Idalopirdine (BioDeep_00000858882)
代谢物信息卡片
化学式: C20H19F5N2O (398.1417464)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=CC(=C1)OCC(C(F)F)(F)F)CNCCC2=CNC3=C2C=CC(=C3)F
InChI: InChI=1S/C20H19F5N2O/c21-15-4-5-17-14(11-27-18(17)9-15)6-7-26-10-13-2-1-3-16(8-13)28-12-20(24,25)19(22)23/h1-5,8-9,11,19,26-27H,6-7,10,12H2
描述信息
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
C78272 - Agent Affecting Nervous System > C66885 - Serotonin Antagonist
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D10710
- PubChem: 21071390
- DrugBank: DB11957
- ChEMBL: CHEMBL3286580
- CAS: 467459-31-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Jakub Staroń, Rafał Kurczab, Dawid Warszycki, Grzegorz Satała, Martyna Krawczyk, Ryszard Bugno, Tomasz Lenda, Piotr Popik, Adam S Hogendorf, Agata Hogendorf, Krzysztof Dubiel, Mikołaj Matłoka, Rafał Moszczyński-Pętkowski, Jerzy Pieczykolan, Maciej Wieczorek, Paweł Zajdel, Andrzej J Bojarski. Virtual screening-driven discovery of dual 5-HT6/5-HT2A receptor ligands with pro-cognitive properties.
European journal of medicinal chemistry.
2020 Jan; 185(?):111857. doi:
10.1016/j.ejmech.2019.111857
. [PMID: 31734022] - Magdalena Kotańska, Klaudia Lustyk, Adam Bucki, Monika Marcinkowska, Joanna Śniecikowska, Marcin Kołaczkowski. Idalopirdine, a selective 5-HT6 receptor antagonist, reduces food intake and body weight in a model of excessive eating.
Metabolic brain disease.
2018 06; 33(3):733-740. doi:
10.1007/s11011-017-0175-1
. [PMID: 29297106] - J S Dileep Kumar, Mary Walker, Mathivanan Packiarajan, Vrej Jubian, Jaya Prabhakaran, Gamini Chandrasena, Mali Pratap, Ramin V Parsey, J John Mann. Radiosynthesis and in Vivo Evaluation of Neuropeptide Y5 Receptor (NPY5R) PET Tracers.
ACS chemical neuroscience.
2016 05; 7(5):540-5. doi:
10.1021/acschemneuro.5b00315
. [PMID: 26886507] - Magdalena Dudek, Monika Marcinkowska, Adam Bucki, Adrian Olczyk, Marcin Kołaczkowski. Idalopirdine - a small molecule antagonist of 5-HT6 with therapeutic potential against obesity.
Metabolic brain disease.
2015 Dec; 30(6):1487-94. doi:
10.1007/s11011-015-9736-3
. [PMID: 26419385] - Jorn Arnt, Benny Bang-Andersen, Ben Grayson, Franklin P Bymaster, Michael P Cohen, Neil W DeLapp, Bruno Giethlen, Mads Kreilgaard, David L McKinzie, Joanna C Neill, David L Nelson, Søren M Nielsen, Mette N Poulsen, John M Schaus, Louise M Witten. Lu AE58054, a 5-HT6 antagonist, reverses cognitive impairment induced by subchronic phencyclidine in a novel object recognition test in rats.
The international journal of neuropsychopharmacology.
2010 Sep; 13(8):1021-33. doi:
10.1017/s1461145710000659
. [PMID: 20569520]