Loxiglumide (BioDeep_00000858946)
代谢物信息卡片
Loxiglumide
化学式: C21H30Cl2N2O5 (460.1532)
中文名称: 氯谷胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCN(CCCOC)C(=O)C(CCC(=O)O)NC(=O)C1=CC(=C(C=C1)Cl)Cl
InChI: InChI=1S/C21H30Cl2N2O5/c1-3-4-5-11-25(12-6-13-30-2)21(29)18(9-10-19(26)27)24-20(28)15-7-8-16(22)17(23)14-15/h7-8,14,18H,3-6,9-13H2,1-2H3,(H,24,28)(H,26,27)
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists
C78276 - Agent Affecting Digestive System or Metabolism > C29701 - Anti-ulcer Agent
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
Loxiglumide is a cholecystokinin (CCK-1) receptor antagonist.
同义名列表
2 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:31785
- KEGGdrug: D01113
- PubChem: 60182
- ChEMBL: CHEMBL206025
- CAS: 107097-80-3
- medchemexpress: HY-B2154
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Tomasz Brzozowski, Peter C Konturek, Anthony P Moran, Robert Pajdo, Slawomir Kwiecien, Stanislaw J Konturek, Zbigniew Sliwowski, Danuta Drozdowicz, Wieslaw W Pawlik, Eckhart G Hahn. Involvement of capsaicin-sensitive afferent nerves and cholecystokinin 2/gastrin receptors in gastroprotection and adaptation of gastric mucosa to Helicobacter pylori-lipopolysaccharide.
The Journal of pharmacology and experimental therapeutics.
2004 Jul; 310(1):116-25. doi:
10.1124/jpet.104.065128. [PMID: 15024038] - Michinaga Takahashi, Hiroo Naito, Iwao Sasaki, Yuji Funayama, Chikashi Shibata, Seiki Matsuno. Long-term bile diversion enhances basal and duodenal oleate-stimulated pancreatic exocrine secretion in dogs.
The Tohoku journal of experimental medicine.
2004 Jun; 203(2):87-95. doi:
10.1620/tjem.203.87. [PMID: 15212143] - M Rizzo, D Ventrice, F Monforte, S Procopio, G De Sarro, M Anzini, A Cappelli, F Makovec. Sensitive SPE-HPLC method to determine a novel angiotensin-AT1 antagonist in biological samples.
Journal of pharmaceutical and biomedical analysis.
2004 Apr; 35(2):321-9. doi:
10.1016/j.jpba.2003.12.004. [PMID: 15063465] - Mitsuyoshi Yamamoto, Munenori Otani, Dong-Mei Jia, Ken-Ichiro Fukumitsu, Hiroyuki Yoshikawa, Toshiharu Akiyama, Makoto Otsuki. Differential mechanism and site of action of CCK on the pancreatic secretion and growth in rats.
American journal of physiology. Gastrointestinal and liver physiology.
2003 Oct; 285(4):G681-7. doi:
10.1152/ajpgi.00312.2002. [PMID: 12801885] - L Hidalgo, P Clavé, M Estorch, J Rodríguez-Espinosa, L Rovati, G H Greeley, G Capellà, F Lluís. Effect of cholecystokinin-A receptor blockade on postprandial insulinaemia and gastric emptying in humans.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
2002 Oct; 14(5):519-25. doi:
10.1046/j.1365-2982.2002.00355.x. [PMID: 12358680] - Keiko Shiratori, Tadashi Takeuchi, Katsusuke Satake, Seiki Matsuno. Clinical evaluation of oral administration of a cholecystokinin-A receptor antagonist (loxiglumide) to patients with acute, painful attacks of chronic pancreatitis: a multicenter dose-response study in Japan.
Pancreas.
2002 Jul; 25(1):e1-5. doi:
10.1097/00006676-200207000-00003. [PMID: 12131781] - D Matzinger, J P Gutzwiller, J Drewe, A Orban, R Engel, M D'Amato, L Rovati, C Beglinger. Inhibition of food intake in response to intestinal lipid is mediated by cholecystokinin in humans.
The American journal of physiology.
1999 12; 277(6):R1718-24. doi:
10.1152/ajpregu.1999.277.6.r1718. [PMID: 10600919] - T Brzozowski, P C Konturek, S J Konturek, R Pajdo, D Drozdowicz, S Kwiecień, E G Hahn. Acceleration of ulcer healing by cholecystokinin (CCK): role of CCK-A receptors, somatostatin, nitric oxide and sensory nerves.
Regulatory peptides.
1999 Jun; 82(1-3):19-33. doi:
10.1016/s0167-0115(99)00029-4. [PMID: 10458643] - K Ochi, H Harada, K Satake. Clinical evaluation of cholecystokinin-A- receptor antagonist (loxiglumide) for the treatment of acute pancreatitis. A preliminary clinical trial. Study Group of Loxiglumide in Japan.
Digestion.
1999; 60 Suppl 1(?):81-5. doi:
10.1159/000051460. [PMID: 10026438] - J McLaughlin, M Grazia Lucà, M N Jones, M D'Amato, G J Dockray, D G Thompson. Fatty acid chain length determines cholecystokinin secretion and effect on human gastric motility.
Gastroenterology.
1999 Jan; 116(1):46-53. doi:
10.1016/s0016-5085(99)70227-1. [PMID: 9869601] - C Feinle. Role of intestinal chemoreception in the induction of gastrointestinal sensations.
DTW. Deutsche tierarztliche Wochenschrift.
1998 Dec; 105(12):441-4. doi:
". [PMID: 9932012] - J W Konturek, K Hengst, S J Konturek, E Sito, J Stachura, W Domschke. Physiological role of cholecystokinin in gastroprotection in humans.
The American journal of gastroenterology.
1998 Dec; 93(12):2385-90. doi:
10.1111/j.1572-0241.1998.00692.x. [PMID: 9860397] - S T Lee, K Y Lee, P Li, D Coy, T M Chang, W Y Chey. Pituitary adenylate cyclase-activating peptide stimulates rat pancreatic secretion via secretin and cholecystokinin releases.
Gastroenterology.
1998 May; 114(5):1054-60. doi:
10.1016/s0016-5085(98)70326-9. [PMID: 9558296] - T Brzozowski, P C Konturek, S J Konturek, S Kwiecién, R Pajdo, I Brzozowska, E G Hahn. Involvement of endogenous cholecystokinin and somatostatin in gastroprotection induced by intraduodenal fat.
Journal of clinical gastroenterology.
1998; 27 Suppl 1(?):S125-37. doi:
10.1097/00004836-199800001-00020. [PMID: 9872509] - K Ninomiya, T Saito, K Wakatsuki, M Saeki, T Kato, K Edano, H Kasai, K Kimura, M Fujii. Effects of loxiglumide on pancreatic exocrine secretion stimulated by meal in conscious dogs.
Arzneimittel-Forschung.
1998 Jan; 48(1):55-7. doi:
NULL. [PMID: 9522033] - K Kimura, K Tominaga, M Fujii, T Saito, H Kasai. Effects of loxiglumide on experimental acute pancreatitis in comparison with gabexate mesilate.
Arzneimittel-Forschung.
1998 Jan; 48(1):65-9. doi:
NULL. [PMID: 9522035] - H A Gielkens, S Y de Boer, W F Lam, L C Rovati, C B Lamers, A A Masclee. The role of cholecystokinin and the cholinergic system in intravenous amino acid-induced gallbladder emptying.
European journal of gastroenterology & hepatology.
1997 Dec; 9(12):1227-31. doi:
NULL. [PMID: 9471030] - T Saito, K Ukai, T Masuda, T Nakagawa, K Kimura, M Fujii, K Wakatsuki, M Saeki, H Kasai. General pharmacological profile of the novel cholecystokinin-A antagonist loxiglumide.
Arzneimittel-Forschung.
1997 Dec; 47(12):1375-82. doi:
NULL. [PMID: 9450167] - I Imoto, M Yamamoto, D M Jia, M Otsuki. Effect of chronic oral administration of the CCK receptor antagonist loxiglumide on exocrine and endocrine pancreas in normal rats.
International journal of pancreatology : official journal of the International Association of Pancreatology.
1997 Dec; 22(3):177-85. doi:
10.1007/bf02788382. [PMID: 9444548] - K Hayashi, S Kishimoto, M Kannbe. Endogenous CCK inhibits colonic contractions in unrestrained conscious rats.
Regulatory peptides.
1997 Oct; 72(2-3):131-7. doi:
10.1016/s0167-0115(97)01051-3. [PMID: 9652972] - I Arai, Y Komatsu, Y Hirai, K Shingu, Y Ida, H Yamaura, T Yamamoto, Y Kuroiwa, K Sasaki, S Taguchi. Stimulative effects of saponin from kikyo-to, a Japanese herbal medicine, on pancreatic exocrine secretion of conscious rats.
Planta medica.
1997 Oct; 63(5):419-24. doi:
10.1055/s-2006-957725. [PMID: 9342945] - M A Mesquita, D G Thompson, L E Troncon, M D'Amato, L C Rovati, J Barlow. Effect of cholecystokinin-A receptor blockade on lipid-induced gastric relaxation in humans.
The American journal of physiology.
1997 Jul; 273(1 Pt 1):G118-23. doi:
10.1152/ajpgi.1997.273.1.g118. [PMID: 9252517] - C Niederau, K Meereis-Schwanke, H Klonowski-Stumpe, L Herberg. CCK-resistance in Zucker obese versus lean rats.
Regulatory peptides.
1997 Jun; 70(2-3):97-104. doi:
10.1016/s0167-0115(97)00014-1. [PMID: 9272621] - A Pusztai, G Grant, S Bardocz, K Baintner, E Gelencsér, S W Ewen. Both free and complexed trypsin inhibitors stimulate pancreatic secretion and change duodenal enzyme levels.
The American journal of physiology.
1997 Feb; 272(2 Pt 1):G340-50. doi:
10.1152/ajpgi.1997.272.2.g340. [PMID: 9124359] - H Taniguchi, E Yomota, E Kume, T Shikano, T Endo, M Nagasaki. Effect of T-0632, a cholecystokininA receptor antagonist, on experimental acute pancreatitis.
Japanese journal of pharmacology.
1997 Feb; 73(2):105-12. doi:
10.1254/jjp.73.105. [PMID: 9074944] - L Czakó, M Yamamoto, M Otsuki. Pancreatic fluid hypersecretion in rats after acute pancreatitis.
Digestive diseases and sciences.
1997 Feb; 42(2):265-72. doi:
10.1023/a:1018893230319. [PMID: 9052504] - S Teyssen, E Niebergall-Roth, A Rausch, C Beglinger, R L Riepl, S Chari, M V Singer. Comparison of the effects of the M1-receptor antagonist telenzepine and the CCK-receptor antagonist loxiglumide on the pancreatic secretory response to intraduodenal tryptophan in dogs.
Pancreas.
1996 Nov; 13(4):407-16. doi:
10.1097/00006676-199611000-00011. [PMID: 8899802] - I Koop, M Schindler, A Bosshammer, J Scheibner, E Stange, H Koop. Physiological control of cholecystokinin release and pancreatic enzyme secretion by intraduodenal bile acids.
Gut.
1996 Nov; 39(5):661-7. doi:
10.1136/gut.39.5.661. [PMID: 9026479] - K Tsubo, M Arai, H Omachi, K Mitamura. Effect of a cholecystokinin receptor antagonist (loxiglumide) on gallbladder contractile function in guinea pigs.
Journal of gastroenterology.
1996 Aug; 31(4):578-81. doi:
10.1007/bf02355060. [PMID: 8844481] - E Niebergall-Roth, S Teyssen, D Wetzel, M Hartel, C Beglinger, R L Riepl, M V Singer. Comparison of the effects of two cholecystokinin-receptor antagonists, loxiglumide and L-364,718, on the pancreatic secretory response to intraduodenal tryptophan in dogs.
Scandinavian journal of gastroenterology.
1996 Jul; 31(7):723-32. doi:
10.3109/00365529609009157. [PMID: 8819225] - M Katschinski, J Schirra, C Begliner, S Langbein, U Wank, M D'Amato, R Arnold. Intestinal phase of human antro-pyloro-duodenal motility: cholinergic and CCK-mediated regulation.
European journal of clinical investigation.
1996 Jul; 26(7):574-83. doi:
10.1046/j.1365-2362.1996.1790522.x. [PMID: 8864420] - C Feinle, M D'Amato, N W Read. Cholecystokinin-A receptors modulate gastric sensory and motor responses to gastric distension and duodenal lipid.
Gastroenterology.
1996 May; 110(5):1379-85. doi:
10.1053/gast.1996.v110.pm8613041. [PMID: 8613041] - J W Konturek, W Bielański, S J Konturek, W Domschke. Eradication of Helicobacter pylori and gastrin-somatostatin link in duodenal ulcer patients.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
1996 Mar; 47(1):161-75. doi:
NULL. [PMID: 8777296] - H Hasegawa, H Shirohara, Y Okabayashi, T Nakamura, M Fujii, M Koide, M Otsuki. Oral glucose ingestion stimulates cholecystokinin release in normal subjects and patients with non-insulin-dependent diabetes mellitus.
Metabolism: clinical and experimental.
1996 Feb; 45(2):196-202. doi:
10.1016/s0026-0495(96)90053-0. [PMID: 8596489] - W Song, H Yamaguchi, I Nakano, T Kimura, H Nawata. Role of endogenous cholecystokinin in the regeneration of pancreatic tissue after acute hemorrhagic pancreatitis in rats.
Fukuoka igaku zasshi = Hukuoka acta medica.
1996 Jan; 87(1):14-22. doi:
NULL. [PMID: 8820983] - N Sazaki, K Miyasaka, M Matsumoto, A Funakoshi. Effects of intraduodenal administration of a low dose of cholecystokinin (CCK) antagonist (CR-1505) on plasma CCK concentration, intestinal CCK content, and levels of CCK mRNA.
Journal of gastroenterology.
1995 Oct; 30(5):599-606. doi:
10.1007/bf02367785. [PMID: 8574331] - K Miyasaka, A Funakoshi, E Nakamura, H Teraoka. Regulation of gene expression of pancreatic secretory trypsin inhibitor-61 and -56 by bile and pancreatic juice in rats.
Pancreas.
1995 Oct; 11(3):246-55. doi:
10.1097/00006676-199510000-00006. [PMID: 8577678] - J W Konturek, A Gillessen, S J Konturek, W Domschke. Eradication of Helicobacter pylori restores the inhibitory effect of cholecystokinin on postprandial gastrin release in duodenal ulcer patients.
Gut.
1995 Oct; 37(4):482-7. doi:
10.1136/gut.37.4.482. [PMID: 7489932] - J W Konturek, S J Konturek, W Domschke. Cholecystokinin in the control of gastric acid secretion and gastrin release in response to a meal at low and high pH in healthy subjects and duodenal ulcer patients.
Scandinavian journal of gastroenterology.
1995 Aug; 30(8):738-44. doi:
10.3109/00365529509096321. [PMID: 7481540] - C Niederau, M Niederau, H Klonowski, R Lüthen, L D Ferrell. Effect of hypergastrinemia and blockade of gastrin-receptors on pancreatic growth in the mouse.
Hepato-gastroenterology.
1995 Jul; 42(4):423-31. doi:
NULL. [PMID: 8586382] - M Karaus, C Niederau. Effects of CCK-receptor antagonist on colonic motor activity in dogs.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
1995 Jun; 7(2):63-71. doi:
10.1111/j.1365-2982.1995.tb00210.x. [PMID: 7621322] - Y Nakae, S Naruse, M Kitagawa, S Hirao, R Yamamoto, T Hayakawa. Activation of trypsinogen in experimental models of acute pancreatitis in rats.
Pancreas.
1995 Apr; 10(3):306-13. doi:
10.1097/00006676-199504000-00014. [PMID: 7542773] - C D Kim, K Y Lee, T M Chang, W Y Chey. Negative feedback regulation of pancreatic exocrine secretion in guinea pigs.
Pancreas.
1995 Mar; 10(2):173-9. doi:
10.1097/00006676-199503000-00011. [PMID: 7716142] - J W Konturek, A Gabryelewicz, E Kulesza, S J Konturek, W Domschke. Cholecystokinin (CCK) in the amino acid uptake and enzyme protein secretion by the pancreas in humans.
International journal of pancreatology : official journal of the International Association of Pancreatology.
1995 Feb; 17(1):55-61. doi:
10.1007/bf02788359. [PMID: 8568335] - R J Lieverse, J B Jansen, M C Jebbink, A A Masclee, L C Rovati, C B Lamers. Effects of somatostatin and loxiglumide on gallbladder motility.
European journal of clinical pharmacology.
1995; 47(6):489-92. doi:
10.1007/bf00193699. [PMID: 7768249] - J W Konturek. Cholecystokinin in the control of gastric acid and plasma gastrin and somatostatin secretion in healthy subjects and duodenal ulcer patients before and after eradication of Helicobacter pylori.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
1994 Dec; 45(4 Suppl 1):3-66. doi:
NULL. [PMID: 7787215] - W E Schmidt, S Schenk, R Nustede, J J Holst, U R Fölsch, W Creutzfeldt. Cholecystokinin is a negative regulator of gastric acid secretion and postprandial release of gastrin in humans.
Gastroenterology.
1994 Dec; 107(6):1610-20. doi:
10.1016/0016-5085(94)90799-4. [PMID: 7958670] - H O Jin, K Y Lee, T M Chang, W Y Chey, A Dubois. Physiological role of cholecystokinin on gastric emptying and acid output in dogs.
Digestive diseases and sciences.
1994 Nov; 39(11):2306-14. doi:
10.1007/bf02087643. [PMID: 7956596] - M L Verhulst, H A Gielkens, W P Hopman, A van Schaik, A Tangerman, L C Rovati, J B Jansen. Loxiglumide inhibits cholecystokinin stimulated somatostatin secretion and simultaneously enhances gastric acid secretion in humans.
Regulatory peptides.
1994 Oct; 53(3):185-93. doi:
10.1016/0167-0115(94)90167-8. [PMID: 7846294] - K Shimizu, K Shiratori, S Watanabe, T Takeuchi, T M Chang, W Y Chey. Effect of protein derivatives on pancreatic secretion and release of secretin and CCK in rats.
The American journal of physiology.
1994 Oct; 267(4 Pt 1):G508-14. doi:
10.1152/ajpgi.1994.267.4.g508. [PMID: 7943315] - H Tomita, K Miyasaka, A Jimi, Y Mishima, A Funakoshi. Lack of effect of cholecystokinin receptor antagonist (CR1505) on recovery of experimental pancreatitis after pancreatic duct occlusion in rats.
Pancreas.
1994 Sep; 9(5):638-45. doi:
10.1097/00006676-199409000-00015. [PMID: 7809019] - M Otsuki, S Nakano, I Tachibana. Treatment with cholecystokinin receptor antagonist loxiglumide enhances insulin response to intravenous glucose stimulation in postpancreatitic rats.
Regulatory peptides.
1994 Jul; 52(2):85-95. doi:
10.1016/0167-0115(94)90041-8. [PMID: 7972939] - S Nakano, I Tachibana, M Otsuki. Effects of cholecystokinin receptor antagonist loxiglumide on rat exocrine pancreas.
Pancreas.
1994 Jul; 9(4):425-33. doi:
10.1097/00006676-199407000-00003. [PMID: 7937691] - J W Konturek, P Thor, M Maczka, R Stoll, W Domschke, S J Konturek. Role of cholecystokinin in the control of gastric emptying and secretory response to a fatty meal in normal subjects and duodenal ulcer patients.
Scandinavian journal of gastroenterology.
1994 Jul; 29(7):583-90. doi:
10.3109/00365529409092476. [PMID: 7939393] - M Imamura, H Yamauchi, W Y Chey. Effect of intraduodenal infusion of tocamphyl on pancreatic exocrine secretion and gastrointestinal hormone release in rats.
International journal of pancreatology : official journal of the International Association of Pancreatology.
1994 Jun; 15(3):187-93. doi:
10.1007/bf02924193. [PMID: 7930779] - M Blackmore, E Doherty, J E Manning, B H Hirst. Autocrine growth stimulation of human renal Wilms' tumour G401 cells by a gastrin-like peptide.
International journal of cancer.
1994 May; 57(3):385-91. doi:
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Gut.
1994 Apr; 35(4):501-5. doi:
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Annals of the New York Academy of Sciences.
1994 Mar; 713(?):180-98. doi:
10.1111/j.1749-6632.1994.tb44065.x. [PMID: 8185159] - C Beglinger. Effect of cholecystokinin on gastric motility in humans.
Annals of the New York Academy of Sciences.
1994 Mar; 713(?):219-25. doi:
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Digestion.
1994; 55(6):374-9. doi:
10.1159/000201168. [PMID: 7705550] - M Moriyasu, Y L Lee, K Y Lee, T M Chang, W Y Chey. Effect of digested protein on pancreatic exocrine secretion and gut hormone release in the dog.
Pancreas.
1994 Jan; 9(1):129-33. doi:
10.1097/00006676-199401000-00019. [PMID: 8108365] - C Niederau, W Mecklenbeck, T Heindges. Cholecystokinin does not delay gastric emptying of regular meals in healthy humans.
Hepato-gastroenterology.
1993 Aug; 40(4):380-3. doi:
NULL. [PMID: 8406310] - J W Konturek, R Stoll, M Gutwinska-Konturek, S J Konturek, W Domschke. Cholecystokinin in the regulation of gastric acid and endocrine pancreatic secretion in humans.
Scandinavian journal of gastroenterology.
1993 May; 28(5):401-7. doi:
10.3109/00365529309098239. [PMID: 8511500] - T Bamba, Y Ishizuka, S Hosoda. Effect of intrinsic CCK and CCK antagonist on pancreatic growth and pancreatic enzyme secretion in pancreaticobiliary diversion rats.
Digestive diseases and sciences.
1993 Apr; 38(4):653-9. doi:
10.1007/bf01316796. [PMID: 7681747] - J W Konturek, R Stoll, S J Konturek, W Domschke. Cholecystokinin in the control of gastric acid secretion in man.
Gut.
1993 Mar; 34(3):321-8. doi:
10.1136/gut.34.3.321. [PMID: 8472978] - S Tani, H Itoh, M Koide, Y Okabayashi, M Otsuki. Involvement of endogenous cholecystokinin in the development of acute pancreatitis induced by closed duodenal loop.
Pancreas.
1993 Jan; 8(1):109-15. doi:
10.1097/00006676-199301000-00019. [PMID: 7678322] - J W Konturek, M Gutwinska-Konturek, A Gabryelewicz, S J Konturek, W Domschke. Cholecystokinin in the control of gastric acid secretion in humans.
Journal of clinical gastroenterology.
1993; 17 Suppl 1(?):S40-5. doi:
10.1097/00004836-199312001-00010. [PMID: 7904286] - M Tanikawa, T Hayakawa, T Kondo, T Shibata, M Kitagawa, T Kodaira, T Hamaoka. Inhibitory effect of intraduodenal infusion of loxiglumide on pancreatic exocrine secretion.
Arzneimittel-Forschung.
1993 Jan; 43(1):35-9. doi:
NULL. [PMID: 8447844] - C Beglinger, P Hildebrand, G Adler, B Werth, H Luo, F Delco, K Gyr. Postprandial control of gallbladder contraction and exocrine pancreatic secretion in man.
European journal of clinical investigation.
1992 Dec; 22(12):827-34. doi:
10.1111/j.1365-2362.1992.tb01453.x. [PMID: 1282465] - A Malesci, C De Fazio, S Festorazzi, C Bonato, A Valentini, M Tacconi, M Bekkering, G Giacovelli, M D'Amato, L C Rovati. Dose-response effects of oral loxiglumide on postprandial gall-bladder emptying in man.
Arzneimittel-Forschung.
1992 Nov; 42(11):1359-62. doi:
NULL. [PMID: 1492852] - M C Jebbink, A A Masclee, F G van der Kleij, J Schipper, L C Rovati, J B Jansen, C B Lamers. Effect of loxiglumide and atropine on erythromycin-induced reduction in gallbladder volume in human subjects.
Hepatology (Baltimore, Md.).
1992 Oct; 16(4):937-42. doi:
10.1002/hep.1840160414. [PMID: 1398500] - M C Jebbink, C B Lamers, D M Mooy, L C Rovati, J B Jansen. Effect of loxiglumide on basal and gastrin- and bombesin-stimulated gastric acid and serum gastrin levels.
Gastroenterology.
1992 Oct; 103(4):1215-20. doi:
10.1016/0016-5085(92)91506-y. [PMID: 1397878] - C Beglinger, P Hildebrand, R Meier, P Bauerfeind, H Hasslocher, N Urscheler, F Delco, A Eberle, K Gyr. A physiological role for cholecystokinin as a regulator of gastrin secretion.
Gastroenterology.
1992 Aug; 103(2):490-5. doi:
10.1016/0016-5085(92)90838-p. [PMID: 1634067] - C Niederau, S Faber, M Karaus. Cholecystokinin's role in regulation of colonic motility in health and in irritable bowel syndrome.
Gastroenterology.
1992 Jun; 102(6):1889-98. doi:
10.1016/0016-5085(92)90310-u. [PMID: 1587408] - J Drewe, A Gadient, L C Rovati, C Beglinger. Role of circulating cholecystokinin in control of fat-induced inhibition of food intake in humans.
Gastroenterology.
1992 May; 102(5):1654-9. doi:
10.1016/0016-5085(92)91726-k. [PMID: 1568575] - S Taguchi, G M Green, I Nakano, Y Hatta. Inhibitory effects of the cholecystokinin antagonist loxiglumide on pancreatic exocrine secretion and pancreatic growth in conscious rats.
International journal of pancreatology : official journal of the International Association of Pancreatology.
1992 Apr; 11(2):67-73. doi:
10.1007/bf02925977. [PMID: 1607730] - M Höcker, W E Schmidt, W Creutzfeldt, A R Choudhury, R Nustede, A Schafmayer, U R Fölsch. Determination of plasma cholecystokinin (CCK) concentrations by bioassay and radioimmunoassay in man. A critical evaluation.
Regulatory peptides.
1992 Feb; 37(3):255-69. doi:
10.1016/0167-0115(92)90619-6. [PMID: 1557514] - F Baum, M A Nauck, R Ebert, P Cantor, G Hoffmann, A R Choudhury, W E Schmidt, W Creutzfeldt. Role of endogenously released cholecystokinin in determining postprandial insulin levels in man: effects of loxiglumide, a specific cholecystokinin receptor antagonist.
Digestion.
1992; 53(3-4):189-99. doi:
10.1159/000200994. [PMID: 1291406] - G S Spencer, C Berry, S Johnston. Neuroendocrine regulation of growth hormone secretion in sheep. IV. Central and peripheral cholecystokinin.
Domestic animal endocrinology.
1991 Oct; 8(4):555-63. doi:
10.1016/0739-7240(91)90025-f. [PMID: 1786702] - W E Schmidt, W Creutzfeldt, M Höcker, R Nustede, A R Choudhury, A Schleser, L C Rovati, U R Fölsch. Cholecystokinin receptor antagonist loxiglumide modulates plasma levels of gastro-entero-pancreatic hormones in man. Feedback control of cholecystokinin and gastrin secretion.
European journal of clinical investigation.
1991 Oct; 21(5):501-11. doi:
10.1111/j.1365-2362.1991.tb01402.x. [PMID: 1752290] - M Fried, U Erlacher, W Schwizer, C Löchner, J Koerfer, C Beglinger, J B Jansen, C B Lamers, F Harder, A Bischof-Delaloye. Role of cholecystokinin in the regulation of gastric emptying and pancreatic enzyme secretion in humans. Studies with the cholecystokinin-receptor antagonist loxiglumide.
Gastroenterology.
1991 Aug; 101(2):503-11. doi:
10.1016/0016-5085(91)90031-f. [PMID: 2065926] - J Schwarzendrube, M Niederau, R Lüthen, C Niederau. Effects of cholecystokinin-receptor blockade on pancreatic and biliary function in healthy volunteers.
Gastroenterology.
1991 Jun; 100(6):1683-90. doi:
10.1016/0016-5085(91)90670-g. [PMID: 2019374] - P Hildebrand, J W Ensinck, S Ketterer, F Delco, S Mossi, U Bangerter, C Beglinger. Effect of a cholecystokinin antagonist on meal-stimulated insulin and pancreatic polypeptide release in humans.
The Journal of clinical endocrinology and metabolism.
1991 May; 72(5):1123-9. doi:
10.1210/jcem-72-5-1123. [PMID: 2022712] - M C Jebbink, J B Jansen, D M Mooy, L C Rovati, C B Lamers. Effect of the specific cholecystokinin-receptor antagonist loxiglumide on bombesin stimulated pancreatic enzyme secretion in man.
Regulatory peptides.
1991 Feb; 32(3):361-8. doi:
10.1016/0167-0115(91)90029-g. [PMID: 1714084] - W E Schmidt, W Creutzfeldt, A Schleser, A R Choudhury, R Nustede, M Höcker, R Nitsche, H Sostmann, L C Rovati, U R Fölsch. Role of CCK in regulation of pancreaticobiliary functions and GI motility in humans: effects of loxiglumide.
The American journal of physiology.
1991 Feb; 260(2 Pt 1):G197-206. doi:
10.1152/ajpgi.1991.260.2.g197. [PMID: 1996640] - G Adler, C Beglinger, U Braun, M Reinshagen, I Koop, A Schafmayer, L Rovati, R Arnold. Interaction of the cholinergic system and cholecystokinin in the regulation of endogenous and exogenous stimulation of pancreatic secretion in humans.
Gastroenterology.
1991 Feb; 100(2):537-43. doi:
10.1016/0016-5085(91)90227-c. [PMID: 1702077] - C Niederau, M Karaus. Effects of CCK receptor blockade on intestinal motor activity in conscious dogs.
The American journal of physiology.
1991 Feb; 260(2 Pt 1):G315-24. doi:
10.1152/ajpgi.1991.260.2.g315. [PMID: 1996649] - M Otsuki, S Tani, Y Okabayashi, M Fujii, T Nakamura, T Fujisawa, M Koide, H Itoh. Fasting prevents acute pancreatitis induced by cerulein in rats.
Digestive diseases and sciences.
1990 Jul; 35(7):840-8. doi:
10.1007/bf01536797. [PMID: 2364838] - A Gabryelewicz, E Kulesza, S J Konturek. Comparison of loxiglumide, a cholecystokinin receptor antagonist, and atropine on hormonal and meal-stimulated pancreatic secretion in man.
Scandinavian journal of gastroenterology.
1990 Jul; 25(7):731-8. doi:
10.3109/00365529008997600. [PMID: 2396088] - M C Jebbink, J B Jansen, A A Masclee, C B Lamers. Lack of effect of the specific cholecystokinin receptor antagonist loxiglumide on cholecystokinin clearance from plasma in man.
British journal of clinical pharmacology.
1990 Jun; 29(6):770-3. doi:
10.1111/j.1365-2125.1990.tb03701.x. [PMID: 2378793] - S Tani, Y Okabayashi, T Nakamura, M Fujii, H Itoh, M Otsuki. Effect of a new cholecystokinin receptor antagonist loxiglumide on acute pancreatitis in two experimental animal models.
Pancreas.
1990 May; 5(3):284-90. doi:
10.1097/00006676-199005000-00007. [PMID: 2343042] - J B Jansen, M C Jebbink, B R Douglas, C B Lamers. Effect of loxiglumide (CR-1505) on bombesin- and meal-stimulated plasma cholecystokinin in man.
European journal of clinical pharmacology.
1990; 38(4):367-70. doi:
10.1007/bf00315577. [PMID: 2344859] - W E Schmidt, W Creutzfeldt, M Höcker, A R Choudhury, R Nustede, A Schleser, R Nitsche, L C Rovati, A Schafmayer, U R Fölsch. Cholecystokinin receptor antagonist loxiglumide: influence on bilio-pancreatic secretion and gastrointestinal hormones in man.
Digestion.
1990; 46 Suppl 2(?):232-9. doi:
10.1159/000200391. [PMID: 2262057] - I Setnikar, R Chisté, G Giacovelli, L C Rovati. Pharmacokinetics and tolerance of repeated oral doses of loxiglumide.
Arzneimittel-Forschung.
1989 Nov; 39(11):1454-9. doi:
NULL. [PMID: 2619779] - J W Konturek, S J Konturek, A Kurek, J Bogdal, J Oleksy, L Rovati. CCK receptor antagonism by loxiglumide and gall bladder contractions in response to cholecystokinin, sham feeding and ordinary feeding in man.
Gut.
1989 Aug; 30(8):1136-42. doi:
10.1136/gut.30.8.1136. [PMID: 2767511] - G Adler, M Reinshagen, I Koop, B Göke, A Schafmayer, L C Rovati, R Arnold. Differential effects of atropine and a cholecystokinin receptor antagonist on pancreatic secretion.
Gastroenterology.
1989 Apr; 96(4):1158-64. doi:
10.1016/0016-5085(89)91636-3. [PMID: 2647576] - K Shiratori, K Shimizu, S Watanabe, T Takeuchi, Y Moriyoshi. Effect of CCK antagonists CR 1409 and CR 1505 on rat pancreatic exocrine secretion in vivo.
Pancreas.
1989; 4(6):744-50. doi:
10.1097/00006676-198912000-00014. [PMID: 2813333] - I Setnikar, R Chisté, F Makovec, L C Rovati, S J Warrington. Pharmacokinetics of loxiglumide after single intravenous or oral doses in man.
Arzneimittel-Forschung.
1988 May; 38(5):716-20. doi:
NULL. [PMID: 3415715]
