GS-9620 (BioDeep_00000858996)

   


代谢物信息卡片


Vesatolimod

化学式: C22H30N6O2 (410.24301199999996)
中文名称: 维托莫德
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCOC1=NC(=C2C(=N1)N(CC(=O)N2)CC3=CC=CC(=C3)CN4CCCC4)N
InChI: InChI=1S/C22H30N6O2/c1-2-3-11-30-22-25-20(23)19-21(26-22)28(15-18(29)24-19)14-17-8-6-7-16(12-17)13-27-9-4-5-10-27/h6-8,12H,2-5,9-11,13-15H2,1H3,(H,24,29)(H2,23,25,26)

描述信息

D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
C308 - Immunotherapeutic Agent > C2139 - Immunostimulant
C254 - Anti-Infective Agent > C281 - Antiviral Agent

同义名列表

2 个代谢物同义名

Vesatolimod; GS-9620



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Gyeongmin Lee, Hyo Rin Kang, Aro Kim, Jong-Hyeon Park, Min Ja Lee, Su-Mi Kim. Antiviral effect of vesatolimod (GS-9620) against foot-and-mouth disease virus both in vitro and invivo. Antiviral research. 2022 09; 205(?):105384. doi: 10.1016/j.antiviral.2022.105384. [PMID: 35863499]
  • Sharon A Riddler, Michael Para, Constance A Benson, Anthony Mills, Moti Ramgopal, Edwin DeJesus, Cynthia Brinson, Joshua Cyktor, Jana Jacobs, Dianna Koontz, John W Mellors, Gregory M Laird, Terri Wrin, Heena Patel, Susan Guo, Jeffrey Wallin, Jillian Boice, Liao Zhang, Rita Humeniuk, Rebecca Begley, Polina German, Hiba Graham, Romas Geleziunas, Diana M Brainard, Devi SenGupta. Vesatolimod, a Toll-like Receptor 7 Agonist, Induces Immune Activation in Virally Suppressed Adults Living With Human Immunodeficiency Virus-1. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2021 06; 72(11):e815-e824. doi: 10.1093/cid/ciaa1534. [PMID: 33043969]
  • Elena Bekerman, Joseph Hesselgesser, Brian Carr, Mark Nagel, Magdeleine Hung, Adele Wang, Lance Stapleton, Agneta von Gegerfelt, Hanne Andersen Elyard, Jeffrey D Lifson, Romas Geleziunas. PD-1 Blockade and TLR7 Activation Lack Therapeutic Benefit in Chronic Simian Immunodeficiency Virus-Infected Macaques on Antiretroviral Therapy. Antimicrobial agents and chemotherapy. 2019 11; 63(11):. doi: 10.1128/aac.01163-19. [PMID: 31501143]
  • Gregory Q Del Prete, W Gregory Alvord, Yuan Li, Claire Deleage, Mukta Nag, Kelli Oswald, James A Thomas, Cathi Pyle, William J Bosche, Vicky Coalter, Adam Wiles, Rodney Wiles, Brian Berkemeier, Michael Hull, Elizabeth Chipriano, Lorna Silipino, Randy Fast, Jacob Kiser, Rebecca Kiser, Tyler Malys, Joshua Kramer, Matthew W Breed, Charles M Trubey, Jacob D Estes, Tiffany L Barnes, Joseph Hesselgesser, Romas Geleziunas, Jeffrey D Lifson. TLR7 agonist administration to SIV-infected macaques receiving early initiated cART does not induce plasma viremia. JCI insight. 2019 06; 4(11):. doi: 10.1172/jci.insight.127717. [PMID: 31167974]
  • K Agarwal, S H Ahn, M Elkhashab, A H Lau, A Gaggar, A Bulusu, X Tian, A L Cathcart, J Woo, G M Subramanian, P Andreone, H J Kim, W L Chuang, M H Nguyen. Safety and efficacy of vesatolimod (GS-9620) in patients with chronic hepatitis B who are not currently on antiviral treatment. Journal of viral hepatitis. 2018 11; 25(11):1331-1340. doi: 10.1111/jvh.12942. [PMID: 29851204]
  • Carolina Boni, Andrea Vecchi, Marzia Rossi, Diletta Laccabue, Tiziana Giuberti, Arianna Alfieri, Pietro Lampertico, Glenda Grossi, Floriana Facchetti, Maurizia R Brunetto, Barbara Coco, Daniela Cavallone, Alessandra Mangia, Rosanna Santoro, Valeria Piazzolla, Audrey Lau, Anuj Gaggar, G Mani Subramanian, Carlo Ferrari. TLR7 Agonist Increases Responses of Hepatitis B Virus-Specific T Cells and Natural Killer Cells in Patients With Chronic Hepatitis B Treated With Nucleos(T)Ide Analogues. Gastroenterology. 2018 05; 154(6):1764-1777.e7. doi: 10.1053/j.gastro.2018.01.030. [PMID: 29378197]
  • Li Li, Vivian Barry, Stephane Daffis, Congrong Niu, Erik Huntzicker, Dorothy M French, Igor Mikaelian, Robert E Lanford, William E Delaney, Simon P Fletcher. Anti-HBV response to toll-like receptor 7 agonist GS-9620 is associated with intrahepatic aggregates of T cells and B cells. Journal of hepatology. 2018 05; 68(5):912-921. doi: 10.1016/j.jhep.2017.12.008. [PMID: 29247724]
  • Qian Zhang, Binbin Zhao, Xin Chen, Nan Song, Jing Wu, Guangchao Li, Pin Yu, Yunlin Han, Jiangning Liu, Chuan Qin. GS-9620 inhibits enterovirus 71 replication mainly through the NF-κB and PI3K-AKT signaling pathways. Antiviral research. 2018 05; 153(?):39-48. doi: 10.1016/j.antiviral.2018.02.002. [PMID: 29425831]
  • Harry L A Janssen, Maurizia R Brunetto, Yoon Jun Kim, Carlo Ferrari, Benedetta Massetto, Anh-Hoa Nguyen, Adarsh Joshi, Jacky Woo, Audrey H Lau, Anuj Gaggar, G Mani Subramanian, Eric M Yoshida, Sang Hoon Ahn, Naoky C S Tsai, Scott Fung, Edward J Gane. Safety, efficacy and pharmacodynamics of vesatolimod (GS-9620) in virally suppressed patients with chronic hepatitis B. Journal of hepatology. 2018 03; 68(3):431-440. doi: 10.1016/j.jhep.2017.10.027. [PMID: 29104121]
  • Edward J Gane, Young-Suk Lim, Stuart C Gordon, Kumar Visvanathan, Eric Sicard, Richard N Fedorak, Stuart Roberts, Benedetta Massetto, Zhishen Ye, Stefan Pflanz, Kimberly L Garrison, Anuj Gaggar, G Mani Subramanian, John G McHutchison, Shyamasundaran Kottilil, Bradley Freilich, Carla S Coffin, Wendy Cheng, Yoon Jun Kim. The oral toll-like receptor-7 agonist GS-9620 in patients with chronic hepatitis B virus infection. Journal of hepatology. 2015 Aug; 63(2):320-8. doi: 10.1016/j.jhep.2015.02.037. [PMID: 25733157]
  • Stephan Menne, Daniel B Tumas, Katherine H Liu, Linta Thampi, Dalal AlDeghaither, Betty H Baldwin, Christine A Bellezza, Paul J Cote, Jim Zheng, Randall Halcomb, Abigail Fosdick, Simon P Fletcher, Stephane Daffis, Li Li, Peng Yue, Grushenka H I Wolfgang, Bud C Tennant. Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B. Journal of hepatology. 2015 Jun; 62(6):1237-45. doi: 10.1016/j.jhep.2014.12.026. [PMID: 25559326]
  • Eric Lawitz, Daniel Gruener, Thomas Marbury, John Hill, Lynn Webster, David Hassman, Anh-Hoa Nguyen, Stefan Pflanz, Erik Mogalian, Anuj Gaggar, Benedetta Massetto, G Mani Subramanian, John G McHutchison, Ira M Jacobson, Bradley Freilich, Maribel Rodriguez-Torres. Safety, pharmacokinetics and pharmacodynamics of the oral toll-like receptor 7 agonist GS-9620 in treatment-naive patients with chronic hepatitis C. Antiviral therapy. 2015; 20(7):699-708. doi: 10.3851/imp2845. [PMID: 25105516]
  • Abigail Fosdick, Jim Zheng, Stefan Pflanz, Christian R Frey, Joseph Hesselgesser, Randall L Halcomb, Grushenka Wolfgang, Daniel B Tumas. Pharmacokinetic and pharmacodynamic properties of GS-9620, a novel Toll-like receptor 7 agonist, demonstrate interferon-stimulated gene induction without detectable serum interferon at low oral doses. The Journal of pharmacology and experimental therapeutics. 2014 Jan; 348(1):96-105. doi: 10.1124/jpet.113.207878. [PMID: 24133297]
  • Robert E Lanford, Bernadette Guerra, Deborah Chavez, Luis Giavedoni, Vida L Hodara, Kathleen M Brasky, Abigail Fosdick, Christian R Frey, Jim Zheng, Grushenka Wolfgang, Randall L Halcomb, Daniel B Tumas. GS-9620, an oral agonist of Toll-like receptor-7, induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees. Gastroenterology. 2013 Jun; 144(7):1508-17, 1517.e1. doi: 10.1053/j.gastro.2013.02.003. [PMID: 23415804]
  • Uri Lopatin, Grushenka Wolfgang, Daniel Tumas, Christian R Frey, Carol Ohmstede, Joseph Hesselgesser, Brian Kearney, Lisa Moorehead, G Mani Subramanian, John G McHutchison. Safety, pharmacokinetics and pharmacodynamics of GS-9620, an oral Toll-like receptor 7 agonist. Antiviral therapy. 2013; 18(3):409-18. doi: 10.3851/imp2548. [PMID: 23416308]