Nemiralisib (BioDeep_00000858890)
代谢物信息卡片
化学式: C26H28N6O (440.2324478)
中文名称: 奈米利塞
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)N1CCN(CC1)CC2=CN=C(O2)C3=C4C=NNC4=CC(=C3)C5=C6C=CNC6=CC=C5
InChI: InChI=1S/C26H28N6O/c1-17(2)32-10-8-31(9-11-32)16-19-14-28-26(33-19)22-12-18(13-25-23(22)15-29-30-25)20-4-3-5-24-21(20)6-7-27-24/h3-7,12-15,17,27H,8-11,16H2,1-2H3,(H,29,30)
描述信息
D004791 - Enzyme Inhibitors > D047428 - Protein Kinase Inhibitors
C78273 - Agent Affecting Respiratory System
同义名列表
1 个代谢物同义名
数据库引用编号
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相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Neil A Miller, Rebecca H Graves, Chris D Edwards, Augustin Amour, Ed Taylor, Olivia Robb, Brett O'Brien, Aarti Patel, Andrew W Harrell, Edith M Hessel. Physiologically Based Pharmacokinetic Modelling of Inhaled Nemiralisib: Mechanistic Components for Pulmonary Absorption, Systemic Distribution, and Oral Absorption.
Clinical pharmacokinetics.
2022 02; 61(2):281-293. doi:
10.1007/s40262-021-01066-2. [PMID: 34458976] - William A Fahy, Farshid Homayoun-Valiani, Anthony Cahn, Jon Robertson, Alison Templeton, Wilhelmine H Meeraus, Robert Wilson, Mike Lowings, Miriam Marotti, Sarah L West, Maggie Tabberer, Edith M Hessel. Nemiralisib in Patients with an Acute Exacerbation of COPD: Placebo-Controlled, Dose-Ranging Study.
International journal of chronic obstructive pulmonary disease.
2021; 16(?):1637-1646. doi:
10.2147/copd.s309320. [PMID: 34113095] - Andrew W Harrell, Robert Wilson, Yau Lun Man, Kylie Riddell, Emily Jarvis, Graeme Young, Robert Chambers, Lee Crossman, Alex Georgiou, Adrian Pereira, David Kenworthy, Claire Beaumont, Miriam Marotti, Denisa Wilkes, Edith M Hessel, William A Fahy. An Innovative Approach to Characterize Clinical ADME and Pharmacokinetics of the Inhaled Drug Nemiralisib Using an Intravenous Microtracer Combined with an Inhaled Dose and an Oral Radiolabel Dose in Healthy Male Subjects.
Drug metabolism and disposition: the biological fate of chemicals.
2019 12; 47(12):1457-1468. doi:
10.1124/dmd.119.088344. [PMID: 31649125] - M Begg, R Wilson, J N Hamblin, M Montembault, J Green, A Deans, A Amour, S Worsley, K Fantom, Y Cui, G Dear, S Ahmad, A Kielkowska, J Clark, M Boyce, A Cahn, E M Hessel. Relationship between Pharmacokinetics and Pharmacodynamic Responses in Healthy Smokers Informs a Once-Daily Dosing Regimen for Nemiralisib.
The Journal of pharmacology and experimental therapeutics.
2019 06; 369(3):337-344. doi:
10.1124/jpet.118.255109. [PMID: 30886125] - Robert Wilson, Alison Templeton, Claudia Leemereise, Rhena Eames, Edward Banham-Hall, Edith M Hessel, Anthony Cahn. Safety, Tolerability, and Pharmacokinetics of a New Formulation of Nemiralisib Administered via a Dry Powder Inhaler to Healthy Individuals.
Clinical therapeutics.
2019 06; 41(6):1214-1220. doi:
10.1016/j.clinthera.2019.04.008. [PMID: 31076203] - Aimie E Garces, Michael J Stocks. Class 1 PI3K Clinical Candidates and Recent Inhibitor Design Strategies: A Medicinal Chemistry Perspective.
Journal of medicinal chemistry.
2019 05; 62(10):4815-4850. doi:
10.1021/acs.jmedchem.8b01492. [PMID: 30582807] - Hiroko Ino, Robert Wilson, Takumi Terao, Hirofumi Ogura, Harue Igarashi, Anthony Cahn, Yotaro Numachi. Evaluation of the Safety, Tolerability, and Pharmacokinetics of GSK2269557 (Nemiralisib) Administered Via Dry Powder Inhaler to Healthy Japanese Subjects.
Clinical pharmacology in drug development.
2019 01; 8(1):78-86. doi:
10.1002/cpdd.614. [PMID: 30303626] - Nick Barton, Máire Convery, Anthony W J Cooper, Kenneth Down, J Nicole Hamblin, Graham Inglis, Simon Peace, James Rowedder, Paul Rowland, Jonathan A Taylor, Natalie Wellaway. Discovery of Potent, Efficient, and Selective Inhibitors of Phosphoinositide 3-Kinase δ through a Deconstruction and Regrowth Approach.
Journal of medicinal chemistry.
2018 12; 61(24):11061-11073. doi:
10.1021/acs.jmedchem.8b01556. [PMID: 30532965] - Sanjeev Khindri, Anthony Cahn, Malcolm Begg, Mickael Montembault, Claudia Leemereise, Yi Cui, Annabel Hogg, Hannah Wajdner, Shuying Yang, Jon Robertson, J Nicole Hamblin, Andrea Ludwig-Sengpiel, Oliver Kornmann, Edith M Hessel. A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Crossover Study To Investigate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Repeat Doses of Inhaled Nemiralisib in Adults with Persistent, Uncontrolled Asthma.
The Journal of pharmacology and experimental therapeutics.
2018 12; 367(3):405-413. doi:
10.1124/jpet.118.249516. [PMID: 30217958] - Robert Wilson, Emily Jarvis, Mickael Montembault, J Nicole Hamblin, Edith M Hessel, Anthony Cahn. Safety, Tolerability, and Pharmacokinetics of Single and Repeat Doses of Nemiralisib Administered via the Ellipta Dry Powder Inhaler to Healthy Subjects.
Clinical therapeutics.
2018 08; 40(8):1410-1417. doi:
10.1016/j.clinthera.2018.06.011. [PMID: 30055824] - A Cahn, J N Hamblin, M Begg, R Wilson, L Dunsire, S Sriskantharajah, M Montembault, C N Leemereise, L Galinanes-Garcia, H Watz, A M Kirsten, R Fuhr, E M Hessel. Safety, pharmacokinetics and dose-response characteristics of GSK2269557, an inhaled PI3Kδ inhibitor under development for the treatment of COPD.
Pulmonary pharmacology & therapeutics.
2017 Oct; 46(?):69-77. doi:
10.1016/j.pupt.2017.08.008. [PMID: 28823947]