(-)-(S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, hemihydrate (BioDeep_00000859013)
代谢物信息卡片
(-)-(S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, hemihydrate
化学式: C36H42F2N6O9 (740.2981186000001)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)O.CC1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)O.O
InChI: /m00./s1
描述信息
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors > D065609 - Cytochrome P-450 CYP1A2 Inhibitors
D000970 - Antineoplastic Agents > D059003 - Topoisomerase Inhibitors > D059005 - Topoisomerase II Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D024841 - Fluoroquinolones
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C254 - Anti-Infective Agent > C258 - Antibiotic > C795 - Quinolone Antibiotic
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yang Zhou, Mingyan Chi, Zuying Zhou, Ling Wang, Li Yuan, Lin Zheng, Yong Huang. Herb-drug interactions: Quantitative analysis of levofloxacin absorption and transporter expression in the rat intestine following combined treatment with Persicaria capitata (Buch.-Ham. ex D. Don) H. Gross.
Journal of pharmaceutical and biomedical analysis.
2024 Aug; 245(?):116156. doi:
10.1016/j.jpba.2024.116156. [PMID: 38636190] - Shisui Feng, Yue Guo, Qianyi Wang, Mingwei Meng, Xi Liu, Chi Zhang, Hua Zheng, Hongwei Guo, Rigang Lu, Danfeng Li, Zhiheng Su, Hui Song, Yonghong Liang. UPLC/Q-TOF-MS-based metabolomics and molecular docking analysis of Bifidobacterium adolescentis exposure to levofloxacin.
Biomedical chromatography : BMC.
2024 Jun; 38(6):e5862. doi:
10.1002/bmc.5862. [PMID: 38684194] - Klaudia Stando, Michał Grzybowski, Anna Byczek-Wyrostek, Sylwia Bajkacz. Efficiency of phytoremediation and identification of biotransformation pathways of fluoroquinolones in the aquatic environment.
International journal of phytoremediation.
2024 May; 26(7):1027-1037. doi:
10.1080/15226514.2023.2288898. [PMID: 38069676] - Yingli Xu, Lei Bao, Shan Cao, Bo Pang, Jingsheng Zhang, Yu Zhang, Mengping Chen, Yaxin Wang, Qiyue Sun, Ronghua Zhao, Shanshan Guo, Jing Sun, Xiaolan Cui. Pharmacological effects and mechanism of Maxing Shigan decoction in the treatment of Pseudomonas aeruginosa pneumonia.
Journal of ethnopharmacology.
2024 Feb; 320(?):117424. doi:
10.1016/j.jep.2023.117424. [PMID: 37984543] - Amal Ben Ayed, Imen Akrout, Karima Staita, Quentin Albert, Stéphane Greff, Charlotte Simmler, Steven Ahrendt, Kurt LaButti, Anna Lipzen, Guifen He, Emily Savage, Jean Armengaud, Mélodie Kielbasa, David Navarro, Elodie Drula, Annick Turbé-Doan, Emmanuel Bertrand, Anne Lomascolo, Delphine Chaduli, Craig B Faulds, Mohamed Chamkha, Amina Maalej, Kerrie Barry, Igor V Grigoriev, Francis Martin, Héla Zouari-Mechichi, Giuliano Sciara, Tahar Mechichi, Eric Record. Genome sequencing of Porostereum spadiceum to study the degradation of levofloxacin.
Ecotoxicology and environmental safety.
2024 Jan; 270(?):115808. doi:
10.1016/j.ecoenv.2023.115808. [PMID: 38198896] - Gisele Canan-Rochenbach, Marco A B Barreiros, André O S Lima, Pascale Bauda, Eric Sanches-Simões, Wendell Pimentel-Almeida, Rafael Ariente-Neto, Cleder A Somensi, Tito C M Almeida, Rogério Corrêa, Claudemir M Radetski. Characterization of bacterial resistance in treated hospital wastewater.
Environmental technology.
2024 Jan; 45(1):120-128. doi:
10.1080/09593330.2022.2100282. [PMID: 35802062] - Zong-Ping Li, Jun Li, Tong-Lu Li, Zhi-Yong Song, Xue-Zhong Gong. Uropathogenic Escherichia coli infection: innate immune disorder, bladder damage, and Tailin Fang II.
Frontiers in cellular and infection microbiology.
2024; 14(?):1322119. doi:
10.3389/fcimb.2024.1322119. [PMID: 38638825] - Yuxuan He, Jin Qian, Yuanyuan Li, Peifang Wang, Bianhe Lu, Yin Liu, Yuhang Zhang, Feng Liu. Responses of Phragmites communis and its rhizosphere bacteria to different exposure sequences of molybdenum disulfide and levofloxacin.
Environmental pollution (Barking, Essex : 1987).
2023 Oct; 335(?):122273. doi:
10.1016/j.envpol.2023.122273. [PMID: 37506800] - Fatma M El-Demerdash, Manal M Ahmed, Hoda H Baghdadi. Punica granatum peel extract modulates levofloxacin-induced oxidative stress and testicular damage in rats.
Tissue & cell.
2023 Sep; 85(?):102227. doi:
10.1016/j.tice.2023.102227. [PMID: 37793207] - Florence Nantaba, John Wasswa, Henrik Kylin, Hindrik Bouwman, Wolf-Ulrich Palm, Klaus Kümmerer. Spatial trends and ecotoxic risk assessment of selected pharmaceuticals in sediments from Lake Victoria, Uganda, East Africa.
The Science of the total environment.
2023 Sep; 906(?):167348. doi:
10.1016/j.scitotenv.2023.167348. [PMID: 37769731] - Yuxiang Wang, Jinran Du, Dayan Zhang, Cong Jin, Jiangpo Chen, Zeyuan Wang, Tonglin Mei, Kaili Fu, Qingzeng Qian, Tieliang Pang. Primary antibiotic resistance in Helicobacter pylori in China: a systematic review and meta-analysis.
Journal of global antimicrobial resistance.
2023 09; 34(?):30-38. doi:
10.1016/j.jgar.2023.05.014. [PMID: 37315738] - Shengjuan Hu, Yan Zhou, Yanhong Deng, Yang Bo, Xianmei Chen, Wei Yang, Ruichun Shi, Wei Zhao, Zhanbing Hou, Jianping Hu, Jianguo Liu, Xilong Zhang, Heli Yong, Ping Wang, Fei Li, Hailong Qi, Xiaoyun Wang, Lijuan Jin, Ting Cui, Haijiang Yong, Xue Li, Bin Yang, Yuehua Yu, Bin Ma, Lei Fu, Xuemei Wang, Zhen Ma, Na Tang, Yanjie You, Jianyang Guo, Xiaobing Yu, Li Yao, Ruiping Gao, Yanling Li, Ruijuan Xin, Jianfang Liu, Zhenzi Cao, Hongliang Li, Linke Ma, Shoucheng Ma, Ying Cao, Yuanyuan Tang, Jun Liu, Qian Hao, Xiaofei Li, Xuemei Li, Rui Mu, Min Niu, Xiaoming Su, Hengjun Gao. Characteristics of phenotypic antibiotic resistance of Helicobacter pylori and its correlation with genotypic antibiotic resistance: A retrospective study in Ningxia.
Helicobacter.
2023 Jun; 28(3):e12960. doi:
10.1111/hel.12960. [PMID: 37042045] - Anum Amin, Maria Manzoor, Muhammad Wajahat Ramay, Ali Hassan, Kiran Hina, Asad Syed, Ali H Bahkali, Muhammad Arshad. Metallic nanoparticles photodegraded antibiotics and co-application improved wheat growth and nutritional quality through stress alleviation.
Chemosphere.
2023 May; 323(?):138189. doi:
10.1016/j.chemosphere.2023.138189. [PMID: 36812989] - Jiaojun Jin, Linling Xu, Siyi Zhang, MingKang Jin, Ping Zhang, Luoqin Shen, Jiayao Chen, Zhiheng Li, Wenlu Zhao, Huijun Liu. Oxidative response of rice (Oryza sativa L.) seedlings to quinolone antibiotics and its correlation with phyllosphere microbes and antibiotic resistance genes.
The Science of the total environment.
2023 Apr; 867(?):161544. doi:
10.1016/j.scitotenv.2023.161544. [PMID: 36642277] - Igor Bosevski, Andreja Žgajnar Gotvajn. Biotreatability Improvement of Antibiotic-Contaminated Waters: High Efficiency of Direct Ozonation in Comparison to Hydroxyl Radical Oxidation.
Acta chimica Slovenica.
2023 Mar; 70(1):65-73. doi:
10.17344/acsi.2022.7793. [PMID: 37005620] - S Karthick Raja Namasivayam, L Vigneshwaraprakash, K Samrat, M Kavisri, Meivelu Moovendhan, R S Arvind Bharani. Enhanced Antibacterial Activity of Highly Biocompatible Polymeric Core-Shell Levofloxacin Gold Nanocomposite Formulation Against Pseudomonas aeruginosa.
Applied biochemistry and biotechnology.
2023 Mar; 195(3):1837-1861. doi:
10.1007/s12010-022-04256-1. [PMID: 36399305] - Majid Mahjoore, Moones Honarmand, Ahmad Aryafar. Plant-based green fabrication of CuO-CdO-bentonite S-scheme heterojunction with enhanced photocatalytic performance for the degradation of levofloxacin.
Environmental science and pollution research international.
2023 Mar; 30(15):44439-44456. doi:
10.1007/s11356-023-25277-1. [PMID: 36692716] - Marium Fiaz, Iftikhar Ahmed, Sumara Masood Ul Hassan, Adnan Khan Niazi, Muhammad Fahim Khokhar, Zeshan, Muhammad Ansar Farooq, Muhammad Arshad. Antibiotic induced changes in nitrogen metabolism and antioxidative enzymes in mung bean (Vigna radiata).
The Science of the total environment.
2023 Feb; ?(?):162449. doi:
10.1016/j.scitotenv.2023.162449. [PMID: 36841411] - Sunday Amos Onikanni, Bashir Lawal, Adewale Oluwaseun Fadaka, Oluwafemi Bakare, Ezekiel Adewole, Muhammad Taher, Junaidi Khotib, Deny Susanti, Babatunji Emmanuel Oyinloye, Basiru Olaitan Ajiboye, Oluwafemi Adeleke Ojo, Nicole Remaliah Samantha Sibuyi. Computational and Preclinical Prediction of the Antimicrobial Properties of an Agent Isolated from Monodora myristica: A Novel DNA Gyrase Inhibitor.
Molecules (Basel, Switzerland).
2023 Feb; 28(4):. doi:
10.3390/molecules28041593. [PMID: 36838579] - Nazish Mohy-U-Din, Muhammad Farhan, Abdul Wahid, Lena Ciric, Faiza Sharif. Human health risk estimation of antibiotics transferred from wastewater and soil to crops.
Environmental science and pollution research international.
2023 Feb; 30(8):20601-20614. doi:
10.1007/s11356-022-23412-y. [PMID: 36255570] - Haiyan Sun, Xinlou Chai, Guangxun Xu, Shuangying Wei. The Formation and Drug Resistance Mechanism of Biofilm for Streptococcus pneumoniae Infection in Severe Respiratory Patients.
Cellular and molecular biology (Noisy-le-Grand, France).
2023 Jan; 69(1):75-80. doi:
10.14715/cmb/2022.69.1.13. [PMID: 37213152] - Hui Zhang, Huiyun Zou, Ling Zhao, Xuewen Li. Seasonal distribution and dynamic evolution of antibiotics and evaluation of their resistance selection potential and ecotoxicological risk at a wastewater treatment plant in Jinan, China.
Environmental science and pollution research international.
2023 Jan; ?(?):. doi:
10.1007/s11356-023-25202-6. [PMID: 36690854] - Zhang Ruijuan, Xiao Li, Wang Yingjie, Wang Rui, Lu Chunqing. Effects of Catheter Tracking Management on Urinary Tract Function and Infection Rates in Patients With Spinal Cord Injury.
Alternative therapies in health and medicine.
2023 Jan; ?(?):. doi:
. [PMID: 36634314] - Laijun Yan, Haiya Ge, Yan Zhang, Nan Li. Epidemiology of pathogens and antimicrobial resistance of nosocomial urinary tract infections in patients with spinal cord injuries in China: A systematic review and meta-analysis.
The journal of spinal cord medicine.
2023 Jan; ?(?):1-17. doi:
10.1080/10790268.2022.2129154. [PMID: 36622339] - Xueping Huang, Baihe Wu, Qiuzhao Chen, Yushan Chen, Xinhua Ji, Xiang Zhou, Biao Suo, Zhihui Lin, Xiaoling Zheng. Antibiotic resistance profile of Helicobacter pylori to 14 antibiotics: a multicenter study in Fujian, China.
PeerJ.
2023; 11(?):e15611. doi:
10.7717/peerj.15611. [PMID: 37456872] - Sunidhi Bhatt, Subhankar Chatterjee. Fluoroquinolone antibiotics: Occurrence, mode of action, resistance, environmental detection, and remediation - A comprehensive review.
Environmental pollution (Barking, Essex : 1987).
2022 Dec; 315(?):120440. doi:
10.1016/j.envpol.2022.120440. [PMID: 36265724] - Fatih Donmez, Abdulahad Dogan. Investigation of the effects of three different generations of fluoroquinolone derivatives on antioxidant and immunotoxic enzyme levels in different rat tissues.
Drug and chemical toxicology.
2022 Nov; 45(6):2686-2698. doi:
10.1080/01480545.2021.1982624. [PMID: 34601990] - Murugan Thulasi Meenu, Grace Kaul, Abdul Akhir, Manjulika Shukla, Kokkuvayil Vasu Radhakrishnan, Sidharth Chopra. Developing the Natural Prenylflavone Artocarpin from Artocarpus hirsutus as a Potential Lead Targeting Pathogenic, Multidrug-Resistant Staphylococcus aureus, Persisters and Biofilms with No Detectable Resistance.
Journal of natural products.
2022 10; 85(10):2413-2423. doi:
10.1021/acs.jnatprod.2c00621. [PMID: 36222797] - Peiyao Jia, Xinmiao Jia, Ying Zhu, Xiaoyu Liu, Wei Yu, Rui Li, Xue Li, Mei Kang, Yingchun Xu, Qiwen Yang. Emergence of a Novel NDM-5-Producing Sequence Type 4523 Klebsiella pneumoniae Strain Causing Bloodstream Infection in China.
Microbiology spectrum.
2022 10; 10(5):e0084222. doi:
10.1128/spectrum.00842-22. [PMID: 35993711] - Viviane Lucia Beraldo-Araújo, Ana Flávia Siqueira Vicente, Marcelo van Vliet Lima, Anita Umerska, Eliana B Souto, Lidia Tajber, Laura Oliveira-Nascimento. Levofloxacin in nanostructured lipid carriers: Preformulation and critical process parameters for a highly incorporated formulation.
International journal of pharmaceutics.
2022 Oct; 626(?):122193. doi:
10.1016/j.ijpharm.2022.122193. [PMID: 36108993] - Junjun Feng, Haiyun Jiang, Jing Wang, Zhengyi Jing, Fan Zhang, Tianyu Tan, Feng He, Lihua Jiang, Haiqin Li, Shimin Chang, Tengfei Li. [Simultaneous determination of 40 plant growth regulators, fungicides, insecticides, and antibiotics in bean sprouts by QuEChERS-high performance liquid chromatography-tandem mass spectrometry].
Se pu = Chinese journal of chromatography.
2022 Sep; 40(9):843-853. doi:
10.3724/sp.j.1123.2021.12028. [PMID: 36156631] - C Campo-Beleño, R A Villamizar-Gallardo, L E López-Jácome, E E González, S Muñoz-Carranza, B Franco, R Morales-Espinosa, R Coria-Jimenez, R Franco-Cendejas, M Hernández-Durán, R Lara-Martínez, L F Jiménez-García, A M Fernández-Presas, R García-Contreras. Biologically synthesized silver nanoparticles as potent antibacterial effective against multidrug-resistant Pseudomonas aeruginosa.
Letters in applied microbiology.
2022 Sep; 75(3):680-688. doi:
10.1111/lam.13759. [PMID: 35687297] - Seiya Hanamoto, Ryoko Yamamoto-Ikemoto. In-stream sorption of azithromycin and levofloxacin in a river receiving sewage treatment plant effluent.
Environmental pollution (Barking, Essex : 1987).
2022 Aug; 307(?):119568. doi:
10.1016/j.envpol.2022.119568. [PMID: 35661806] - I-Fan Lin, Chung-Hsu Lai, Shang-Yi Lin, Ching-Chi Lee, Nan-Yao Lee, Po-Yu Liu, Chih-Hui Yang, Yi-Han Huang, Jiun-Nong Lin. Mutant Prevention Concentrations of Ciprofloxacin and Levofloxacin and Target Gene Mutations of Fluoroquinolones in Elizabethkingia anophelis.
Antimicrobial agents and chemotherapy.
2022 07; 66(7):e0030122. doi:
10.1128/aac.00301-22. [PMID: 35708332] - Kelei Zhao, Jing Li, Xiting Yang, Qianglin Zeng, Wei Liu, Yi Wu, Hui Zhou, Balakrishnan Prithiviraj, Xinrong Wang, Xikun Zhou, Yiwen Chu. Subinhibitory Cefotaxime and Levofloxacin Concentrations Contribute to Selection of Pseudomonas aeruginosa in Coculture with Staphylococcus aureus.
Applied and environmental microbiology.
2022 06; 88(12):e0059222. doi:
10.1128/aem.00592-22. [PMID: 35638844] - Volodymyr Volodymyrovych Bezruk, Igor Dmytrovych Shkrobanets, Oleksii Serhiiovych Godovanets, Oleksandr Hryhorovych Buriak, Olga Ivanivna Pervozvanska, Ludmila Mykhailivna Honcharuk, Nina Ivanivna Voytkevich, Olena Victorivna Makarova, Oksana Ivanivna Yurkiv, Michael Ivanovych Sheremet, Mykhailo Mykhailovich Hresko, Mariya Ivanivna Velia, Svyatoslava Vasylivna Yurniuk, Maryna Dmytrivna Hresko, Tetiana Sergiivna Bulyk, Larysa Vasylyvna Rynzhuk. Management of antibacterial therapy of infectious and inflammatory diseases of the urinary tract in children and regional peculiarities during the COVID-19 pandemic.
Journal of medicine and life.
2022 May; 15(5):617-619. doi:
10.25122/jml-2021-0293. [PMID: 35815078] - Mingming Xu, Junfei Zhou, Ding Heng, Xiaorong Su, Monday M Onakpa, Yuefan Bai, Jin-Ao Duan, Chun-Tao Che, Hongkai Bi, Ming Zhao. Quinone Derivatives as Promising Anti-Helicobacter pylori Agents from Aerial Parts of Mitracarpus hirtus.
Journal of natural products.
2022 04; 85(4):1029-1038. doi:
10.1021/acs.jnatprod.1c01163. [PMID: 35412828] - Rikeshwer Prasad Dewangan, Devesh Pratap Verma, Neeraj Kumar Verma, Ankit Gupta, Garima Pant, Kalyan Mitra, Saman Habib, Jimut Kanti Ghosh. Spermine-Conjugated Short Proline-Rich Lipopeptides as Broad-Spectrum Intracellular Targeting Antibacterial Agents.
Journal of medicinal chemistry.
2022 04; 65(7):5433-5448. doi:
10.1021/acs.jmedchem.1c01809. [PMID: 35297625] - Yan Cao, Tao Wang, Ke He, Juanmin Xue, Xinjing Wang, Jianqin Liang. High-dose rifampicin for the treatment of tuberculous meningitis: a meta-analysis of randomized controlled trials.
Journal of clinical pharmacy and therapeutics.
2022 Apr; 47(4):445-454. doi:
10.1111/jcpt.13555. [PMID: 34897758] - Ibtisam H Al-Azawi, Mahasin S Al-Bidiri. DISTRIBUTION OF INTEGRON III AND PHYLOGENIC CLADE AMONG MDR UROPATHOGENIC E. COLI FROM PATIENT IN AL-DIWANIYAH CITY, IRAQ.
Wiadomosci lekarskie (Warsaw, Poland : 1960).
2022; 75(5 pt 2):1254-1260. doi:
10.36740/wlek202205205. [PMID: 35758440] - Licai Mo, Jiajia Wang, Jiao Qian, Minfei Peng. Antibiotic Sensitivity of Proteus mirabilis Urinary Tract Infection in Patients with Urinary Calculi.
International journal of clinical practice.
2022; 2022(?):7273627. doi:
10.1155/2022/7273627. [PMID: 36628152] - Rania S Abdel-Rashid, Eman S El-Leithy, Raghda Abdel-Monem. Formulation and Evaluation of Topical Biodegradable Films Loaded with Levofloxacin Lipid Nanocarriers.
AAPS PharmSciTech.
2021 Dec; 23(1):34. doi:
10.1208/s12249-021-02189-2. [PMID: 34950989] - Veena R Gujju, Bushra Akram, Dena R Shibib, Miranda A McGhee, Douglas A Drevets. Bordetella bronchiseptica infections in patients with HIV/AIDS: A case report and review of the literature.
Medicine.
2021 Dec; 100(51):e28244. doi:
10.1097/md.0000000000028244. [PMID: 34941094] - Dolly Patel, Adeel Ahmad, Parth Maheshwari, Benjamin Bird, Adam Albert. Bacillus pumilus-Borne Food Poisoning in an Immunosuppressed Host.
The American journal of medicine.
2021 12; 134(12):e573-e574. doi:
10.1016/j.amjmed.2021.06.025. [PMID: 34297978] - Shuhei Urata, Naoki Yoshikawa, Kiyotaka Saito, Tomoya Tazaki, Rie Ohno, Hideo Takeshima, Ryuji Ikeda. Delayed methotrexate elimination in a patient with primary central nervous system lymphoma: A case report.
Journal of clinical pharmacy and therapeutics.
2021 Dec; 46(6):1796-1799. doi:
10.1111/jcpt.13425. [PMID: 34008211] - Krzysztof Marciniec, Artur Beberok, Stanisław Boryczka, Dorota Wrześniok. The application of in silico experimental model in the assessment of ciprofloxacin and levofloxacin interaction with main SARS-CoV-2 targets: S-, E- and TMPRSS2 proteins, RNA-dependent RNA polymerase and papain-like protease (PLpro)-preliminary molecular docking analysis.
Pharmacological reports : PR.
2021 Dec; 73(6):1765-1780. doi:
10.1007/s43440-021-00282-8. [PMID: 34052981] - Muhammad Shahid, Hira Munir, Naheed Akhter, Nadia Akram, Fozia Anjum, Yasir Iqbal, Muhammad Afzal. Nanoparticles encapsulation of Phoenix dactylifera (date palm) mucilage for colonic drug delivery.
International journal of biological macromolecules.
2021 Nov; 191(?):861-871. doi:
10.1016/j.ijbiomac.2021.09.126. [PMID: 34571126] - Murugan Thulasi Meenu, Grace Kaul, Manjulika Shukla, Kokkuvayil Vasu Radhakrishnan, Sidharth Chopra. Cudraflavone C from Artocarpus hirsutus as a Promising Inhibitor of Pathogenic, Multidrug-Resistant S. aureus, Persisters, and Biofilms: A New Insight into a Rational Explanation of Traditional Wisdom.
Journal of natural products.
2021 10; 84(10):2700-2708. doi:
10.1021/acs.jnatprod.1c00578. [PMID: 34546736] - George P Allen, Kristina M Deao, Stephanie A Hill, Sandra M Schipelliti, Thomas Tran. In vitro evaluation of antimicrobial resistance selection in Neisseria gonorrhoeae.
International journal of antimicrobial agents.
2021 Oct; 58(4):106417. doi:
10.1016/j.ijantimicag.2021.106417. [PMID: 34391903] - Yuika Osada, Shunsaku Nakagawa, Kanako Ishibe, Shota Takao, Aimi Shimazaki, Kotaro Itohara, Satoshi Imai, Atsushi Yonezawa, Takayuki Nakagawa, Kazuo Matsubara. Antibiotic-induced microbiome depletion alters renal glucose metabolism and exacerbates renal injury after ischemia-reperfusion injury in mice.
American journal of physiology. Renal physiology.
2021 10; 321(4):F455-F465. doi:
10.1152/ajprenal.00111.2021. [PMID: 34423680] - Khaleque N Khan, Akira Fujishita, Hideki Muto, Hiroshi Masumoto, Kanae Ogawa, Akemi Koshiba, Taisuke Mori, Kyoko Itoh, Satoshi Teramukai, Katsuya Matsuda, Masahiro Nakashima, Jo Kitawaki. Levofloxacin or gonadotropin releasing hormone agonist treatment decreases intrauterine microbial colonization in human endometriosis.
European journal of obstetrics, gynecology, and reproductive biology.
2021 Sep; 264(?):103-116. doi:
10.1016/j.ejogrb.2021.07.014. [PMID: 34298448] - Marouf Alhalabi, Mohammed Waleed Alassi, Kamal Alaa Eddin, Khaled Cheha. Efficacy of two-week therapy with doxycycline-based quadruple regimen versus levofloxacin concomitant regimen for helicobacter pylori infection: a prospective single-center randomized controlled trial.
BMC infectious diseases.
2021 Jul; 21(1):642. doi:
10.1186/s12879-021-06356-5. [PMID: 34218802] - Chengdong Wang, Linhua Deng, Yanqiu Zhu, Kai Wu, Ming Wei, Shang Huang, Rongping Wei, Weiping Liu, Yan Huang, Hemin Zhang, Desheng Li. Pharmacokinetics of levofloxacin mesylate in healthy adult giant panda after single-dose administration via different routes.
Journal of veterinary pharmacology and therapeutics.
2021 Jul; 44(4):644-649. doi:
10.1111/jvp.12945. [PMID: 33565110] - Dhakrit Rungkitwattanakul, Weerachai Chaijamorn, Taniya Charoensareerat, Pratarn Charntrakarn, Orapan Khamkampud, Nakumporn Rattanaponpasert, Nattachai Srisawat, Sutthiporn Pattharachayakul. Optimal levofloxacin dosing regimens in critically ill patients with acute kidney injury receiving continuous renal replacement therapy.
Journal of critical care.
2021 06; 63(?):154-160. doi:
10.1016/j.jcrc.2020.09.018. [PMID: 33012583] - Fang-Fang Dai, Feng-Qin Liu, Xing Chen, Juan Yang, Ke Wang, Chun-Yan Guo. The treatment of macrolide-resistant Mycoplasma pneumoniae pneumonia in children.
Journal of clinical pharmacy and therapeutics.
2021 Jun; 46(3):705-710. doi:
10.1111/jcpt.13331. [PMID: 33403672] - Sagal Mohamed, Happiness C Mvungi, Margaretha Sariko, Prakruti Rao, Peter Mbelele, Erwin M Jongedijk, Claudia A J van Winkel, Daan J Touw, Suzanne Stroup, Jan-Willem C Alffenaar, Stellah Mpagama, Scott K Heysell. Levofloxacin pharmacokinetics in saliva as measured by a mobile microvolume UV spectrophotometer among people treated for rifampicin-resistant TB in Tanzania.
The Journal of antimicrobial chemotherapy.
2021 05; 76(6):1547-1552. doi:
10.1093/jac/dkab057. [PMID: 33675664] - Tata Sanjay Kanna Sharma, Kuo-Yuan Hwa. Facile Synthesis of Ag/AgVO3/N-rGO Hybrid Nanocomposites for Electrochemical Detection of Levofloxacin for Complex Biological Samples Using Screen-Printed Carbon Paste Electrodes.
Inorganic chemistry.
2021 May; 60(9):6585-6599. doi:
10.1021/acs.inorgchem.1c00389. [PMID: 33878862] - Fatehy M Abdel-Haleem, Sonia Mahmoud, Nour Eldin T Abdel-Ghani, Rasha Mohamed El Nashar, Mikhael Bechelany, Ahmed Barhoum. Polyvinyl Chloride Modified Carbon Paste Electrodes for Sensitive Determination of Levofloxacin Drug in Serum, Urine, and Pharmaceutical Formulations.
Sensors (Basel, Switzerland).
2021 May; 21(9):. doi:
10.3390/s21093150. [PMID: 34062895] - Jiyun Zhu, Jiangfeng Qiu, Kaibo Chen, Wenbo Wang, Siming Zheng. Tea polyphenols and Levofloxacin alleviate the lung injury of hepatopulmonary syndrome in common bile duct ligation rats through Endotoxin -TNF signaling.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 May; 137(?):111263. doi:
10.1016/j.biopha.2021.111263. [PMID: 33516071] - I Sartini, B Łebkowska-Wieruszewska, A Sitovs, A Lisowski, A Poapolathep, M Giorgi. Levofloxacin pharmacokinetics and tissue residue concentrations after oral administration in Bilgorajska geese.
British poultry science.
2021 Apr; 62(2):193-198. doi:
10.1080/00071668.2020.1842855. [PMID: 33121260] - Makoto Kai, Ryota Tanaka, Yosuke Suzuki, Koji Goto, Yoshifumi Ohchi, Norihisa Yasuda, Ryosuke Tatsuta, Takaaki Kitano, Hiroki Itoh. Simultaneous quantification of plasma levels of 12 antimicrobial agents including carbapenem, anti-methicillin-resistant Staphylococcus aureus agent, quinolone and azole used in intensive care unit using UHPLC-MS/MS method.
Clinical biochemistry.
2021 Apr; 90(?):40-49. doi:
10.1016/j.clinbiochem.2021.01.012. [PMID: 33539809] - Burcu Uğurlu Ilgın, İrem Müge Akbulut Koyuncu, Emrullah Kızıltunç. Effect of triple antimicrobial therapy on electrocardiography parameters in patients with mild-to-moderate coronavirus disease 2019.
Anatolian journal of cardiology.
2021 03; 25(3):184-190. doi:
10.14744/anatoljcardiol.2020.79138. [PMID: 33690133] - David Busse, André Schaeftlein, Alexander Solms, Luis Ilia, Robin Michelet, Markus Zeitlinger, Wilhelm Huisinga, Charlotte Kloft. Which Analysis Approach Is Adequate to Leverage Clinical Microdialysis Data? A Quantitative Comparison to Investigate Exposure and Reponse Exemplified by Levofloxacin.
Pharmaceutical research.
2021 Mar; 38(3):381-395. doi:
10.1007/s11095-021-02994-1. [PMID: 33723793] - Hao Chen, Li Yuan, Xue Ma, Zi-Peng Gong, Yue-Ting Li, Si-Ying Chen, Jie Pan, Ai-Min Wang, Lin Zheng, Yong Huang. Herb-drug interaction: The effect of Polygonum capitatum extract on pharmacokinetics of levofloxacin in rats.
Journal of pharmaceutical and biomedical analysis.
2021 Feb; 195(?):113832. doi:
10.1016/j.jpba.2020.113832. [PMID: 33349475] - Krishan Lal Gupta, Sahil Bagai, Harsha Kumar, Saurabh Nayak, Valliappan Muthu, Vivek Kumar, Manish Rathi, Harbir S Kohli, Ashish Sharma, Raja Ramachandran. Levofloxacin based non-rifampicin anti-tuberculous therapy: An effective alternative in renal transplant recipients in resource limited setting.
Nephrology (Carlton, Vic.).
2021 Feb; 26(2):178-184. doi:
10.1111/nep.13816. [PMID: 33155329] - Cristina Oana Mărginean, Anca Meda Georgescu, Lorena Elena Meliţ. Arthritis associated with Mycoplasma pneumoniae in a pediatric patient: A case report.
Medicine.
2021 Jan; 100(2):e24316. doi:
10.1097/md.0000000000024316. [PMID: 33466220] - Xueping Huang, Yuan Liu, Zhihui Lin, Baihe Wu, Gaohui Nong, Yushan Chen, Yuping Lu, Xinhua Ji, Xiang Zhou, Biao Suo, Qiuzhao Chen, Jinqi Wei. Minimum inhibitory concentrations of commonly used antibiotics against Helicobacter Pylori: A multicenter study in South China.
PloS one.
2021; 16(9):e0256225. doi:
10.1371/journal.pone.0256225. [PMID: 34473713] - Msolli Mohamed Amine, Messous Selma, Sekma Adel, Bel Haj Ali Khaoula, Khalil Mohamed Hassene, Trabelsi Imen, Abdelghani Ahmed, Ben Brahim Nadia, Ben Dhaya Yosra, Razgallah Rabie, Grissa Mohamed Habib, Beltaief Kaouthar, Methamem Mehdi, Belguith Asma, Bouida Wahid, Boukef Riadh, Boubaker Hamdi, Nouira Semir. 2-Day versus C-reactive protein guided antibiotherapy with levofloxacin in acute COPD exacerbation: A randomized controlled trial.
PloS one.
2021; 16(5):e0251716. doi:
10.1371/journal.pone.0251716. [PMID: 34015041] - Satomi Suga, Yasuhiko Mukai, Satoshi Ishikawa, Shiomi Yoshida, Sarad Paudel, Takayuki Wada. INTENSIVE TREATMENT OF A CAPTIVE BORNEAN ELEPHANT (ELEPHAS MAXIMUS BORNEENSIS) INFECTED WITH MYCOBACTERIUM CAPRAE IN JAPAN.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2021 Jan; 51(4):1062-1066. doi:
10.1638/2019-0152. [PMID: 33480591] - Stacey L P Scroggs, Danielle K Offerdahl, Dylan P Flather, Ciera N Morris, Benjamin L Kendall, Rebecca M Broeckel, Paul A Beare, Marshall E Bloom. Fluoroquinolone Antibiotics Exhibit Low Antiviral Activity against SARS-CoV-2 and MERS-CoV.
Viruses.
2020 12; 13(1):. doi:
10.3390/v13010008. [PMID: 33374514] - Matthew B Allen, Joseph M Neal, Kamen Vlassakov. Neuraxial anaesthesia in the context of bacterial meningitis and COVID-19.
British journal of anaesthesia.
2020 12; 125(6):e488-e490. doi:
10.1016/j.bja.2020.09.008. [PMID: 33041013] - Natalia Urzúa, María Jimena Messina, Matías Caverzan, Guillermo Prieto, Carlos Lüders, Carlos Errecalde. Pharmacokinetics of levofloxacin after single intravenous and oral administration, and its interaction with sucralfate in mixed-breed dogs.
Xenobiotica; the fate of foreign compounds in biological systems.
2020 Dec; 50(12):1490-1493. doi:
10.1080/00498254.2020.1793031. [PMID: 32628058] - Daniel J Morris, Lucy C Jones, Rebecca L Davies, Kirsty Sands, Edward Portal, Owen B Spiller. MYCO WELL D-ONE detection of Ureaplasma spp. and Mycoplasma hominis in sexual health patients in Wales.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
2020 Dec; 39(12):2427-2440. doi:
10.1007/s10096-020-03993-7. [PMID: 32725499] - Ensieh Vahedi, Mostafa Ghanei, Ali Ghazvini, Hossein Azadi, Morteza Izadi, Yunes Panahi, Saeid Fathi, Mahmood Salesi, Seyed Hassan Saadat, Amir Hossein Ghazale, Mohammad Rezapour, Abolfazl Mozafari, Nahid Zand, Mohammadreza Raesi Parsaei, Mohammad Hossein Ranjkesh, Ramezan Jafari, Fatemeh Movaseghi, Enayat Darabi. The clinical value of two combination regimens in the Management of Patients Suffering from Covid-19 pneumonia: a single centered, retrospective, observational study.
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences.
2020 Dec; 28(2):507-516. doi:
10.1007/s40199-020-00353-w. [PMID: 32562159] - Cristina Vercelli, Beata Łebkowska-Wieruszewska, Raffaella Barbero, Andrzej Lisowski, Giovanni Re, Mario Giorgi. Pharmacokinetics of levofloxacin in non-lactating goats and evaluation of drug effects on resistance in coliform rectal flora.
Research in veterinary science.
2020 Dec; 133(?):283-288. doi:
10.1016/j.rvsc.2020.09.028. [PMID: 33039880] - Shirui Tan, Jing Gao, Qingrong Li, Tieying Guo, Xiangshu Dong, Xuehui Bai, Jinghui Yang, Shumei Hao, Feifei He. Synergistic effect of chlorogenic acid and levofloxacin against Klebsiella pneumonia infection in vitro and in vivo.
Scientific reports.
2020 11; 10(1):20013. doi:
10.1038/s41598-020-76895-5. [PMID: 33203903] - Yuqiong Yang, Xiaoyan Zhu, Jun Yang, Anjie Shi, Meng Jiang, Yue Peng, Min Li, Yaling Wang, Hongfeng Yuan. An Environmental Control Experiment for Contamination of the Production and Storage of 20\% Autologous Serum Eye Drops.
Current eye research.
2020 11; 45(11):1364-1368. doi:
10.1080/02713683.2020.1741008. [PMID: 32150475] - K Shinmachi, Y Takahashi, Y Kaneuji, R Kawamura, K Kohama, Y Hieda, T Goromaru, S Eto, T Murakami, Y Maeda. Effect of aluminium ion on bioavailability of levofloxacin following oral administration of cilexetil ester of levofloxacin as prodrug in rats.
Die Pharmazie.
2020 11; 75(11):554-558. doi:
10.1691/ph.2020.0601. [PMID: 33239128] - Yuan Qin, Ning-Hong Song, He-Song Ye, Long-Long Tang, Ming Yang, Wen-Tao Gong, Qi He, Wei Zhang. [Linshu Decoction combined with levofloxacin for lower urinary tract symptoms in patients with type ⅢA prostatitis].
Zhonghua nan ke xue = National journal of andrology.
2020 Nov; 26(11):1025-1029. doi:
". [PMID: 34898075] - Ayman Samir Farid, Ahmed Medhat Hegazy. Ameliorative effects of Moringa oleifera leaf extract on levofloxacin-induced hepatic toxicity in rats.
Drug and chemical toxicology.
2020 Nov; 43(6):616-622. doi:
10.1080/01480545.2019.1574811. [PMID: 30782023] - Antonio Desai, Orazio Giuseppe Santonocito, Giuseppe Caltagirone, Maria Kogan, Federica Ghetti, Ilaria Donadoni, Francesca Porro, Victor Savevski, Dario Poretti, Michele Ciccarelli, Filippo Martinelli Boneschi, Antonio Voza. Effectiveness of Streptococcus Pneumoniae Urinary Antigen Testing in Decreasing Mortality of COVID-19 Co-Infected Patients: A Clinical Investigation.
Medicina (Kaunas, Lithuania).
2020 Oct; 56(11):. doi:
10.3390/medicina56110572. [PMID: 33138045] - Irene Karampela, Maria Dalamaga. Could Respiratory Fluoroquinolones, Levofloxacin and Moxifloxacin, Prove to be Beneficial as an Adjunct Treatment in COVID-19?.
Archives of medical research.
2020 10; 51(7):741-742. doi:
10.1016/j.arcmed.2020.06.004. [PMID: 32546446] - Prakruti Rao, Svetlana Zhdanova, Oleg Ogarkov, Elizaveta Orlova, Andrew Ebers, Suzanne Stroup, Shino Mirawdaly, Daniel Van Aartsen, Olga Koshkina, Alexey Suzdalnitsky, Elena Moiseeva, Rebecca Dillingham, Scott K Heysell. Urine colorimetry for levofloxacin pharmacokinetics and personalized dosing in people with drug-resistant tuberculosis.
International journal of mycobacteriology.
2020 Oct; 9(4):411-416. doi:
10.4103/ijmy.ijmy_186_20. [PMID: 33323657] - C Liu, H Huang, Q Zhou, B Liu, Y Wang, P Li, K Liao, W Su. Pithecellobium clypearia extract enriched in gallic acid and luteolin has antibacterial activity against MRSA and reduces resistance to erythromycin, ceftriaxone sodium and levofloxacin.
Journal of applied microbiology.
2020 Oct; 129(4):848-859. doi:
10.1111/jam.14668. [PMID: 32301544] - Ping Ao, Ling Shu, Zhenxing Zhang, Dong Zhuo, Zhongqin Wei. Levofloxacin: Is It Still Suitable as an Empirically Used Antibiotic During the Perioperative Period of Flexible Ureteroscopic Lithotripsy? A Single-center Experience with 754 Patients.
Urology journal.
2020 Oct; 18(4):445-451. doi:
10.22037/uj.v16i7.6033. [PMID: 33000455] - Mayssa Abdel Hady, Ossama M Sayed, Mohamed A Akl. Brain uptake and accumulation of new levofloxacin-doxycycline combination through the use of solid lipid nanoparticles: Formulation; Optimization and in-vivo evaluation.
Colloids and surfaces. B, Biointerfaces.
2020 Sep; 193(?):111076. doi:
10.1016/j.colsurfb.2020.111076. [PMID: 32408259] - Noha Mahmoud Elkhodary, Khaled Abdalkader Farrag, Amany Mahmoud Elokaby, Gamal Abd El-Hay Omran. Efficacy and safety of 7 days versus 10 days triple therapy based on levofloxacin-dexlansoprazole for eradication of Helicobacter pylori: A pilot randomized trial.
Indian journal of pharmacology.
2020 Sep; 52(5):356-364. doi:
10.4103/ijp.ijp_364_19. [PMID: 33283766] - Paul Pagano, Andrea Marra, Dean Shinabarger, Chris Pillar. In vitro activity of omadacycline and levofloxacin against Escherichia coli, Klebsiella pneumoniae and Staphylococcus saprophyticus in human urine supplemented with calcium and magnesium.
The Journal of antimicrobial chemotherapy.
2020 08; 75(8):2160-2163. doi:
10.1093/jac/dkaa138. [PMID: 32428235] - Qian Xiong, You-Sheng Liu, Li-Xin Hu, Zhou-Qi Shi, Guang-Guo Ying. Levofloxacin and sulfamethoxazole induced alterations of biomolecules in Pseudokirchneriella subcapitata.
Chemosphere.
2020 Aug; 253(?):126722. doi:
10.1016/j.chemosphere.2020.126722. [PMID: 32289608] - Claudia Palazzolo, Gaetano Maffongelli, Alessandra D'Abramo, Luciana Lepore, Andrea Mariano, Antonella Vulcano, Tommaso Ascoli Bartoli, Nazario Bevilacqua, Maria Letizia Giancola, Enrico Di Rosa, Emanuele Nicastri. Legionella pneumonia: increased risk after COVID-19 lockdown? Italy, May to June 2020.
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.
2020 07; 25(30):. doi:
10.2807/1560-7917.es.2020.25.30.2001372. [PMID: 32734857] - Bernardo Guevara, Asha Gupta Cogdill. Helicobacter pylori: A Review of Current Diagnostic and Management Strategies.
Digestive diseases and sciences.
2020 07; 65(7):1917-1931. doi:
10.1007/s10620-020-06193-7. [PMID: 32170476] - Natalia Ptaszyńska, Katarzyna Gucwa, Katarzyna Olkiewicz, Mateusz Heldt, Marcin Serocki, Anna Stupak, Dorota Martynow, Dawid Dębowski, Agata Gitlin-Domagalska, Jan Lica, Anna Łęgowska, Sławomir Milewski, Krzysztof Rolka. Conjugates of Ciprofloxacin and Levofloxacin with Cell-Penetrating Peptide Exhibit Antifungal Activity and Mammalian Cytotoxicity.
International journal of molecular sciences.
2020 Jun; 21(13):. doi:
10.3390/ijms21134696. [PMID: 32630159] - Benoit LLopis, Christian Funck-Brentano, Nadine Tissot, Alexandre Bleibtreu, Stéphane Jaureguiberry, Eric Fourniols, Alexandra Aubry, Noël Zahr. Development and validation of a UPLC-MS/MS method for simultaneous quantification of levofloxacin, ciprofloxacin, moxifloxacin and rifampicin in human plasma: Application to the therapeutic drug monitoring in osteoarticular infections.
Journal of pharmaceutical and biomedical analysis.
2020 May; 183(?):113137. doi:
10.1016/j.jpba.2020.113137. [PMID: 32086125] - Junjie Ding, Nguyen Thuy Thuong Thuong, Toi Van Pham, Dorothee Heemskerk, Thomas Pouplin, Chau Thi Hong Tran, Mai Thi Hoang Nguyen, Phu Hoan Nguyen, Loc Phu Phan, Chau Van Vinh Nguyen, Guy Thwaites, Joel Tarning. Pharmacokinetics and Pharmacodynamics of Intensive Antituberculosis Treatment of Tuberculous Meningitis.
Clinical pharmacology and therapeutics.
2020 04; 107(4):1023-1033. doi:
10.1002/cpt.1783. [PMID: 31956998] - Zaid Kaloti, Kendall Bell, Mowyad Khalid, Diane Levine. Cerebellar ataxia a unique initial presentation of Legionnaires' disease.
BMJ case reports.
2020 Mar; 13(3):. doi:
10.1136/bcr-2019-230710. [PMID: 32161074] - L Zhao, X Li, X He, L Jian. Levofloxacin-ceftazidime administration regimens combat Pseudomonas aeruginosa in the hollow-fiber infection model simulating abnormal renal function in critically ill patients.
BMC pharmacology & toxicology.
2020 03; 21(1):20. doi:
10.1186/s40360-020-0396-5. [PMID: 32131897] - Andrejs Sitovs, Laura Voiko, Dmitrijs Kustovs, Liga Kovalcuka, Dace Bandere, Santa Purvina, Mario Giorgi. Pharmacokinetic profiles of levofloxacin after intravenous, intramuscular and subcutaneous administration to rabbits (Oryctolagus cuniculus).
Journal of veterinary science.
2020 Mar; 21(2):e32. doi:
10.4142/jvs.2020.21.e32. [PMID: 32233138] - Duygu Durna Corum, Orhan Corum, Ramazan Yildiz, Hatice Eser Faki, Merve Ider, Gul Cetin, Kamil Uney. Influences of tolfenamic acid and flunixin meglumine on the disposition kinetics of levofloxacin in sheep.
Acta veterinaria Hungarica.
2020 03; 68(1):65-70. doi:
10.1556/004.2020.00015. [PMID: 32384070] - Jie Pan, Zhengchao Shi, Dingsai Lin, Ningmin Yang, Fei Meng, Lang Lin, Zhencheng Jin, Qingjie Zhou, Jiansheng Wu, Jianzhong Zhang, Youming Li. Is tailored therapy based on antibiotic susceptibility effective ? a multicenter, open-label, randomized trial.
Frontiers of medicine.
2020 Feb; 14(1):43-50. doi:
10.1007/s11684-019-0706-8. [PMID: 31907860]