Dilazep (BioDeep_00000858871)
Volatile Flavor Compounds
代谢物信息卡片
3-[4-[3-(3,4,5-trimethoxybenzoyl)oxypropyl]-1,4-diazepan-1-yl]propyl 3,4,5-trimethoxybenzoate
化学式: C31H44N2O10 (604.2995804)
中文名称: 双酯嗪
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=CC(=CC(=C1OC)OC)C(=O)OCCCN2CCCN(CC2)CCCOC(=O)C3=CC(=C(C(=C3)OC)OC)OC
InChI: InChI=1S/C31H44N2O10/c1-36-24-18-22(19-25(37-2)28(24)40-5)30(34)42-16-8-12-32-10-7-11-33(15-14-32)13-9-17-43-31(35)23-20-26(38-3)29(41-6)27(21-23)39-4/h18-21H,7-17H2,1-6H3
描述信息
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist
C - Cardiovascular system > C01 - Cardiac therapy > C01D - Vasodilators used in cardiac diseases
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
同义名列表
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:92842
- KEGGdrug: D07843
- PubChem: 3074
- DrugBank: DB13715
- ChEMBL: CHEMBL126075
- MeSH: Dilazep
- CAS: 20153-98-4
- CAS: 35898-87-4
- KEGG: C12954
- PubChem: 583343
- KNApSAcK: 31493
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Natalia Grañe-Boladeras, Declan Williams, Zlatina Tarmakova, Katarina Stevanovic, Linda A Villani, Pedram Mehrabi, K W Michael Siu, Marçal Pastor-Anglada, Imogen R Coe. Oligomerization of equilibrative nucleoside transporters: a novel regulatory and functional mechanism involving PKC and PP1.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2019 03; 33(3):3841-3850. doi:
10.1096/fj.201800440rr. [PMID: 30521377] - Yukihiko Kawasaki, Ryo Maeda, Shinichiro Ohara, Kazuhide Suyama, Mitsuaki Hosoya. Serum IgA/C3 and glomerular C3 staining predict severity of IgA nephropathy.
Pediatrics international : official journal of the Japan Pediatric Society.
2018 Feb; 60(2):162-167. doi:
10.1111/ped.13461. [PMID: 29178575] - Tao Sun, Bin Liu, Peng Li. Nerve Protective Effect of Asiaticoside against Ischemia-Hypoxia in Cultured Rat Cortex Neurons.
Medical science monitor : international medical journal of experimental and clinical research.
2015 Oct; 21(?):3036-41. doi:
10.12659/msm.894024. [PMID: 26447863] - Yukihiko Kawasaki, Kazuhide Suyama, Kyohei Miyazaki, Shuto Kanno, Atsushi Ono, Yuichi Suzuki, Masatoki Sato, Koichi Hashimoto, Mitsuaki Hosoya. Resistance factors for the treatment of immunoglobulin A nephropathy with diffuse mesangial proliferation.
Nephrology (Carlton, Vic.).
2014 Jul; 19(7):384-91. doi:
10.1111/nep.12232. [PMID: 24646214] - Sumeeta Warraich, Derek B J Bone, Diana Quinonez, Hisataka Ii, Doo-Sup Choi, David W Holdsworth, Maria Drangova, S Jeffrey Dixon, Cheryle A Séguin, James R Hammond. Loss of equilibrative nucleoside transporter 1 in mice leads to progressive ectopic mineralization of spinal tissues resembling diffuse idiopathic skeletal hyperostosis in humans.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
2013 May; 28(5):1135-49. doi:
10.1002/jbmr.1826. [PMID: 23184610] - Takahito Moriyama, Chihiro Iwasaki, Kayu Tanaka, Ayami Ochi, Ari Shimizu, Syunji Shiohira, Mitsuyo Itabashi, Takashi Takei, Keiko Uchida, Ken Tsuchiya, Kosaku Nitta. Effects of combination therapy with renin-angiotensin system inhibitors and eicosapentaenoic acid on IgA nephropathy.
Internal medicine (Tokyo, Japan).
2013; 52(2):193-9. doi:
10.2169/internalmedicine.52.8323. [PMID: 23318848] - Horace T B Ho, Li Xia, Joanne Wang. Residue Ile89 in human plasma membrane monoamine transporter influences its organic cation transport activity and sensitivity to inhibition by dilazep.
Biochemical pharmacology.
2012 Aug; 84(3):383-90. doi:
10.1016/j.bcp.2012.04.018. [PMID: 22562044] - Tatsuo Hashimoto, Yoshiyuki Toya, Minoru Kihara, Machiko Yabana, Yoshiaki Inayama, Ken-Ichiro Tanaka, Kousaku Iwatsubo, Mai Yanagi, Jin Oshikawa, Toshiharu Kokuho, Tadashi Kuji, Shin-Ichiro Yoshida, Kouichi Tamura, Satoshi Umemura. Behçet's disease complicated by IgA nephropathy with nephrotic syndrome.
Clinical and experimental nephrology.
2008 Jun; 12(3):224-7. doi:
10.1007/s10157-008-0029-6. [PMID: 18224274] - Hiroshi Nakamoto, Yasuo Ogasawara, Fumihiko Kajiya. Visualisation of the effects of dilazep on rat afferent and efferent arterioles in vivo.
Hypertension research : official journal of the Japanese Society of Hypertension.
2008 Feb; 31(2):315-24. doi:
10.1291/hypres.31.315. [PMID: 18360052] - Yoshinori Taji, Takashi Kuwahara, Satoru Shikata, Takeshi Morimoto. Meta-analysis of antiplatelet therapy for IgA nephropathy.
Clinical and experimental nephrology.
2006 Dec; 10(4):268-73. doi:
10.1007/s10157-006-0433-8. [PMID: 17186331] - Hiroshi Satonaka, Etsu Suzuki, Hiroshi Hayakawa, Hiroaki Nishimatsu, Daisuke Nagata, Shigeyoshi Oba, Atsuko Kamijo, Ryo Takeda, Masao Takahashi, Yuji Yamamoto, Kenjiro Kimura, Yasunobu Hirata. Long-term effect of imidapril hydrochloride compared with dilazep hydrochloride administration on blood pressure and renal function in patients with chronic glomerulonephritis.
International heart journal.
2005 Jul; 46(4):701-10. doi:
10.1536/ihj.46.701. [PMID: 16157961] - M Fukuda, K Morozumi, T Oikawa, M Motokawa, T Usami, A Yoshida, G Kimura. Immunotactoid glomerulopathy with microtubular deposits, with reference to the characteristics of Japanese cases.
Clinical nephrology.
2005 May; 63(5):368-74. doi:
10.5414/cnp63368. [PMID: 15909596] - Balaram Shrestha, Chiaki Hidai, Hiromi Ikeda, Masako Okada-Ohno, Hiroshi Kasanuki, Masatoshi Kawana. Endothelin-1 gene expression in endothelial cells is potently inhibited by a vasodilator, dilazep.
Hypertension research : official journal of the Japanese Society of Hypertension.
2004 Jun; 27(6):409-15. doi:
10.1291/hypres.27.409. [PMID: 15253106] - James R Hammond, Meaghan Stolk, Richard G E Archer, Kristy McConnell. Pharmacological analysis and molecular cloning of the canine equilibrative nucleoside transporter 1.
European journal of pharmacology.
2004 Apr; 491(1):9-19. doi:
10.1016/j.ejphar.2004.03.026. [PMID: 15102528] - Yukihiko Kawasaki, Junzo Suzuki, Nobuko Sakai, Shigehiko Etoh, Hiromitch Murai, Ruriko Nozawa, Hitoshi Suzuki. Efficacy of prednisolone and mizoribine therapy for diffuse IgA nephropathy.
American journal of nephrology.
2004 Jan; 24(1):147-53. doi:
10.1159/000076243. [PMID: 14726626] - Kazuo Sonoki, Masanori Iwase, Kenzo Iino, Kojiro Ichikawa, Mototaka Yoshinari, Shigehiro Ohdo, Shun Higuchi, Mitsuo Iida. Dilazep and fenofibric acid inhibit MCP-1 mRNA expression in glycoxidized LDL-stimulated human endothelial cells.
European journal of pharmacology.
2003 Aug; 475(1-3):139-47. doi:
10.1016/s0014-2999(03)02109-5. [PMID: 12954370] - Atsushi Numabe, Nusrat Ara, Rie Hakamada-Taguchi, Noriko Suzuki, Nobuhito Hirawa, Yukari Kawabata, Toshiyuki Negoro, Taiji Nagata, Atsuo Goto, Teruhiko Toyo-Oka, Toshiro Fujita, Yoshio Uehara. Effects of the anti-platelet aggregation drug dilazep on cognitive function in Dahl salt-sensitive rats.
Hypertension research : official journal of the Japanese Society of Hypertension.
2003 Feb; 26(2):185-91. doi:
10.1291/hypres.26.185. [PMID: 12627880] - Tsukasa Nakamura, Kaoru Hirokawa, Takaharu Matsuda, Shiori Osada, Yutaka Takahashi, Noriaki Shimada, Hikaru Koide. Combination AST-120 and dilazep dihydrochloride therapy reduced urinary protein excretion and serum creatinine levels in patients with chronic renal failure.
Renal failure.
2002 Sep; 24(5):683-5. doi:
10.1081/jdi-120013975. [PMID: 12380917] - Masahiko Kawabata, Manabu Haneda, Tao Wang, Michiru Imai, Toshikazu Takabatake. Effects of a nucleoside transporter inhibitor, dilazep, on renal microcirculation in rats.
Hypertension research : official journal of the Japanese Society of Hypertension.
2002 Jul; 25(4):615-21. doi:
10.1291/hypres.25.615. [PMID: 12358150] - Tsukasa Nakamura, Chifuyu Ushiyama, Shiwori Osada, Kazuya Ugai, Yutaka Takahashi, Araki Tanaka, Noriaki Shimada, Isao Ebihara, Hikaru Koide. Effect of dilazep dihydrochloride on serum cardiac troponin T levels in hemodialysis patients.
Kidney & blood pressure research.
2002; 25(1):50-4. doi:
10.1159/000049435. [PMID: 11834877] - S Yamagishi, K Koga, Y Inagaki, S Amano, T Okamoto, M Takeuchi. Dilazep hydrochloride, an antiplatelet drug, prevents progression of diabetic nephropathy in Otsuka Long-Evans Tokushima fatty rats.
Drugs under experimental and clinical research.
2002; 28(6):221-7. doi:
NULL. [PMID: 12776575] - R Haramaki, K Tamaki, M Fujisawa, H Ikedo, N Haramaki, S Okuda. Steroid therapy and urinary transforming growth factor-beta1 in IgA nephropathy.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2001 Dec; 38(6):1191-8. doi:
10.1053/ajkd.2001.29209. [PMID: 11728950] - T Nakamura, C Ushiyama, Y Takahashi, A Tanaka, N Shimada, I Ebihara, H Koide. Effect of dilazep dihydrochloride on urinary albumin excretion in patients with autosomal dominant polycystic kidney disease.
Nephron.
2001 May; 88(1):80-2. doi:
10.1159/000045963. [PMID: 11340355] - M W Ritzel, A M Ng, S Y Yao, K Graham, S K Loewen, K M Smith, R G Ritzel, D A Mowles, P Carpenter, X Z Chen, E Karpinski, R J Hyde, S A Baldwin, C E Cass, J D Young. Molecular identification and characterization of novel human and mouse concentrative Na+-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib).
The Journal of biological chemistry.
2001 Jan; 276(4):2914-27. doi:
10.1074/jbc.m007746200. [PMID: 11032837] - T Gohda, Y Makita, T Shike, K Funabiki, I Shirato, Y Tomino. Dilazep hydrochloride, an antiplatelet drug, inhibits lipopolysaccharide-induced mouse mesangial cell IL-6 secretion and proliferation.
Kidney & blood pressure research.
2001; 24(1):33-8. doi:
10.1159/000054203. [PMID: 11174004] - T Nakamura, C Ushiyama, N Shimada, K Sekizuka, I Ebihara, M Hara, H Koide. Effect of the antiplatelet drug dilazep dihydrochloride on urinary podocytes in patients in the early stage of diabetic nephropathy.
Diabetes care.
2000 Aug; 23(8):1168-71. doi:
10.2337/diacare.23.8.1168. [PMID: 10937516] - I Ebihara, T Nakamura, S Suzuki, C Ushiyama, N Shimada, M Suzaki, H Koide. Effect of dilazep dihydrochloride on plasma P-selectin concentrations in patients with IgA nephropathy.
Nephron.
2000 Jul; 85(3):281-2. doi:
10.1159/000045675. [PMID: 10867547] - S Leung, R Bendayan. Role of P-glycoprotein in the renal transport of dideoxynucleoside analog drugs.
Canadian journal of physiology and pharmacology.
1999 Aug; 77(8):625-30. doi:
. [PMID: 10543726] - S Kuriyama, H Tomonari, T Hosoya. Antiplatelet therapy decreases the incidence of erythropoietin-induced hypertension in predialysis patients.
Clinical and experimental hypertension (New York, N.Y. : 1993).
1999 Apr; 21(3):213-22. doi:
10.3109/10641969909068662. [PMID: 10225477] - K Nakamura, K Kojima, T Arai, M Shirai, S Usutani, H Akimoto, H Masaoka, M Nagase, M Yamamoto. Dipyridamole and dilazep suppress oxygen radicals in puromycin aminonucleoside nephrosis rats.
European journal of clinical investigation.
1998 Nov; 28(11):877-83. doi:
10.1046/j.1365-2362.1998.00378.x. [PMID: 9824428] - M Kitakaze, T Minamino, K Node, Y Koretsune, K Komamura, H Funaya, T Kuzuya, M Hori. Elevation of plasma adenosine levels may attenuate the severity of chronic heart failure.
Cardiovascular drugs and therapy.
1998 Jul; 12(3):307-9. doi:
10.1023/a:1007726018470. [PMID: 9784911] - A N Hoque, N Hoque, A Hara, H Hashizume, K Ichihara, Y Abiko. Cardioprotective effect of K-7259, a novel dilazep derivative, against ischemia-reperfusion damage in isolated, working rat hearts.
Japanese journal of pharmacology.
1997 Apr; 73(4):365-9. doi:
10.1254/jjp.73.365. [PMID: 9165376] - A Gumieniczek, L Przyborowski. High-performance liquid chromatographic assay of dilazep in plasma after solid-phase extraction.
Journal of pharmaceutical and biomedical analysis.
1997 Apr; 15(7):997-1000. doi:
10.1016/s0731-7085(96)01925-5. [PMID: 9160267] - N Opartkiattikul, S Sukpanichnant, W Wanachiwanawin, S Fucharoen, Y Funahara, A Sumiyoshi, K Imai, W Sangtawesin, P Thientadakul. A double-blind placebo control trial of dilazep in beta-thalassemia/hemoglobin E patients.
The Southeast Asian journal of tropical medicine and public health.
1997; 28 Suppl 3(?):167-71. doi:
NULL. [PMID: 9640622] - X Fang, F E Parkinson, D A Mowles, J D Young, C E Cass. Functional characterization of a recombinant sodium-dependent nucleoside transporter with selectivity for pyrimidine nucleosides (cNT1rat) by transient expression in cultured mammalian cells.
The Biochemical journal.
1996 Jul; 317 ( Pt 2)(?):457-65. doi:
10.1042/bj3170457. [PMID: 8713072] - A Hara, Y Abiko. Protective effects of dilazep and its novel derivative, K-7259, on mechanical and metabolic derangements induced by hydrogen peroxide in the isolated perfused rat heart.
The Journal of pharmacology and experimental therapeutics.
1996 May; 277(2):565-71. doi:
". [PMID: 8627532] - H Koide, Y Totsuka, T Sugisaki, T Kitajima, Y Ohmori, S Kuriyama, K Oi, S Isogai, H Ohi, Y Tomino. Clinical effect of the anti-platelet drug, dilazep dihydrochloride, in patients at the microalbuminuric stage of diabetic nephropathy--a multi-center study.
Nihon Jinzo Gakkai shi.
1995 Nov; 37(11):644-8. doi:
NULL. [PMID: 8583701] - M Yamamoto, M Fukui, T Kuramoto, K Kabuki, Y Tomino. Effects of antiplatelet drug dilazep dihydrochloride on anionic sites and extracellular matrix (ECM) components in glomerular basement membrane of STZ-induced diabetic rats.
Journal of clinical laboratory analysis.
1995; 9(6):380-6. doi:
10.1002/jcla.1860090608. [PMID: 8587006] - T Nagai. The effect of pancreatic elastase on diabetic nephropathy.
Diabetes research and clinical practice.
1994 Jul; 24(3):161-5. doi:
10.1016/0168-8227(94)90111-2. [PMID: 7988347] - C W Lee. Decrease in equilibrative uridine transport during monocytic differentiation of HL-60 leukaemia: involvement of protein kinase C.
The Biochemical journal.
1994 Jun; 300 ( Pt 2)(?):407-12. doi:
10.1042/bj3000407. [PMID: 8002945] - Y L Zhang, W W Lautt. Release and regulation of endogenous adenosine during hemorrhage.
Pharmacology.
1994 Apr; 48(4):265-72. doi:
10.1159/000139189. [PMID: 8177912] - H Yoshida, K Kanatsu, E Muso, T Kuwahara, K Sekita, T Ono, N Konishi, C Kanda, T Minakata, K Morimoto. Effects of an anti-platelet drug (dilazep) in IgA nephropathy: comparison of clinical effects with renal biopsy findings.
Nihon Jinzo Gakkai shi.
1994 Apr; 36(4):339-44. doi:
NULL. [PMID: 8022106] - Y Zhang, W W Lautt. Effects of the liver on circulating adenosine in blood.
Canadian journal of physiology and pharmacology.
1993 Dec; 71(12):874-8. doi:
10.1139/y93-132. [PMID: 8180881] - D A Griffith, S M Jarvis. High affinity sodium-dependent nucleobase transport in cultured renal epithelial cells (LLC-PK1).
The Journal of biological chemistry.
1993 Sep; 268(27):20085-90. doi:
10.1016/s0021-9258(20)80697-8. [PMID: 8376366] - T Nagai, T Tomizawa, M Mori. Effect of pancreatic elastase on diabetic nephropathy.
Diabetes care.
1993 Aug; 16(8):1214-5. doi:
10.2337/diacare.16.8.1214. [PMID: 8375257] - K Nakazawa, T Moriya, S Kasai, T Yamazaki, Y Komiyama, H Shigematsu, T Akiba, T Koga. Dilazep prevents glomerulosclerosis in accelerated Masugi nephritis in the rat.
Nihon Jinzo Gakkai shi.
1993 Apr; 35(4):329-35. doi:
NULL. [PMID: 8341008] - A Morikawa, M Eto, I Makino. The effect of dilazep on urinary protein excretion in spontaneous diabetic Chinese hamster.
Nephron.
1993; 65(1):125-32. doi:
10.1159/000187453. [PMID: 8413770] - D A Griffith, A J Doherty, S M Jarvis. Nucleoside transport in cultured LLC-PK1 epithelia.
Biochimica et biophysica acta.
1992 May; 1106(2):303-10. doi:
10.1016/0005-2736(92)90010-j. [PMID: 1596509] - N Opartkiattikul, Y Funahara, S Fucharoen, P Talalak. Increase in spontaneous platelet aggregation in beta-thalassemia/hemoglobin E disease: a consequence of splenectomy.
The Southeast Asian journal of tropical medicine and public health.
1992; 23 Suppl 2(?):36-41. doi:
NULL. [PMID: 1298991] - P Pandhi, N R Biswas, P L Wahi, P L Sharma. Controlled clinical trial of nifedipine alone and in combination with dilazep in patients with angina pectoris.
International journal of clinical pharmacology, therapy, and toxicology.
1991 Nov; 29(11):454-6. doi:
NULL. [PMID: 1800394] - Y Zhang, D J Legare, J D Geiger, W W Lautt. Dilazep potentiation of adenosine-mediated superior mesenteric arterial vasodilation.
The Journal of pharmacology and experimental therapeutics.
1991 Sep; 258(3):767-71. doi:
NULL. [PMID: 1890619] - H Sakai, S Watanabe, I Inoue, K Tanaka, M Yagame, H Machimura, H Kaneshige, Y Nomoto. Effect of urokinase on preservation of renal function in patients with diabetic nephropathy.
The Journal of diabetic complications.
1991 Apr; 5(2-3):95-7. doi:
10.1016/0891-6632(91)90031-j. [PMID: 1770066] - Y Zhang, W W Lautt. Dilazep increases plasma adenosine levels during adenosine infusion in the anesthetized cat.
Proceedings of the Western Pharmacology Society.
1991; 34(?):167-9. doi:
NULL. [PMID: 1788277] - Y Zhang, J D Geiger, D J Légaré, W W Lautt. Dilazep-induced vasodilation is mediated through adenosine receptors.
Life sciences.
1991; 49(18):PL129-33. doi:
10.1016/0024-3205(91)90202-m. [PMID: 1921643] - Y Yamauchi, J Ikuta, S Shimizu, M Nakamura. [Effect of dilazep dihydrochloride on ischemia and reperfusion-induced cerebral injury in spontaneously hypertensive rats].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
1990 May; 95(5):239-46. doi:
10.1254/fpj.95.5_239. [PMID: 2354833] - P O Ogbunude, H P Baer. Binding of [G-3H]6-(4-nitrobenzylmercapto)purine ribonucleoside to isolated membranes. Inhibitory effect of mioflazine and its derivatives.
Biochemical pharmacology.
1989 Sep; 38(18):3011-5. doi:
10.1016/0006-2952(89)90009-9. [PMID: 2783156] - M P Sambhi, R Kannan, C Thananopavarn, M Ookhtens, M Gudenzi. Therapeutic tolerance, hemodynamic effects, and oral dose kinetics of dilazep dihydrochloride in hypertensive patients.
Journal of pharmaceutical sciences.
1989 Apr; 78(4):281-4. doi:
10.1002/jps.2600780404. [PMID: 2724090] - K C Agarwal, B A Zielinski, R S Maitra. Significance of plasma adenosine in the antiplatelet activity of forskolin: potentiation by dipyridamole and dilazep.
Thrombosis and haemostasis.
1989 Feb; 61(1):106-10. doi:
. [PMID: 2749584] - L E Gustafsson. Mechanisms involved in the action of prostaglandins as modulators of neurotransmission.
Annals of the New York Academy of Sciences.
1989; 559(?):178-91. doi:
10.1111/j.1749-6632.1989.tb22608.x. [PMID: 2774397] - J D Geiger, M E Johnston, V Yago. Pharmacological characterization of rapidly accumulated adenosine by dissociated brain cells from adult rat.
Journal of neurochemistry.
1988 Jul; 51(1):283-91. doi:
10.1111/j.1471-4159.1988.tb04868.x. [PMID: 3379409] - P G Plagemann, C Woffendin. Species differences in sensitivity of nucleoside transport in erythrocytes and cultured cells to inhibition by nitrobenzylthioinosine, dipyridamole, dilazep and lidoflazine.
Biochimica et biophysica acta.
1988 Apr; 969(1):1-8. doi:
10.1016/0167-4889(88)90081-x. [PMID: 3349106] - D D Dawicki, K C Agarwal, R E Parks. Adenosine metabolism in human whole blood. Effects of nucleoside transport inhibitors and phosphate concentration.
Biochemical pharmacology.
1988 Feb; 37(4):621-6. doi:
10.1016/0006-2952(88)90134-7. [PMID: 3342099] - K C Agarwal, R S Buckley, R E Parks. Role of plasma adenosine in the antiplatelet action of HL 725, a potent inhibitor of cAMP phosphodiesterase: species differences.
Thrombosis research.
1987 Jul; 47(2):191-200. doi:
10.1016/0049-3848(87)90376-8. [PMID: 2821650] - M Tada, T Kondo, Y Ogawa, S Sugiyama, T Ozawa. The effect of dilazep on puromycin-induced rat renal mitochondrial dysfunction.
Arzneimittel-Forschung.
1987 May; 37(5):509-12. doi:
. [PMID: 3040017] - P G Plagemann, M Kraupp. Inhibition of nucleoside and nucleobase transport and nitrobenzylthioinosine binding by dilazep and hexobendine.
Biochemical pharmacology.
1986 Aug; 35(15):2559-67. doi:
10.1016/0006-2952(86)90054-7. [PMID: 3741459] - D D Dawicki, K C Agarwal, R E Parks. Potentiation of the antiplatelet action of adenosine in whole blood by dipyridamole or dilazep and the cAMP phosphodiesterase inhibitor, RA 233.
Thrombosis research.
1986 Jul; 43(2):161-75. doi:
10.1016/0049-3848(86)90057-5. [PMID: 3016942] - R Setiabudy-Dharma, Y Funahara. Enhancement of collagen-induced aggregation of platelets in whole blood.
Thrombosis research.
1986 Jun; 42(5):621-34. doi:
10.1016/0049-3848(86)90341-5. [PMID: 3715821] - T Yukimura, K Miura, K Ito, K Yamamoto. Renal vascular effects of dilazep antagonized by 3-isobutyl-1-methyl-xanthine.
Journal of cardiovascular pharmacology.
1986 May; 8(3):649-55. doi:
10.1097/00005344-198605000-00031. [PMID: 2425186] - D D Dawicki, K C Agarwal, R E Parks. Role of adenosine uptake and metabolism by blood cells in the antiplatelet actions of dipyridamole, dilazep and nitrobenzylthioinosine.
Biochemical pharmacology.
1985 Nov; 34(22):3965-72. doi:
10.1016/0006-2952(85)90373-9. [PMID: 4062970] - H Inage, A Koyama, M Narita, S Tojo. Effects of dilazep dihydrochloride (Dilazep) and its dose-dependent influence on rabbit acute serum sickness nephritis.
Nihon Jinzo Gakkai shi.
1985 Sep; 27(9):1253-60. doi:
NULL. [PMID: 4087546] - H Saito, A Saito, H Ogawa. [The effect of dilazep on red cell survival].
[Rinsho ketsueki] The Japanese journal of clinical hematology.
1985 Jan; 26(1):15-9. doi:
NULL. [PMID: 3999398] - M Marzilli, M G Trivella, D Levantesi, G Pelosi, M Dalle Vacche, L Taddei, A L'Abbate. Effect of dilazep on coronary and systemic circulations.
Pharmacology.
1985; 31(2):82-7. doi:
10.1159/000138102. [PMID: 4023048] - S Sugiyama, T Kondo, M Ajioka, M Hattori, S Nagai, T Ozawa. The effects of dilazep on reperfusion arrhythmias.
Arzneimittel-Forschung.
1985; 35(12):1802-4. doi:
NULL. [PMID: 4096732] - R Koren, C E Cass, A R Paterson. The kinetics of dissociation of the inhibitor of nucleoside transport, nitrobenzylthioinosine, from the high-affinity binding sites of cultured hamster cells.
The Biochemical journal.
1983 Nov; 216(2):299-308. doi:
10.1042/bj2160299. [PMID: 6661198] - K Nakajima, S Yamamoto, M Tsukamoto, M Nagakura. Effects of dilazep on fibrinolytic system in animals. I. Enhancement of fibrinolytic activity by administered dilazep in ex vivo experiment.
Journal of pharmacobio-dynamics.
1982 May; 5(5):356-62. doi:
10.1248/bpb1978.5.356. [PMID: 6181245] - A Sollevi, B B Fredholm. The antilipolytic effect of endogenous and exogenous adenosine in canine adipose tissue in situ.
Acta physiologica Scandinavica.
1981 Sep; 113(1):53-60. doi:
10.1111/j.1748-1716.1981.tb06861.x. [PMID: 7315438] - A Sollevi, B B Fredholm. Role of adenosine in adipose tissue circulation.
Acta physiologica Scandinavica.
1981 Jul; 112(3):293-8. doi:
10.1111/j.1748-1716.1981.tb06819.x. [PMID: 7293798] - O Ponari, C Manotti. Human platelet aggregation tests in vitro. Effects of dilazep.
Arzneimittel-Forschung.
1981; 31(1):97-101. doi:
NULL. [PMID: 7194099] - F Kuzuya. Effects of dilazep (AS-05) on human blood platelet aggregation.
Arzneimittel-Forschung.
1979; 29(3):539-42. doi:
NULL. [PMID: 582740] - Y Ohtaki, H Nakanishi, J Ueda. [Effects of adenosine compounds of the vascular bed and effects of dilazep, theophylline, and indomethacin on blood flow changes of the postocclusive renal vessels].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
1977 Jan; 73(1):93-102. doi:
10.1254/fpj.73.93. [PMID: 558949] - E Schaumlöffel, R Prignitz. [Studies on the bioavailability of the individual components from a combination of dilazep and beta-acetyldigoxin (author's transl)].
Arzneimittel-Forschung.
1976; 26(12):2208-13. doi:
NULL. [PMID: 1037278]