Ganetespib (BioDeep_00000858942)
代谢物信息卡片
化学式: C20H20N4O3 (364.15353300000004)
中文名称: 的ganetespib
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)C1=C(C=C(C(=C1)C2=NNC(=O)N2C3=CC4=C(C=C3)N(C=C4)C)O)O
InChI: InChI=1S/C20H20N4O3/c1-11(2)14-9-15(18(26)10-17(14)25)19-21-22-20(27)24(19)13-4-5-16-12(8-13)6-7-23(16)3/h4-11,25-26H,1-3H3,(H,22,27)
描述信息
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
同义名列表
2 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:177770
- KEGGdrug: D10126
- PubChem: 135564985
- DrugBank: DB12047
- ChEMBL: CHEMBL2103879
- CAS: 888216-25-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Krzysztof Sitko, Michał Starke, Stefan Tukaj. Heat shock protein 90 (Hsp90) inhibitor STA-9090 (Ganetespib) ameliorates inflammation in a mouse model of atopic dermatitis.
Cell stress & chaperones.
2023 Oct; ?(?):. doi:
10.1007/s12192-023-01387-0. [PMID: 37851180] - Weili Miao, Lin Li, Yonghui Zhao, Xiaoxia Dai, Xuemei Chen, Yinsheng Wang. HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N6-methyladenosine.
Nature communications.
2019 08; 10(1):3613. doi:
10.1038/s41467-019-11552-8. [PMID: 31399576] - Julie Kang, Jun Young Lee, İsa Taş, Kunal N More, Hangun Kim, Jeong-Hoon Park, Dong-Jo Chang. Radiosynthesis, biological evaluation and preliminary microPET study of 18F-labeled 5-resorcinolic triazolone derivative based on ganetespib targeting HSP90.
Bioorganic & medicinal chemistry letters.
2018 12; 28(23-24):3658-3664. doi:
10.1016/j.bmcl.2018.10.035. [PMID: 30528977] - Anna S Nikonova, Alexander Y Deneka, Anna A Kiseleva, Vladislav Korobeynikov, Anna Gaponova, Ilya G Serebriiskii, Meghan C Kopp, Harvey H Hensley, Tamina N Seeger-Nukpezah, Stefan Somlo, David A Proia, Erica A Golemis. Ganetespib limits ciliation and cystogenesis in autosomal-dominant polycystic kidney disease (ADPKD).
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2018 05; 32(5):2735-2746. doi:
10.1096/fj.201700909r. [PMID: 29401581] - Chao Lv, Hua-Wu Zeng, Jin-Xin Wang, Xing Yuan, Chuang Zhang, Ting Fang, Pei-Ming Yang, Tong Wu, Yu-Dong Zhou, Dale G Nagle, Wei-Dong Zhang. The antitumor natural product tanshinone IIA inhibits protein kinase C and acts synergistically with 17-AAG.
Cell death & disease.
2018 02; 9(2):165. doi:
10.1038/s41419-017-0247-5. [PMID: 29416003] - Alice Cavanaugh, Brendon Juengst, Kathleen Sheridan, John F Danella, Heinric Williams. Combined inhibition of heat shock proteins 90 and 70 leads to simultaneous degradation of the oncogenic signaling proteins involved in muscle invasive bladder cancer.
Oncotarget.
2015 Nov; 6(37):39821-38. doi:
10.18632/oncotarget.5496. [PMID: 26556859] - Xia Zhou, Lucy X Fan, Dorien J M Peters, Marie Trudel, James E Bradner, Xiaogang Li. Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD.
Human molecular genetics.
2015 Jul; 24(14):3982-93. doi:
10.1093/hmg/ddv136. [PMID: 25877301] - Anna S Nikonova, Olga V Plotnikova, Victoria Serzhanova, Andrey Efimov, Igor Bogush, Kathy Q Cai, Harvey H Hensley, Brian L Egleston, Andres Klein-Szanto, Tamina Seeger-Nukpezah, Erica A Golemis. Nedd9 restrains renal cystogenesis in Pkd1-/- mice.
Proceedings of the National Academy of Sciences of the United States of America.
2014 Sep; 111(35):12859-64. doi:
10.1073/pnas.1405362111. [PMID: 25139996] - Jonathan W Goldman, Robert N Raju, Gregory A Gordon, Iman El-Hariry, Florentina Teofilivici, Vojo M Vukovic, Robert Bradley, Michael D Karol, Yu Chen, Wei Guo, Takayo Inoue, Lee S Rosen. A first in human, safety, pharmacokinetics, and clinical activity phase I study of once weekly administration of the Hsp90 inhibitor ganetespib (STA-9090) in patients with solid malignancies.
BMC cancer.
2013 Mar; 13(?):152. doi:
10.1186/1471-2407-13-152. [PMID: 23530663] - Alessio Giubellino, Carole Sourbier, Min-Jung Lee, Brad Scroggins, Petra Bullova, Michael Landau, Weiwen Ying, Len Neckers, Jane B Trepel, Karel Pacak. Targeting heat shock protein 90 for the treatment of malignant pheochromocytoma.
PloS one.
2013; 8(2):e56083. doi:
10.1371/journal.pone.0056083. [PMID: 23457505] - Takeshi Shimamura, Samanthi A Perera, Kevin P Foley, Jim Sang, Scott J Rodig, Takayo Inoue, Liang Chen, Danan Li, Julian Carretero, Yu-Chen Li, Papiya Sinha, Christopher D Carey, Christa L Borgman, John-Paul Jimenez, Matthew Meyerson, Weiwen Ying, James Barsoum, Kwok-Kin Wong, Geoffrey I Shapiro. Ganetespib (STA-9090), a nongeldanamycin HSP90 inhibitor, has potent antitumor activity in in vitro and in vivo models of non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2012 Sep; 18(18):4973-85. doi:
10.1158/1078-0432.ccr-11-2967. [PMID: 22806877]