Clazosentan (BioDeep_00000858965)

   


代谢物信息卡片


N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-[2-(2H-tetrazol-5-yl)pyridin-4-yl]pyrimidin-4-yl]-5-methyl-pyridine-2-sulfonamide

化学式: C25H23N9O6S (577.1491938)
中文名称: 克拉生坦
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CN=C(C=C1)S(=O)(=O)NC2=C(C(=NC(=N2)C3=CC(=NC=C3)C4=NNN=N4)OCCO)OC5=CC=CC=C5OC
InChI: InChI=1S/C25H23N9O6S/c1-15-7-8-20(27-14-15)41(36,37)32-24-21(40-19-6-4-3-5-18(19)38-2)25(39-12-11-35)29-22(28-24)16-9-10-26-17(13-16)23-30-33-34-31-23/h3-10,13-14,35H,11-12H2,1-2H3,(H,28,29,32)(H,30,31,33,34)

描述信息

C28313 - Endothelin Receptor Antagonist
Clazosentan (Ro 61-1790) is a selective endothelin A (ETA) receptor antagonist. Clazosentan inhibits ET-1-mediated vasoconstriction. Clazosentan prevents cerebral vasospasm, vasospasm-related cerebral infarction[1][5].

同义名列表

5 个代谢物同义名

N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-[2-(2H-tetrazol-5-yl)pyridin-4-yl]pyrimidin-4-yl]-5-methyl-pyridine-2-sulfonamide; Clazosentan; Ro 61-1790; VML 588; AXV-034343



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Pierre-Eric Juif, Jasper Dingemanse, Christine Voors-Pette, Mike Ufer. Association Between Vomiting and QT Hysteresis: Data from a TQT Study with the Endothelin A Receptor Antagonist Clazosentan. The AAPS journal. 2020 08; 22(5):103. doi: 10.1208/s12248-020-00485-6. [PMID: 32748293]
  • Pierre-Eric Juif, Christine Voors-Pette, Mike Ufer, Peter Dogterom, Jasper Dingemanse. Influence of Rifampin-Mediated Organic Anion-Transporting Polypeptide 1B1/1B3 Inhibition on the Pharmacokinetics of Clazosentan. Clinical and translational science. 2019 09; 12(5):440-444. doi: 10.1111/cts.12639. [PMID: 31004470]
  • Octavio Moldes, Tomás Sobrino, Miguel Blanco, Jesús Agulla, David Barral, Pedro Ramos-Cabrer, José Castillo. Neuroprotection afforded by antagonists of endothelin-1 receptors in experimental stroke. Neuropharmacology. 2012 Dec; 63(8):1279-85. doi: 10.1016/j.neuropharm.2012.08.019. [PMID: 22975409]
  • Patricia N Sidharta, Paul L M van Giersbergen, Atef Halabi, Jasper Dingemanse. Macitentan: entry-into-humans study with a new endothelin receptor antagonist. European journal of clinical pharmacology. 2011 Oct; 67(10):977-84. doi: 10.1007/s00228-011-1043-2. [PMID: 21541781]
  • Mervyn D I Vergouwen, Don Ilodigwe, R Loch Macdonald. Cerebral infarction after subarachnoid hemorrhage contributes to poor outcome by vasospasm-dependent and -independent effects. Stroke. 2011 Apr; 42(4):924-9. doi: 10.1161/strokeaha.110.597914. [PMID: 21311062]
  • Shirin Bruderer, Boris Sasu, Nahum Tsvitbaum, Jasper Dingemanse. Influence of severe renal impairment on the pharmacokinetics of clazosentan. Journal of clinical pharmacology. 2011 Mar; 51(3):413-21. doi: 10.1177/0091270010368975. [PMID: 20926750]
  • Shirin Bruderer, Victor Detishin, Nahum Tsvitbaum, Jasper Dingemanse. Influence of different degrees of liver impairment on the pharmacokinetics of clazosentan. British journal of clinical pharmacology. 2011 Jan; 71(1):52-60. doi: 10.1111/j.1365-2125.2010.03804.x. [PMID: 21143501]
  • P L M van Giersbergen, A Treiber, J Dingemanse. In vitro and in vivo pharmacokinetic characteristics of clazosentan, an intravenous endothelin receptor antagonist, in humans. International journal of clinical pharmacology and therapeutics. 2009 Mar; 47(3):169-77. doi: 10.5414/cpp47169. [PMID: 19281726]
  • Waldiceu A Verri, Ana T G Guerrero, Sandra Y Fukada, Daniel A Valerio, Thiago M Cunha, Damo Xu, Sérgio H Ferreira, Foo Y Liew, Fernando Q Cunha. IL-33 mediates antigen-induced cutaneous and articular hypernociception in mice. Proceedings of the National Academy of Sciences of the United States of America. 2008 Feb; 105(7):2723-8. doi: 10.1073/pnas.0712116105. [PMID: 18250323]
  • Paul L M van Giersbergen, Kulasiri A Gunawardena, Jasper Dingemanse. Influence of ethnic origin and sex on the pharmacokinetics of clazosentan. Journal of clinical pharmacology. 2007 Nov; 47(11):1374-80. doi: 10.1177/0091270007307337. [PMID: 17906281]
  • Paul L M van Giersbergen, Jasper Dingemanse. Tolerability, pharmacokinetics, and pharmacodynamics of clazosentan, a parenteral endothelin receptor antagonist. European journal of clinical pharmacology. 2007 Feb; 63(2):151-8. doi: 10.1007/s00228-006-0117-z. [PMID: 16636870]
  • J L Tycho Vuurmans, Peter Boer, Hein A Koomans. Effects of endothelin-1 and endothelin-1-receptor blockade on renal function in humans. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2004 Nov; 19(11):2742-6. doi: 10.1093/ndt/gfh471. [PMID: 15328386]
  • Masaki Okajima, Robert Parent, Eric Thorin, Michel Lavallée. Pathophysiological plasma ET-1 levels antagonize beta-adrenergic dilation of coronary resistance vessels in conscious dogs. American journal of physiology. Heart and circulatory physiology. 2004 Oct; 287(4):H1476-83. doi: 10.1152/ajpheart.00297.2004. [PMID: 15205173]
  • Tycho J L Vuurmans, Peter Boer, Hein A Koomans. Effects of endothelin-1 and endothelin-1 receptor blockade on cardiac output, aortic pressure, and pulse wave velocity in humans. Hypertension (Dallas, Tex. : 1979). 2003 Jun; 41(6):1253-8. doi: 10.1161/01.hyp.0000072982.70666.e8. [PMID: 12743011]
  • A Bhardwaj, Y Wu, P D Hurn, J R Kirsch, R J Traystman. Administration of selective endothelin receptor type A antagonist Ro 61-1790 does not improve outcome in focal cerebral ischemia in cat. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2000 Mar; 20(3):499-504. doi: 10.1097/00004647-200003000-00008. [PMID: 10724114]
  • S Roux, C Qiu, U Sprecher, R Osterwalder, J P Clozel. Protective effects of endothelin receptor antagonists in dogs with aortic cross-clamping. Journal of cardiovascular pharmacology. 1999 Aug; 34(2):199-205. doi: 10.1097/00005344-199908000-00004. [PMID: 10445670]