DETOMIDINE (BioDeep_00000858857)
代谢物信息卡片
DETOMIDINE
化学式: C12H14N2 (186.1156924)
中文名称: 地托咪定
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C(=CC=C1)CC2=CN=CN2)C
InChI: InChI=1S/C12H14N2/c1-9-4-3-5-11(10(9)2)6-12-7-13-8-14-12/h3-5,7-8H,6H2,1-2H3,(H,13,14)
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D07795
- PubChem: 56032
- DrugBank: DB11556
- ChEMBL: CHEMBL2110829
- CAS: 76631-46-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Seyed Morteza Aghamiri, Amir Saeed Samimi, Mehdi Hajian, Amir Masoud Samimi, Amin Oroumieh. Effect of xylazine, detomidine, medetomidine and dexmedetomidine during laparoscopic SCNT embryo transfer on pregnancy rate and some physiological variables in goats.
BMC veterinary research.
2022 Mar; 18(1):98. doi:
10.1186/s12917-022-03194-8. [PMID: 35292035] - J R Box, N P Karikoski, H E Tanskanen, M R Raekallio. The effects of an alpha-2-adrenoceptor agonist, antagonist, and their combination on the blood insulin, glucose, and glucagon concentrations in insulin sensitive and dysregulated horses.
Veterinary journal (London, England : 1997).
2021 Mar; 269(?):105610. doi:
10.1016/j.tvjl.2021.105610. [PMID: 33593492] - E L Oberhaus, D L Thompson, L E Kerrigan, A M Chapman. Plasma prolactin, thyroid-stimulating hormone, melanocyte-stimulating hormone, and adrenocorticotropin responses to thyrotropin-releasing hormone in mares treated with detomidine and butorphanol.
Domestic animal endocrinology.
2021 01; 74(?):106536. doi:
10.1016/j.domaniend.2020.106536. [PMID: 32871339] - Preston Smith, M Katherine Tolbert, Emily Gould, Alex Taylor, Heather Knych, Kristen Messenger. Pharmacokinetics, sedation and hemodynamic changes following the administration of oral transmucosal detomidine gel in cats.
Journal of feline medicine and surgery.
2020 12; 22(12):1184-1190. doi:
10.1177/1098612x20917305. [PMID: 32643979] - Thaís Mendes Sanches Cavalero, Lorenzo Garrido Teixeira M Segabinazzi, Verônica Flores da Cunha Scheeren, Camila P Freitas-Dell'Aqua, Frederico Ozanam Papa. Characterization of semen collected by pharmacologically induced ejaculation from a stallion with seminal vesiculitis.
Reproduction in domestic animals = Zuchthygiene.
2020 Dec; 55(12):1808-1811. doi:
10.1111/rda.13860. [PMID: 33179824] - Natalie S Chow, Reza Seddighi, Heather K Knych, Xiacun Sun, Thomas J Doherty. Sedative effects and pharmacokinetics of detomidine when administered intravenously and intravaginally as a gel in alpacas.
Veterinary anaesthesia and analgesia.
2020 Nov; 47(6):773-780. doi:
10.1016/j.vaa.2020.07.002. [PMID: 32863105] - Stuart W Paine, Jane Bright, James P Scarth, Pamela R Hincks, Clive M Pearce, Colette Hannan, Marc Machnik, Lynn Hillyer. The intravenous pharmacokinetics of butorphanol and detomidine dosed in combination compared with individual dose administrations to exercised horses.
Journal of veterinary pharmacology and therapeutics.
2020 Mar; 43(2):162-170. doi:
10.1111/jvp.12838. [PMID: 32012314] - T M S Cavalero, F O Papa, R A Schmith, V F C Scheeren, L E F Canuto, M L M Gobato, L T Rodrigues, C P Freitas-Dell'aqua. Protocols using detomidine and oxytocin induce ex copula ejaculation in stallions.
Theriogenology.
2019 Dec; 140(?):93-98. doi:
10.1016/j.theriogenology.2019.08.024. [PMID: 31454723] - Miguel Gozalo-Marcilla, Rodrigo Moreira da Silva, Stelio Pacca Loureiro Luna, Alice Rodrigues de Oliveira, Mariana Werneck Fonseca, Norberto Peporine Lopes, Polly M Taylor, Ludovic Pelligand. A possible solution to model nonlinearity in elimination and distributional clearances with α2 -adrenergic receptor agonists: Example of the intravenous detomidine and methadone combination in sedated horses.
Journal of veterinary pharmacology and therapeutics.
2019 Nov; 42(6):738-744. doi:
10.1111/jvp.12815. [PMID: 31584710] - Reza Seddighi, Heather K Knych, Sherry K Cox, Xiaocun Sun, Kaitlin A Moorhead, Thomas J Doherty. Evaluation of the sedative effects and pharmacokinetics of detomidine gel administered intravaginally to horses.
Veterinary anaesthesia and analgesia.
2019 Nov; 46(6):772-779. doi:
10.1016/j.vaa.2019.06.002. [PMID: 31474339] - Christopher J Thibault, Deborah V Wilson, Sheilah A Robertson, Dhruv Sharma, Marc A Kinsley. A retrospective study of fecal output and postprocedure colic in 246 horses undergoing standing sedation with detomidine, or general anesthesia with or without detomidine.
Veterinary anaesthesia and analgesia.
2019 Jul; 46(4):458-465. doi:
10.1016/j.vaa.2019.03.006. [PMID: 31196750] - M Gozalo-Marcilla, S P L Luna, R Moreira da Silva, N Crosignani, N P Lopes, P M Taylor, L Pelligand. Characterisation of the in vivo interactions between detomidine and methadone in horses: Pharmacokinetic and pharmacodynamic modelling.
Equine veterinary journal.
2019 Jul; 51(4):517-529. doi:
10.1111/evj.13031. [PMID: 30298682] - Aileen L Rowland, Kati G Glass, Sicilia T Grady, Kevin J Cummings, Katrin Hinrichs, Ashlee E Watts. Influence of caudal epidural analgesia on cortisol concentrations and pain-related behavioral responses in mares during and after ovariectomy via colpotomy.
Veterinary surgery : VS.
2018 Jul; 47(5):715-721. doi:
10.1111/vsu.12908. [PMID: 29774961] - Heidi A Tapio, Marja R Raekallio, Anna Mykkänen, Khursheed Mama, Jóse L Mendez-Angulo, Heidi Hautajärvi, Outi M Vainio. Effects of MK-467 hydrochloride and hyoscine butylbromide on cardiorespiratory and gastrointestinal changes induced by detomidine hydrochloride in horses.
American journal of veterinary research.
2018 Apr; 79(4):376-387. doi:
10.2460/ajvr.79.4.376. [PMID: 29583040] - M C Niimura Del Barrio, Rachel C Bennett, J M Lynne Hughes. Effect of detomidine or romifidine constant rate infusion on plasma lactate concentration and inhalant requirements during isoflurane anaesthesia in horses.
Veterinary anaesthesia and analgesia.
2017 May; 44(3):473-482. doi:
10.1016/j.vaa.2016.01.002. [PMID: 28462846] - Soile Ae Pakkanen, Marja R Raekallio, Anna K Mykkänen, Kati M Salla, Annemarie de Vries, Lauri Vuorilehto, Mika Scheinin, Outi M Vainio. Detomidine and the combination of detomidine and MK-467, a peripheral alpha-2 adrenoceptor antagonist, as premedication in horses anaesthetized with isoflurane.
Veterinary anaesthesia and analgesia.
2015 Sep; 42(5):527-36. doi:
10.1111/vaa.12238. [PMID: 25529045] - Ann-Helena Hokkanen, Marja R Raekallio, Kati Salla, Laura Hänninen, Elina Viitasaari, Marianna Norring, Satu Raussi, Valtteri M Rinne, Mika Scheinin, Outi M Vainio. Sublingual administration of detomidine to calves prior to disbudding: a comparison with the intravenous route.
Veterinary anaesthesia and analgesia.
2014 Jul; 41(4):372-7. doi:
10.1111/vaa.12150. [PMID: 24628898] - Annie Kullmann, Macarena Sanz, Geoffrey T Fosgate, Montague N Saulez, Patrick C Page, Eva Rioja. Effects of xylazine, romifidine, or detomidine on hematology, biochemistry, and splenic thickness in healthy horses.
The Canadian veterinary journal = La revue veterinaire canadienne.
2014 Apr; 55(4):334-40. doi:
NULL. [PMID: 24688132] - Heather K Knych, Scott D Stanley. Effects of three antagonists on selected pharmacodynamic effects of sublingually administered detomidine in the horse.
Veterinary anaesthesia and analgesia.
2014 Jan; 41(1):36-47. doi:
10.1111/vaa.12081. [PMID: 24134603] - Jiske J L'Ami, Lian E Vermunt, Johannes P A M van Loon, Marianne M Sloet van Oldruitenborgh-Oosterbaan. Sublingual administration of detomidine in horses: sedative effect, analgesia and detection time.
Veterinary journal (London, England : 1997).
2013 May; 196(2):253-9. doi:
10.1016/j.tvjl.2012.08.016. [PMID: 23062724] - Mari H Vainionpää, Marja R Raekallio, Soile A E Pakkanen, Ville Ranta-Panula, Valtteri M Rinne, Mika Scheinin, Outi M Vainio. Plasma drug concentrations and clinical effects of a peripheral alpha-2-adrenoceptor antagonist, MK-467, in horses sedated with detomidine.
Veterinary anaesthesia and analgesia.
2013 May; 40(3):257-64. doi:
10.1111/vaa.12012. [PMID: 23368795] - Heather K DiMaio Knych, Vanessa Covarrubias, Eugene P Steffey. Effect of yohimbine on detomidine induced changes in behavior, cardiac and blood parameters in the horse.
Veterinary anaesthesia and analgesia.
2012 Nov; 39(6):574-83. doi:
10.1111/j.1467-2995.2012.00776.x. [PMID: 23035904] - D C Williams, M Aleman, B Tharp, D J Fletcher, P H Kass, E P Steffey, R A LeCouteur, T A Holliday. Qualitative and quantitative characteristics of the electroencephalogram in normal horses after sedation.
Journal of veterinary internal medicine.
2012 May; 26(3):645-53. doi:
10.1111/j.1939-1676.2012.00921.x. [PMID: 22489924] - Heather K Knych, Eugene P Steffey, Scott D Stanley. The effects of yohimbine on the pharmacokinetic parameters of detomidine in the horse.
Veterinary anaesthesia and analgesia.
2012 May; 39(3):221-9. doi:
10.1111/j.1467-2995.2011.00690.x. [PMID: 22405129] - Anthony P Kett, Christine M Bruen, Fiona O'Halloran, Valérie Chaurin, Peadar G Lawlor, James A O'Mahony, Linda Giblin, Mark A Fenelon. The effect of α- or β-casein addition to waxy maize starch on postprandial levels of glucose, insulin, and incretin hormones in pigs as a model for humans.
Food & nutrition research.
2012; 56(?):. doi:
10.3402/fnr.v56i0.7989. [PMID: 22509144] - Heather K Dimaio Knych, Scott D Stanley. Pharmacokinetics and pharmacodynamics of detomidine following sublingual administration to horses.
American journal of veterinary research.
2011 Oct; 72(10):1378-85. doi:
10.2460/ajvr.72.10.1378. [PMID: 21962281] - B P S Thakur, S K Sharma, Arvind Sharma, Adarsh Kumar. Clinical evaluation of detomidine-butorphanol-guaifenesin-ketamine as short term TIVA in Spiti ponies.
Pakistan journal of biological sciences : PJBS.
2011 Jun; 14(11):647-52. doi:
10.3923/pjbs.2011.647.652. [PMID: 22235506] - J Santiago-Moreno, A Toledano-Díaz, A Sookhthezary, F Gómez-Guillamón, R Salas de la Vega, A Pulido-Pastor, A López-Sebastián. Effects of anesthetic protocols on electroejaculation variables of Iberian ibex (Capra pyrenaica).
Research in veterinary science.
2011 Feb; 90(1):150-5. doi:
10.1016/j.rvsc.2010.05.011. [PMID: 20542308] - H K Dimaio Knych, E P Steffey, J L Deuel, R A Shepard, S D Stanley. Pharmacokinetics of yohimbine following intravenous administration to horses.
Journal of veterinary pharmacology and therapeutics.
2011 Feb; 34(1):58-63. doi:
10.1111/j.1365-2885.2010.01194.x. [PMID: 21219345] - H Kaukinen, J Aspegrén, S Hyyppä, L Tamm, J S Salonen. Bioavailability of detomidine administered sublingually to horses as an oromucosal gel.
Journal of veterinary pharmacology and therapeutics.
2011 Feb; 34(1):76-81. doi:
10.1111/j.1365-2885.2010.01193.x. [PMID: 21219348] - Joanna Virgin, Dean Hendrickson, Ty Wallis, Sangeeta Rao. Comparison of intraoperative behavioral and hormonal responses to noxious stimuli between mares sedated with caudal epidural detomidine hydrochloride or a continuous intravenous infusion of detomidine hydrochloride for standing laparoscopic ovariectomy.
Veterinary surgery : VS.
2010 Aug; 39(6):754-60. doi:
10.1111/j.1532-950x.2010.00702.x. [PMID: 20459483] - Jo Stephen, Ms Harty, Ar Hollis, Jm Yeomans, Ktt Corley. A non-invasive technique for standing surgical repair of urinary bladder rupture in a post-partum mare: a case report.
Irish veterinary journal.
2009 Nov; 62(11):734-6. doi:
10.1186/2046-0481-62-11-734. [PMID: 21851726] - K R Mama, K Grimsrud, T Snell, S Stanley. Plasma concentrations, behavioural and physiological effects following intravenous and intramuscular detomidine in horses.
Equine veterinary journal.
2009 Nov; 41(8):772-7. doi:
10.2746/042516409x421624. [PMID: 20095225] - J A E Hubbell, R A Sams, L M Schmall, J T Robertson, K W Hinchcliff, W W Muir. Pharmacokinetics of detomidine administered to horses at rest and after maximal exercise.
Equine veterinary journal.
2009 May; 41(5):419-22. doi:
10.2746/042516409x382079. [PMID: 19642399] - K N Grimsrud, K R Mama, S M Thomasy, S D Stanley. Pharmacokinetics of detomidine and its metabolites following intravenous and intramuscular administration in horses.
Equine veterinary journal.
2009 Apr; 41(4):361-5. doi:
10.2746/042516409x370900. [PMID: 19562897] - Anna H Edner, Birgitta Essén-Gustavsson, Görel C Nyman. Metabolism during anaesthesia and recovery in colic and healthy horses: a microdialysis study.
Acta veterinaria Scandinavica.
2009 Mar; 51(?):10. doi:
10.1186/1751-0147-51-10. [PMID: 19284560] - Johanna R Elfenbein, L Chris Sanchez, Sheilah A Robertson, Cynthia A Cole, Richard Sams. Effect of detomidine on visceral and somatic nociception and duodenal motility in conscious adult horses.
Veterinary anaesthesia and analgesia.
2009 Mar; 36(2):162-72. doi:
10.1111/j.1467-2995.2008.00441.x. [PMID: 19239655] - Anna H Edner, Görel C Nyman, Birgitta Essén-Gustavsson. Metabolism before, during and after anaesthesia in colic and healthy horses.
Acta veterinaria Scandinavica.
2007 Nov; 49(?):34. doi:
10.1186/1751-0147-49-34. [PMID: 18001483] - Michael Röcken, Gesine Mosel, Christiane Stehle, Julia Rass, Lutz F Litzke. Left- and right-sided laparoscopic-assisted nephrectomy in standing horses with unilateral renal disease.
Veterinary surgery : VS.
2007 Aug; 36(6):568-72. doi:
10.1111/j.1532-950x.2007.00306.x. [PMID: 17686131] - Bela M Arosalo, Marja Raekallio, Minna Rajamäki, Elina Holopainen, Tuulia Kastevaara, Hanna Salonen, Satu Sankari. Detecting early kidney damage in horses with colic by measuring matrix metalloproteinase -9 and -2, other enzymes, urinary glucose and total proteins.
Acta veterinaria Scandinavica.
2007 Jan; 49(?):4. doi:
10.1186/1751-0147-49-4. [PMID: 17244354] - Jolynn Joyce, Dean A Hendrickson. Comparison of intraoperative pain responses following intratesticular or mesorchial injection of lidocaine in standing horses undergoing laparoscopic cryptorchidectomy.
Journal of the American Veterinary Medical Association.
2006 Dec; 229(11):1779-83. doi:
10.2460/javma.229.11.1779. [PMID: 17144826] - Z Gajewski, R Thun, R Faundez, B Pawliński. The influence of alpha-adrenergic receptors stimulator and blockers and beta-blocker on the ovary and endocrinological activity in heifers during superovulation.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2006 Nov; 57 Suppl 8(?):173-88. doi:
NULL. [PMID: 17242481] - K J Stafford, J P Chambers, S P Sylvester, P R Kenyon, S T Morris, I Lizarraga, G de Nicolo. The stress caused by laparoscopy in sheep and its alleviation.
New Zealand veterinary journal.
2006 Jun; 54(3):109-13. doi:
10.1080/00480169.2006.36621. [PMID: 16751840] - A Edner, B Essén-Gustavsson, G Nyman. Muscle metabolic changes associated with long-term inhalation anaesthesia in the horse analysed by muscle biopsy and microdialysis techniques.
Journal of veterinary medicine. A, Physiology, pathology, clinical medicine.
2005 Mar; 52(2):99-107. doi:
10.1111/j.1439-0442.2004.00685.x. [PMID: 15737180] - Enrique Nuñez, Eugene P Steffey, Luis Ocampo, Alejandro Rodriguez, Alma A Garcia. Effects of alpha2-adrenergic receptor agonists on urine production in horses deprived of food and water.
American journal of veterinary research.
2004 Oct; 65(10):1342-6. doi:
10.2460/ajvr.2004.65.1342. [PMID: 15524320] - Maria Elena Dell'Aquila, Maud Caillaud, Filippo Maritato, Alain Martoriati, Nadine Gérard, Giulio Aiudi, Paolo Minoia, Ghylène Goudet. Cumulus expansion, nuclear maturation and connexin 43, cyclooxygenase-2 and FSH receptor mRNA expression in equine cumulus-oocyte complexes cultured in vitro in the presence of FSH and precursors for hyaluronic acid synthesis.
Reproductive biology and endocrinology : RB&E.
2004 Jun; 2(?):44. doi:
10.1186/1477-7827-2-44. [PMID: 15212696] - D C Rankin, S A Greene, R D Keegan, A B Weil, R K Schneider, W M Bayly. Anesthesia of horses with a combination of detomidine, zolazepam, tiletamine, and isoflurane immediately after strenuous treadmill exercise.
American journal of veterinary research.
1999 Jun; 60(6):743-8. doi:
NULL. [PMID: 10376905] - P M Taylor, J J Kirby, D J Shrimpton, C B Johnson. Cardiovascular effects of surgical castration during anaesthesia maintained with halothane or infusion of detomidine, ketamine and guaifenesin in ponies.
Equine veterinary journal.
1998 Jul; 30(4):304-9. doi:
10.1111/j.2042-3306.1998.tb04102.x. [PMID: 9705113] - J M Sleeman, W Carter, T Tobin, E C Ramsay. Immobilization of domestic goats (Capra hircus) using orally administered carfentanil citrate and detomidine hydrochloride.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
1997 Jun; 28(2):158-65. doi:
NULL. [PMID: 9279404] - A Nolan, J Reid, E Welsh, D Flaherty, R McCormack, A M Monteiro. Simultaneous infusions of propofol and ketamine in ponies premedicated with detomidine: a pharmacokinetic study.
Research in veterinary science.
1996 May; 60(3):262-6. doi:
10.1016/s0034-5288(96)90051-x. [PMID: 8735519] - P M Taylor, S P Luna, J W Sear, M J Wheeler. Total intravenous anaesthesia in ponies using detomidine, ketamine and guaiphenesin: pharmacokinetics, cardiopulmonary and endocrine effects.
Research in veterinary science.
1995 Jul; 59(1):17-23. doi:
10.1016/0034-5288(95)90024-1. [PMID: 8525079] - R T Skarda, W W Muir. Caudal analgesia induced by epidural or subarachnoid administration of detomidine hydrochloride solution in mares.
American journal of veterinary research.
1994 May; 55(5):670-80. doi:
NULL. [PMID: 8067616] - P van Dijk. Intravenous anaesthesia in horses by guaiphenesin-ketamine-detomidine infusion: some effects.
The veterinary quarterly.
1994 May; 16 Suppl 2(?):S122-4. doi:
NULL. [PMID: 7801504] - D A Daunt, C I Dunlop, P L Chapman, S L Shafer, H Ruskoaho, O Vakkuri, D S Hodgson, L M Tyler, M Maze. Cardiopulmonary and behavioral responses to computer-driven infusion of detomidine in standing horses.
American journal of veterinary research.
1993 Dec; 54(12):2075-82. doi:
NULL. [PMID: 8116941] - N Rangel, S Uhlén, J E Wikberg. Detomidine binding to guinea pig liver imidazoline receptors (I-receptors) shows marked positive cooperativity.
Pharmacology & toxicology.
1993 Aug; 73(2):86-90. doi:
10.1111/j.1600-0773.1993.tb01541.x. [PMID: 8248011] - O Vakkuri, H Rintamäki, J Leppäluoto. Noradrenergic inhibition and alpha 2-adrenergic stimulation of melatonin secretion in the pigeon.
Journal of neurochemistry.
1992 Sep; 59(3):915-8. doi:
10.1111/j.1471-4159.1992.tb08330.x. [PMID: 1322974] - M Raekallio, A Leino, O Vainio, M Scheinin. Sympatho-adrenal activity and the clinical sedative effect of detomidine in horses.
Equine veterinary journal. Supplement.
1992 Feb; ?(11):66-8. doi:
10.1111/j.2042-3306.1992.tb04777.x. [PMID: 9109965] - J S Salonen, L Vuorilehto, M Gilbert, G A Maylin. Identification of detomidine carboxylic acid as the major urinary metabolite of detomidine in the horse.
European journal of drug metabolism and pharmacokinetics.
1992 Jan; 17(1):13-20. doi:
10.1007/bf03189982. [PMID: 1499593] - J S Salonen. Tissue-specificity of hydroxylation and N-methylation of arylalkylimidazoles.
Pharmacology & toxicology.
1991 Jul; 69(1):1-4. doi:
10.1111/j.1600-0773.1991.tb00398.x. [PMID: 1946187] - M Raekallio, O Vainio, M Scheinin. Detomidine reduces the plasma catecholamine, but not cortisol concentrations in horses.
Zentralblatt fur Veterinarmedizin. Reihe A.
1991 Apr; 38(3):153-6. doi:
10.1111/j.1439-0442.1991.tb00996.x. [PMID: 1907061] - P K Peshin, A P Singh, J Singh, D B Patil, D Sharifi. Sedative effect of detomidine in infant calves.
Acta veterinaria Hungarica.
1991; 39(3-4):103-7. doi:
NULL. [PMID: 1785429] - A P Singh, P K Peshin, J Singh, D Sharifi, D B Patil. Evaluation of detomidine as a sedative in goats.
Acta veterinaria Hungarica.
1991; 39(3-4):109-14. doi:
NULL. [PMID: 1785430] - M A Seymour, P Teale, M W Horner. Metabolites of detomidine in horse urine.
Biomedical & environmental mass spectrometry.
1990 Jul; 19(7):447-9. doi:
10.1002/bms.1200190710. [PMID: 2169321] - J S Salonen, T Vähä-Vahe, O Vainio, O Vakkuri. Single-dose pharmacokinetics of detomidine in the horse and cow.
Journal of veterinary pharmacology and therapeutics.
1989 Mar; 12(1):65-72. doi:
10.1111/j.1365-2885.1989.tb00643.x. [PMID: 2704064] - T Wood, C L Tai, D G Taylor, W E Woods, C J Wang, P K Houtz, H H Tai, T J Weckman, J M Yang, L Sturma. Immunoassay detection of drugs in racing horses. IX. Detection of detomidine in equine blood and urine by radioimmunoassay.
Research communications in chemical pathology and pharmacology.
1989 Feb; 63(2):263-79. doi:
NULL. [PMID: 2711028] - F Gasthuys, C van den Hende, A De Moor. Biochemical changes in blood and urine during halothane anaesthesia with detomidine premedication in the horse.
Zentralblatt fur Veterinarmedizin. Reihe A.
1988 Nov; 35(9):655-64. doi:
NULL. [PMID: 3143194] - J S Salonen, E M Suolinna. Metabolism of detomidine in the rat. I. Comparison of 3H-labelled metabolites formed in vitro and in vivo.
European journal of drug metabolism and pharmacokinetics.
1988 Jan; 13(1):53-8. doi:
10.1007/bf03189929. [PMID: 3396614] - J S Salonen, L Vuorilehto, M Eloranta, A Karjalainen. Metabolism of detomidine in the rat. II. Characterisation of metabolites in urine.
European journal of drug metabolism and pharmacokinetics.
1988 Jan; 13(1):59-65. doi:
10.1007/bf03189930. [PMID: 3396615] - F Gasthuys, P Terpstra, C van den Hende, A De Moor. Hyperglycaemia and diuresis during sedation with detomidine in the horse.
Zentralblatt fur Veterinarmedizin. Reihe A.
1987 Nov; 34(9):641-8. doi:
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