Lisinopril diydrate (BioDeep_00000858877)
代谢物信息卡片
Lisinopril dihydrate
化学式: C21H35N3O7 (441.2475)
中文名称: 赖诺普利 二水合物
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC(N(C1)C(=O)C(CCCCN)NC(CCC2=CC=CC=C2)C(=O)O)C(=O)O.O.O
InChI: /m0../s1
描述信息
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D000806 - Angiotensin-Converting Enzyme Inhibitors
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor > C247 - ACE Inhibitor
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D020011 - Protective Agents > D002316 - Cardiotonic Agents
同义名列表
2 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:6503
- KEGGdrug: D00362
- PubChem: 5362118
- ChEMBL: CHEMBL419213
- MeSH: Lisinopril
- CAS: 83915-83-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Juan Cruz Carrizo, Sung Vo Duy, Gabriel Munoz, Guido Marconi, María Valeria Amé, Sébastien Sauvé. Suspect screening of pharmaceuticals, illicit drugs, pesticides, and other emerging contaminants in Argentinean Piaractus mesopotamicus, a fish species used for local consumption and export.
Chemosphere.
2022 Dec; 309(Pt 1):136769. doi:
10.1016/j.chemosphere.2022.136769. [PMID: 36209849] - Stephen Y Wang, Jonathan M Hanna, Prajesh Gongal, Oyere K Onuma, Michael G Nanna. Choice of antihypertensive agent in isolated systolic hypertension and isolated diastolic hypertension: A secondary analysis of the ALLHAT trial.
American heart journal.
2022 Dec; 254(?):30-34. doi:
10.1016/j.ahj.2022.07.006. [PMID: 35932912] - Adeniyi A Adebayo, Leye J Babatola, Christianah B Fasanya, Ganiyu Oboh. Persea americana seed extract restores defective sperm quality and biochemical parameters relevant to reproduction in male wistar rats treated with cyclosporine A.
Journal of food biochemistry.
2022 11; 46(11):e14220. doi:
10.1111/jfbc.14220. [PMID: 35561037] - Hany H Arab, Sarah A Abd El-Aal, Ahmed M Ashour, Azza A K El-Sheikh, Hana J Al Khabbaz, El-Shaimaa A Arafa, Ayman M Mahmoud, Ahmed M Kabel. Targeting inflammation and redox perturbations by lisinopril mitigates Freund's adjuvant-induced arthritis in rats: role of JAK-2/STAT-3/RANKL axis, MMPs, and VEGF.
Inflammopharmacology.
2022 Oct; 30(5):1909-1926. doi:
10.1007/s10787-022-00998-w. [PMID: 35764864] - Ting Li, Yan-Ping Liu, Shu-Qin Liu, Ping Shi, Xin Jiang, Ye Tao, Xiao-Meng Gao, Ya-Ping Ma, Yu Cao. Bioequivalence evaluation and food effect assessment of Lisinopril/amlodipine tablets in healthy Chinese subjects under fasting and fed conditions.
BMC pharmacology & toxicology.
2022 07; 23(1):45. doi:
10.1186/s40360-022-00590-6. [PMID: 35794660] - Feng Gao, Wei Dong, Pengyuan Liu, Jayashree Narayanan, Brian L Fish, Elizabeth R Jacobs, Meetha Medhora. Molecular Changes in miRNA in Irradiated Rat Kidneys: Role of miR-34a and its Vascular Targets in the Notch Pathway.
Radiation research.
2021 12; 196(6):611-622. doi:
10.1667/rade-20-00078.1. [PMID: 34330145] - Robert Krysiak, Marcin Basiak, Bogusław Okopień. Impact of Lisinopril on Cardiometabolic Risk Factors in Men With Hypertension and Early-onset Androgenetic Alopecia: A Pilot Study.
Journal of cardiovascular pharmacology.
2021 11; 78(5):e738-e742. doi:
10.1097/fjc.0000000000001113. [PMID: 34321400] - Nathan K Itoga, Daniel S Tawfik, Maria E Montez-Rath, Tara I Chang. Contributions of Systolic and Diastolic Blood Pressures to Cardiovascular Outcomes in the ALLHAT Study.
Journal of the American College of Cardiology.
2021 10; 78(17):1671-1678. doi:
10.1016/j.jacc.2021.08.035. [PMID: 34674811] - Jessika Iwanski, Sobhi G Kazmouz, Shuaizhi Li, Ben Stansfield, Tori T Salem, Samantha Perez-Miller, Toshinobu Kazui, Lipsa Jena, Jennifer L Uhrlaub, Scott Lick, Janko Nikolich-Žugich, John P Konhilas, Carol C Gregorio, May Khanna, Samuel K Campos, Jared M Churko. Antihypertensive drug treatment and susceptibility to SARS-CoV-2 infection in human PSC-derived cardiomyocytes and primary endothelial cells.
Stem cell reports.
2021 10; 16(10):2459-2472. doi:
10.1016/j.stemcr.2021.08.018. [PMID: 34525378] - Xuming Sun, Hao Wang, Hunter Hodge, Kendra N Wright, Sarfaraz Ahmad, Carlos M Ferrario, Leanne Groban. Amplifying effect of chronic lisinopril therapy on diastolic function and the angiotensin-(1-7) Axis by the G1 agonist in ovariectomized spontaneously hypertensive rats.
Translational research : the journal of laboratory and clinical medicine.
2021 09; 235(?):62-76. doi:
10.1016/j.trsl.2021.04.004. [PMID: 33915312] - Mette V Østergaard, Thomas Secher, Michael Christensen, Casper Gravesen Salinas, Urmas Roostalu, Jacob Lercke Skytte, Ida Rune, Henrik H Hansen, Jacob Jelsing, Niels Vrang, Lisbeth N Fink. Therapeutic effects of lisinopril and empagliflozin in a mouse model of hypertension-accelerated diabetic kidney disease.
American journal of physiology. Renal physiology.
2021 08; 321(2):F149-F161. doi:
10.1152/ajprenal.00154.2021. [PMID: 34180715] - Mohamed Salem, Al-Aliaa M Sallam, Eman Abdel-Aleem, Hala O El-Mesallamy. Effect of Lisinopril and Verapamil on Angiopoietin 2 and Endostatin in Hypertensive Diabetic Patients with Nephropathy: A Randomized Trial.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2021 Jul; 53(7):470-477. doi:
10.1055/a-1517-6643. [PMID: 34282598] - Latifat Bolanle Ibrahim, Patience Funmilayo Idowu, S Opemipo Adekanye Mose, Mutiu Adewunmi Alabi, Emmanuel Oladipo Ajani. Antidiabetic Potential of Stem Bark Extract of Enantia chlorantha and Lack of Modulation of Its Therapeutic Efficacy in Diabetic Rats Co-Administered with Lisinopril.
Acta chimica Slovenica.
2021 Mar; 68(1):127. doi:
10.17344/acsi.2020.6212. [PMID: 34057517] - Shingen Misaka, Yuko Ono, Atsushi Uchida, Tomoyuki Ono, Osamu Abe, Hiroshi Ogata, Hideyuki Sato, Masahiko Suzuki, Satomi Onoue, Yayoi Shikama, Kenju Shimomura. Impact of Green Tea Catechin Ingestion on the Pharmacokinetics of Lisinopril in Healthy Volunteers.
Clinical and translational science.
2021 03; 14(2):476-480. doi:
10.1111/cts.12905. [PMID: 33048477] - Xianglin L Du, Lara M Simpson, Brian C Tandy, Judith L Bettencourt, Barry R Davis. Risk of hospitalized and non-hospitalized gastrointestinal bleeding in ALLHAT trial participants receiving diuretic, ACE-inhibitor, or calcium-channel blocker.
PloS one.
2021; 16(11):e0260107. doi:
10.1371/journal.pone.0260107. [PMID: 34793552] - Yogesh A Kulkarni, Sachin V Suryavanshi. Combination of Naringenin and Lisinopril Ameliorates Nephropathy in Type-1 Diabetic Rats.
Endocrine, metabolic & immune disorders drug targets.
2021; 21(1):173-182. doi:
10.2174/1871530320666200516163919. [PMID: 32416710] - Juanping Wu, Hongmei Wang, Bingyu Li. Structure-aided ACEI-capped remdesivir-loaded novel PLGA nanoparticles: toward a computational simulation design for anti-SARS-CoV-2 therapy.
Physical chemistry chemical physics : PCCP.
2020 Dec; 22(48):28434-28439. doi:
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Neurologia (Barcelona, Spain).
2020 Nov; 35(9):628-632. doi:
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The Cochrane database of systematic reviews.
2020 10; 10(?):CD012569. doi:
10.1002/14651858.cd012569.pub2. [PMID: 33089502] - Kentaro Nishi, Mai Sato, Masao Ogura, Mika Okutsu, Kenji Ishikura, Koichi Kamei. Two cases of idiopathic steroid-resistant nephrotic syndrome complicated with thrombotic microangiopathy.
BMC nephrology.
2020 08; 21(1):323. doi:
10.1186/s12882-020-01985-5. [PMID: 32746791] - Stephen P Juraschek, Lara M Simpson, Barry R Davis, Robert H Shmerling, Jennifer L Beach, Anthony Ishak, Kenneth J Mukamal. The effects of antihypertensive class on gout in older adults: secondary analysis of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial.
Journal of hypertension.
2020 05; 38(5):954-960. doi:
10.1097/hjh.0000000000002359. [PMID: 31977576] - Simonetta Bossoni, Laura Chiesa, Andrea Giustina. Severe hypocalcemia in a thyroidectomized woman with Covid-19 infection.
Endocrine.
2020 May; 68(2):253-254. doi:
10.1007/s12020-020-02326-0. [PMID: 32346814] - José María Lamas-Barreiro, Mario Alonso-Suárez, Jorge Julián Fernández-Martín, Jesus Angel Saavedra-Alonso. [Angiotensin II suppression in SARS-CoV-2 infection: a therapeutic approach].
Nefrologia.
2020 May; 40(3):213-216. doi:
10.1016/j.nefro.2020.04.006. [PMID: 32456945] - Zhongchao Ma, Wenwen Zang, Huaiguo Wang, Xiaojing Wei. Silibinin enhances anti-renal fibrosis effect of MK-521 via downregulation of TGF-β signaling pathway.
Human cell.
2020 Apr; 33(2):330-336. doi:
10.1007/s13577-019-00314-9. [PMID: 31953678] - Josh Bankston, David Thomas House. Angiotensin-Converting Enzyme Inhibitor Angioedema.
Advanced emergency nursing journal.
2020 Apr; 42(2):103-107. doi:
10.1097/tme.0000000000000294. [PMID: 32358424] - Pooja Kesari, Shivendra Pratap, Poonam Dhankhar, Vikram Dalal, Manisha Mishra, Pradyumna Kumar Singh, Harsh Chauhan, Pravindra Kumar. Structural characterization and in-silico analysis of Momordica charantia 7S globulin for stability and ACE inhibition.
Scientific reports.
2020 01; 10(1):1160. doi:
10.1038/s41598-020-58138-9. [PMID: 31980708] - Sarah Ahmad, Muhammad Jamshaid, Rizwan Mehmood, Irfan Bashir, Rabia Ali, Sana Jameel. Blend of guar gum and Eudragit shows excellent drug release retarding behavior in sustained release tablets.
Pakistan journal of pharmaceutical sciences.
2020 Jan; 33(1):71-77. doi:
". [PMID: 32122833] - Catherine G Derington, Jordan B King, Thomas Delate, Sheila R Botts, Miranda Kroehl, David P Kao, Katy E Trinkley. Twice-daily versus once-daily lisinopril and losartan for hypertension: Real-world effectiveness and safety.
PloS one.
2020; 15(12):e0243371. doi:
10.1371/journal.pone.0243371. [PMID: 33270787] - Sarah Al Fawaz, Mohammad Al Deeb, James L Huffman, Naji A Al Kholaif, Fiona Garlich, Ryan Chuang. A Case of Status Epilepticus and Transient Stress Cardiomyopathy Associated with Smoking the Synthetic Psychoactive Cannabinoid, UR-144.
The American journal of case reports.
2019 Dec; 20(?):1902-1906. doi:
10.12659/ajcr.918918. [PMID: 31857571] - Panagiotis I Georgianos, Rajiv Agarwal. Systolic and diastolic hypertension among patients on hemodialysis: Musings on volume overload, arterial stiffness, and erythropoietin.
Seminars in dialysis.
2019 11; 32(6):507-512. doi:
10.1111/sdi.12837. [PMID: 31463996] - Brandon J Sonn, Jessica L Saben, Glenn McWilliams, Shelby K Shelton, Hania K Flaten, Angelo D'Alessandro, Andrew A Monte. Predicting response to lisinopril in treating hypertension: a pilot study.
Metabolomics : Official journal of the Metabolomic Society.
2019 10; 15(10):133. doi:
10.1007/s11306-019-1601-7. [PMID: 31583478] - Alonso Marquez, Daniel Batlle. Angiotensin-(1-7) for diabetic kidney disease: better than an angiotensin-converting enzyme inhibitor alone?.
Kidney international.
2019 10; 96(4):815-817. doi:
10.1016/j.kint.2019.05.028. [PMID: 31543149] - Paola Cassis, Monica Locatelli, Daniela Corna, Sebastian Villa, Daniela Rottoli, Domenico Cerullo, Mauro Abbate, Giuseppe Remuzzi, Ariela Benigni, Carlamaria Zoja. Addition of cyclic angiotensin-(1-7) to angiotensin-converting enzyme inhibitor therapy has a positive add-on effect in experimental diabetic nephropathy.
Kidney international.
2019 10; 96(4):906-917. doi:
10.1016/j.kint.2019.04.024. [PMID: 31307778] - Yucai Yee, Stanley Angkodjojo, Puay Hoon Tan. Chronic thrombotic microangiopathy secondary to antiphospholipid syndrome, presenting with severe hypertension and chronic renal impairment.
BMJ case reports.
2019 Sep; 12(9):. doi:
10.1136/bcr-2019-231434. [PMID: 31527221] - Katrijn Bogman, Jochen Brumm, Carsten Hofmann, Mylène Giraudon, Markus Niggli, Carolina Sturm-Pellanda, Annette Sauter, Stefan Sturm, Bernhard Mangold, Christophe Schmitt. Assessment of Drug-Drug Interactions between Taspoglutide, a Glucagon-Like Peptide-1 Agonist, and Drugs Commonly Used in Type 2 Diabetes Mellitus: Results of Five Phase I Trials.
Clinical pharmacokinetics.
2019 09; 58(9):1205-1214. doi:
10.1007/s40262-019-00757-1. [PMID: 30968335] - Tine A Bækdal, Jeanett Borregaard, Cilie W Hansen, Mette Thomsen, Thomas W Anderson. Effect of Oral Semaglutide on the Pharmacokinetics of Lisinopril, Warfarin, Digoxin, and Metformin in Healthy Subjects.
Clinical pharmacokinetics.
2019 09; 58(9):1193-1203. doi:
10.1007/s40262-019-00756-2. [PMID: 30945118] - Shima Mehrvar, Mette Funding la Cour, Meetha Medhora, Amadou K S Camara, Mahsa Ranji. Optical Metabolic Imaging for Assessment of Radiation-Induced Injury to Rat Kidney and Mitigation by Lisinopril.
Annals of biomedical engineering.
2019 Jul; 47(7):1564-1574. doi:
10.1007/s10439-019-02255-8. [PMID: 30963380] - I V Sergienko, A A Ansheles, О М Drapkina, N B Gornyakova, M Yu Zubareva, R N Shepel, V V Kuharchuk, S A Boytsov. ANICHKOV study: the effect of combined hypotensive and lipid-lowering therapy on cardiovascular complications in patients of high and very high risk.
Terapevticheskii arkhiv.
2019 May; 91(4):90-98. doi:
10.26442/00403660.2019.04.000104. [PMID: 31094482] - Yuko Shima, Koichi Nakanishi, Mayumi Sako, Mari Saito-Oba, Yuko Hamasaki, Hiroshi Hataya, Masataka Honda, Koichi Kamei, Kenji Ishikura, Shuichi Ito, Hiroshi Kaito, Ryojiro Tanaka, Kandai Nozu, Hidefumi Nakamura, Yasuo Ohashi, Kazumoto Iijima, Norishige Yoshikawa. Lisinopril versus lisinopril and losartan for mild childhood IgA nephropathy: a randomized controlled trial (JSKDC01 study).
Pediatric nephrology (Berlin, Germany).
2019 05; 34(5):837-846. doi:
10.1007/s00467-018-4099-8. [PMID: 30284023] - Kyle Johnson, Suzanne Oparil, Barry R Davis, Larisa G Tereshchenko. Prevention of Heart Failure in Hypertension-Disentangling the Role of Evolving Left Ventricular Hypertrophy and Blood Pressure Lowering: The ALLHAT Study.
Journal of the American Heart Association.
2019 04; 8(8):e011961. doi:
10.1161/jaha.119.011961. [PMID: 30943832] - Terence T Sio, Pamela J Atherton, Levi D Pederson, W Ken Zhen, Robert W Mutter, Yolanda I Garces, Daniel J Ma, James L Leenstra, Jean-Claude M Rwigema, Shaker Dakhil, James D Bearden, Sonja J van der Veen, Apar K Ganti, Steven E Schild, Robert C Miller. Daily Lisinopril vs Placebo for Prevention of Chemoradiation-Induced Pulmonary Distress in Patients With Lung Cancer (Alliance MC1221): A Pilot Double-Blind Randomized Trial.
International journal of radiation oncology, biology, physics.
2019 03; 103(3):686-696. doi:
10.1016/j.ijrobp.2018.10.035. [PMID: 30395904] - Reza Khorsan, Ramy M Hanna, Khalid Ameen, Farid Arman, Niloofar Nobakht, Huma Hasnain, Ashley Hyunh, Anjay Rastogi. Primary membranous nephropathy with concomitant IgA nephropathy.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia.
2019 Mar; 30(2):531-536. doi:
10.4103/1319-2442.256863. [PMID: 31031392] - Seth J Lichtenstein, Michael J Herring, Pravir V Baxi, Richard I Abrams, Stephen M Korbet. Without Warning: Scleroderma Renal Crisis.
The American journal of medicine.
2019 02; 132(2):175-178. doi:
10.1016/j.amjmed.2018.09.024. [PMID: 30290189] - Mandeep Kumar Arora, Yogesh Sarup, Ritu Tomar, Mary Singh, Puspendra Kumar. Amelioration of Diabetes-Induced Diabetic Nephropathy by Aloe vera: Implication of Oxidative Stress and Hyperlipidemia.
Journal of dietary supplements.
2019; 16(2):227-244. doi:
10.1080/19390211.2018.1449159. [PMID: 29621403] - O Chernatska, N Demikhova. IMPROVEMENT OF TREATMENT IN PERSONS WITH ARTERIAL HYPERTENSION AND TYPE 2 DIABETES MELLITUS.
Georgian medical news.
2018 Nov; ?(284):47-51. doi:
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British journal of clinical pharmacology.
2018 11; 84(11):2502-2521. doi:
10.1111/bcp.13705. [PMID: 29971804] - Noushin Rastkari, Reza Ahmadkhaniha. Development and validation of a high-performance liquid chromatography method for determination of lisinopril in human plasma by magnetic solid-phase extraction and pre-column derivatization.
Biomedical chromatography : BMC.
2018 Mar; 32(3):. doi:
10.1002/bmc.4120. [PMID: 29148163] - Shannon M Harlan, Kathleen M Heinz-Taheny, John M Sullivan, Tao Wei, Hana E Baker, Dianna L Jaqua, Zhonghua Qi, Martin S Cramer, Tatiyana L Shiyanova, Matthew D Breyer, Josef G Heuer. Progressive Renal Disease Established by Renin-Coding Adeno-Associated Virus-Driven Hypertension in Diverse Diabetic Models.
Journal of the American Society of Nephrology : JASN.
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Pharmaceutical biology.
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Circulation. Arrhythmia and electrophysiology.
2017 Dec; 10(12):. doi:
10.1161/circep.117.005463. [PMID: 29212812] - Vivek Kataria, Hueyyoung Wang, Joyce W Wald, Yvonne L Phan. Lisinopril-Induced Alopecia: A Case Report.
Journal of pharmacy practice.
2017 Oct; 30(5):562-566. doi:
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The Journal of pharmacy and pharmacology.
2017 Sep; 69(9):1219-1229. doi:
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
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Nephrology (Carlton, Vic.).
2017 Jul; 22(7):531-540. doi:
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Hypertension (Dallas, Tex. : 1979).
2017 07; 70(1):94-102. doi:
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Pharmacological reports : PR.
2017 Jun; 69(3):536-541. doi:
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Journal of molecular modeling.
2017 May; 23(5):158. doi:
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The American journal of medicine.
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Histology and histopathology.
2017 Apr; 32(4):405-412. doi:
10.14670/hh-11-809. [PMID: 27615269] - Aisha Sana, Safila Naveed, Fatima Qamar, Sadia Shakeel. Simultaneous determination of ACE inhibitors and dexibuprofen in active pharmaceutical ingredient, formulations and human serum by RP-HPLC.
Pakistan journal of pharmaceutical sciences.
2017 Mar; 30(2(Suppl.)):635-639. doi:
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Journal of ethnopharmacology.
2017 Feb; 198(?):432-443. doi:
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The American journal of emergency medicine.
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