Crenolanib (BioDeep_00000858940)
代谢物信息卡片
化学式: C26H29N5O2 (443.2321)
中文名称: 克莱拉尼
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1(COC1)COC2=CC3=C(C=C2)N(C=N3)C4=NC5=C(C=CC=C5N6CCC(CC6)N)C=C4
InChI: InChI=1S/C26H29N5O2/c1-26(14-32-15-26)16-33-20-6-7-22-21(13-20)28-17-31(22)24-8-5-18-3-2-4-23(25(18)29-24)30-11-9-19(27)10-12-30/h2-8,13,17,19H,9-12,14-16,27H2,1H3
描述信息
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C1967 - Tyrosine Kinase Inhibitor
D000970 - Antineoplastic Agents
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:145365
- KEGGdrug: D10102
- PubChem: 10366136
- DrugBank: DB11832
- ChEMBL: CHEMBL2105728
- CAS: 670220-88-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Cora Bisbee, Olivia Campagne, Amar Gajjar, Christopher L Tinkle, Clinton F Stewart. Population pharmacokinetics of crenolanib in children and young adults with brain tumors.
Cancer chemotherapy and pharmacology.
2022 04; 89(4):459-468. doi:
10.1007/s00280-022-04412-8. [PMID: 35212779] - Maarten van der Kroef, Tiago Carvalheiro, Marzia Rossato, Floor de Wit, Marta Cossu, Eleni Chouri, Catharina G K Wichers, Cornelis P J Bekker, Lorenzo Beretta, Nadia Vazirpanah, Elena Trombetta, Timothy R D J Radstake, Chiara Angiolilli. CXCL4 triggers monocytes and macrophages to produce PDGF-BB, culminating in fibroblast activation: Implications for systemic sclerosis.
Journal of autoimmunity.
2020 07; 111(?):102444. doi:
10.1016/j.jaut.2020.102444. [PMID: 32284212] - Yu Chang, Dongsheng Zhu, Haijun Guo, Xingfeng Yin, Ke Ding, Zhengqiu Li. Crenolanib-Derived Probes Suitable for Cell- and Tissue-Based Protein Profiling and Single-Cell Imaging.
Chembiochem : a European journal of chemical biology.
2019 07; 20(14):1783-1788. doi:
10.1002/cbic.201900067. [PMID: 30942519] - Mohammed Dany, Salih Gencer, Rose Nganga, Raquela J Thomas, Natalia Oleinik, Kyla D Baron, Zdzislaw M Szulc, Peter Ruvolo, Steven Kornblau, Michael Andreeff, Besim Ogretmen. Targeting FLT3-ITD signaling mediates ceramide-dependent mitophagy and attenuates drug resistance in AML.
Blood.
2016 10; 128(15):1944-1958. doi:
10.1182/blood-2016-04-708750. [PMID: 27540013] - Michael S Roberts, David C Turner, Thandranese S Owens, Abhijit Ramachandran, Cynthia Wetmore, Stacy L Throm, Clinton F Stewart. Determination of crenolanib in human serum and cerebrospinal fluid by liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS).
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2013 Jun; 929(?):1-5. doi:
10.1016/j.jchromb.2013.04.002. [PMID: 23644495] - Nancy L Lewis, Lionel D Lewis, Joseph P Eder, Nandi J Reddy, Feng Guo, Kristen J Pierce, Anthony J Olszanski, Roger B Cohen. Phase I study of the safety, tolerability, and pharmacokinetics of oral CP-868,596, a highly specific platelet-derived growth factor receptor tyrosine kinase inhibitor in patients with advanced cancers.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2009 Nov; 27(31):5262-9. doi:
10.1200/jco.2009.21.8487. [PMID: 19738123]
