Laromustine (BioDeep_00000859007)

   


代谢物信息卡片


1-[2-chloroethyl(methylsulfonyl)amino]-3-methyl-1-methylsulfonylurea

化学式: C6H14ClN3O5S2 (307.0063384)
中文名称: 1,2-双(甲磺酰基)-1-(2-氯乙基)-2-(甲氨羰基)肼
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CNC(=O)N(N(CCCl)S(=O)(=O)C)S(=O)(=O)C
InChI: InChI=1S/C6H14ClN3O5S2/c1-8-6(11)10(17(3,14)15)9(5-4-7)16(2,12)13/h4-5H2,1-3H3,(H,8,11)

描述信息

C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
C471 - Enzyme Inhibitor > C2134 - O6-Alkylguanine-DNA Alkyltransferase Inhibitor

同义名列表

2 个代谢物同义名

1-[2-chloroethyl(methylsulfonyl)amino]-3-methyl-1-methylsulfonylurea; Laromustine



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

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Plant Reactome(0)

INOH(0)

PlantCyc(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Ala F Nassar, Adam V Wisnewski, Terence Wu, Tukiet T Lam, Ivan King. Development and Validation of LC-MS-MS Assay for the Determination of the Emerging Alkylating Agent Laromustine and Its Active Metabolite in Human Plasma. Journal of chromatographic science. 2019 Mar; 57(3):195-203. doi: 10.1093/chromsci/bmy100. [PMID: 30395213]
  • Ala F Nassar, Adam Wisnewski, Ivan King. Metabolic disposition of the anti-cancer agent [(14)C]laromustine in male rats. Xenobiotica; the fate of foreign compounds in biological systems. 2015; 45(8):711-21. doi: 10.3109/00498254.2015.1016475. [PMID: 25798740]
  • Alaa-Eldin F Nassar, Ivan King, Brandy L Paris, Lois Haupt, Florence Ndikum-Moffor, Rebecca Campbell, Etsuko Usuki, Jennifer Skibbe, Dan Brobst, Brian W Ogilvie, Andrew Parkinson. An in vitro evaluation of the victim and perpetrator potential of the anticancer agent laromustine (VNP40101M), based on reaction phenotyping and inhibition and induction of cytochrome P450 enzymes. Drug metabolism and disposition: the biological fate of chemicals. 2009 Sep; 37(9):1922-30. doi: 10.1124/dmd.109.027516. [PMID: 19520774]
  • Feng Bai, Patton Minkin, Charles H Fraga, Melinda A O'Shaughnessy, Sri Gururangan, Clinton F Stewart. Determination of Cloretazine (VNP40101M) and its active metabolite (VNP4090CE) in human plasma by liquid chromatography electrospray tandem mass spectrometry (LC-ESI-MS/MS). Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Jun; 853(1-2):97-104. doi: 10.1016/j.jchromb.2007.02.062. [PMID: 17446145]
  • John Murren, Manuel Modiano, Shivaani Kummar, Caroline Clairmont, Merrill Egorin, Edward Chu, Mario Sznol. A phase I and pharmacokinetic study of VNP40101M, a new alkylating agent, in patients with advanced or metastatic cancer. Investigational new drugs. 2005 Mar; 23(2):123-35. doi: 10.1007/s10637-005-5857-6. [PMID: 15744588]
  • John Mao, Yang Xu, Diana Wu, Bijan Almassain. Pharmacokinetics, mass balance, and tissue distribution of a novel DNA alkylating agent, VNP40101M, in rat. AAPS pharmSci. 2002; 4(4):E24. doi: 10.1208/ps040424. [PMID: 12645996]