Benzcyclane (BioDeep_00000859018)

   


代谢物信息卡片


Benzcyclane

化学式: C19H31NO (289.2405516)
中文名称: 平痉可宁
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN(C)CCCOC1(CCCCCC1)CC2=CC=CC=C2
InChI: InChI=1S/C19H31NO/c1-20(2)15-10-16-21-19(13-8-3-4-9-14-19)17-18-11-6-5-7-12-18/h5-7,11-12H,3-4,8-10,13-17H2,1-2H3

描述信息

C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
C - Cardiovascular system > C04 - Peripheral vasodilators > C04A - Peripheral vasodilators
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker

同义名列表

2 个代谢物同义名

Benzcyclane; BENCYCLANE



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Ibrahim Barut, Omer R Tarhan, Nilgun Kapucuoglu, Recep Sutcu, Yusuf Akdeniz. Effect of bencyclane fumarate on intestinal ischaemia reperfusion injury. ANZ journal of surgery. 2008 Jun; 78(6):476-81. doi: 10.1111/j.1445-2197.2008.04358.x. [PMID: 18522569]
  • A Lohmann, N Diekmann, R Walters, R Kraft. Determination of bencyclane in human plasma by means of capillary gas chromatography and nitrogen-phosphorus selective detection. Journal of chromatography. 1991 Mar; 564(1):283-8. doi: 10.1016/0378-4347(91)80092-q. [PMID: 1860923]
  • G W Bielenberg, C Hayn, J Krieglstein. Effects of cerebro-protective agents on enzyme activities of rat primary glial cultures and rat cerebral cortex. Biochemical pharmacology. 1986 Aug; 35(16):2693-702. doi: 10.1016/0006-2952(86)90177-2. [PMID: 2943286]
  • Z Mohri, T Yasuda, K Kawahara, F Shono, A Yoshitake. Radioimmunoassay of bencyclane in human serum. Journal of pharmacobio-dynamics. 1985 Mar; 8(3):227-33. doi: 10.1248/bpb1978.8.227. [PMID: 4009414]
  • R Eckard, R Weyhenmeyer. Pharmacokinetics of bencyclane after single dose administration to healthy volunteers. Arzneimittel-Forschung. 1985; 35(10):1587-90. doi: NULL. [PMID: 4074419]
  • N Ogawa, S Tsukamoto, S Ohara, Y Hirose, T Kishimoto, A Mori. Effects of bencyclane on concussion following head injury in mice. Research communications in chemical pathology and pharmacology. 1985 Jan; 47(1):115-22. doi: NULL. [PMID: 3920736]
  • W Gielsdorf, J A Settlage, H Jaeger. Quantitative determination of bencyclane in human plasma by capillary gas chromatography/chemical ionization mass spectrometry. Arzneimittel-Forschung. 1984; 34(3):290-2. doi: NULL. [PMID: 6539608]
  • L A Leshchinskiĭ, L T Pimenov, V V Trusov. [Changes in renal hemodynamics and renal function in patients with cardiac insufficiency treated with vasodilators]. Terapevticheskii arkhiv. 1981; 53(8):80-4. doi: NULL. [PMID: 7292349]
  • K Kimura, A Nagata, H Miyawaki. The metabolism of benzyclane [1-benzyl-1-(3-N,N-dimethylaminopropoxy)cycloheptane] in rat and man. Xenobiotica; the fate of foreign compounds in biological systems. 1979 Feb; 9(2):119-27. doi: 10.3109/00498257909038712. [PMID: 433310]
  • B Störmer, F Kleinschmidt, D Loose, K Kremer. [Blood rheology in chronic arterial occlusive disease as influenced by vasodilators (author's transl)]. Deutsche medizinische Wochenschrift (1946). 1978 Apr; 103(16):694-8. doi: 10.1055/s-0028-1104502. [PMID: 639718]
  • H Heidrich, T Schirop, K Fichte. [Influence of vasoactive substances on blood sugar and serum insulin in normal and diabetic carbohydrate metabolism (author's transl)]. Medizinische Klinik. 1977 Jan; 72(3):94-101. doi: NULL. [PMID: 402543]
  • B Störmer, K Kleinschmidt, D Loose, K Kremer. Rheological changes in the blood of patients with chronic arterial occlusive disease after the administration of vasoactive drugs. Current medical research and opinion. 1977; 4(8):588-95. doi: 10.1185/03007997709115275. [PMID: 872611]
  • J P Radó. Interference of bencyclan with 11-hydroxycorticosteroids determinations. International journal of clinical pharmacology and biopharmacy. 1976 Oct; 14(3):186-8. doi: NULL. [PMID: 1002354]
  • P R Bock. A contribution to the pharmacokinetics of bencyclane (Fludilat) in man. International journal of clinical pharmacology and biopharmacy. 1976 Jun; 13(4):246-52. doi: NULL. [PMID: 965131]
  • A Ia Ivleva, V F Kremneva, S I Zolotukhin. [Effect of no-shpa, halidor, dibazol and euphylline on the fibrinogen content and fibrinolytic activity of blood]. Farmakologiia i toksikologiia. 1976 May; 39(3):304-8. doi: NULL. [PMID: 1026513]
  • O Ponari, E Civardi, G Dettori, A Magha, R Potì, G Bulletti. In vitro effects of bencyclan on coagulation, fibrinolysis and platelet function. Arzneimittel-Forschung. 1976; 26(8):1532-8. doi: NULL. [PMID: 12770]
  • V F Kremeva, I B Zagorskaia. [Effect of dibazol, euphylline, No-Spa and galidor on thrombocyte osmotic resistance and blood clot retraction]. Farmakologiia i toksikologiia. 1975 May; 38(3):324-7. doi: NULL. [PMID: 1227905]
  • H Nishino. [Regional blood flow in the brain. 4. Effects of various vasodilators on the blood flow in the brain and other organs]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1974 Sep; 70(5):621-8. doi: 10.1254/fpj.70.621. [PMID: 4477094]