Cibenzoline (BioDeep_00000858957)

   


代谢物信息卡片


Cibenzoline

化学式: C18H18N2 (262.1469908)
中文名称: 邻苯二酚
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CN=C(N1)C2CC2(C3=CC=CC=C3)C4=CC=CC=C4
InChI: InChI=1S/C18H18N2/c1-3-7-14(8-4-1)18(15-9-5-2-6-10-15)13-16(18)17-19-11-12-20-17/h1-10,16H,11-13H2,(H,19,20)

描述信息

C - Cardiovascular system > C01 - Cardiac therapy > C01B - Antiarrhythmics, class i and iii
C78274 - Agent Affecting Cardiovascular System > C47793 - Antiarrhythmic Agent
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents

同义名列表

1 个代谢物同义名

Cibenzoline



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Yoshihiro Nakagawa, Masatoshi Ishizaki, Aki Kozono, Kiyonori Hanada, Toshinobu Higashi, Hidetsugu Ueyama. [A case of myasthenia-like symptoms induced by cibenzoline overdosage]. Rinsho shinkeigaku = Clinical neurology. 2018 Jan; 58(1):41-44. doi: 10.5692/clinicalneurol.cn-001070. [PMID: 29269691]
  • Yutaro Mukai, Kyoichi Wada, Mai Fujimoto, Kouichi Hosomi, Takeshi Kuwahara, Mitsutaka Takada. Long-term impact of therapeutic drug monitoring on the risk of hypoglycemia in HOCM patients on cibenzoline therapy
. International journal of clinical pharmacology and therapeutics. 2016 Oct; 54(10):795-803. doi: 10.5414/cp202655. [PMID: 27443663]
  • Mareomi Hamada, Shuntaro Ikeda, Kiyotaka Ohshima, Masayuki Nakamura, Norio Kubota, Akiyoshi Ogimoto, Yuji Shigematsu. Impact of chronic use of cibenzoline on left ventricular pressure gradient and left ventricular remodeling in patients with hypertrophic obstructive cardiomyopathy. Journal of cardiology. 2016 Mar; 67(3):279-86. doi: 10.1016/j.jjcc.2015.05.014. [PMID: 26116980]
  • Liang Guo, Luke Coyle, Rory M C Abrams, Raymond Kemper, Eric T Chiao, Kyle L Kolaja. Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model. Toxicological sciences : an official journal of the Society of Toxicology. 2013 Dec; 136(2):581-94. doi: 10.1093/toxsci/kft205. [PMID: 24052561]
  • Yutaka Takahashi, Yasuyoshi Ishiwata, Yuko Kojima, Masato Yasuhara. Pharmacodynamics of cibenzoline-induced hypoglycemia in rats. Drug metabolism and pharmacokinetics. 2011 Jun; 26(3):242-7. doi: 10.2133/dmpk.dmpk-10-rg-127. [PMID: 21273730]
  • Toshihiro Ohata, Hideki Ueda, Yasuyuki Yamada. Cibenzoline intoxication necessitating implantation of a biventricular assist system in a patient with severe cardiomyopathy. Interactive cardiovascular and thoracic surgery. 2010 Jul; 11(1):95-7. doi: 10.1510/icvts.2010.236182. [PMID: 20421279]
  • Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance. Journal of medicinal chemistry. 2009 Aug; 52(15):4844-52. doi: 10.1021/jm900403j. [PMID: 19445515]
  • Atsushi Tamura, Takehiko Ogura, Hiroko Uemura, Yoshie Reien, Takashi Kishimoto, Toshio Nagai, Issei Komuro, Masaru Miyazaki, Haruaki Nakaya. Effects of antiarrhythmic drugs on the hyperpolarization-activated cyclic nucleotide-gated channel current. Journal of pharmacological sciences. 2009 Jun; 110(2):150-9. doi: 10.1254/jphs.08312fp. [PMID: 19498275]
  • Takashi Komatsu, Hideaki Tachibana, Yoshihiro Sato, Mahito Ozawa, Kyoko Ohshima, Makoto Orii, Fusanori Kunigida, Motoyuki Nakamura. A randomized study on the efficacy of intravenous cibenzoline and pilsicainide administered prior to electrical cardioversion in patients with lone paroxysmal and persistent atrial fibrillation. Journal of cardiology. 2009 Feb; 53(1):35-42. doi: 10.1016/j.jjcc.2008.08.007. [PMID: 19167636]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • Roel Meeus, Gert A Verpooten, Rudi De Paep, Bernard P Paelinck, Hugo Neels, Sarah Cooreman, Mireiile De Doncker, Philippe G Jorens. Cibenzoline intoxication: effect of combined hemoperfusion-hemodialysis on plasma clearance. Clinical toxicology (Philadelphia, Pa.). 2008 Apr; 46(4):303-6. doi: 10.1080/15563650701458134. [PMID: 18363124]
  • Hidenori Kawasaki, Kensei Yahata, Chinatsu Okamoto, Hirotaka Imamaki, Koichi Seta, Akira Sugawara. [Myasthenia-like syndrome induced by cibenzoline overdose in a patient with chronic kidney disease]. Nihon Jinzo Gakkai shi. 2008; 50(7):942-7. doi: NULL. [PMID: 19069153]
  • Takahiro Iwamoto, Yasuhide Watanabe, Satomi Kita, Mordecai P Blaustein. Na+/Ca2+ exchange inhibitors: a new class of calcium regulators. Cardiovascular & hematological disorders drug targets. 2007 Sep; 7(3):188-98. doi: 10.2174/187152907781745288. [PMID: 17896959]
  • Tetsuya Saita, Akira Tokunaga, Masayoshi Egoshi, Hideaki Tokushima, Hiroshi Fujito. Quantification of cibenzoline by enzyme-linked immunosorbent assay. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2007 Jun; 127(6):1007-12. doi: 10.1248/yakushi.127.1007. [PMID: 17541252]
  • P Vandecandelaere, J Verbanck, K Matthys, J de Hoon, R Verbesselt. Symptomatic hypoglycemia in a patient with chronic hemodialysis. Acta clinica Belgica. 2006 Sep; 61(5):249-51. doi: 10.1179/acb.2006.041. [PMID: 17240739]
  • Takeshi Kotake, Mitsutaka Takada, Kazuo Komamura, Shiro Kamakura, Kunio Miyatake, Masafumi Kitakaze, Hideki Morishita. Heart failure elevates serum levels of cibenzoline in arrhythmic patients. Circulation journal : official journal of the Japanese Circulation Society. 2006 May; 70(5):588-92. doi: 10.1253/circj.70.588. [PMID: 16636495]
  • Kazuyuki Kuriu, Hiroyuki Tanaka, Kenzo Hirao, Satoru Makita, Fusahiko Ito, Tomohiro Mizuno, Noriyuki Tabuchi, Hirokuni Arai, Makoto Sunamori. Oral cibenzoline reduces postoperative atrial fibrillation in coronary artery bypass grafting. The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi. 2005 Jan; 53(1):8-15. doi: 10.1007/s11748-005-1002-x. [PMID: 15724496]
  • Yoichi Ozasa, Seishi Takamura, I Seishi, Hideki Kitada, Soichi Uekihara, Shunichi Hayano. [A case of acute cibenzoline intoxication in a hemodialysis patient]. Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology. 2003 Jul; 16(3):335-8. doi: NULL. [PMID: 14582357]
  • Mikio Kakumoto, Kohji Takara, Toshiyuki Sakaeda, Yusuke Tanigawara, Tomoko Kita, Katsuhiko Okumura. MDR1-mediated interaction of digoxin with antiarrhythmic or antianginal drugs. Biological & pharmaceutical bulletin. 2002 Dec; 25(12):1604-7. doi: 10.1248/bpb.25.1604. [PMID: 12499648]
  • Masaaki Takahashi, Hirotoshi Echizen, Keiko Takahashi, Shigehiko Shimada, Naoyoshi Aoyama, Tohru Izumi. Extremely prolonged elimination of cibenzoline at toxic plasma concentrations in patients with renal impairments. Therapeutic drug monitoring. 2002 Aug; 24(4):492-6. doi: 10.1097/00007691-200208000-00005. [PMID: 12142632]
  • Takashi Komatsu, Shin Nakamura, Masao Kimura, Shingen Owada, Kunihiko Yomogida, Kunihiko Kameda, Koichi Oikawa, Hirofumi Tomita, Ken Okumura. [Relationship between long-term preventive efficacy of cibenzoline and atrial natriuretic peptide in patients with paroxysmal atrial fibrillation]. Journal of cardiology. 2002 Feb; 39(2):93-9. doi: NULL. [PMID: 11873440]
  • Kei-ichi Inada, Gaku Sekita, Daigo Sawaki, Yoshitaka Otani, Kazuyuki Fukushima, Hiroaki Takeuchi, Teruhiko Aoyagi. A case of severe respiratory depression due to cibenzoline overdosage induced by a transient renal dysfunction. International journal of cardiology. 2002 Feb; 82(2):177-8. doi: 10.1016/s0167-5273(01)00606-4. [PMID: 11853904]
  • M Takada, M Shibakawa. Efficacy of therapeutic drug monitoring in prevention of hypoglycemia caused by cibenzoline. European journal of clinical pharmacology. 2001 Dec; 57(10):695-700. doi: 10.1007/s00228-001-0381-x. [PMID: 11829197]
  • Y Tabuchi, H Yashiro, S Hoshina, S Asano, N Takeguchi. Cibenzoline, an ATP-sensitive K(+) channel blocker, binds to the K(+)-binding site from the cytoplasmic side of gastric H(+),K(+)-ATPase. British journal of pharmacology. 2001 Dec; 134(8):1655-62. doi: 10.1038/sj.bjp.0704422. [PMID: 11739241]
  • A Ogimoto, M Hamada, H Saeki, G Hiasa, T Ohtsuka, H Hashida, Y Hara, T Okura, Y Shigematsu, K Hiwada. Hypoglycemic syncope induced by a combination of cibenzoline and angiotensin converting enzyme inhibitor. Japanese heart journal. 2001 Mar; 42(2):255-9. doi: 10.1536/jhj.42.255. [PMID: 11384085]
  • T Saikawa, M Arita, K Yamaguchi, M Ito. Hypoglycemic effect of cibenzoline in patients with abnormal glucose tolerance and frequent ventricular arrhythmias. Cardiovascular drugs and therapy. 2000 Dec; 14(6):665-9. doi: 10.1023/a:1007827217400. [PMID: 11300368]
  • M Horie, M Watanuki, K Tsuji, H Ishida, A Ishida-Takahashi, Y Yuzuki, Y Seino, S Sasayama. Blockade of cardiac ATP-sensitive K+ channel by cibenzoline targets its pore-forming subunit. Journal of cardiovascular pharmacology. 2000 Mar; 35(3):434-42. doi: 10.1097/00005344-200003000-00014. [PMID: 10710130]
  • T Honda, H Soejima, T Honda. Long-term low-dose cibenzoline in patients with chronic renal failure undergoing hemodialysis. Japanese circulation journal. 2000 Jan; 64(1):72-5. doi: 10.1253/jcj.64.72. [PMID: 10651210]
  • N Aoyama, T Sasaki, M Yoshida, K Suzuki, K Matsuyama, T Aizaki, T Izumi, R Kondo, Y Kamijo, K Soma, T Ohwada. Effect of charcoal hemoperfusion on clearance of cibenzoline succinate (cifenline) poisoning. Journal of toxicology. Clinical toxicology. 1999; 37(4):505-8. doi: 10.1081/clt-100102443. [PMID: 10465249]
  • Y Wakutani, E Matsushima, A Son, Y Shimizu, Y Goto, H Ishida. Myasthenialike syndrome due to adverse effects of cibenzoline in a patient with chronic renal failure. Muscle & nerve. 1998 Mar; 21(3):416-7. doi: 10.1002/(sici)1097-4598(199803)21:3<416::aid-mus23>3.0.co;2-i. [PMID: 9486877]
  • I Mahmood. Prediction of absolute bioavailability for drugs using oral and renal clearance following a single oral dose: a critical view. Biopharmaceutics & drug disposition. 1997 Aug; 18(6):465-73. doi: 10.1002/(sici)1099-081x(199708)18:6<465::aid-bdd41>3.0.co;2-c. [PMID: 9267680]
  • T Similowski, C Straus, V Attali, F Girard, F Philippe, G Deray, D Thomas, J P Derenne. Neuromuscular blockade with acute respiratory failure in a patient receiving cibenzoline. Thorax. 1997 Jun; 52(6):582-4. doi: 10.1136/thx.52.6.582. [PMID: 9227733]
  • A Kasuga, H Maruyama, T Sato, S Nogawa, H Mitamura, T Saruta. Myasthenia-like syndrome induced by overdosage of cibenzoline. Internal medicine (Tokyo, Japan). 1996 Jun; 35(6):512-4. doi: 10.2169/internalmedicine.35.512. [PMID: 8835607]
  • J P Fauchier, P Rouesnel, J C Breuillac, P Cosnay, F Scheck, L F Garnier. [Injectable and oral cibenzoline in the treatment of supraventricular tachycardia related to intranodal reentry or accessory atrioventricular conduction pathway]. Annales de cardiologie et d'angeiologie. 1994 Apr; 43(4):194-203. doi: NULL. [PMID: 8024234]
  • H Sakuta, K Okamoto, Y Watanabe. Antiarrhythmic drugs, clofilium and cibenzoline are potent inhibitors of glibenclamide-sensitive K+ currents in Xenopus oocytes. British journal of pharmacology. 1993 Jul; 109(3):866-72. doi: 10.1111/j.1476-5381.1993.tb13655.x. [PMID: 8358576]
  • S M Mohiuddin, T T Hee, C B Hunter, D E Hilleman, M H Sketch. Loss of efficacy during long-term cifenline therapy: development of antiarrhythmic resistance?. The Annals of pharmacotherapy. 1993 May; 27(5):550-4. doi: 10.1177/106002809302700502. [PMID: 8347900]
  • L F Garnier, F Bine-Scheck, P Pruvost, H Wanszelbaum, R Arnaud. [Combination of oral administration of cibenzoline and digoxin in patients with supraventricular arrhythmia]. Annales de cardiologie et d'angeiologie. 1992 Sep; 41(7):411-7. doi: NULL. [PMID: 1285630]
  • G Bertrand, R Gross, P Petit, M M Loubatières-Mariani, G Ribes. Evidence for a direct stimulatory effect of cibenzoline on insulin secretion in rats. European journal of pharmacology. 1992 Apr; 214(2-3):159-63. doi: 10.1016/0014-2999(92)90113-i. [PMID: 1516637]
  • D Babuty, P Cosnay, P Rouesnel, F Bine-Scheck, R Arnaud, J P Fauchier. [Comparison of the efficacy/tolerability ratio of cibenzoline and propafenone in the treatment of ventricular arrhythmia]. Annales de cardiologie et d'angeiologie. 1992 Apr; 41(4):225-34. doi: NULL. [PMID: 1642441]
  • M P Barbalas, W A Garland. A computer program for the deconvolution of mass spectral peak abundance data from experiments using stable isotopes. Journal of pharmaceutical sciences. 1991 Oct; 80(10):922-7. doi: 10.1002/jps.2600801004. [PMID: 1783999]
  • V Kühlkamp, F Schmid, T Risler, L Seipel. Randomized comparison of flecainide and cibenzoline in the conversion of atrial fibrillation. International journal of cardiology. 1991 Apr; 31(1):65-9. doi: 10.1016/0167-5273(91)90269-u. [PMID: 1906432]
  • G Aronoff, M Brier, M L Mayer, M Barbalas, K Aogaichi, R Sloan, R Brazzell, J Massarella. Bioavailability and kinetics of cibenzoline in patients with normal and impaired renal function. Journal of clinical pharmacology. 1991 Jan; 31(1):38-44. doi: 10.1002/j.1552-4604.1991.tb01884.x. [PMID: 2045527]
  • A Haruno, T Matsuzaki, K Hashimoto. Antiarrhythmic effects of optical isomers of cibenzoline on canine ventricular arrhythmias. Journal of cardiovascular pharmacology. 1990 Sep; 16(3):376-82. doi: 10.1097/00005344-199009000-00005. [PMID: 1700207]
  • Q Timour, M Freysz, P Couzon, J Loufoua, L Bertrix, I Gerentes, G Faucon. Possible role of drug interactions in bupivacaine-induced problems related to intraventricular conduction disorders. Regional anesthesia. 1990 Jul; 15(4):180-5. doi: NULL. [PMID: 2127373]
  • V Kühlkamp, F Schmid, K M Ress, B K Krämer, F Mayer, H M Liebich, T Risler, L Seipel. Quantification of cibenzoline and its imidazole metabolite by high-performance liquid chromatography in human serum. Journal of chromatography. 1990 Jun; 528(1):267-73. doi: 10.1016/s0378-4347(00)82385-3. [PMID: 2384563]
  • V Kühlkamp, F Schmid, F Mayer, O Ickrath, R Haasis, L Seipel. Effects of intravenous cibenzoline on ventricular vulnerability and electrophysiology in patients with sustained ventricular tachycardia in comparison to a control group. Journal of cardiovascular pharmacology. 1990 Mar; 15(3):472-5. doi: 10.1097/00005344-199003000-00018. [PMID: 1691372]
  • M Boucher, C Dubray, J P Kantelip, J M Talmant, A Dufour, P Duchêne-Marullaz. Cardiac electrophysiological effects of cibenzoline in the conscious dog: plasma concentration-response relationships. Journal of cardiovascular pharmacology. 1989 Oct; 14(4):616-21. doi: 10.1097/00005344-198910000-00013. [PMID: 2478775]
  • J F Noury, J C Delvaux. [Hypoglycemia caused by cibenzoline. Apropos of a new case]. Annales de cardiologie et d'angeiologie. 1989 Jan; 38(1):7-8. doi: NULL. [PMID: 2648968]
  • G Lefort, M Haissaguerre, J Floro, P Beauffigeau, J F Warin, J L Latapie. [Hypoglycemia caused by overdose of a new anti-arrhythmia agent: cibenzoline. 3 cases]. Presse medicale (Paris, France : 1983). 1988 Apr; 17(14):687-91. doi: NULL. [PMID: 2966953]
  • T Tanabe, H Yoshikawa, H Furuya, Y Goto. Therapeutic effectiveness and plasma levels of single or combination use of class I antiarrhythmic agents for ventricular arrhythmias. Japanese circulation journal. 1988 Mar; 52(3):298-305. doi: 10.1253/jcj.52.298. [PMID: 3373722]
  • J W Massarella, K C Khoo, K Aogaichi, D Di Persio, M Smith, J Kluger, M S Chow. Effect of renal impairment on the pharmacokinetics of cibenzoline. Clinical pharmacology and therapeutics. 1988 Mar; 43(3):317-23. doi: 10.1038/clpt.1988.38. [PMID: 3345622]
  • K C Khoo, S V Givens, M Parsonnet, J W Massarella. Effect of oral cibenzoline on steady-state digoxin concentrations in healthy volunteers. Journal of clinical pharmacology. 1988 Jan; 28(1):29-35. doi: 10.1002/j.1552-4604.1988.tb03097.x. [PMID: 3350991]
  • M M Reidenberg, B J Lorenzo, D E Drayer, J Kluger, T Nestor, J C Regnier, B A Kowal, I Bekersky. A nonradioactive iothalamate method for measuring glomerular filtration rate and its use to study the renal handling of cibenzoline. Therapeutic drug monitoring. 1988; 10(4):434-7. doi: 10.1097/00007691-198804000-00010. [PMID: 3201528]
  • D P Humen, R Lesoway, W J Kostuk. Acute, single, intravenous doses of cibenzoline: an evaluation of safety, tolerance, and hemodynamic effects. Clinical pharmacology and therapeutics. 1987 May; 41(5):537-45. doi: 10.1038/clpt.1987.69. [PMID: 3568538]
  • J W Massarella, T Silvestri, F DeGrazia, B Miwa, D Keefe. Effect of congestive heart failure on the pharmacokinetics of cibenzoline. Journal of clinical pharmacology. 1987 Mar; 27(3):187-92. doi: 10.1002/j.1552-4604.1987.tb02182.x. [PMID: 3680572]
  • K Hashimoto, K Akiyama, H Mitsuhashi. Antiarrhythmic plasma concentrations of cibenzoline on canine ventricular arrhythmias. Journal of cardiovascular pharmacology. 1987 Feb; 9(2):148-53. doi: 10.1097/00005344-198702000-00004. [PMID: 2435991]
  • D E Hilleman, S M Mohiuddin, I S Ahmed, J M Dahl. Cibenzoline-induced hypoglycemia. Drug intelligence & clinical pharmacy. 1987 Jan; 21(1 Pt 1):38-40. doi: 10.1177/10600280870211p104. [PMID: 3545736]
  • J Massarella, T Silvestri, A Lin. Relative and absolute bioavailability of cibenzoline capsules and tablets in healthy subjects. Journal of pharmaceutical sciences. 1986 Sep; 75(9):894-6. doi: 10.1002/jps.2600750915. [PMID: 3783460]
  • P Touboul, G Atallah, G Kirkorian, C de Zuloaga, A Dufour, M F Aymard, P Lavaud, P Moleur. Electrophysiologic effects of cibenzoline in humans related to dose and plasma concentration. American heart journal. 1986 Aug; 112(2):333-9. doi: 10.1016/0002-8703(86)90271-1. [PMID: 3526853]
  • A A Holazo, R K Brazzell, W A Colburn. Pharmacokinetic and pharmacodynamic modeling of cibenzoline plasma concentrations and antiarrhythmic effect. Journal of clinical pharmacology. 1986 May; 26(5):336-45. doi: 10.1002/j.1552-4604.1986.tb03535.x. [PMID: 3700689]
  • A C Loh, T H Williams, J W Tilley, G J Sasso, A J Szuna, J J Carbone, V Toome, F J Leinweber. The metabolism of 14C-cibenzoline in dogs and rats. Drug metabolism and disposition: the biological fate of chemicals. 1986 May; 14(3):325-30. doi: NULL. [PMID: 2872033]
  • R C Klein, L D Horwitz, N Rushforth. Efficacy and safety of oral cibenzoline for ventricular arrhythmias. The American journal of cardiology. 1986 Mar; 57(8):592-7. doi: 10.1016/0002-9149(86)90841-6. [PMID: 3953445]
  • J W Massarella, K C Khoo, A J Szuna, D A Sandor, J Morganroth, K Aogaichi. Pharmacokinetics of cibenzoline after single and repetitive dosing in healthy volunteers. Journal of clinical pharmacology. 1986 Feb; 26(2):125-30. doi: 10.1002/j.1552-4604.1986.tb02920.x. [PMID: 3950056]
  • J W Massarella, A C Loh, T H Williams, A J Szuna, D Sandor, R Bressler, F J Leinweber. The disposition and metabolic fate of 14C-cibenzoline in man. Drug metabolism and disposition: the biological fate of chemicals. 1986 Jan; 14(1):59-64. doi: NULL. [PMID: 2868867]
  • N Wasty, S Saksena, M J Barr. Comparative efficacy and safety of oral cibenzoline and quinidine in ventricular arrhythmias: a randomized crossover study. American heart journal. 1985 Dec; 110(6):1181-8. doi: 10.1016/0002-8703(85)90009-2. [PMID: 4072875]
  • R Haiat, M F Aymard, A Dufour. [Intravenous cibenzoline in the treatment of ventricular and supraventricular arrhythmias]. Archives des maladies du coeur et des vaisseaux. 1985 Oct; 78 Spec No(?):95-7. doi: NULL. [PMID: 2420300]
  • R K Brazzell, K C Khoo, D W Schneck. Effect of time of dosing on the disposition of oral cibenzoline. Biopharmaceutics & drug disposition. 1985 Oct; 6(4):433-40. doi: 10.1002/bdd.2510060409. [PMID: 4084668]
  • Y Frances, R Luccioni, M Delaage, G Donnarel, J L Medvedowsky, J C Quiret. [Long-term prevention of the recurrence of auricular fibrillation using cibenzoline. Multicenter study apropos of 89 case reports]. Archives des maladies du coeur et des vaisseaux. 1985 Oct; 78 Spec No(?):99-103. doi: NULL. [PMID: 3938266]
  • R K Brazzell, K C Khoo, A J Szuna, D Sandor, K Aogaichi, R J Wills. Pharmacokinetics and pharmacodynamics of intravenous cibenzoline in normal volunteers. Journal of clinical pharmacology. 1985 Sep; 25(6):418-23. doi: 10.1002/j.1552-4604.1985.tb02869.x. [PMID: 4056077]
  • M Rigaud, G Jouret, M Canal, J Bardet, B Flouvat, J P Bourdarias. Hemodynamic effects of a new antiarrhythmic agent: cibenzoline. Journal de pharmacologie. 1985 Jul; 16(3):247-57. doi: NULL. [PMID: 4068726]
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