Ipratropium bromide hydrate (BioDeep_00000858919)

   


代谢物信息卡片


Ipratropium bromide hydrate

化学式: C20H32BrNO4 (429.15145720000004)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)[N+]1(C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3)C.O.[Br-]
InChI: 1H

描述信息

D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents

同义名列表

1 个代谢物同义名

Ipratropium bromide hydrate



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Changlin Wen, Zhengqiang Yu, Juan Wang, Qing Deng, Jiajia Deng, Zhenhua Sun, Qiaobo Ye, Zhen Ye, Kaihua Qin, Xi Peng. Inhalation of Citrus Reticulata essential oil alleviates airway inflammation and emphysema in COPD rats through regulation of macrophages. Journal of ethnopharmacology. 2024 Feb; 320(?):117407. doi: 10.1016/j.jep.2023.117407. [PMID: 37981111]
  • Ravina Barrett, Robert Barrett. Asthma and COPD medicines prescription-claims: A time-series analysis of England's national prescriptions during the COVID-19 pandemic (Jan 2019 to Oct 2020). Expert review of respiratory medicine. 2021 12; 15(12):1605-1612. doi: 10.1080/17476348.2022.1985470. [PMID: 34555287]
  • Ismael García-Moguel, Rocío Díaz Campos, Sergio Alonso Charterina, Consuelo Fernández Rodríguez, Jesús Fernández Crespo. COVID-19, severe asthma, and biologics. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2020 09; 125(3):357-359.e1. doi: 10.1016/j.anai.2020.06.012. [PMID: 32553608]
  • Weiguo Xu, Junhua Wu, Yong Feng, Jing Zhu, Rong Cui. Comparison of the efficacy of aerosol inhalation between the ipratropium bromide and terbutaline on the patients with AECOPD. Pakistan journal of pharmaceutical sciences. 2019 Sep; 32(5(Special)):2489-2493. doi: . [PMID: 31894040]
  • D-H Jiang, X Wang, L-S Liu, D-D Ji, N Zhang. The effect of ventilator mask atomization inhalation of ipratropium bromide and budesonide suspension liquid in the treatment of COPD in acute exacerbation period on circulating levels of inflammation and prognosis. European review for medical and pharmacological sciences. 2017 Nov; 21(22):5211-5216. doi: 10.26355/eurrev_201711_13843. [PMID: 29228436]
  • Jiayin Chen, Jürgen Brockmöller, Tina Seitz, Jörg König, Xijing Chen, Mladen V Tzvetkov. Tropane alkaloids as substrates and inhibitors of human organic cation transporters of the SLC22 (OCT) and the SLC47 (MATE) families. Biological chemistry. 2017 02; 398(2):237-249. doi: 10.1515/hsz-2016-0236. [PMID: 27676604]
  • Xiaoxi Liu, Tian Yu, Joseph E Rower, Sarah C Campbell, Catherine M T Sherwin, Michael D Johnson. Optimizing the use of intravenous magnesium sulfate for acute asthma treatment in children. Pediatric pulmonology. 2016 12; 51(12):1414-1421. doi: 10.1002/ppul.23482. [PMID: 27218606]
  • T R MacGregor, R ZuWallack, V Rubano, M A Castles, H Dewberry, M Ghafouri, C C Wood. Efficiency of Ipratropium Bromide and Albuterol Deposition in the Lung Delivered via a Soft Mist Inhaler or Chlorofluorocarbon Metered-Dose Inhaler. Clinical and translational science. 2016 Apr; 9(2):105-13. doi: 10.1111/cts.12387. [PMID: 26945929]
  • Yong-Hun Lee, Gu-Youn Kwon, Do-Yang Park, Ji-Yeon Bang, Dong-Min Jang, Soo-Han Lee, Eun-Kyung Lee, Byung-Moon Choi, Gyu-Jeong Noh. Efficiency of a New Mesh-Type Nebulizer (NE-SM1 NEPLUS) for Intrapulmonary Delivery of Ipratropium Bromide in Surgical Patients. Basic & clinical pharmacology & toxicology. 2016 Apr; 118(4):313-9. doi: 10.1111/bcpt.12499. [PMID: 26440415]
  • Amadeu Gavaldà, Israel Ramos, Carla Carcasona, Elena Calama, Raquel Otal, José Luis Montero, Sonia Sentellas, Monica Aparici, Dolors Vilella, Joan Alberti, Jorge Beleta, Montserrat Miralpeix. The in vitro and in vivo profile of aclidinium bromide in comparison with glycopyrronium bromide. Pulmonary pharmacology & therapeutics. 2014 Aug; 28(2):114-21. doi: 10.1016/j.pupt.2014.05.005. [PMID: 24928173]
  • Ahmed Daoud, Zuozheng Xie, Yanhong Ma, Tiansheng Wang, Guolin Tan. Changes of T-helper type 1/2 cell balance by anticholinergic treatment in allergic mice. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2014 Mar; 112(3):249-55. doi: 10.1016/j.anai.2013.12.014. [PMID: 24428969]
  • G Michael Allan, Bruce Arroll. Prevention and treatment of the common cold: making sense of the evidence. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. 2014 Feb; 186(3):190-9. doi: 10.1503/cmaj.121442. [PMID: 24468694]
  • Lawrence M Lewis, Ian Ferguson, Stacey L House, Kristen Aubuchon, John Schneider, Kirk Johnson, Kazuko Matsuda. Albuterol administration is commonly associated with increases in serum lactate in patients with asthma treated for acute exacerbation of asthma. Chest. 2014 Jan; 145(1):53-59. doi: 10.1378/chest.13-0930. [PMID: 23949578]
  • Vandana Gupta, Dave Singh. Aclidinium bromide for the treatment of chronic obstructive pulmonary disease. Expert review of respiratory medicine. 2012 Dec; 6(6):581-8. doi: 10.1586/ers.12.61. [PMID: 23234445]
  • Jonathan I Silverberg, Mario Rodenas, Richard Sinert, Rauno Joks. Emergency department treatment of adults with acute asthma exacerbations: effect on exhaled nitric oxide levels. Allergy and asthma proceedings. 2012 Nov; 33(6):514-8. doi: 10.2500/aap.2012.33.3613. [PMID: 23394510]
  • Barbro Dahlén, Federico P Gómez, Alejandro Casas, Peter H Howarth, Sven-Erik Dahlén, Robert Rodriguez-Roisin. Salbutamol but not ipratropium abolishes leukotriene D4-induced gas exchange abnormalities in asthma. European journal of clinical pharmacology. 2012 Oct; 68(10):1375-83. doi: 10.1007/s00228-012-1256-z. [PMID: 22457014]
  • Huang-Pin Wu, Yu-Chih Liu, Shi-Chuan Lin, Ming-Yi Chien, Fang-Chun Liao, Shu-Chuan Chang, Wen-Bin Shieh. Comparison of respiratory parameters and plasma cytokine levels between treatment with Salmeterol/fluticasone and ipratropium/terbutaline/budesonide in mechanically ventilated COPD patients. Chang Gung medical journal. 2012 Sep; 35(5):373-81. doi: 10.4103/2319-4170.105481. [PMID: 23127342]
  • P Garcia, A-C Paris, A Leufroy, M-A Popot, Y Bonnaire. Quantitative analysis of a quaternary ammonium drug: ipratropium bromide by LC/ESI-MS(n) in horse plasma and urine. Biomedical chromatography : BMC. 2012 Apr; 26(4):534-40. doi: 10.1002/bmc.1701. [PMID: 21989922]
  • Jingwen Wu, Cungang Ding, Qinghua Ge, Zhou Li, Zhen Zhou, Xiaojin Zhi. Simultaneous determination of ipratropium and salbutamol in rat plasma by LC-MS/MS and its application to a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 Nov; 879(30):3475-83. doi: 10.1016/j.jchromb.2011.09.027. [PMID: 21983198]
  • Takeo Nakanishi, Tsunemitsu Haruta, Yoshiyuki Shirasaka, Ikumi Tamai. Organic cation transporter-mediated renal secretion of ipratropium and tiotropium in rats and humans. Drug metabolism and disposition: the biological fate of chemicals. 2011 Jan; 39(1):117-22. doi: 10.1124/dmd.110.035402. [PMID: 20962061]
  • Jean-Jacques Moraine, Karine Truflandier, Nicolas Vandenbergen, Jacques Berré, Christian Mélot, Jean-Louis Vincent. Placement of the nebulizer before the humidifier during mechanical ventilation: Effect on aerosol delivery. Heart & lung : the journal of critical care. 2009 Sep; 38(5):435-9. doi: 10.1016/j.hrtlng.2008.12.005. [PMID: 19755194]
  • Timothy Andrews, Erin McGintee, Manoj K Mittal, Lisa Tyler, Amber Chew, Xuemei Zhang, Nicholas Pawlowski, Joseph J Zorc. High-dose continuous nebulized levalbuterol for pediatric status asthmaticus: a randomized trial. The Journal of pediatrics. 2009 Aug; 155(2):205-10.e1. doi: 10.1016/j.jpeds.2009.01.073. [PMID: 19464028]
  • Sedat Kuleci, Ismail Hanta, Ali Kocabas, Necmiye Canacankatan. The effect of different treatment modalities on oxidative stress in COPD. Advances in therapy. 2008 Jul; 25(7):710-7. doi: 10.1007/s12325-008-0064-4. [PMID: 18592146]
  • M E M Hassouna, S A A Elsuccary. PVC membrane electrode for the potentiometric determination of Ipratropium bromide using batch and flow injection techniques. Talanta. 2008 Jun; 75(5):1175-83. doi: 10.1016/j.talanta.2008.01.014. [PMID: 18585199]
  • Patrick H Conway, Sarah Edwards, Erin R Stucky, Vincent W Chiang, Mary C Ottolini, Christopher P Landrigan. Variations in management of common inpatient pediatric illnesses: hospitalists and community pediatricians. Pediatrics. 2006 Aug; 118(2):441-7. doi: 10.1542/peds.2006-0484. [PMID: 16882793]
  • V I Makolkin, S I Ovcharenko, O A Peredel'skaia, A S Axel'rod. [Effect of high doses of broncholytics on the state of cardiovascular system during treatment of sever exacerbation of bronchial asthma]. Kardiologiia. 2004; 44(2):65-9. doi: NULL. [PMID: 15125428]
  • L I Volkova, A A Budkova, N N Filonova, E I Khristoliubova, E B Kutuzova, N V Koroleva, T T Radzivil, Z R Aminova, A G Chuchalin. [Efficacy of a complementary antiinflammatory treatment with erespal in chronic obstructive and nonobstructive bronchitis]. Terapevticheskii arkhiv. 2004; 76(8):51-6. doi: . [PMID: 15471398]
  • S Coskun, H Yuksel, H Tikiz, S Danahaliloğlu. Standard dose of inhaled albuterol significantly increases QT dispersion compared to low dose of albuterol plus ipratropium bromide therapy in moderate to severe acute asthma attacks in children. Pediatrics international : official journal of the Japan Pediatric Society. 2001 Dec; 43(6):631-6. doi: 10.1046/j.1442-200x.2001.01471.x. [PMID: 11737740]
  • A Leusch, B Eichhorn, G Müller, K L Rominger. Pharmacokinetics and tissue distribution of the anticholinergics tiotropium and ipratropium in the rat and dog. Biopharmaceutics & drug disposition. 2001 Jul; 22(5):199-212. doi: 10.1002/bdd.280. [PMID: 11745922]
  • F P Tang, G N Leung, T S Wan. Analyses of quaternary ammonium drugs in horse urine by capillary electrophoresis-mass spectrometry. Electrophoresis. 2001 Jul; 22(11):2201-9. doi: 10.1002/1522-2683(20017)22:11<2201::aid-elps2201>3.0.co;2-s. [PMID: 11504053]
  • D H Duvivier, W M Bayly, D Votion, S Vandenput, T Art, F Farnir, P Lekeux. Effects of inhaled dry powder ipratropium bromide on recovery from exercise of horses with COPD. Equine veterinary journal. 1999 Jan; 31(1):20-4. doi: 10.1111/j.2042-3306.1999.tb03786.x. [PMID: 9952325]
  • M Tsukino, K Nishimura, A Ikeda, T Hajiro, H Koyama, T Izumi. Effects of theophylline and ipratropium bromide on exercise performance in patients with stable chronic obstructive pulmonary disease. Thorax. 1998 Apr; 53(4):269-73. doi: 10.1136/thx.53.4.269. [PMID: 9741369]
  • A Pitkäranta, M T Wecker, D C Korts, F G Hayden. Combined intranasal ipratropium bromide and oxymetazoline in experimental rhinovirus infection. American journal of rhinology. 1998 Mar; 12(2):125-9. doi: 10.2500/105065898781390316. [PMID: 9578931]
  • S R Rutgers, G H Koëter, T W van der Mark, D S Postma. Short-term treatment with budesonide does not improve hyperresponsiveness to adenosine 5'-monophosphate in COPD. American journal of respiratory and critical care medicine. 1998 Mar; 157(3 Pt 1):880-6. doi: 10.1164/ajrccm.157.3.9709100. [PMID: 9517606]
  • J E Garrett, G I Town, P Rodwell, A M Kelly. Nebulized salbutamol with and without ipratropium bromide in the treatment of acute asthma. The Journal of allergy and clinical immunology. 1997 Aug; 100(2):165-70. doi: 10.1016/s0091-6749(97)70219-7. [PMID: 9275135]
  • I Rahman, E Skwarska, W MacNee. Attenuation of oxidant/antioxidant imbalance during treatment of exacerbations of chronic obstructive pulmonary disease. Thorax. 1997 Jun; 52(6):565-8. doi: 10.1136/thx.52.6.565. [PMID: 9227727]
  • J P Karpel, E N Schacter, C Fanta, D Levey, P Spiro, T Aldrich, S S Menjoge, T J Witek. A comparison of ipratropium and albuterol vs albuterol alone for the treatment of acute asthma. Chest. 1996 Sep; 110(3):611-6. doi: 10.1378/chest.110.3.611. [PMID: 8797400]
  • C C Wood, P Fireman, J Grossman, M Wecker, T MacGregor. Product characteristics and pharmacokinetics of intranasal ipratropium bromide. The Journal of allergy and clinical immunology. 1995 May; 95(5 Pt 2):1111-6. doi: 10.1016/s0091-6749(95)70214-8. [PMID: 7751527]
  • K Nishimura, H Koyama, A Ikeda, N Sugiura, K Kawakatsu, T Izumi. The additive effect of theophylline on a high-dose combination of inhaled salbutamol and ipratropium bromide in stable COPD. Chest. 1995 Mar; 107(3):718-23. doi: 10.1378/chest.107.3.718. [PMID: 7874943]
  • J N Baraniuk, P B Silver, M A Kaliner, P J Barnes. Effects of ipratropium bromide on bradykinin nasal provocation in chronic allergic rhinitis. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 1994 Aug; 24(8):724-9. doi: 10.1111/j.1365-2222.1994.tb00982.x. [PMID: 7982121]
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  • R Chazan, A Jaworski, W Tadeusiak, M Azzabi, W Droszcz. [Comparison of the influence of ipratropium bromide and salbutamol on activity of phosphocreatine kinase (CK) and isoenzyme CK-MB]. Pneumonologia i alergologia polska. 1994; 62(1-2):70-4. doi: NULL. [PMID: 8075616]
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