Protonix (BioDeep_00000859039)
代谢物信息卡片
Protonix
化学式: C32H34F4N6Na2O11S2 (864.1458422000002)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=C(C(=NC=C1)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC(F)F)OC.COC1=C(C(=NC=C1)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC(F)F)OC.O.O.O.[Na+].[Na+]
InChI: 2*+1
描述信息
C78276 - Agent Affecting Digestive System or Metabolism > C29701 - Anti-ulcer Agent > C29723 - Proton Pump Inhibitor
D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents
D004791 - Enzyme Inhibitors > D054328 - Proton Pump Inhibitors
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Finnian Freeling, Dominic Armbruster, Karsten Nödler, Uwe Kunkel, Marco Scheurer, Jan Koschorreck, Thomas A Ternes. Metabolites are overlooked in environmental risk assessments and monitoring of pharmaceuticals: The case study of pantoprazole.
Water research.
2024 Jun; 256(?):121596. doi:
10.1016/j.watres.2024.121596. [PMID: 38685172] - Yue Ma, Shu Li, Hongxi Yang, Yuan Zhang, Huiping Li, Lihui Zhou, Jing Lin, Yanchun Chen, Yabing Hou, Xinyu Zhang, Tong Liu, Xin Zhou, Yaogang Wang. Acid suppressants use and risk of atherosclerotic cardiovascular disease in middle-aged and older adults.
Atherosclerosis.
2022 10; 358(?):47-54. doi:
10.1016/j.atherosclerosis.2022.09.001. [PMID: 36113328] - Zhimin Chen, Fangliang Gan, Xiali Rao, Xiaoxiao Huang, Huafang Chen. Pharmacokinetics, Bioequivalence, and Safety Studies of Pantoprazole Sodium Enteric-Coated Tablets in Healthy Subjects.
Clinical pharmacology in drug development.
2021 05; 10(5):502-509. doi:
10.1002/cpdd.888. [PMID: 33128847] - Syed Mohammed Basheeruddin Asdaq, Earla Swathi, Sunil S Dhamanigi, Mohammed Asad, Yahya Ali Mohzari, Ahmed A Alrashed, Abdulrahman S Alotaibi, Batool Mohammed Alhassan, Sreeharsha Nagaraja. Role of Daucus carota in Enhancing Antiulcer Profile of Pantoprazole in Experimental Animals.
Molecules (Basel, Switzerland).
2020 Nov; 25(22):. doi:
10.3390/molecules25225287. [PMID: 33202703] - Jae Ho Cho, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee. Efficacy of DA-5204 (Stillen 2X) for patients with gastroesophageal reflux disease: A randomized, double-blind, placebo-controlled pilot study.
Medicine.
2020 Oct; 99(44):e22729. doi:
10.1097/md.0000000000022729. [PMID: 33126310] - Gaurav Taneja, Punniyakoti V Thanikachalam, Satyendra K Rajput. Dose and time-dependent toxicological impact of pantoprazole on vascular endothelium and renal tissue.
Toxicology letters.
2020 Oct; 333(?):97-104. doi:
10.1016/j.toxlet.2020.07.031. [PMID: 32763312] - Raed S Ismail, Mohammed S El-Awady, Memy H Hassan. Pantoprazole abrogated cisplatin-induced nephrotoxicity in mice via suppression of inflammation, apoptosis, and oxidative stress.
Naunyn-Schmiedeberg's archives of pharmacology.
2020 07; 393(7):1161-1171. doi:
10.1007/s00210-020-01823-3. [PMID: 31950223] - Sara Kadkhodaei, Farideh Siavoshi, Alireza Foroumadi, Abdolfattah Sarrafnejad, Shadi Kolahdoozan. Proton Pump Inhibitor-Treated H. pylori Adjust Cell Envelope Fatty Acid and Cholesterol Content to Survive.
Archives of Iranian medicine.
2020 01; 23(1):7-14. doi:
. [PMID: 31910629] - Qianqian Cai, Tianyu Zhao, Lianjun Zhang, Pan Zhao, Yajie Zhu, Haiyan Xu, Xiaohong Hou. A new strategy for extraction and depuration of pantoprazole in rat plasma: Vortex assisted dispersive micro-solid-phase extraction employing metal organic framework MIL-101(Cr) as sorbent followed by dispersive liquid-liquid microextraction based on solidification of a floating organic droplet.
Journal of pharmaceutical and biomedical analysis.
2019 Aug; 172(?):86-93. doi:
10.1016/j.jpba.2019.04.016. [PMID: 31029803] - Wiebke Kempin, Vanessa Domsta, Iris Brecht, Beatrice Semmling, Susan Tillmann, Werner Weitschies, Anne Seidlitz. Development of a dual extrusion printing technique for an acid- and thermo-labile drug.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2018 Oct; 123(?):191-198. doi:
10.1016/j.ejps.2018.07.041. [PMID: 30031859] - Wiebke Kempin, Vanessa Domsta, Georg Grathoff, Iris Brecht, Beatrice Semmling, Susan Tillmann, Werner Weitschies, Anne Seidlitz. Immediate Release 3D-Printed Tablets Produced Via Fused Deposition Modeling of a Thermo-Sensitive Drug.
Pharmaceutical research.
2018 Apr; 35(6):124. doi:
10.1007/s11095-018-2405-6. [PMID: 29679157] - Lalehan Akyuz, Idris Sargin, Murat Kaya, Talip Ceter, Ilgaz Akata. A new pollen-derived microcarrier for pantoprazole delivery.
Materials science & engineering. C, Materials for biological applications.
2017 Feb; 71(?):937-942. doi:
10.1016/j.msec.2016.11.009. [PMID: 27987792] - Erick V S Motta, Marivane Lemos, Juliana C Costa, Vilmar C Banderó-Filho, Astrid Sasse, Helen Sheridan, Jairo K Bastos. Galloylquinic acid derivatives from Copaifera langsdorffii leaves display gastroprotective activity.
Chemico-biological interactions.
2017 Jan; 261(?):145-155. doi:
10.1016/j.cbi.2016.11.028. [PMID: 27894855] - Devendra Pratap Singh, Swapnil P Borse, Manish Nivsarkar. Co-administration of quercetin with pantoprazole sodium prevents NSAID-induced severe gastroenteropathic damage efficiently: Evidence from a preclinical study in rats.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.
2017 Jan; 69(1):17-26. doi:
10.1016/j.etp.2016.10.004. [PMID: 27780667] - Xiaoyu Zeng, Lin Liu, Mengzhu Zheng, Huimin Sun, Juanjuan Xiao, Tao Lu, Guangqian Huang, Pianpian Chen, Jianmin Zhang, Feng Zhu, Hua Li, Qiuhong Duan. Pantoprazole, an FDA-approved proton-pump inhibitor, suppresses colorectal cancer growth by targeting T-cell-originated protein kinase.
Oncotarget.
2016 Apr; 7(16):22460-73. doi:
10.18632/oncotarget.7984. [PMID: 26967058] - Devendra Pratap Singh, Swapnil P Borse, Manish Nivsarkar. A novel model for NSAID induced gastroenteropathy in rats.
Journal of pharmacological and toxicological methods.
2016 Mar; 78(?):66-75. doi:
10.1016/j.vascn.2015.11.008. [PMID: 26655077] - Natalie Bordag, Sebastian Klie, Kathrin Jürchott, Janine Vierheller, Hajo Schiewe, Valerie Albrecht, Jörg-Christian Tonn, Christoph Schwartz, Christian Schichor, Joachim Selbig. Glucocorticoid (dexamethasone)-induced metabolome changes in healthy males suggest prediction of response and side effects.
Scientific reports.
2015 Nov; 5(?):15954. doi:
10.1038/srep15954. [PMID: 26526738] - Akhileshwar K Srivastava, Mallika Tewari, Hari S Shukla, Bijoy K Roy. In Silico Profiling of the Potentiality of Curcumin and Conventional Drugs for CagA Oncoprotein Inactivation.
Archiv der Pharmazie.
2015 Aug; 348(8):548-55. doi:
10.1002/ardp.201400438. [PMID: 25996140] - Arvind Kumar Giri, Jitendra Kumar Rawat, Manjari Singh, Swetlana Gautam, Gaurav Kaithwas. Effect of lycopene against gastroesophageal reflux disease in experimental animals.
BMC complementary and alternative medicine.
2015 Apr; 15(?):110. doi:
10.1186/s12906-015-0631-6. [PMID: 25888837] - L S Babinets', I M Halabits'ka, N Ie Botsiuk, S S Riabokon'. [Pathogenetic grounds of trophological impact of chronic pancreatitis complex therapy].
Likars'ka sprava.
2014 Nov; ?(11):128-31. doi:
". [PMID: 25528850] - Chuan Tian, Lixin Zhu, Dan Yu, Zhiwei Cao, Tingguo Kang, Ruixin Zhu. The stereoselectivity of CYP2C19 on R- and S-isomers of proton pump inhibitors.
Chemical biology & drug design.
2014 May; 83(5):610-21. doi:
10.1111/cbdd.12274. [PMID: 24350826] - Jong-Min Park, Yoon-Jae Kim, Ju-Seung Kim, Young-Min Han, Napapan Kangwan, Ki Baik Hahm, Tae-Sok Kim, Oran Kwon, Eun-Hee Kim. Anti-inflammatory and carbonic anhydrase restoring actions of yam powder (Dioscorea spp) contribute to the prevention of cysteamine-induced duodenal ulcer in a rat model.
Nutrition research (New York, N.Y.).
2013 Aug; 33(8):677-85. doi:
10.1016/j.nutres.2013.05.019. [PMID: 23890358] - Lucie Bouchoud, Caroline Fonzo-Christe, Martin Klingmüller, Pascal Bonnabry. Compatibility of intravenous medications with parenteral nutrition: in vitro evaluation.
JPEN. Journal of parenteral and enteral nutrition.
2013 May; 37(3):416-24. doi:
10.1177/0148607112464239. [PMID: 23112277] - Ekta Arya, Sudipta Saha, Shubhini A Saraf, Gaurav Kaithwas. Effect of Perilla frutescens fixed oil on experimental esophagitis in albino Wistar rats.
BioMed research international.
2013; 2013(?):981372. doi:
10.1155/2013/981372. [PMID: 24027769] - Xiao-bo Mao, Shi-qi Wang, Yi Mao. [Effects of rhubarb on the intestinal barrier function of patients with acute myocardial infarction-heart].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2012 Aug; 32(8):1046-50. doi:
. [PMID: 23173250] - Yuning Wei, Ping Liu, Xinrong He, Qin Chen. [Microdialysis and HPLC method for determination of concentration of pantoprazole in rat striatum aftercombined administration with borneol].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2010 Oct; 35(19):2605-8. doi:
10.4268/cjcmm20101923. [PMID: 21174774] - K J Dabos, E Sfika, L J Vlatta, G Giannikopoulos. The effect of mastic gum on Helicobacter pylori: a randomized pilot study.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2010 Mar; 17(3-4):296-9. doi:
10.1016/j.phymed.2009.09.010. [PMID: 19879118] - Ramazan Gen, Mehmet Demir, Hilmi Ataseven. Effect of Helicobacter pylori eradication on insulin resistance, serum lipids and low-grade inflammation.
Southern medical journal.
2010 Mar; 103(3):190-6. doi:
10.1097/smj.0b013e3181cf373f. [PMID: 20134372] - Payal J Shah, Mitesh S Gandhi, Mamta B Shah, Sunita S Goswami, Devdas Santani. Study of Mimusops elengi bark in experimental gastric ulcers.
Journal of ethnopharmacology.
2003 Dec; 89(2-3):305-11. doi:
10.1016/j.jep.2003.09.003. [PMID: 14611897] - Chang-Hong Wang, Li-Xin Wang, Zhuo Yang, Shan-Quan Chen, Hong Zhu, Yu-Ping Lu. [Treatment of reflux esophagitis by Xuanfu Daizhe Decoction combined with pantoprazole or omeprazole: a comparative study].
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine.
2003 Nov; 1(4):284, 311. doi:
10.3736/jcim20030416. [PMID: 15339533] - Solveigh Krusekopf, Ivar Roots, Ullrich Kleeberg. Differential drug-induced mRNA expression of human CYP3A4 compared to CYP3A5, CYP3A7 and CYP3A43.
European journal of pharmacology.
2003 Apr; 466(1-2):7-12. doi:
10.1016/s0014-2999(03)01481-x. [PMID: 12679136] - Tom C Martinsen, Nan E T Skogaker, Marianne Ø Bendheim, Helge L Waldum. Antral G cells in rats during dosing with a PPAR alpha agonist: a morphometric and immunocytochemical study.
Medical electron microscopy : official journal of the Clinical Electron Microscopy Society of Japan.
2003 Mar; 36(1):18-32. doi:
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