomedical analysis.
2018 Feb; 149(?):358-364. doi:
10.1016/j.jpba.2017.11.022. [PMID: 29145097] - Toshio Shimizu, Kazuya Fukuoka, Masayuki Takeda, Tutomu Iwasa, Takeshi Yoshida, Joanna Horobin, Mitchell Keegan, Lou Vaickus, Ajit Chavan, Mahesh Padval, Kazuhiko Nakagawa. A first-in-Asian phase 1 study to evaluate safety, pharmacokinetics and clinical activity of VS-6063, a focal adhesion kinase (FAK) inhibitor in Japanese patients with advanced solid tumors.
Cancer chemotherapy and pharmacology.
2016 05; 77(5):997-1003. doi:
10.1007/s00280-016-3010-1. [PMID: 27025608] - Suzanne F Jones, Lillian L Siu, Johanna C Bendell, James M Cleary, Albiruni R A Razak, Jeffrey R Infante, Shuchi S Pandya, Philippe L Bedard, Kristen J Pierce, Brett Houk, W Gregory Roberts, S Martin Shreeve, Geoffrey I Shapiro. A phase I study of VS-6063, a second-generation focal adhesion kinase inhibitor, in patients with advanced solid tumors.
Investigational new drugs.
2015 10; 33(5):1100-7. doi:
10.1007/s10637-015-0282-y. [PMID: 26334219] - Noelia A-González, Antonio Castrillo. Liver X receptors as regulators of macrophage inflammatory and metabolic pathways.
Biochimica et biophysica acta.
2011 Aug; 1812(8):982-94. doi:
10.1016/j.bbadis.2010.12.015. [PMID: 21193033]
