Preladenant (BioDeep_00000858939)

   


代谢物信息卡片


Preladenant

化学式: C25H29N9O3 (503.2393244)
中文名称: 瑞德南特
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COCCOC1=CC=C(C=C1)N2CCN(CC2)CCN3C4=C(C=N3)C5=NC(=NN5C(=N4)N)C6=CC=CO6
InChI: InChI=1S/C25H29N9O3/c1-35-15-16-36-19-6-4-18(5-7-19)32-11-8-31(9-12-32)10-13-33-23-20(17-27-33)24-28-22(21-3-2-14-37-21)30-34(24)25(26)29-23/h2-7,14,17H,8-13,15-16H2,1H3,(H2,26,29)

描述信息

C78272 - Agent Affecting Nervous System > C38149 - Antiparkinsonian Agent
Preladenant is a potent and competitive antagonist of the human adenosine A2A receptor with a Ki of 1.1 nM and has over 1000-fold selectivity over other adenosine receptors.

同义名列表

2 个代谢物同义名

Preladenant; SCH-420814



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

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PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jun Toyohara, Muneyuki Sakata, Kei Wagatsuma, Tetsuro Tago, Kenji Ishibashi, Kenji Ishii, Philip Elsinga, Kiichi Ishiwata. Test-retest reproducibility of cerebral adenosine A2A receptor quantification using [11C]preladenant. Annals of nuclear medicine. 2022 Jan; 36(1):15-23. doi: 10.1007/s12149-021-01678-5. [PMID: 34564828]
  • Stephanie Federico, Enrico Margiotta, Silvia Paoletta, Sonja Kachler, Karl-Norbert Klotz, Kenneth A Jacobson, Giorgia Pastorin, Stefano Moro, Giampiero Spalluto. Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines to develop functionalized ligands to target adenosine receptors: fluorescent ligands as an example. MedChemComm. 2019 Jul; 10(7):1094-1108. doi: 10.1039/c9md00014c. [PMID: 31391881]
  • Muneyuki Sakata, Kenji Ishibashi, Masamichi Imai, Kei Wagatsuma, Kenji Ishii, Xiaoyun Zhou, Erik F J de Vries, Philip H Elsinga, Kiichi Ishiwata, Jun Toyohara. Initial Evaluation of an Adenosine A2A Receptor Ligand, 11C-Preladenant, in Healthy Human Subjects. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2017 09; 58(9):1464-1470. doi: 10.2967/jnumed.116.188474. [PMID: 28280214]
  • Olivier Barret, Jonas Hannestad, David Alagille, Christine Vala, Adriana Tavares, Caroline Papin, Thomas Morley, Krista Fowles, Hsiaoju Lee, John Seibyl, Dominique Tytgat, Marc Laruelle, Gilles Tamagnan. Adenosine 2A receptor occupancy by tozadenant and preladenant in rhesus monkeys. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2014 Oct; 55(10):1712-8. doi: 10.2967/jnumed.114.142067. [PMID: 25082853]
  • Z Wang, F Xuan, W H Lin, M D Troyer, A Tendolkar, D L Cutler. Preladenant, a selective adenosine A₂A receptor antagonist, is not associated with QT/QTc prolongation. European journal of clinical pharmacology. 2013 Oct; 69(10):1761-7. doi: 10.1007/s00228-013-1541-5. [PMID: 23857248]
  • David L Cutler, Amol Tendolkar, Igor D Grachev. Evaluation of the effects of a high-fat meal on the oral bioavailability of a single dose of preladenant in healthy subjects. Journal of clinical pharmacology. 2012 Nov; 52(11):1698-703. doi: 10.1177/0091270011428321. [PMID: 22167566]
  • D L Cutler, A Tendolkar, I D Grachev. Safety, tolerability and pharmacokinetics after single and multiple doses of preladenant (SCH420814) administered in healthy subjects. Journal of clinical pharmacy and therapeutics. 2012 Oct; 37(5):578-87. doi: 10.1111/j.1365-2710.2012.01349.x. [PMID: 22676397]
  • Anette G Sams, Gitte K Mikkelsen, Mogens Larsen, Morten Langgård, Mark E Howells, Tenna J Schrøder, Lise T Brennum, Lars Torup, Erling B Jørgensen, Christoffer Bundgaard, Mads Kreilgård, Benny Bang-Andersen. Discovery of phosphoric acid mono-{2-[(E/Z)-4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-benzoylimino]-thiazol-3-ylmethyl} ester (Lu AA47070): a phosphonooxymethylene prodrug of a potent and selective hA(2A) receptor antagonist. Journal of medicinal chemistry. 2011 Feb; 54(3):751-64. doi: 10.1021/jm1008659. [PMID: 21210664]
  • Bernard R Neustadt, Hong Liu, Jinsong Hao, William J Greenlee, Andrew W Stamford, Carolyn Foster, Leyla Arik, Jean Lachowicz, Hongtao Zhang, Rosalia Bertorelli, Silva Fredduzzi, Geoffrey Varty, Mary Cohen-Williams, Kwokei Ng. Potent and selective adenosine A2A receptor antagonists: 1,2,4-Triazolo[1,5-c]pyrimidines. Bioorganic & medicinal chemistry letters. 2009 Feb; 19(3):967-71. doi: 10.1016/j.bmcl.2008.11.075. [PMID: 19109019]