Diammonium Glycyrrhizinate (BioDeep_00000858914)
Main id: BioDeep_00000230670
PANOMIX_OTCML-2023 Chemicals and Drugs
代谢物信息卡片
Diammonium Glycyrrhizinate
化学式: C42H68N2O16 (856.4569)
中文名称: 甘草酸二铵
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1(C2CCC3(C(C2(CCC1OC4C(C(C(C(O4)C(=O)O)O)O)OC5C(C(C(C(O5)C(=O)O)O)O)O)C)C(=O)C=C6C3(CCC7(C6CC(CC7)(C)C(=O)O)C)C)C)C.N.N
InChI: /m0../s1
描述信息
D000893 - Anti-Inflammatory Agents
C1907 - Drug, Natural Product
Diammonium Glycyrrhizinate, isolated from the licorice root, is a widely used anti-inflammatory agent[1].
Diammonium Glycyrrhizinate, isolated from the licorice root, is a widely used anti-inflammatory agent[1].
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D02028
- PubChem: 656656
- MeSH: Glycyrrhizic Acid
- CAS: 79165-06-3
- medchemexpress: HY-N6804
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Sijue Chen, Wei Cao, Xianjun Xiao, Lu Wang, Renhong Wan, Zihao Zou, Qian Yang, Ying Li. A systematic review and meta-analysis of efficacy and safety of compound glycyrrhizin combined with second-generation non-sedated antihistamine for the treatment of chronic urticaria.
The Journal of dermatological treatment.
2024 Dec; 35(1):2299597. doi:
10.1080/09546634.2023.2299597. [PMID: 38166511] - Shanbo Ma, Ye Chong, Rui Zhang, Wei Quan, Jiayue Gui, Long Li, Jin Wang, Shan Miao, Xiaopeng Shi, Minggao Zhao, Kun Zhang. Glycyrrhizic acid treatment ameliorates anxiety-like behaviour via GLT1 and Per1/2-dependent pathways.
Journal of ethnopharmacology.
2024 Jun; 328(?):118013. doi:
10.1016/j.jep.2024.118013. [PMID: 38453099] - Jialing Sun, Mengqing Ma, Xin Zhong, Jing Li, Jinyu Yi, Renjie Zhang, Xingning Liu, Lanfen Peng, Xinfeng Sun, Wenxing Feng, Rui Hu, Qi Huang, Minling Lv, Kongli Fan, Xiaozhou Zhou. Investigating the molecular mechanism of Qizhu anticancer prescription in inhibiting hepatocellular carcinoma based on high-resolution mass spectrometry and network pharmacology.
Journal of ethnopharmacology.
2024 Jun; 328(?):117985. doi:
10.1016/j.jep.2024.117985. [PMID: 38417600] - Yiting Hu, Zhongfei Luo, Siyi Cai, Qinfen Xie, Shusen Zheng. Glycyrrhizic acid attenuates sorafenib resistance by inducing ferroptosis via targeting mTOR signaling in hepatocellular carcinoma.
Scandinavian journal of gastroenterology.
2024 Jun; 59(6):730-736. doi:
10.1080/00365521.2024.2315317. [PMID: 38426342] - Kai Chen, Yan-Yan Hu, Shan-Shan Qian, Jin-Zhao Wu, Li-Juan Cao, Lin-Lin Wang, Meng Li, Yu-Xin Xia, Qian Jiang, Hong-Ying Chen, Liu-Qing Chen, Dong-Sheng Li. A novel glycyrrhizic acid-based dressing effectively improved photodynamic therapy-caused skin barrier damage in port-wine stains.
Journal of cosmetic dermatology.
2024 Jun; 23(6):2301-2303. doi:
10.1111/jocd.16250. [PMID: 38410871] - Hassan Esmaeili, Mohammad Hossein Mirjalili, Akbar Karami, Samad Nejad Ebrahimi. Introducing the glycyrrhizic acid and glabridin rich genotypes from the cultivated Iranian licorice (Glycyrrhiza glabra L.) populations to exploit in production systems.
Scientific reports.
2024 05; 14(1):11034. doi:
10.1038/s41598-024-61711-1. [PMID: 38744977] - Lingfeng Du, Chunfang Ma, Bingnan Liu, Wei Liu, Yue Zhu, Zuhua Wang, Teng Chen, Luqi Huang, Yuxin Pang. Green Synthesis of Blumea balsamifera Oil Nanoemulsions Stabilized by Natural Emulsifiers and Its Effect on Wound Healing.
Molecules (Basel, Switzerland).
2024 Apr; 29(9):. doi:
10.3390/molecules29091994. [PMID: 38731484] - José Bryan García-Cambrón, José Luis Cerriteño-Sánchez, Rocío Lara-Romero, David Quintanar-Guerrero, Gerardo Blancas-Flores, Brenda L Sánchez-Gaytán, Irma Herrera-Camacho, Julieta Sandra Cuevas-Romero. Development of Glycyrrhizinic Acid-Based Lipid Nanoparticle (LNP-GA) as An Adjuvant That Improves the Immune Response to Porcine Epidemic Diarrhea Virus Spike Recombinant Protein.
Viruses.
2024 03; 16(3):. doi:
10.3390/v16030431. [PMID: 38543796] - Wenjing Su, Anna V Mastova, Maya A Ul'yanova, Polina A Kononova, Olga Yu Selyutina, Veronika I Evseenko, Elizaveta S Meteleva, Alexander V Dushkin, Weike Su, Nikolay E Polyakov. NMR Study of Water-Soluble Carotenoid Crocin: Formation of Mixed Micelles, Interaction with Lipid Membrane and Antioxidant Activity.
International journal of molecular sciences.
2024 Mar; 25(6):. doi:
10.3390/ijms25063194. [PMID: 38542168] - Longyue Zhou, Shankang Chen, Yuanyi Wei, Yihui Sun, Yifan Yang, Bingqi Lin, Yuhao Li, Chunxia Wang. Glycyrrhizic acid restores the downregulated hepatic ACE2 signaling in the attenuation of mouse steatohepatitis.
European journal of pharmacology.
2024 Feb; ?(?):176365. doi:
10.1016/j.ejphar.2024.176365. [PMID: 38316247] - Liangliang Chen, Lin Zhao, Ju Han, Ping Xiao, Mingzhe Zhao, Sen Zhang, Jinao Duan. Biosynthesis of Chryseno[2,1,c]oxepin-12-Carboxylic Acid from Glycyrrhizic Acid in Aspergillus terreus TMZ05-2, and Analysis of Its Anti-inflammatory Activity.
Journal of microbiology (Seoul, Korea).
2024 Feb; 62(2):113-124. doi:
10.1007/s12275-024-00105-4. [PMID: 38411880] - Liu Zhou, Yifei Yang, Xiaotong Fu, Bing Xia, Chun Li, Chenna Lu, Ying Qi, Haijing Zhang, Ting Liu. The protective effect and molecular mechanism of glycyrrhizic acid glycosides against Tripterygium glycosides induced nephrotoxicity based on the RhoA/ROCK1 signalling pathway.
Journal of ethnopharmacology.
2024 Jan; 319(Pt 1):117100. doi:
10.1016/j.jep.2023.117100. [PMID: 37648177] - Rui Zhang, Aiminuer Asikaer, Qi Chen, Fang Wang, Junjie Lan, Yang Liu, Linfang Hu, Huaye Zhao, Hongtao Duan. Network pharmacology and in vitro experimental verification unveil glycyrrhizin from glycyrrhiza glabra alleviates acute pancreatitis via modulation of MAPK and STAT3 signaling pathways.
BMC complementary medicine and therapies.
2024 Jan; 24(1):58. doi:
10.1186/s12906-024-04372-x. [PMID: 38280993] - Peter Fischer, Viviane Lutz-Bueno. Glycyrrhizic acid aggregates seen from a synthetic surfactant perspective.
Physical chemistry chemical physics : PCCP.
2024 Jan; 26(4):2806-2814. doi:
10.1039/d3cp04835g. [PMID: 38196347] - Xuecheng Wang, Xiaohui Wang, Yutian Zhang, Yaqi Wang, Yuanhui Li, Yaokun Xiong, Ming Yang, Xiaorong Luo, Zhenfeng Wu. Effects of ultrasonic power on drying kinetics and product quality of licorice extract during ultrasound-assisted vacuum drying.
Journal of the science of food and agriculture.
2024 Jan; ?(?):. doi:
10.1002/jsfa.13283. [PMID: 38252708] - Yaoyao Xiao, Lele Zhou, Wenkang Tao, Xuan Yang, Junying Li, Rulin Wang, Yanan Zhao, Can Peng, Caiyun Zhang. Preparation of paeoniflorin-glycyrrhizic acid complex transethosome gel and its preventive and therapeutic effects on melasma.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2024 Jan; 192(?):106664. doi:
10.1016/j.ejps.2023.106664. [PMID: 38061662] - Kavita J Lanjekar, Virendra K Rathod. Recovery and separation of glycyrrhizic acid from Natural Deep Eutectic Solvent (NADES) extract by macroporous resin: adsorption kinetics and isotherm studies.
Preparative biochemistry & biotechnology.
2024 Jan; 54(1):39-48. doi:
10.1080/10826068.2023.2204485. [PMID: 37204086] - Yu Mou, Wenhao Liao, Yuchen Li, Lina Wan, Jingwen Liu, Xialing Luo, Hongping Shen, Qin Sun, Jing Wang, Jianyuan Tang, Zhilei Wang. Glycyrrhizin and the Related Preparations: An Inspiring Resource for the Treatment of Liver Diseases.
The American journal of Chinese medicine.
2024; 52(2):315-354. doi:
10.1142/s0192415x24500149. [PMID: 38553799] - Naoki Chiyo, Hikaru Seki, Takuya Kanamoto, Hiroshi Ueda, Mareshige Kojoma, Toshiya Muranaka. Glycyrrhizin Production in Licorice Hairy Roots Based on Metabolic Redirection of Triterpenoid Biosynthetic Pathway by Genome Editing.
Plant & cell physiology.
2023 Dec; ?(?):. doi:
10.1093/pcp/pcad161. [PMID: 38153756] - Manami Sakanishi, Soo Yeon Chung, Kentaro Fujiwara, Mareshige Kojoma, Toshiya Muranaka, Hikaru Seki. Disruption of a licorice cellulose synthase-derived glycosyltransferase gene demonstrates its in planta role in soyasaponin biosynthesis.
Plant cell reports.
2023 Dec; 43(1):15. doi:
10.1007/s00299-023-03095-6. [PMID: 38135741] - Ruchi Sharma, Rajeev K Singla, Subhadip Banerjee, Rohit Sharma. Revisiting Licorice as a functional food in the management of neurological disorders: bench to trend.
Neuroscience and biobehavioral reviews.
2023 Nov; ?(?):105452. doi:
10.1016/j.neubiorev.2023.105452. [PMID: 37925093] - Yang Jian, Xiaoyu Wang, Yunming Li, Dali Fu, Yalin Gong, Huiqing Shi. Efficacy and safety of compound glycyrrhizin in combination with conventional therapy in treatment of vitiligo: A systematic review and meta-analysis of randomized controlled trials.
Medicine.
2023 Oct; 102(43):e35533. doi:
10.1097/md.0000000000035533. [PMID: 37904437] - Chengcheng Wang, Dawei Wu, Liying Jiang, Xunhong Liu, Tiantian Xie. Multi-Omics Elucidates Difference in Accumulation of Bioactive Constituents in Licorice (Glycyrrhiza uralensis) under Drought Stress.
Molecules (Basel, Switzerland).
2023 Oct; 28(20):. doi:
10.3390/molecules28207042. [PMID: 37894521] - Kun Ren, Xuanmeng Zhang, Ruijie Wang, Shumeng Ren, Huiming Hua, Dongmei Wang, Yingni Pan, Xiaoqiu Liu. The inhibitory effect of licorice on the hepatotoxicity induced by the metabolic activation of Euodiae Fructus.
Journal of ethnopharmacology.
2023 Oct; 319(Pt 2):117233. doi:
10.1016/j.jep.2023.117233. [PMID: 37793580] - Fengyu Dong, Mengdi Xie, Manwen Xu, Lu Lu, Yan Miao, Panpan Zhang, Xiaopeng Li, Xinjing Gui, Ruixin Liu. Quality consistency evaluation of chemical composition and pharmacology of Shaoyao-Gancao decoction dispensing granules and traditional decoction.
Biomedical chromatography : BMC.
2023 Sep; ?(?):e5745. doi:
10.1002/bmc.5745. [PMID: 37736670] - Jingyuan Zeng, Xican Li, Rongxin Cai, Ban Chen, Chunhou Li, Qingzhong Hu, Yue Sun. Proposing anti-counterfeiting pharmacopoeia quality markers for Shenlingbaizhu granule based on UHPLC-Q-orbitrap-MS identification.
Phytochemical analysis : PCA.
2023 Sep; ?(?):. doi:
10.1002/pca.3284. [PMID: 37735858] - Jishuai Sun, Mingyang Sun, Jiachen Zang, Tuo Zhang, Chenyan Lv, Guanghua Zhao. Highly Stretchable, Transparent, and Adhesive Double-Network Hydrogel Dressings Tailored with Fish Gelatin and Glycyrrhizic Acid for Wound Healing.
ACS applied materials & interfaces.
2023 Sep; 15(36):42304-42316. doi:
10.1021/acsami.3c09615. [PMID: 37647580] - Ziyi Xu, Yu Huang, Yihan Wu, Jiamei Chen, Sai-Wang Seto, George Pak-Heng Leung, Yin Cai, Jingjing Li, Jinming Zhang. Glycyrrhizic Acid-Lipid Framework Nanovehicle Loading Triptolide for Combined Immunochemotherapy.
ACS applied materials & interfaces.
2023 Aug; ?(?):. doi:
10.1021/acsami.3c08003. [PMID: 37615350] - Yue Zhu, Teng Chen, Tingting Feng, Jiaojiao Zhang, Zejing Meng, Ning Zhang, Gang Luo, Zuhua Wang, Yuxin Pang, Ying Zhou. Fabrication and Biological Activities of All-in-One Composite Nanoemulsion Based on Blumea balsamifera Oil-Tea Tree Oil.
Molecules (Basel, Switzerland).
2023 Aug; 28(15):. doi:
10.3390/molecules28155889. [PMID: 37570859] - Zhuobin Xu, Ze Xu, Jiake Gu, Juan Zhou, Gengyu Sha, Ying Huang, Tong Wang, Lei Fan, Yanfeng Zhang, Juqun Xi. In situ formation of ferrous sulfide in glycyrrhizic acid hydrogels to promote healing of multi-drug resistant Staphylococcus aureus-infected diabetic wounds.
Journal of colloid and interface science.
2023 Jul; 650(Pt B):1918-1929. doi:
10.1016/j.jcis.2023.07.141. [PMID: 37517191] - Dalia Elebeedy, Aml Ghanem, Shaza H Aly, Mohamed A Ali, Ahmed H I Faraag, Mohamed K El-Ashrey, Aya M Salem, Mahmoud A El Hassab, Ahmed I Abd El Maksoud. Synergistic antiviral activity of Lactobacillus acidophilus and Glycyrrhiza glabra against Herpes Simplex-1 Virus (HSV-1) and Vesicular Stomatitis Virus (VSV): experimental and In Silico insights.
BMC microbiology.
2023 06; 23(1):173. doi:
10.1186/s12866-023-02911-z. [PMID: 37391715] - Xia Cao, Tianwen Deng, Qin Zhu, Jianping Wang, Wenwan Shi, Qi Liu, Qintong Yu, Wenwen Deng, Jiangnan Yu, Qilong Wang, Gao Xiao, Ximing Xu. Photothermal Therapy Mediated Hybrid Membrane Derived Nano-formulation for Enhanced Cancer Therapy.
AAPS PharmSciTech.
2023 Jun; 24(6):146. doi:
10.1208/s12249-023-02594-9. [PMID: 37380936] - Monojit Bhattacharjee, Suryaa Manoharan, Umamaheswari Sathisaran, Anand Tamatam, Ekambaram Perumal. MAO inhibiting phytochemicals from the roots of Glycyrrhiza glabra L.
Journal of biomolecular structure & dynamics.
2023 May; ?(?):1-19. doi:
10.1080/07391102.2023.2216298. [PMID: 37243713] - Yang Liu, Hao Wang, Xun Qian, Jie Gu, Weimin Chen, Xihui Shen, Shiheng Tao, Shuo Jiao, Gehong Wei. Metagenomics insights into responses of rhizobacteria and their alleviation role in licorice allelopathy.
Microbiome.
2023 05; 11(1):109. doi:
10.1186/s40168-023-01511-3. [PMID: 37211607] - Tahereh Naseriyeh, Danial Kahrizi, Hosna Alvandi, Faranak Aghaz, Ghazal Nowroozi, Alireza Shamsi, Omid Hosseini, Elham Arkan. Glycyrrhizic acid delivery system Chitosan-coated liposome as an adhesive anti-inflammation.
Cellular and molecular biology (Noisy-le-Grand, France).
2023 Apr; 69(4):1-6. doi:
10.14715/cmb/2023.69.4.1. [PMID: 37329555] - Kei Kawada, Tomoaki Ishida, Kohei Jobu, Shumpei Morisawa, Motoki Nishida, Naohisa Tamura, Saburo Yoshioka, Mitsuhiko Miyamura. Glycyrrhizae Radix suppresses lipopolysaccharide- and diazepam-induced nerve inflammation in the hippocampus, and contracts the duration of pentobarbital- induced loss of righting reflex in a mouse model.
Journal of natural medicines.
2023 Apr; ?(?):. doi:
10.1007/s11418-023-01700-2. [PMID: 37115471] - Jun-Pu Yang, Amin Ullah, Ya-Nan Su, Antonia Otoo, Enoch Appiah Adu-Gyamfi, Qian Feng, Ying-Xiong Wang, Mei-Jiao Wang, Yu-Bin Ding. Glycyrrhizin ameliorates impaired glucose metabolism and ovarian dysfunction in a polycystic ovary syndrome mouse model.
Biology of reproduction.
2023 Apr; ?(?):. doi:
10.1093/biolre/ioad048. [PMID: 37115805] - Alireza Poustforoosh, Sanaz Faramarz, Manica Negahdaripour, Burak Tüzün, Hassan Hashemipour. Tracing the pathways and mechanisms involved in the anti-breast cancer activity of glycyrrhizin using bioinformatics tools and computational methods.
Journal of biomolecular structure & dynamics.
2023 Apr; ?(?):1-15. doi:
10.1080/07391102.2023.2196347. [PMID: 37042955] - Yun Chen, Weiqiang Han, Shanshan Li, Yuntao Nie, Peng Chen, Juan Sun, Yuhua Chen, Lisha Li. Effects of mesotherapy introduction of compound glycyrrhizin injection on the treatment of moderate to severe acne.
Journal of cosmetic dermatology.
2023 Apr; ?(?):. doi:
10.1111/jocd.15681. [PMID: 37036158] - W Caré, G Grenet, C Schmitt, S Michel, J Langrand, G Le Roux, D Vodovar. [Adverse effects of licorice consumed as food: An update].
La Revue de medecine interne.
2023 Mar; ?(?):. doi:
10.1016/j.revmed.2023.03.004. [PMID: 37005098] - Yanyan Wang, Shuhua An. A rare pathogen causing pulmonary infection and liver dysfunction in a 46-day-old infant: Rhizobium radiobacter.
Paediatrics and international child health.
2023 Mar; ?(?):1-4. doi:
10.1080/20469047.2023.2188383. [PMID: 36914262] - JunMei Wang, Chunxiu Ren, WenHui Bi, Wuliji Batu. Glycyrrhizin mitigates acute lung injury by inhibiting the NLRP3 inflammasome in vitro and in vivo.
Journal of ethnopharmacology.
2023 Mar; 303(?):115948. doi:
10.1016/j.jep.2022.115948. [PMID: 36423713] - Shasha Kong, Pengyue Li, Robert Verpoorte, Mingqian Li, Yuntao Dai. Chemical and pharmacological difference between honey-fried licorice and fried licorice.
Journal of ethnopharmacology.
2023 Feb; 302(Pt A):115841. doi:
10.1016/j.jep.2022.115841. [PMID: 36270557] - Ting-Ting Yi, Li-Mei Zhang, Xiang-Nan Huang. Glycyrrhizic acid protects against temporal lobe epilepsy in young rats by regulating neuronal ferroptosis through the miR-194-5p/PTGS2 axis.
The Kaohsiung journal of medical sciences.
2023 Feb; 39(2):154-165. doi:
10.1002/kjm2.12642. [PMID: 36647717] - Qiming Yin, Xiang Song, Peng Yang, Wen Yang, Xinyu Li, Xuejun Wang, Shengqi Wang. Incorporation of glycyrrhizic acid and polyene phosphatidylcholine in lipid nanoparticles ameliorates acute liver injury via delivering p65 siRNA.
Nanomedicine : nanotechnology, biology, and medicine.
2023 02; 48(?):102649. doi:
10.1016/j.nano.2022.102649. [PMID: 36584740] - Xin Xu, Tong Wei, Qianqian Xue, Jiahao Ai, Guixin Li, Zhongguo Liu, Dan Li, Jincai Hou, Hongli Jin, Yanfang Liu, Xinmiao Liang. [Analysis on quality value transmitting of Qinggusan reference sample of classical prescription based on quantitative fingerprint technology].
Se pu = Chinese journal of chromatography.
2023 Feb; 41(2):142-151. doi:
10.3724/sp.j.1123.2022.09024. [PMID: 36725710] - Youngseok Ham, Tae-Jong Kim. Synergistic inhibitory activity of Glycyrrhizae Radix and Rubi Fructus extracts on biofilm formation of Streptococcus mutans.
BMC complementary medicine and therapies.
2023 Jan; 23(1):22. doi:
10.1186/s12906-023-03861-9. [PMID: 36709283] - Huihui Xu, Liang Fang, Qinghe Zeng, Jiali Chen, Houfu Ling, Hanting Xia, Qinwen Ge, Congzi Wu, Kaiao Zou, Xu Wang, Pinger Wang, Wenhua Yuan, Rui Dong, Songfeng Hu, Luwei Xiao, Bangjian He, Peijian Tong, Hongting Jin. Glycyrrhizic acid alters the hyperoxidative stress-induced differentiation commitment of MSCs by activating the Wnt/β-catenin pathway to prevent SONFH.
Food & function.
2023 Jan; 14(2):946-960. doi:
10.1039/d2fo02337g. [PMID: 36541285] - Yongfeng Zhou, Junnan Wang, Peng Tan, Qinghua Wu, Jiang Chen, Jiaxin Liu, Ping Zhang, Dingkun Zhang, Jin Pei. A novel method for quality consistency evaluation of Glycyrrhiza formula granules based on a spectrum-effect study.
Journal of separation science.
2023 Jan; 46(2):e202200433. doi:
10.1002/jssc.202200433. [PMID: 36373183] - Ulises Zendejas-Hernandez, Nemi Alcántara-Martínez, Diana Tovar Vivar, Fermín Valenzuela, Alejandro Sosa Espinoza, Eduardo Emir Cervera Ceballos. Nebulized glycyrrhizin/enoxolone drug modulates IL-17A in COVID-19 patients: a randomized clinical trial.
Frontiers in immunology.
2023; 14(?):1282280. doi:
10.3389/fimmu.2023.1282280. [PMID: 38283346] - Ze Xu, Zhiqi Gao, Jianxiu Lu, Tong Wang, Wenjuan Wang, Lei Fan, Juqun Xi, Benhong Han. Ferrous iron-induced formation of glycyrrhizic acid hydrogels for Staphylococcus aureus-infected wound healing.
Colloids and surfaces. B, Biointerfaces.
2023 Jan; 221(?):112977. doi:
10.1016/j.colsurfb.2022.112977. [PMID: 36343479] - Xiangjie Fu, Yaqiong Ni, Guanchen Wang, Runda Nie, Yang Wang, Run Yao, Danyang Yan, Mingming Guo, Ning Li. Synergistic and Long-Lasting Wound Dressings Promote Multidrug-Resistant Staphylococcus Aureus-Infected Wound Healing.
International journal of nanomedicine.
2023; 18(?):4663-4679. doi:
10.2147/ijn.s418671. [PMID: 37605733] - Huifang Li, Jing Wang, Yifan Fu, Ke Zhu, Zhiling Dong, Jinjun Shan, Liuqing Di, Shu Jiang, Tianjie Yuan. The Bioavailability of Glycyrrhizinic Acid Was Enhanced by Probiotic Lactobacillus rhamnosus R0011 Supplementation in Liver Fibrosis Rats.
Nutrients.
2022 Dec; 14(24):. doi:
10.3390/nu14245278. [PMID: 36558437] - Manman Guo, Zhongda Wang, Jinya Dai, Haizhen Fan, Ningning Yuan, Liming Gao, Huiping Peng, Xiaolan Cheng. Glycyrrhizic acid alleviates liver fibrosis in vitro and in vivo via activating CUGBP1-mediated IFN-γ/STAT1/Smad7 pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Dec; 112(?):154587. doi:
10.1016/j.phymed.2022.154587. [PMID: 36805480] - Xiaoxiang Xu, Juan Chang, Ping Wang, Chaoqi Liu, Mengjie Liu, Ting Zhou, Qingqiang Yin, Guorong Yan. Glycyrrhizic Acid and Compound Probiotics Supplementation Alters the Intestinal Transcriptome and Microbiome of Weaned Piglets Exposed to Deoxynivalenol.
Toxins.
2022 12; 14(12):. doi:
10.3390/toxins14120856. [PMID: 36548753] - Dian-Dong Hou, Xin-Xin Wang, Si-Jia Li, De-Cheng Wang, Yuan Niu, Zi-Ran Xu, Zhuo-Qun Jin. Glycyrrhizic acid suppresses atopic dermatitis-like symptoms by regulating the immune balance.
Journal of cosmetic dermatology.
2022 Dec; 21(12):7090-7099. doi:
10.1111/jocd.15383. [PMID: 36099014] - Chunjing Guo, Yanguo Su, Hui Wang, Min Cao, Ningning Diao, Zhongxin Liu, Daquan Chen, Ming Kong. A novel saponin liposomes based on the couplet medicines of Platycodon grandiflorum-Glycyrrhiza uralensis for targeting lung cancer.
Drug delivery.
2022 Dec; 29(1):2743-2750. doi:
10.1080/10717544.2022.2112997. [PMID: 35999702] - Sai Wang, Xin-Yu Li, Hong-Fang Ji, Liang Shen. Modulation of gut microbiota by glycyrrhizic acid may contribute to its anti-NAFLD effect in rats fed a high-fat diet.
Life sciences.
2022 Dec; 310(?):121110. doi:
10.1016/j.lfs.2022.121110. [PMID: 36272466] - Subhrojit Sen. Liposome-encapsulated glycyrrhizin alleviates hyperglycemia and glycation-induced iron-catalyzed oxidative reactions in streptozotocin-induced diabetic rats.
Journal of liposome research.
2022 Dec; 32(4):376-385. doi:
10.1080/08982104.2022.2036756. [PMID: 35166624] - Alexander N Shikov, Veronika A Shikova, Anastasiia O Whaley, Marina A Burakova, Elena V Flisyuk, Andrei K Whaley, Inna I Terninko, Yulia E Generalova, Irina V Gravel, Olga N Pozharitskaya. The Ability of Acid-Based Natural Deep Eutectic Solvents to Co-Extract Elements from the Roots of Glycyrrhiza glabra L. and Associated Health Risks.
Molecules (Basel, Switzerland).
2022 Nov; 27(22):. doi:
10.3390/molecules27227690. [PMID: 36431791] - Jomin Choe, Phaik Har Yong, Zhi Xiang Ng. The Efficacy of Traditional Medicinal Plants in Modulating the Main Protease of SARS-CoV-2 and Cytokine Storm.
Chemistry & biodiversity.
2022 Nov; 19(11):e202200655. doi:
10.1002/cbdv.202200655. [PMID: 36125969] - Rui Fan, Yanxiang Gao. Maillard and Hydrolytic Reactions in Subcritical Water Extraction of Bioactive Compounds from Licorice.
Molecules (Basel, Switzerland).
2022 Oct; 27(20):. doi:
10.3390/molecules27206851. [PMID: 36296445] - Fei Liu, Xin Tang, Bingyong Mao, Qiuxiang Zhang, Jianxin Zhao, Shumao Cui, Wei Chen. Ethanol Extract of Licorice Alleviates HFD-Induced Liver Fat Accumulation in Association with Modulation of Gut Microbiota and Intestinal Metabolites in Obesity Mice.
Nutrients.
2022 Oct; 14(19):. doi:
10.3390/nu14194180. [PMID: 36235833] - Liangyu Mu, Peiyao Wu, Ying Zhang, Shiqi Li, Rui Yang, ShuJun Wang. Development of a novel oral complex lipid emulsion containing triptolide for targeting pancreatic cancer.
Pharmaceutical development and technology.
2022 Oct; 27(8):881-891. doi:
10.1080/10837450.2022.2127767. [PMID: 36154850] - Chaofang Zhong, Chaoyun Chen, Xi Gao, Chongyang Tan, Hong Bai, Kang Ning. Multi-omics profiling reveals comprehensive microbe-plant-metabolite regulation patterns for medicinal plant Glycyrrhiza uralensis Fisch.
Plant biotechnology journal.
2022 10; 20(10):1874-1887. doi:
10.1111/pbi.13868. [PMID: 35668676] - Quanfu Zeng, Zhuxian Wang, Zhaoming Zhu, Yi Hu, Yuan Wang, Yaqi Xue, Yufan Wu, Yinglin Guo, Peiyi Liang, Hongkai Chen, Zeying Zheng, Chunyan Shen, Cuiping Jiang, Hongxia Zhu, Qun Shen, Yankui Yi, Hui Li, Zhijun Yang, Li Liu, Qiang Liu. Glycyrrhizin micellar nanocarriers for topical delivery of baicalin to the hair follicles: A targeted approach tailored for alopecia treatment.
International journal of pharmaceutics.
2022 Sep; 625(?):122109. doi:
10.1016/j.ijpharm.2022.122109. [PMID: 35973589] - Seyyed Sasan Mousavi, Akbar Karami, Mohammad Jamal Saharkhiz, Mohammad Etemadi, Mohammad Mehdi Zarshenas. Evaluation of metabolites in Iranian Licorice accessions under salinity stress and Azotobacter sp. inoculation.
Scientific reports.
2022 09; 12(1):15837. doi:
10.1038/s41598-022-20366-6. [PMID: 36151202] - Dechao Tan, Hisa Hui Ling Tseng, Zhangfeng Zhong, Shengpeng Wang, Chi Teng Vong, Yitao Wang. Glycyrrhizic Acid and Its Derivatives: Promising Candidates for the Management of Type 2 Diabetes Mellitus and Its Complications.
International journal of molecular sciences.
2022 Sep; 23(19):. doi:
10.3390/ijms231910988. [PMID: 36232291] - Botir Khaitov, Aziz Karimov, Jamila Khaitbaeva, Obidjon Sindarov, Akmal Karimov, Yongqing Li. Perspectives of Licorice Production in Harsh Environments of the Aral Sea Regions.
International journal of environmental research and public health.
2022 09; 19(18):. doi:
10.3390/ijerph191811770. [PMID: 36142045] - Huanyu Guan, Pengfei Li, Qian Wang, Fanli Zeng, Jiashuo Wu, Fangqing Zhang, Shanggao Liao, Yue Shi. Deciphering the chemical constituents of Shengjiang Xiexin decoction by ultrahigh-performance liquid chromatography-quadrupole/orbitrap high-resolution mass spectrometry and the impact of 20 characteristic components on multidrug resistance-associated protein 2 in the vesicular transport assay.
Journal of separation science.
2022 Sep; 45(18):3459-3479. doi:
10.1002/jssc.202200370. [PMID: 35838583] - Xia Mao, Yudong Liu, Weijie Li, Kexin Wang, Congchong Li, Qian Wang, Wenjia Chen, Zhaochen Ma, Xiaoyue Wang, Zihe Ding, Yanqiong Zhang, Na Lin. A promising drug combination of mangiferin and glycyrrhizic acid ameliorates disease severity of rheumatoid arthritis by reversing the disturbance of thermogenesis and energy metabolism.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Sep; 104(?):154216. doi:
10.1016/j.phymed.2022.154216. [PMID: 35749826] - Caiyun Chen, Gaotian Li, Long Dai, Huijuan Zhao, Ning Li, Wei Mi, Shuying Yin, Shaoping Wang, Jiayu Zhang. Simultaneous separation of glycyrrhizic acid, baicalein and wogonin from Radix Glycyrrhizae and Radix Scutellariae using foam fractionation and in vitro activity evaluation.
Journal of the science of food and agriculture.
2022 Sep; 102(12):5200-5209. doi:
10.1002/jsfa.11872. [PMID: 35289954] - Fei Gao, Fei Zhou, Shuai Gan, Ya-Lan Chen, Shu Fu, Mei-Si Lin, Chao-Mei Fu. [Comparative study on intestinal absorption kinetics of main active components in Sini Decoction and its separated recipes].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Sep; 47(18):5064-5070. doi:
10.19540/j.cnki.cjcmm.20220421.701. [PMID: 36164916] - Cai Zhang, Chenxu Li, Qi Shao, Sudan Meng, Xueying Wang, Tao Kong, Yu Li. Antioxidant monoammonium glycyrrhizinate alleviates damage from oxidative stress in perinatal cows.
Journal of animal physiology and animal nutrition.
2022 Aug; ?(?):. doi:
10.1111/jpn.13764. [PMID: 35989475] - Pooja Goyal, Malik Muzafar Manzoor, Ajai P Gupta, Pankaj Pandotra, Suphla Gupta. Molecular dissection of genes and promoters involved in glycyrrhizin biosynthesis revealed phytohormone induced modulation in Glycyrrhiza glabra L.
Gene.
2022 Aug; 836(?):146682. doi:
10.1016/j.gene.2022.146682. [PMID: 35714794] - Xin Zhao, Lingyu Li, Shuang Li, Jinyu Liu, Hongya Wang, Yulin Lin, Dayong Cai. Diammonium glycyrrhizinate ameliorates portal hypertension by regulating portal macrophage oxidation and superoxide dismutase 3.
European journal of pharmacology.
2022 Aug; 929(?):175115. doi:
10.1016/j.ejphar.2022.175115. [PMID: 35738453] - Jiarun Gu, Xufei Ran, Jin Deng, Anqiang Zhang, Guoxuan Peng, Juan Du, Dalin Wen, Baowei Jiang, Fei Xia. Glycyrrhizin alleviates sepsis-induced acute respiratory distress syndrome via suppressing of HMGB1/TLR9 pathways and neutrophils extracellular traps formation.
International immunopharmacology.
2022 Jul; 108(?):108730. doi:
10.1016/j.intimp.2022.108730. [PMID: 35354111] - Jia-Bo Wang, Ang Huang, Yijin Wang, Dong Ji, Zhengsheng Zou. Editorial: chronic DILI and HILI-corticosteroid plus glycyrrhizin as standard therapy? Authors' reply.
Alimentary pharmacology & therapeutics.
2022 07; 56(1):168-169. doi:
10.1111/apt.16983. [PMID: 35689319] - Yue Liu, Juan Luo, Yong-Zhe Gu, Yun Luo, Ting Tan, Zheng-Gen Liao, Ming Yang. [Comparative analysis of powder and piece decocting processes of Yinqiao Powder based on determination of multiple primary components].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Jul; 47(14):3788-3797. doi:
10.19540/j.cnki.cjcmm.20210913.302. [PMID: 35850836] - Qingyu Ren, Xin Jiang, Yam Nath Paudel, Xin Gao, Daili Gao, Pengyu Zhang, Wenlong Sheng, Xueliang Shang, Kechun Liu, Xiujun Zhang, Meng Jin. Co-treatment with natural HMGB1 inhibitor Glycyrrhizin exerts neuroprotection and reverses Parkinson's disease like pathology in Zebrafish.
Journal of ethnopharmacology.
2022 Jun; 292(?):115234. doi:
10.1016/j.jep.2022.115234. [PMID: 35358621] - Kaili Deng, Ze Dai, Ping Yang, Dongxue Yang, Yuping Zhou. LPS-induced macrophage exosomes promote the activation of hepatic stellate cells and the intervention study of total astragalus saponins combined with glycyrrhizic acid.
Anatomical record (Hoboken, N.J. : 2007).
2022 Jun; ?(?):. doi:
10.1002/ar.25009. [PMID: 35730909] - Kei Kawada, Tomoaki Ishida, Kohei Jobu, Shumpei Morisawa, Tetsushi Kawazoe, Motoki Nishida, Satomi Nishimura, Naohisa Tamura, Saburo Yoshioka, Mitsuhiko Miyamura. Yokukansan suppresses neuroinflammation in the hippocampus of mice and decreases the duration of lipopolysaccharide- and diazepam-mediated loss of righting reflex induced by pentobarbital.
Journal of natural medicines.
2022 Jun; 76(3):634-644. doi:
10.1007/s11418-022-01612-7. [PMID: 35257304] - Juntong Li, Yan Gao, Liyuan Cui, Hongyuan He, Jianyong Zheng, Shu Mo, Xin Zhou, Shifeng Chu, Xiaoyun Sun, Naihong Chen, Hong Wang. Combination of monoammonium glycyrrhizinate and cysteine hydrochloride protects mice against acetaminophen-induced liver injury via Keap1/Nrf2/ARE pathway.
The Journal of pharmacy and pharmacology.
2022 May; 74(5):730-739. doi:
10.1093/jpp/rgab180. [PMID: 35355074] - Gang Wang, Aihua Ye, Xiangyu Xu, Chen Chen, Jiaoli Yang. Desloratadine citrate combined with compound glycyrrhizin in the treatment of subacute eczema: A randomized trial.
Pakistan journal of pharmaceutical sciences.
2022 May; 35(3(Special)):919-922. doi:
. [PMID: 35791588] - Seshu Vardhan, Suban K Sahoo. Computational studies on the interaction of SARS-CoV-2 Omicron SGp RBD with human receptor ACE2, limonin and glycyrrhizic acid.
Computers in biology and medicine.
2022 05; 144(?):105367. doi:
10.1016/j.compbiomed.2022.105367. [PMID: 35247766] - Jia-Bo Wang, Ang Huang, Yijin Wang, Dong Ji, Qing-Sheng Liang, Jun Zhao, Guangde Zhou, Shuhong Liu, Ming Niu, Ying Sun, Hui Tian, Guang-Ju Teng, Bin-Xia Chang, Jing-Feng Bi, Xiao-Xia Peng, Shaojie Xin, Huan Xie, Xiong Ma, Yi-Min Mao, Suthat Liangpunsakul, Romil Saxena, Guruprasad P Aithal, Xiao-He Xiao, Jingmin Zhao, Zhengsheng Zou. Corticosteroid plus glycyrrhizin therapy for chronic drug- or herb-induced liver injury achieves biochemical and histological improvements: a randomised open-label trial.
Alimentary pharmacology & therapeutics.
2022 05; 55(10):1297-1310. doi:
10.1111/apt.16902. [PMID: 35362188] - Rifika Jain, Mohamed Ali Hussein, Shannon Pierce, Chad Martens, Preksha Shahagadkar, Gnanasekar Munirathinam. Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives: Molecular insights.
Pharmacological research.
2022 04; 178(?):106138. doi:
10.1016/j.phrs.2022.106138. [PMID: 35192957] - Adel A Gomaa, Hamdy S Mohamed, Rasha B Abd-Ellatief, Mohamed A Gomaa, Doaa S Hammam. Advancing combination treatment with glycyrrhizin and boswellic acids for hospitalized patients with moderate COVID-19 infection: a randomized clinical trial.
Inflammopharmacology.
2022 Apr; 30(2):477-486. doi:
10.1007/s10787-022-00939-7. [PMID: 35233748] - Yongqing Li, Mingju Hao, Bingyang Zhang, Peijun Wang, Dantong Zhang, Sumei Lu, Wanshan Ma. Meta-analysis of the efficacy of glycyrrhizin for postoperative liver preservation in patients with liver cancer.
Journal of cancer research and therapeutics.
2022 Apr; 18(2):461-469. doi:
10.4103/jcrt.jcrt_1811_21. [PMID: 35645115] - Hui Xie, Li Lin, Huan-Huan Li, Jing Mao, Jin-Guo Xu, Chun-Qin Mao, Peng Li, Yin-Hong Shen-Tu, Tu-Lin Lu. [Characteristic chromatogram and index components content of substance benchmark of Xuanfu Daizhe Decoction].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Apr; 47(8):2090-2098. doi:
10.19540/j.cnki.cjcmm.20210604.301. [PMID: 35531725] - Yang Xin, Kaichen Yu, Yang Yu, Haijun Wang. Filtration and qualification for target biomarkers of traditional Chinese medicine formula "fuzi lizhong decoction" acting on stomach ulcer by UPLC/Q-TOF MS.
Pakistan journal of pharmaceutical sciences.
2022 Mar; 35(2):519-528. doi:
. [PMID: 35642408] - Kritamorn Jitrangsri, Kazuaki Kamata, Mana Akiba, Yoshie Yajiri, Masami Ishibashi, Jin Tatsuzaki, Tsutomu Ishikawa. Is 18α-Glycyrrhizin a real natural product? Improved preparation of 18α-Glycyrrhizin from 18β-Glycyrrhizin as a positive standard for HPLC analysis of licorice extracts.
Journal of natural medicines.
2022 Mar; 76(2):367-378. doi:
10.1007/s11418-021-01589-9. [PMID: 35083719] - R Tan, X Xiang, W Chen, Z Yang, W Hu, H Qu, J Liu. Efficacy of diammonium glycyrrhizinate combined with vitamin C for treating hospitalized COVID-19 patients: a retrospective, observational study.
QJM : monthly journal of the Association of Physicians.
2022 Feb; 115(2):77-83. doi:
10.1093/qjmed/hcab184. [PMID: 34314507] - Pruthvi Gowda, Shruti Patrick, Shanker Datt Joshi, Rajesh Kumar Kumawat, Ellora Sen. Repurposing Methotrexate in Dampening SARS-CoV2-S1-Mediated IL6 Expression: Lessons Learnt from Lung Cancer.
Inflammation.
2022 Feb; 45(1):172-179. doi:
10.1007/s10753-021-01536-6. [PMID: 34480250] - Zhenkui Zuo, Lulu He, Xiaoyu Duan, Zining Peng, Jiarui Han. Glycyrrhizic acid exhibits strong anticancer activity in colorectal cancer cells via SIRT3 inhibition.
Bioengineered.
2022 02; 13(2):2720-2731. doi:
10.1080/21655979.2021.2001925. [PMID: 34747319] - Yangye Chen, Lihua Qu, Yi Li, Chao Chen, Wei He, Li Shen, Ran Zhang. Glycyrrhizic Acid Alleviates Lipopolysaccharide (LPS)-Induced Acute Lung Injury by Regulating Angiotensin-Converting Enzyme-2 (ACE2) and Caveolin-1 Signaling Pathway.
Inflammation.
2022 Feb; 45(1):253-266. doi:
10.1007/s10753-021-01542-8. [PMID: 34427852] - Anxin Wu, Chonghao Chen, Jing Lu, Jiayi Sun, Meng Xiao, Xuan Yue, Ping Zhou, Shiyi Zhao, Guofeng Zhong, Chi Huang, Yan Qu, Chen Zhang. Preparation of Oral Core-Shell Zein Nanoparticles to Improve the Bioavailability of Glycyrrhizic Acid for the Treatment of Ulcerative Colitis.
Biomacromolecules.
2022 01; 23(1):210-225. doi:
10.1021/acs.biomac.1c01233. [PMID: 34905341] - Vladislav V Fomenko, Nadezhda B Rudometova, Olga I Yarovaya, Artem D Rogachev, Anastasia A Fando, Anna V Zaykovskaya, Nina I Komarova, Dmitry N Shcherbakov, Oleg V Pyankov, Andrey G Pokrovsky, Larisa I Karpenko, Rinat A Maksyutov, Nariman F Salakhutdinov. Synthesis and In Vitro Study of Antiviral Activity of Glycyrrhizin Nicotinate Derivatives against HIV-1 Pseudoviruses and SARS-CoV-2 Viruses.
Molecules (Basel, Switzerland).
2022 Jan; 27(1):. doi:
10.3390/molecules27010295. [PMID: 35011529] - Zulfiqar Ali, Mohammed Hawwal, Mohammed M A Ahmed, Bharathi Avula, Amar G Chittiboyina, Jing Li, Charles Wu, Cassandra Taylor, Yen-Ming Chan, Ikhlas A Khan. Licochalcone L, an undescribed retrochalcone from Glycyrrhiza inflata roots.
Natural product research.
2022 Jan; 36(1):200-206. doi:
10.1080/14786419.2020.1775229. [PMID: 32498569]
