Ricolinostat (BioDeep_00000859001)
代谢物信息卡片
化学式: C24H27N5O3 (433.2113792)
中文名称: 2-(二苯基氨基)-N-[7-(羟基氨基)-7-氧代庚基]-5-嘧啶甲酰胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C=C1)N(C2=CC=CC=C2)C3=NC=C(C=N3)C(=O)NCCCCCCC(=O)NO
InChI: InChI=1S/C24H27N5O3/c30-22(28-32)15-9-1-2-10-16-25-23(31)19-17-26-24(27-18-19)29(20-11-5-3-6-12-20)21-13-7-4-8-14-21/h3-8,11-14,17-18,32H,1-2,9-10,15-16H2,(H,25,31)(H,28,30)
描述信息
D004791 - Enzyme Inhibitors > D056572 - Histone Deacetylase Inhibitors
C471 - Enzyme Inhibitor > C1946 - Histone Deacetylase Inhibitor
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent
D000970 - Antineoplastic Agents
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:95073
- KEGGdrug: D10661
- PubChem: 53340666
- DrugBank: DB12376
- ChEMBL: CHEMBL2364628
- CAS: 1316214-52-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Qing He, Changzhi Yu, Yang Li, Peng Hao, Hantao Mai, Ruilian Guo, Guifang Zhong, Kelin Zhang, Chipiu Wong, Qian Chen, Yantao Chen. ERRα contributes to HDAC6-induced chemoresistance of osteosarcoma cells.
Cell biology and toxicology.
2023 06; 39(3):813-825. doi:
10.1007/s10565-021-09651-8
. [PMID: 34524571] - Chorong Kim, Seonmin Lee, Danbee Kim, DA Sol Lee, Eunjung Lee, Changhoon Yoo, Kyu-Pyo Kim. Blockade of GRP78 Translocation to the Cell Surface by HDAC6 Inhibition Suppresses Proliferation of Cholangiocarcinoma Cells.
Anticancer research.
2022 Jan; 42(1):471-482. doi:
10.21873/anticanres.15505
. [PMID: 34969757] - Qian Chen, Yao Wang, Fangzhou Jiao, Pan Cao, Chunxia Shi, Maohua Pei, Luwen Wang, Zuojiong Gong. HDAC6 inhibitor ACY1215 inhibits the activation of NLRP3 inflammasome in acute liver failure by regulating the ATM/F-actin signalling pathway.
Journal of cellular and molecular medicine.
2021 08; 25(15):7218-7228. doi:
10.1111/jcmm.16751
. [PMID: 34180140] - Xingying Chen, Chao Yu, Xiying Hou, Jialu Li, Tingting Li, Andong Qiu, Na Liu, Shougang Zhuang. Histone deacetylase 6 inhibition mitigates renal fibrosis by suppressing TGF-β and EGFR signaling pathways in obstructive nephropathy.
American journal of physiology. Renal physiology.
2020 12; 319(6):F1003-F1014. doi:
10.1152/ajprenal.00261.2020
. [PMID: 33103445] - Chao-Feng Lin, Kai-Cheng Hsu, Wei-Chun HuangFu, Tony Eight Lin, Han-Li Huang, Shiow-Lin Pan. Investigating the potential effects of selective histone deacetylase 6 inhibitor ACY1215 on infarct size in rats with cardiac ischemia-reperfusion injury.
BMC pharmacology & toxicology.
2020 03; 21(1):21. doi:
10.1186/s40360-020-0400-0
. [PMID: 32178737] - Andrew E Shouksmith, Justyna M Gawel, Nabanita Nawar, Diana Sina, Yasir S Raouf, Shazreh Bukhari, Liying He, Alexandra E Johns, Pimyupa Manaswiyoungkul, Olasunkanmi O Olaoye, Aaron D Cabral, Abootaleb Sedighi, Elvin D de Araujo, Patrick T Gunning. Class I/IIb-Selective HDAC Inhibitor Exhibits Oral Bioavailability and Therapeutic Efficacy in Acute Myeloid Leukemia.
ACS medicinal chemistry letters.
2020 Jan; 11(1):56-64. doi:
10.1021/acsmedchemlett.9b00471
. [PMID: 31938464] - Chao-Wu Yu, Pei-Yun Hung, Hui-Ting Yang, Yi-Hsun Ho, Hsing-Yi Lai, Yi-Sheng Cheng, Ji-Wang Chern. Quinazolin-2,4-dione-Based Hydroxamic Acids as Selective Histone Deacetylase-6 Inhibitors for Treatment of Non-Small Cell Lung Cancer.
Journal of medicinal chemistry.
2019 01; 62(2):857-874. doi:
10.1021/acs.jmedchem.8b01590
. [PMID: 30525585] - Maria Lorenzo Pisarello, Tatyana V Masyuk, Sergio A Gradilone, Anatoliy I Masyuk, Jingyi F Ding, Pui-Yuen Lee, Nicholas F LaRusso. Combination of a Histone Deacetylase 6 Inhibitor and a Somatostatin Receptor Agonist Synergistically Reduces Hepatorenal Cystogenesis in an Animal Model of Polycystic Liver Disease.
The American journal of pathology.
2018 04; 188(4):981-994. doi:
10.1016/j.ajpath.2017.12.016
. [PMID: 29366679] - Wen-Bin Zhang, Hai-Yue Zhang, Fang-Zhou Jiao, Lu-Wen Wang, Hong Zhang, Zuo-Jiong Gong. Histone deacetylase 6 inhibitor ACY-1215 protects against experimental acute liver failure by regulating the TLR4-MAPK/NF-κB pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Jan; 97(?):818-824. doi:
10.1016/j.biopha.2017.10.103
. [PMID: 29112935] - Murali K Yanda, Qiangni Liu, Liudmila Cebotaru. An inhibitor of histone deacetylase 6 activity, ACY-1215, reduces cAMP and cyst growth in polycystic kidney disease.
American journal of physiology. Renal physiology.
2017 Oct; 313(4):F997-F1004. doi:
10.1152/ajprenal.00186.2017
. [PMID: 28747357] - Manish Gupta, Abhishek Dixit, V C Devaraj, Mohd Zainuddin, Ravi Kanth Bhamidipati, Mahanandeesha S Hallur, Purushottam Dewang, Sridharan Rajagopal, Sriram Rajagopal, Ramesh Mullangi. Sensitive method for the determination of rocilinostat in small volume mouse plasma by LC-MS/MS and its application to a pharmacokinetic study in mice.
Biomedical chromatography : BMC.
2016 Jul; 30(7):1138-1144. doi:
10.1002/bmc.3665
. [PMID: 26633099] - Loredana Santo, Teru Hideshima, Andrew L Kung, Jen-Chieh Tseng, David Tamang, Min Yang, Matthew Jarpe, John H van Duzer, Ralph Mazitschek, Walter C Ogier, Diana Cirstea, Scott Rodig, Homare Eda, Tyler Scullen, Miriam Canavese, James Bradner, Kenneth C Anderson, Simon S Jones, Noopur Raje. Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma.
Blood.
2012 Mar; 119(11):2579-89. doi:
10.1182/blood-2011-10-387365
. [PMID: 22262760]