Mepindolol (BioDeep_00000858892)

   


代谢物信息卡片


rac Mepindolol-d7

  化学式: C15H22N2O2 (262.1681)
中文名称: 甲吲哚心安
  谱图信息: 最多检出来源 () %

分子结构信息

SMILES: CC1=CC2=C(N1)C=CC=C2OCC(CNC(C)C)O
InChI: InChI=1S/C15H22N2O2/c1-10(2)16-8-12(18)9-19-15-6-4-5-14-13(15)7-11(3)17-14/h4-7,10,12,16-18H,8-9H2,1-3H3


描述信息

C - Cardiovascular system > C07 - Beta blocking agents > C07A - Beta blocking agents > C07AA - Beta blocking agents, non-selective
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists

同义名列表

2 个代谢物同义名

rac Mepindolol-d7; Mepindolol



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome()

BioCyc()

PlantCyc()

代谢反应

个相关的代谢反应过程信息。

Reactome()

BioCyc()

WikiPathways()

Plant Reactome()

INOH()

PlantCyc()

COVID-19 Disease Map()

PathBank()

PharmGKB()

个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • László Gagyi, Arpád Gyéresi, Ferenc Kilár. Role of chemical structure in stereoselective recognition of beta-blockers and H1-antihistamines by human serum transferrin in capillary zone electrophoresis. Electrophoresis. 2006 Apr; 27(8):1510-6. doi: 10.1002/elps.200500787. [PMID: 16609932]
  • B Fabris, F De Biasi, F Fischetti, R Leprini, M Castellano, R Carretta. [Activity and number of lymphocyte beta adrenergic receptors after protracted treatment with mepindolol sulfate of patients with essential arterial hypertension]. Giornale di clinica medica. 1990 Nov; 71(11):639-44. doi: NULL. [PMID: 1964919]
  • I Meineke, S Hartnack, C De Mey. Determination of mepindolol in plasma after transdermal drug delivery by high-performance liquid chromatography with electrochemical detection. Journal of chromatography. 1990 Mar; 526(1):240-5. doi: 10.1016/s0378-4347(00)82505-0. [PMID: 2341539]
  • J B Serro-Azul, M Wajngarten, A Santomauro, A Braga, P Yazbek Júnior, G Bellotti, L G Serro-Azul, F Pileggi. [Effect of beta blockers with intrinsic sympathomimetic activity on blood pressure and blood lipids in patients with essential hypertension]. Arquivos brasileiros de cardiologia. 1989 Dec; 53(6):321-5. doi: NULL. [PMID: 2700113]
  • C de Mey, I Meineke, D Enterling, C Rehbock, H Osterwald. Transdermal delivery of mepindolol and propranolol in normal man. 2nd communication: pharmacokinetic and neuro-endocrine aspects. Arzneimittel-Forschung. 1989 Nov; 39(11A):1508-12. doi: NULL. [PMID: 2576201]
  • R K Liedtke, L S Chen, B Mangold, W Haase. [Human pharmacologic studies on transdermal administration of mepindolol. Pharmacodynamic and orienting pharmacokinetics]. Arzneimittel-Forschung. 1989 Nov; 39(11A):1501-4. doi: NULL. [PMID: 2576199]
  • H Humbert, J Denouel, H P Keller. Column liquid chromatographic determination of hydrolysed bopindolol, in the picogram per millilitre range in plasma, using cartridge extraction and dual electrochemical detection. Journal of chromatography. 1987 Nov; 422(?):205-15. doi: 10.1016/0378-4347(87)80453-x. [PMID: 2893803]
  • C Pasotti, A Zoppi, A Capra, M Rebagliati, R Fogari. Effect of beta-blockers on plasma lipids. International journal of clinical pharmacology, therapy, and toxicology. 1986 Aug; 24(8):448-52. doi: NULL. [PMID: 3759280]
  • O E Brodde, A Daul, N Stuka, N O'Hara, U Borchard. Effects of beta-adrenoceptor antagonist administration on beta 2-adrenoceptor density in human lymphocytes. The role of the 'intrinsic sympathomimetic activity'. Naunyn-Schmiedeberg's archives of pharmacology. 1985 Feb; 328(4):417-22. doi: 10.1007/bf00692910. [PMID: 2859531]
  • W Krause, D Kampf, H C Fischer. Pharmacokinetics of mepindolol in patients with chronic renal failure. European journal of clinical pharmacology. 1984; 27(4):429-33. doi: 10.1007/bf00549590. [PMID: 6519149]
  • W Krause, C Lennert. Pharmacokinetics of mepindolol administered alone and in combination with hydrochlorothiazide--a bioequivalence study. Biopharmaceutics & drug disposition. 1983 Oct; 4(4):339-45. doi: 10.1002/bdd.2510040406. [PMID: 6689277]
  • W Krause, G Kühne. Pharmacokinetics of mepindolol sulfate in the rat, dog, and rhesus monkey. Studies on species differences. Drug metabolism and disposition: the biological fate of chemicals. 1983 Mar; 11(2):91-6. doi: NULL. [PMID: 6133729]
  • W Krause, W Schwartzkopff. Plasma levels of mepindolol in healthy volunteers after oral doses of mepindolol sulphate. Arzneimittel-Forschung. 1983; 33(9):1306-7. doi: NULL. [PMID: 6685513]
  • A Martignoni, G Perani, G Finardi, E Mastropasqua, R Fogari. Effect of mepindolol on serum lipids. International journal of clinical pharmacology, therapy, and toxicology. 1982 Nov; 20(11):543-5. doi: NULL. [PMID: 7174157]
  • W Krause, I Stoppelli, S Milia, E Rainer. Transfer of mepindolol to newborns by breast-feeding mothers after single and repeated daily doses. European journal of clinical pharmacology. 1982; 22(1):53-5. doi: 10.1007/bf00606425. [PMID: 7094975]
  • M B Barontini, C A Feldstein, M I Armando, A Marchezotti, G M Levin, A Vilches, A Olivieri, J E Burucua. Sympathetic nervous system response to graded exercise: effect of beta-blockade. Hypertension (Dallas, Tex. : 1979). 1981 Nov; 3(6 Pt 2):II-155. doi: 10.1161/01.hyp.3.6_pt_2.ii-155. [PMID: 6117516]
  • W Krause. Determination of plasma mepindolol levels by high-performance liquid chromatography and electrochemical detection. Journal of chromatography. 1980 Jan; 181(1):67-75. doi: 10.1016/s0378-4347(00)81270-0. [PMID: 7364917]
  • W Krause, G Kühne, U Täuber. Pharmacokinetics of mepindolol sulphate in animals. European journal of drug metabolism and pharmacokinetics. 1980; 5(4):241-7. doi: 10.1007/bf03189470. [PMID: 6113960]
  • J Bonelli, H Hörtnagl, T Brücke, D Magometschnigg, H Lochs, G Kaik. Effect of calculation stress on hemodynamics and plasma catecholamines before and after beta-blockade with propranolol (Inderal) and mepindolol sulfate (Corindolan). European journal of clinical pharmacology. 1979 Feb; 15(1):1-8. doi: 10.1007/bf00563551. [PMID: 421725]