Sotrastaurin (BioDeep_00000859044)
代谢物信息卡片
Sotrastaurin
化学式: C25H22N6O2 (438.18041519999997)
中文名称: 3-(1H-吲哚-3-基)-4-[2-(4-甲基哌嗪-1-基)喹唑啉-4-基]吡咯-2,5-二酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1CCN(CC1)C2=NC3=CC=CC=C3C(=N2)C4=C(C(=O)NC4=O)C5=CNC6=CC=CC=C65
InChI: InChI=1S/C25H22N6O2/c1-30-10-12-31(13-11-30)25-27-19-9-5-3-7-16(19)22(28-25)21-20(23(32)29-24(21)33)17-14-26-18-8-4-2-6-15(17)18/h2-9,14,26H,10-13H2,1H3,(H,29,32,33)
描述信息
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C61074 - Serine/Threonine Kinase Inhibitor
同义名列表
1 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:90531
- KEGGdrug: D09671
- PubChem: 10296883
- DrugBank: DB12369
- ChEMBL: CHEMBL565612
- CAS: 1058706-31-2
- CAS: 425637-18-9
- CAS: 949935-06-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Pedro Hannun, Claudia Felipe, Alexandra Ferreira, Tainá Sandes-Freitas, Marina Cristelli, Wilson Aguiar, Marcello Franco, Erika Campos, Maria Gerbase de Lima, Hélio Tedesco-Silva, José Medina-Pestana. Efficacy and Safety of Elective Conversion From Sotrastaurin (STN) to Tacrolimus (TAC) or Mycophenolate (MPS) in Stable Kidney Transplant Recipients.
Therapeutic drug monitoring.
2016 06; 38(3):293-9. doi:
10.1097/ftd.0000000000000292. [PMID: 26919549] - Allison B Webber, Flavio Vincenti. An Update on Calcineurin Inhibitor-Free Regimens: The Need Persists, but the Landscape has Changed.
Transplantation.
2016 Apr; 100(4):836-43. doi:
10.1097/tp.0000000000000872. [PMID: 27003097] - Arina Miyoshi, Mai Yamada, Haruki Shida, Daigo Nakazawa, Yoshihiro Kusunoki, Akinobu Nakamura, Hideaki Miyoshi, Utano Tomaru, Tatsuya Atsumi, Akihiro Ishizu. Circulating Neutrophil Extracellular Trap Levels in Well-Controlled Type 2 Diabetes and Pathway Involved in Their Formation Induced by High-Dose Glucose.
Pathobiology : journal of immunopathology, molecular and cellular biology.
2016; 83(5):243-51. doi:
10.1159/000444881. [PMID: 27189166] - Xu-Dong Cheng, Jun-Fei Gu, Jia-Rui Yuan, Liang Feng, Xiao-Bin Jia. Suppression of A549 cell proliferation and metastasis by calycosin via inhibition of the PKC‑α/ERK1/2 pathway: An in vitro investigation.
Molecular medicine reports.
2015 Dec; 12(6):7992-8002. doi:
10.3892/mmr.2015.4449. [PMID: 26498639] - A Pascher, P De Simone, J Pratschke, E Salamé, J Pirenne, H Isoneimi, M Bijarnia, I Krishnan, J Klupp. Protein kinase C inhibitor sotrastaurin in de novo liver transplant recipients: a randomized phase II trial.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
2015 May; 15(5):1283-92. doi:
10.1111/ajt.13175. [PMID: 25677074] - A Hässig, M Roos, A Etter, W Bossart, N Müller, M Schiesser, R P Wüthrich, T Fehr. Association of BK viremia with human leukocyte antigen mismatches and acute rejection, but not with type of calcineurin inhibitor.
Transplant infectious disease : an official journal of the Transplantation Society.
2014 Feb; 16(1):44-54. doi:
10.1111/tid.12153. [PMID: 24134704] - A de Weerd, M Kho, R Kraaijeveld, J Zuiderwijk, W Weimar, C Baan. The protein kinase C inhibitor sotrastaurin allows regulatory T cell function.
Clinical and experimental immunology.
2014 Feb; 175(2):296-304. doi:
10.1111/cei.12225. [PMID: 24131367] - Roberto Marcén, Antonio Dal Canton. Glomerular filtration rate: utility for assessing long-term renal allograft outcomes in kidney allograft recipients.
Journal of nephrology.
2013 Nov; 26(6):1009-24. doi:
10.5301/jn.5000308. [PMID: 24284526] - G R Russ, H Tedesco-Silva, D R Kuypers, S Cohney, R M Langer, O Witzke, J Eris, C Sommerer, B von Zur-Mühlen, E S Woodle, J Gill, J Ng, J Klupp, L Chodoff, K Budde. Efficacy of sotrastaurin plus tacrolimus after de novo kidney transplantation: randomized, phase II trial results.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
2013 Jul; 13(7):1746-56. doi:
10.1111/ajt.12251. [PMID: 23668931] - H Tedesco-Silva, M M L Kho, A Hartmann, S Vitko, G Russ, L Rostaing, K Budde, J M Campistol, J Eris, I Krishnan, U Gopalakrishnan, J Klupp. Sotrastaurin in calcineurin inhibitor-free regimen using everolimus in de novo kidney transplant recipients.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
2013 Jul; 13(7):1757-68. doi:
10.1111/ajt.12255. [PMID: 23659755] - Richard Ruiz, Goran B Klintmalm. Renal-sparing regimens employing new agents.
Current opinion in organ transplantation.
2012 Dec; 17(6):619-25. doi:
10.1097/mot.0b013e328359886a. [PMID: 23111644] - Tom Florian Fuller, Angelika Kusch, Lyubov Chaykovska, Rusan Catar, Jennifer Pützer, Martina Haller, Jakob Troppmair, Uwe Hoff, Duska Dragun. Protein kinase C inhibition ameliorates posttransplantation preservation injury in rat renal transplants.
Transplantation.
2012 Oct; 94(7):679-86. doi:
10.1097/tp.0b013e318265c4d8. [PMID: 22932117] - Marc Bigaud, Grazyna Wieczorek, Christian Beerli, Maxime Audet, Antoine Blancher, Christoph Heusser, Randall E Morris, Jürgen Wagner. Sotrastaurin (AEB071) alone and in combination with cyclosporine A prolongs survival times of non-human primate recipients of life-supporting kidney allografts.
Transplantation.
2012 Jan; 93(2):156-64. doi:
10.1097/tp.0b013e31823cf92f. [PMID: 22179400] - Kenichiro Yamashita, Satoru Todo. Sotrastaurin, a new selective protein kinase C inhibitor, on the way.
Transplantation.
2012 Jan; 93(2):146-7. doi:
10.1097/tp.0b013e31823d4b1f. [PMID: 22129763] - Yu Hui Fang, Dong Jin Joo, Beom Jin Lim, Kyu Ha Huh, Myoung Soo Kim, Hwal Suh, Yu Seun Kim. The effects of AEB071 (sotrastaurin) with tacrolimus on rat heterotopic cardiac allograft rejection and survival.
The Journal of surgical research.
2011 Nov; 171(1):e133-7. doi:
10.1016/j.jss.2011.06.039. [PMID: 21816421] - H Tedesco Silva, C R Felipe, M Abbud-Filho, V Garcia, J O Medina-Pestana. The emerging role of Brazil in clinical trial conduct for transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
2011 Jul; 11(7):1368-75. doi:
10.1111/j.1600-6143.2011.03564.x. [PMID: 21668630] - S Friman, W Arns, B Nashan, F Vincenti, B Banas, K Budde, D Cibrik, L Chan, J Klempnauer, S Mulgaonkar, M Nicholson, J Wahlberg, K-M Wissing, K Abrams, S Witte, E S Woodle. Sotrastaurin, a novel small molecule inhibiting protein-kinase C: randomized phase II study in renal transplant recipients.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
2011 Jul; 11(7):1444-55. doi:
10.1111/j.1600-6143.2011.03538.x. [PMID: 21564523] - H-U Meier-Kriesche, B Kaplan. The search for CNI-free immunosuppression: no free lunch.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
2011 Jul; 11(7):1355-6. doi:
10.1111/j.1600-6143.2011.03541.x. [PMID: 21564526] - B D Kahan. Frontiers in immunosuppression.
Transplantation proceedings.
2011 Apr; 43(3):822-5. doi:
10.1016/j.transproceed.2011.02.001. [PMID: 21486607] - John M Kovarik, Jürg U Steiger, Josep M Grinyo, Lionel Rostaing, Wolfgang Arns, Jacques Dantal, Pieter Proot, Klemens Budde. Pharmacokinetics of sotrastaurin combined with tacrolimus or mycophenolic acid in de novo kidney transplant recipients.
Transplantation.
2011 Feb; 91(3):317-22. doi:
10.1097/tp.0b013e318203860d. [PMID: 21157403] - Mareen Matz, Marcel Naik, Mir-Farzin Mashreghi, Petra Glander, Hans-H Neumayer, Klemens Budde. Evaluation of the novel protein kinase C inhibitor sotrastaurin as immunosuppressive therapy after renal transplantation.
Expert opinion on drug metabolism & toxicology.
2011 Jan; 7(1):103-13. doi:
10.1517/17425255.2011.540238. [PMID: 21142580] - Mareen Matz, Ulrike Weber, Mir-Farzin Mashreghi, Christine Lorkowski, Juliane Ladhoff, Stefan Kramer, Hans-H Neumayer, Klemens Budde. Effects of the new immunosuppressive agent AEB071 on human immune cells.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2010 Jul; 25(7):2159-67. doi:
10.1093/ndt/gfp775. [PMID: 20100729] - J E Cooper, A C Wiseman. Novel immunosuppressive agents in kidney transplantation.
Clinical nephrology.
2010 May; 73(5):333-43. doi:
10.5414/cnp73333. [PMID: 20420793] - K Budde, C Sommerer, T Becker, A Asderakis, F Pietruck, J M Grinyo, P Rigotti, J Dantal, J Ng, M J Barten, M Weber. Sotrastaurin, a novel small molecule inhibiting protein kinase C: first clinical results in renal-transplant recipients.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
2010 Mar; 10(3):571-81. doi:
10.1111/j.1600-6143.2009.02980.x. [PMID: 20121745] - Claudia Sommerer, Martin Zeier. AEB071--a promising immunosuppressive agent.
Clinical transplantation.
2009 Dec; 23 Suppl 21(?):15-8. doi:
10.1111/j.1399-0012.2009.01104.x. [PMID: 19930311] - Santhakumar Manicassamy. Sotrastaurin, a protein kinase C inhibitor for the prevention of transplant rejection and treatment of psoriasis.
Current opinion in investigational drugs (London, England : 2000).
2009 Nov; 10(11):1225-35. doi:
NULL. [PMID: 19876790] - John M Kovarik, Hsun-Lun A Huang, Alan Slade, Nikos Sfikas, Patricia A Chandler. The effect on sotrastaurin pharmacokinetics of strong CYP3A inhibition by ketoconazole.
British journal of clinical pharmacology.
2009 Sep; 68(3):381-5. doi:
10.1111/j.1365-2125.2009.03457.x. [PMID: 19740395]