Paroxetine hydrochloride hemihydrate (BioDeep_00000858923)
代谢物信息卡片
Paroxetine hydrochloride hemihydrate
化学式: C38H44Cl2F2N2O7 (748.2493478000001)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CNCC(C1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4.C1CNCC(C1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4.O.Cl.Cl
InChI: 2*1H
描述信息
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors > D065690 - Cytochrome P-450 CYP2D6 Inhibitors
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017367 - Selective Serotonin Reuptake Inhibitors
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
C78272 - Agent Affecting Nervous System > C94725 - Selective Serotonin Reuptake Inhibitor
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
D049990 - Membrane Transport Modulators
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xiaojie Liu, Mengyu Li, Chen Jian, Xuemei Qin. Characterization of 'microbiome-metabolome-immunity' in depressed rats with divergent responses to Paroxetine.
Journal of affective disorders.
2024 May; 352(?):201-213. doi:
10.1016/j.jad.2024.02.017. [PMID: 38346646] - Fahad Pervaiz, Ayesha Saba, Haya Yasin, Manal Buabeid, Sobia Noreen, Abida Kalsoom Khan, Ghulam Murtaza. Fabrication of solid lipid nanoparticles-based patches of paroxetine and their ex-vivo permeation behaviour.
Artificial cells, nanomedicine, and biotechnology.
2023 Dec; 51(1):108-119. doi:
10.1080/21691401.2023.2179631. [PMID: 36855254] - Li-Lin Jiang, Yu-Lin Wu, Ye Mo, Ling Gou, Mei-Ling Chen, Yan Wang, Qing-Min Zang, De-Qi Jiang. The effects of paroxetine therapy on depressive symptom and motor function in the treatment of depression with Parkinson's disease: A meta-analysis.
Medicine.
2023 Aug; 102(34):e34687. doi:
10.1097/md.0000000000034687. [PMID: 37653795] - Dat T N Ngo, Tho H Ho, Lam K Huynh, Trang T Nguyen. The interplay of membrane fluidity, acyl chain order and area per lipid on the partitioning of two antidepressants paroxetine and sertraline.
Soft matter.
2023 Jul; ?(?):. doi:
10.1039/d3sm00462g. [PMID: 37435937] - Xu Chen, Jiu-Xi Chen, Xue-Yan Han, Yang Zhao, Jing Cao, Xiu-Zhen Jiao, Hong-Mei Liu, Chun-Li Guo, Shuo Meng, Shuai Liang, Jiang-Xia Qi, Dong Chen, Ming-Xia Li, Yun-Xia Jiao, Ting-Ting Wang, Xia Hong. Efficacy and Safety of Jianpi Jieyu Decoction for Patients with Mild-to-Moderate Depression of Xin (Heart)-Pi (Spleen) Deficiency Syndrome: A Multi-centre Randomized Controlled Study.
Chinese journal of integrative medicine.
2023 Apr; 29(4):299-307. doi:
10.1007/s11655-022-3685-6. [PMID: 36301455] - Queen Saikia, Ajit Hazarika, Jogen Chandra Kalita. Isoliquiritigenin ameliorates paroxetine-induced sexual dysfunction in male albino mice.
Reproductive toxicology (Elmsford, N.Y.).
2023 Feb; 117(?):108341. doi:
10.1016/j.reprotox.2023.108341. [PMID: 36740106] - O Godin, B Pignon, A Szoke, L Boyer, B Aouizerate, B Schorr, M André, D Capdevielle, I Chereau, N Coulon, R Dassing, C Dubertret, B Etain, S Leignier, P M Llorca, J Mallet, D Misdrahi, C Passerieux, R Rey, M Urbach, F Schürhoff, M Leboyer, G Fond. 3-year incidence and predictors of metabolic syndrome in schizophrenia in the national FACE-SZ cohort.
Progress in neuro-psychopharmacology & biological psychiatry.
2023 01; 120(?):110641. doi:
10.1016/j.pnpbp.2022.110641. [PMID: 36122839] - Jun Shao, Bo Li, Ai-Hong Yuan, Xiu-Qiang Hu, Jie Guo, Ming-Xing Ren, Jun Yang. [Huayu Tongluo moxibustion combined with intradermal needling in patients with mild to moderate depression after cerebral infarction].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion.
2022 Nov; 42(11):1211-5. doi:
10.13703/j.0255-2930.20220424-k0004. [PMID: 36397216] - Xu He, Ruihuan Zhang, Zhe Li, Zhen Yao, Xiaoxia Xie, Ruoxue Bai, Lan Li, Xu Zhang, Sha Zhang, Yan Shen, Shaowei Li, Zhenliang Hui, Rongrong Liu, Jun Chen. Sini powder with paroxetine ameliorates major depressive disorder by modulating circadian rhythm: A randomized, double-blind, placebo-controlled trial.
Journal of pineal research.
2022 Nov; 73(4):e12832. doi:
10.1111/jpi.12832. [PMID: 36073608] - Ayokunle O Ademosun, Ganiyu Oboh, Adeniyi A Adebayo, Tosin A Olasehinde, Olamide W Fasakin. Grapefruit peel extract mitigates paroxetine-induced erectile dysfunction in rats through stimulation of erectile response, antioxidant status, and inhibition of key enzymes related with impaired penile erection.
Journal of food biochemistry.
2022 11; 46(11):e14193. doi:
10.1111/jfbc.14193. [PMID: 35460094] - Sunday Idowu Oyeleye, Tosin Abiola Olasehinde, Ibrahim Pelumi Odumosu, Ganiyu Oboh. Plantain peels restore sexual performance, hormonal imbalance, and modulate nitric oxide production and key enzymes of penile function in paroxetine-sexually impaired male rats.
Journal of food biochemistry.
2022 11; 46(11):e14261. doi:
10.1111/jfbc.14261. [PMID: 35609010] - Wen-Qing Mu, Guang Xu, Jia Zhao, Yuan-Yuan Chen, Zhao-Fang Bai, Xiao-He Xiao. [Preventive and therapeutic effect of bioactive component of licorice on antidepressant-induced liver injury].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Nov; 47(22):6146-6154. doi:
10.19540/j.cnki.cjcmm.20220608.402. [PMID: 36471939] - Mengjie Zeng, Aimin Gong, Zhiquan Wu. Paroxetine combined with traditional chinese medicine prescriptions in the treatment of postpartum depression: A systematic review of randomized controlled trials.
Frontiers in neuroendocrinology.
2022 10; 67(?):101019. doi:
10.1016/j.yfrne.2022.101019. [PMID: 35926637] - Olalekan Bukunmi Ogunro, Musa Toyin Yakubu. Fadogia agrestis (Schweinf. Ex Hiern) Stem Extract Restores Selected Biomolecules of Erectile Dysfunction in the Testicular and Penile Tissues of Paroxetine-Treated Wistar Rats.
Reproductive sciences (Thousand Oaks, Calif.).
2022 Aug; ?(?):. doi:
10.1007/s43032-022-01050-6. [PMID: 35969364] - Zubeyde Ercan, Meryem Sedef Dogru, Nazife Ulker Ertugrul, Ahmet Yardimci, Sinan Canpolat. Beneficial effects of irisin in experimental paroxetine-induced hyperprolactinemia.
Endocrine.
2022 05; 76(2):419-425. doi:
10.1007/s12020-022-03010-1. [PMID: 35226247] - Fahad Aldosary, Sandhaya Norris, Philippe Tremblay, Jonathan S James, James C Ritchie, Pierre Blier. Differential Potency of Venlafaxine, Paroxetine, and Atomoxetine to Inhibit Serotonin and Norepinephrine Reuptake in Patients With Major Depressive Disorder.
The international journal of neuropsychopharmacology.
2022 04; 25(4):283-292. doi:
10.1093/ijnp/pyab086. [PMID: 34958348] - Kateryna Murlanova, Netanela Cohen, Anna Pinkus, Liudmila Vinnikova, Mikhail Pletnikov, Michael Kirby, Jonathan Gorelick, Elyashiv Drori, Albert Pinhasov. Antidepressant-like effects of a chlorogenic acid- and cynarine-enriched fraction from Dittrichia viscosa root extract.
Scientific reports.
2022 03; 12(1):3647. doi:
10.1038/s41598-022-04840-9. [PMID: 35256610] - Sinan Canpolat, Nazife Ulker, Ahmet Yardimci, Emre Tancan, Elif Sahin, Serap Ozer Yaman, Ozgur Bulmuş, Ahmet Alver, Mete Ozcan. Irisin ameliorates male sexual dysfunction in paroxetine-treated male rats.
Psychoneuroendocrinology.
2022 02; 136(?):105597. doi:
10.1016/j.psyneuen.2021.105597. [PMID: 34861466] - Qi Jin, Jie Li, Guang-Yao Chen, Zi-Yu Wu, Xiao-Yu Liu, Yi Liu, Lin Chen, Xin-Yi Wu, Yan Liu, Xin Zhao, Yue-Han Song. Network and Experimental Pharmacology to Decode the Action of Wendan Decoction Against Generalized Anxiety Disorder.
Drug design, development and therapy.
2022; 16(?):3297-3314. doi:
10.2147/dddt.s367871. [PMID: 36193286] - Mithula Sivasaravanaparan, Louise Ørum Olesen, Maurizio Severino, Christian Ulrich von Linstow, Kate Lykke Lambertsen, Jan Bert Gramsbergen, Jørgen Hasselstrøm, Athanasios Metaxas, Ove Wiborg, Bente Finsen. Efficacy of Chronic Paroxetine Treatment in Mitigating Amyloid Pathology and Microgliosis in APPSWE/PS1ΔE9 Transgenic Mice.
Journal of Alzheimer's disease : JAD.
2022; 87(2):685-699. doi:
10.3233/jad-220019. [PMID: 35342093] - Jialing Zhang, Jiping Zhang, Zhinan Zhang, Yu Zheng, Zheng Zhong, Zengyu Yao, Xiaowen Cai, Lixing Lao, Yong Huang, Shanshan Qu. Dopaminergic signaling in prefrontal cortex contributes to the antidepressant effect of electroacupuncture: An iTRAQ-based proteomics analysis in a rat model of CUMS.
Anatomical record (Hoboken, N.J. : 2007).
2021 11; 304(11):2454-2469. doi:
10.1002/ar.24732. [PMID: 34523244] - Anindita Bhattacharjee, Santosh Kumar Prajapati, Sairam Krishnamurthy. Supplementation of taurine improves ionic homeostasis and mitochondrial function in the rats exhibiting post-traumatic stress disorder-like symptoms.
European journal of pharmacology.
2021 Oct; 908(?):174361. doi:
10.1016/j.ejphar.2021.174361. [PMID: 34297965] - Zihong Liang, Yanbo Jia, Lizhen Zhao, Runxiu Zhu, Xuemei He, Bagen Tong, Fan Yang, Lixia Hao, Pengfei Cui, Jun Yuan. Agomelatine might be more appropriate for elderly, depressed, type 2 diabetes mellitus patients than paroxetine/fluoxetine.
Aging.
2021 10; 13(19):22934-22946. doi:
10.18632/aging.203586. [PMID: 34610580] - Silvia Giatti, Silvia Diviccaro, Lucia Cioffi, Eva Falvo, Donatella Caruso, Roberto C Melcangi. Effects of paroxetine treatment and its withdrawal on neurosteroidogenesis.
Psychoneuroendocrinology.
2021 10; 132(?):105364. doi:
10.1016/j.psyneuen.2021.105364. [PMID: 34325207] - Shannon C Waye, O Chandani Dinesh, Sm Nageeb Hasan, Joshua D Conway, Roger Raymond, José N Nobrega, Jacqueline Blundell, Francis Rodriguez Bambico. Antidepressant action of transcranial direct current stimulation in olfactory bulbectomised adolescent rats.
Journal of psychopharmacology (Oxford, England).
2021 Aug; 35(8):1003-1016. doi:
10.1177/02698811211000765. [PMID: 33908307] - Magdalena Kowalska, Łukasz Fijałkowski, Alicja Nowaczyk. Assessment of Paroxetine Molecular Interactions with Selected Monoamine and γ-Aminobutyric Acid Transporters.
International journal of molecular sciences.
2021 Jun; 22(12):. doi:
10.3390/ijms22126293. [PMID: 34208199] - Lucia Carboni, Bruno Delafont, Elena Ivanchenko, Emiliangelo Ratti, Susan M Learned, Robert Alexander, Enrico Domenici. Folate metabolism biomarkers from two randomised placebo-controlled clinical studies with paroxetine and venlafaxine.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.
2021 04; 22(4):315-321. doi:
10.1080/15622975.2020.1805509. [PMID: 32787676] - Naomi T Jessurun, Annemieke Vermeulen Windsant, Oenone Mikes, Eugène P van Puijenbroek, Rob J van Marum, Koen Grootens, Hieronymus J Derijks. Inhibition of CYP2D6 with low dose (5 mg) paroxetine in patients with high 10-hydroxynortriptyline serum levels-A prospective pharmacokinetic study.
British journal of clinical pharmacology.
2021 03; 87(3):1529-1532. doi:
10.1111/bcp.14455. [PMID: 32621544] - G Drevin, N Picard, N Jousset, M Briet, C Abbara. Pitfalls and challenges associated with phenoconversion in forensic toxcicology.
Forensic science international. Genetics.
2021 03; 51(?):102433. doi:
10.1016/j.fsigen.2020.102433. [PMID: 33278816] - Zaiquan Dong, Weihong Kuang, Xiaoling Shen, Liantian Tian. Plasma levels of interleukin-6 and antidepressant response to Paroxetine in Chinese depressive patients.
Psychiatry research.
2021 03; 297(?):113723. doi:
10.1016/j.psychres.2021.113723. [PMID: 33545432] - Santosh Kumar Prajapati, Sairam Krishnamurthy. Non-selective orexin-receptor antagonist attenuates stress-re-stress-induced core PTSD-like symptoms in rats: Behavioural and neurochemical analyses.
Behavioural brain research.
2021 02; 399(?):113015. doi:
10.1016/j.bbr.2020.113015. [PMID: 33212086] - Michaela Herz, Klaus Brehm. Serotonin stimulates Echinococcus multilocularis larval development.
Parasites & vectors.
2021 Jan; 14(1):14. doi:
10.1186/s13071-020-04533-0. [PMID: 33407815] - Eui Hyun Jung, Yun Jeong Lee, Dong-Hyun Kim, Pureum Kang, Chang Woo Lim, Chang-Keun Cho, Choon-Gon Jang, Seok-Yong Lee, Jung-Woo Bae. Effects of paroxetine on the pharmacokinetics of atomoxetine and its metabolites in different CYP2D6 genotypes.
Archives of pharmacal research.
2020 Dec; 43(12):1356-1363. doi:
10.1007/s12272-020-01300-8. [PMID: 33245517] - Anjing Gong, Dehong Wan, Hui Liang, Liping Yan, Zhou Yu, Huizhen Zhang, Qiuzhen Wang, Mei Dou. Joint replenishment of zinc and folic acid enhances the anti-depressive effect of paroxetine via increasing serum calcium and copper and decreasing serum arsenic.
Neuroscience letters.
2020 10; 737(?):135270. doi:
10.1016/j.neulet.2020.135270. [PMID: 32777348] - Santosh Kumar Prajapati, Neha Singh, Debapriya Garabadu, Sairam Krishnamurthy. A novel stress re-stress model: modification of re-stressor cue induces long-lasting post-traumatic stress disorder-like symptoms in rats.
The International journal of neuroscience.
2020 Sep; 130(9):941-952. doi:
10.1080/00207454.2019.1711078. [PMID: 31903815] - Guangsen Li, Degui Chang, Di'ang Chen, Peihai Zhang, Yaodong You, Xiaopeng Huang, Jian Cai. Selective dorsal neurotomy in the treatment of premature ejaculation: A protocol for systematic review and meta-analysis.
Medicine.
2020 Aug; 99(34):e21866. doi:
10.1097/md.0000000000021866. [PMID: 32846840] - Aminah Almurjan, Hannah Macfarlane, Raj K S Badhan. Precision dosing-based optimisation of paroxetine during pregnancy for poor and ultrarapid CYP2D6 metabolisers: a virtual clinical trial pharmacokinetics study.
The Journal of pharmacy and pharmacology.
2020 Aug; 72(8):1049-1060. doi:
10.1111/jphp.13281. [PMID: 32346890] - Jonathan A Coleman, Vikas Navratna, Daniele Antermite, Dongxue Yang, James A Bull, Eric Gouaux. Chemical and structural investigation of the paroxetine-human serotonin transporter complex.
eLife.
2020 07; 9(?):. doi:
10.7554/elife.56427. [PMID: 32618269] - Manuela Vay, Marleen Julia Meyer, Antje Blank, Gisela Skopp, Peter Rose, Mladen Vassilev Tzvetkov, Gerd Mikus. Oral Yohimbine as a New Probe Drug to Predict CYP2D6 Activity: Results of a Fixed-Sequence Phase I Trial.
Clinical pharmacokinetics.
2020 07; 59(7):927-939. doi:
10.1007/s40262-020-00862-6. [PMID: 32060866] - Estabraq Jaddoa, Jinit Masania, Eva Masiero, Tiziana Sgamma, Randolph Arroo, Daniel Sillence, Tyra Zetterström. Effect of antidepressant drugs on the brain sphingolipid system.
Journal of psychopharmacology (Oxford, England).
2020 07; 34(7):716-725. doi:
10.1177/0269881120915412. [PMID: 32403969] - Nazife Ulker, Ahmet Yardimci, Nalan Kaya Tektemur, Neriman Colakoglu, Mete Ozcan, Sinan Canpolat, Haluk Kelestimur. Chronic exposure to paroxetine or bupropion modulates the pubertal maturation and the reproductive system in female rats.
Reproductive biology.
2020 Jun; 20(2):154-163. doi:
10.1016/j.repbio.2020.03.009. [PMID: 32299777] - Ravi Dutt, Nilima Shankar, Shruti Srivastava, Asha Yadav, Rafat S Ahmed. Cardiac autonomic tone, plasma BDNF levels and paroxetine response in newly diagnosed patients of generalised anxiety disorder.
International journal of psychiatry in clinical practice.
2020 Jun; 24(2):135-142. doi:
10.1080/13651501.2020.1723642. [PMID: 32022607] - Lijuan Li, Zhifen Han, Lingxin Li, Lin Han, Bo Yan. Effectiveness of Paroxetine for Poststroke Depression: A Meta-Analysis.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.
2020 May; 29(5):104664. doi:
10.1016/j.jstrokecerebrovasdis.2020.104664. [PMID: 32093988] - E Kurtoglu Ozdes, B Z Altunkaynak, O G Deniz, F Ilkaya, H Guzel, A Kokcu. A stereological study of the effects of antidepressants on postmenopausal rat kidney.
Biotechnic & histochemistry : official publication of the Biological Stain Commission.
2020 May; 95(4):262-267. doi:
10.1080/10520295.2019.1680865. [PMID: 31746664] - Manjeet Singh Bhatia, Sheenam Goyal, Apala Singh, Ankit Daral. COVID-19 Pandemic-Induced Panic Disorder.
The primary care companion for CNS disorders.
2020 04; 22(3):. doi:
10.4088/pcc.20l02626. [PMID: 32369687] - Markus Svensson, Arne Reimers, Margareta Reis. [Pharmacokinetics of antidepressants during pregnancy].
Lakartidningen.
2020 04; 117(?):. doi:
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The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.
2020 04; 21(4):300-307. doi:
10.1080/15622975.2019.1583373. [PMID: 31012797] - Abbas Hassan Oghli, Ahmad Soleymanpour. Polyoxometalate/reduced graphene oxide modified pencil graphite sensor for the electrochemical trace determination of paroxetine in biological and pharmaceutical media.
Materials science & engineering. C, Materials for biological applications.
2020 Mar; 108(?):110407. doi:
10.1016/j.msec.2019.110407. [PMID: 31923952] - Mirjam Simoons, Hans Mulder, Jerôme T Y Appeldoorn, Arne J Risselada, Aart H Schene, Ron H N van Schaik, Eric N van Roon, Eric G Ruhé. Modification of the association between paroxetine serum concentration and SERT-occupancy by ABCB1 (P-glycoprotein) polymorphisms in major depressive disorder.
Psychiatric genetics.
2020 02; 30(1):19-29. doi:
10.1097/ypg.0000000000000244. [PMID: 31634334] - Peishan Cai, Xiang Xiong, Dan Li, Yu Zhou, Chaomei Xiong. Magnetic solid-phase extraction coupled with UHPLC-MS/MS for four antidepressants and one metabolite in clinical plasma and urine samples.
Bioanalysis.
2020 Jan; 12(1):35-52. doi:
10.4155/bio-2019-0171. [PMID: 31849264] - Ara M Abramyan, Rachel D Slack, Sitaram Meena, Bruce A Davis, Amy Hauck Newman, Satinder K Singh, Lei Shi. Computation-guided analysis of paroxetine binding to hSERT reveals functionally important structural elements and dynamics.
Neuropharmacology.
2019 12; 161(?):107411. doi:
10.1016/j.neuropharm.2018.10.040. [PMID: 30391505] - Wuan Shuen Yap, Anton V Dolzhenko, Zahraa Jalal, Muhammad Abdul Hadi, Tahir Mehmood Khan. Efficacy and safety of lavender essential oil (Silexan) capsules among patients suffering from anxiety disorders: A network meta-analysis.
Scientific reports.
2019 12; 9(1):18042. doi:
10.1038/s41598-019-54529-9. [PMID: 31792285] - Mehran Haidari, Sravan Mansani, Dezaray Ponds, Lissett Romero, Christine Cobb, Saad Alsaab. Storage of urine specimens in point of care (POC) urine drug testing cups reduces concentrations of many drugs.
Clinica chimica acta; international journal of clinical chemistry.
2019 Dec; 499(?):81-86. doi:
10.1016/j.cca.2019.09.001. [PMID: 31491368] - Weibin Zha, Tao Hu, Mary F Hebert, Joanne Wang. Effect of Pregnancy on Paroxetine-Induced Adiposity and Glucose Intolerance in Mice.
The Journal of pharmacology and experimental therapeutics.
2019 10; 371(1):113-120. doi:
10.1124/jpet.118.255380. [PMID: 31308195] - Ayokunle O Ademosun, Adeniyi A Adebayo, Ganiyu Oboh. Orange peels modulate antioxidant markers and key enzymes relevant to erection in the penile tissue of paroxetine-treated rats.
Andrologia.
2019 Oct; 51(9):e13371. doi:
10.1111/and.13371. [PMID: 31347717] - Rachel D Slack, Ara M Abramyan, Helen Tang, Sitaram Meena, Bruce A Davis, Alessandro Bonifazi, JoLynn B Giancola, Jeffrey R Deschamps, Sett Naing, Hideaki Yano, Satinder K Singh, Amy Hauck Newman, Lei Shi. A Novel Bromine-Containing Paroxetine Analogue Provides Mechanistic Clues for Binding Ambiguity at the Central Primary Binding Site of the Serotonin Transporter.
ACS chemical neuroscience.
2019 09; 10(9):3946-3952. doi:
10.1021/acschemneuro.9b00375. [PMID: 31424193] - Lucia Carboni, Dennis J McCarthy, Bruno Delafont, Michele Filosi, Elena Ivanchenko, Emiliangelo Ratti, Susan M Learned, Robert Alexander, Enrico Domenici. Biomarkers for response in major depression: comparing paroxetine and venlafaxine from two randomised placebo-controlled clinical studies.
Translational psychiatry.
2019 08; 9(1):182. doi:
10.1038/s41398-019-0521-7. [PMID: 31375659] - Anne E Cossu, Leigh B Latham, Doris M Hardacker, Andrew H Jea. Pharmacologic chaos: severe hypotension from interactions of anesthetics, marijuana, amphetamines, and paroxetine.
Journal of clinical anesthesia.
2019 08; 55(?):17. doi:
10.1016/j.jclinane.2018.12.040. [PMID: 30586660] - Abdullah Al Maruf, Alexandra Greenslade, Paul D Arnold, Chad Bousman. Antidepressant pharmacogenetics in children and young adults: A systematic review.
Journal of affective disorders.
2019 07; 254(?):98-108. doi:
10.1016/j.jad.2019.05.025. [PMID: 31112844] - Jaydeep Yadav, Ken Korzekwa, Swati Nagar. Impact of Lipid Partitioning on the Design, Analysis, and Interpretation of Microsomal Time-Dependent Inactivation.
Drug metabolism and disposition: the biological fate of chemicals.
2019 07; 47(7):732-742. doi:
10.1124/dmd.118.085969. [PMID: 31043439] - Patrícia Duarte, C Marisa R Almeida, Joana P Fernandes, Daniela Morais, Marta Lino, Carlos R Gomes, Maria F Carvalho, Ana P Mucha. Bioremediation of bezafibrate and paroxetine by microorganisms from estuarine sediment and activated sludge of an associated wastewater treatment plant.
The Science of the total environment.
2019 Mar; 655(?):796-806. doi:
10.1016/j.scitotenv.2018.11.285. [PMID: 30577142] - Ayokunle O Ademosun, Adeniyi A Adebayo, Ganiyu Oboh. Anogeissus leiocarpus attenuates paroxetine-induced erectile dysfunction in male rats via enhanced sexual behavior, nitric oxide level and antioxidant status.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Mar; 111(?):1029-1035. doi:
10.1016/j.biopha.2019.01.022. [PMID: 30841416] - Jaroslava Červeňová. Combination of mirtazapine and paroxetine: possible clinically demonstrated interaction?.
Casopis lekaru ceskych.
2019; 158(7-8):310-313. doi:
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Life sciences.
2018 Nov; 212(?):109-118. doi:
10.1016/j.lfs.2018.09.046. [PMID: 30267788] - Wei-Tsung Kao, Chen-Lin Chang, For-Wey Lung. 5-HTT mRNA level as a potential biomarker of treatment response in patients with major depression in a clinical trial.
Journal of affective disorders.
2018 10; 238(?):597-608. doi:
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Archives italiennes de biologie.
2018 07; 156(1-2):27-39. doi:
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Progress in neuro-psychopharmacology & biological psychiatry.
2018 03; 82(?):332-338. doi:
10.1016/j.pnpbp.2017.07.008. [PMID: 29269186] - Jonathan A Coleman, Eric Gouaux. Structural basis for recognition of diverse antidepressants by the human serotonin transporter.
Nature structural & molecular biology.
2018 02; 25(2):170-175. doi:
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Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
2018; 51(7):e7212. doi:
10.1590/1414-431x20187212. [PMID: 29791588] - Yao Liu, Lin Jia, Shu-Man Jiang, Dong-Yun Chen, Jiang-Shun Song, Jian Xu. Serotonin Transporter Gene (SLC6A4) Polymorphism May Be Associated with Chinese Globus Pharyngeus and Its Antidepressant Effects.
Digestion.
2018; 97(2):146-153. doi:
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Psychoneuroendocrinology.
2018 Jan; 87(?):108-118. doi:
10.1016/j.psyneuen.2017.10.009. [PMID: 29055264] - Wan-Hui Lin, Xiao-Feng Li, Ming-Xing Lin, Ying Zhou, Hua-Pin Huang. Novel insights into the effect of paroxetine administration in pilocarpine‑induced chronic epileptic rats.
Molecular medicine reports.
2017 Dec; 16(6):8245-8252. doi:
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International journal of impotence research.
2017 Nov; 29(6):235-239. doi:
10.1038/ijir.2017.29. [PMID: 28904397] - Hafsteinn Rannversson, Jacob Andersen, Benny Bang-Andersen, Kristian Strømgaard. Mapping the Binding Site for Escitalopram and Paroxetine in the Human Serotonin Transporter Using Genetically Encoded Photo-Cross-Linkers.
ACS chemical biology.
2017 10; 12(10):2558-2562. doi:
10.1021/acschembio.7b00338. [PMID: 28910072] - Paulo Magalhães, Gilberto Alves, Adrián Llerena, Amílcar Falcão. Therapeutic Drug Monitoring of Fluoxetine, Norfluoxetine and Paroxetine: A New Tool Based on Microextraction by Packed Sorbent Coupled to Liquid Chromatography.
Journal of analytical toxicology.
2017 Sep; 41(7):631-638. doi:
10.1093/jat/bkx043. [PMID: 28873974] - Madhavan Seshadri, Madhusudan Deepak Thalitaya, Tuno Simon, Catherine Odelola, Humphrey Enow. Antidepressants and Hyponatremia in a patient with Colectomy - a Case Report.
Psychiatria Danubina.
2017 Sep; 29(Suppl 3):610-614. doi:
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International journal of psychiatry in clinical practice.
2017 Sep; 21(3):177-180. doi:
10.1080/13651501.2017.1301488. [PMID: 28319423] - Zeng-Liang Jin, Xiao-Fei Chen, Yu-Hua Ran, Xiao-Rong Li, Jie Xiong, Yuan-Yuan Zheng, Na-Na Gao, Yun-Feng Li. Mouse strain differences in SSRI sensitivity correlate with serotonin transporter binding and function.
Scientific reports.
2017 08; 7(1):8631. doi:
10.1038/s41598-017-08953-4. [PMID: 28819255] - Rose Anny Costa Silva, Cecília Rocha da Silva, João Batista de Andrade Neto, Anderson Ramos da Silva, Rosana Sousa Campos, Letícia Serpa Sampaio, Francisca Bruna Stefany Aires do Nascimento, Brenda da Silva Gaspar, Said Gonçalves da Cruz Fonseca, Maria Aparecida Alexandre Josino, Thalles Barbosa Grangeiro, Danielle Macedo Gaspar, David Freitas de Lucena, Manoel Odorico de Moraes, Bruno Coêlho Cavalcanti, Hélio Vitoriano Nobre Júnior. In vitro anti-Candida activity of selective serotonin reuptake inhibitors against fluconazole-resistant strains and their activity against biofilm-forming isolates.
Microbial pathogenesis.
2017 Jun; 107(?):341-348. doi:
10.1016/j.micpath.2017.04.008. [PMID: 28411060] - R J T Mocking, T S Nap, A M Westerink, J Assies, F M Vaz, M W J Koeter, H G Ruhé, A H Schene. Biological profiling of prospective antidepressant response in major depressive disorder: Associations with (neuro)inflammation, fatty acid metabolism, and amygdala-reactivity.
Psychoneuroendocrinology.
2017 05; 79(?):84-92. doi:
10.1016/j.psyneuen.2017.02.019. [PMID: 28262603] - Helen V Waldschmidt, Kristoff T Homan, Marilyn C Cato, Osvaldo Cruz-Rodríguez, Alessandro Cannavo, Michael W Wilson, Jianliang Song, Joseph Y Cheung, Walter J Koch, John J G Tesmer, Scott D Larsen. Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine.
Journal of medicinal chemistry.
2017 04; 60(7):3052-3069. doi:
10.1021/acs.jmedchem.7b00112. [PMID: 28323425] - Qingtong Wang, Longsheng Wang, Li Wu, Mei Zhang, Shanshan Hu, Rui Wang, Yongsheng Han, Yujing Wu, Lingling Zhang, Xinming Wang, Wuyi Sun, Wei Wei. Paroxetine alleviates T lymphocyte activation and infiltration to joints of collagen-induced arthritis.
Scientific reports.
2017 03; 7(?):45364. doi:
10.1038/srep45364. [PMID: 28349925] - Feng Li, Zhao-Li Ling, Zhong-Jian Wang, Ze-Yu Zhong, Nan Shu, Mian Zhang, Can Liu, Li Liu, Xiao-Dong Liu. Differential effects of pravastatin on the pharmacokinetics of paroxetine in normal and diabetic rats.
Xenobiotica; the fate of foreign compounds in biological systems.
2017 Jan; 47(1):20-30. doi:
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PloS one.
2017; 12(2):e0172270. doi:
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International clinical psychopharmacology.
2017 01; 32(1):27-35. doi:
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International journal of impotence research.
2017 Jan; 29(1):7-11. doi:
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PloS one.
2017; 12(7):e0181082. doi:
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Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2016 Dec; 32(12):986-990. doi:
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Scientific reports.
2016 10; 6(?):35317. doi:
10.1038/srep35317. [PMID: 27731396] - Suneetha Achanti, Raja Rajeswari Katta. High-throughput liquid chromatography tandem mass spectrometry method for simultaneous determination of fampridine, paroxetine, and quinidine in rat plasma: Application to in vivo perfusion study.
Journal of food and drug analysis.
2016 10; 24(4):866-875. doi:
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East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan.
2016 Sep; 26(3):87-97. doi:
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International journal of psychiatry in clinical practice.
2016 Sep; 20(3):126-32. doi:
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Psychiatry research.
2016 Aug; 242(?):281-287. doi:
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Expert opinion on pharmacotherapy.
2016 Jul; 17(10):1375-85. doi:
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Mayo Clinic proceedings.
2016 07; 91(7):897-907. doi:
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Behavioural brain research.
2016 07; 307(?):73-83. doi:
10.1016/j.bbr.2016.03.049. [PMID: 27036647] - Shu-Man Jiang, Lin Jia, Jing Liu, Man-Man Shi, Ming-Zhi Xu. Beneficial effects of antidepressant mirtazapine in functional dyspepsia patients with weight loss.
World journal of gastroenterology.
2016 Jun; 22(22):5260-6. doi:
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Translational psychiatry.
2016 05; 6(5):e827. doi:
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Psychiatry research. Neuroimaging.
2016 May; 251(?):1-6. doi:
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