Fluralaner (BioDeep_00000858846)
代谢物信息卡片
Fluralaner
化学式: C22H17Cl2F6N3O3 (555.0551104)
中文名称: 氟雷拉纳
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C=CC(=C1)C2=NOC(C2)(C3=CC(=CC(=C3)Cl)Cl)C(F)(F)F)C(=O)NCC(=O)NCC(F)(F)F
InChI: InChI=1S/C22H17Cl2F6N3O3/c1-11-4-12(2-3-16(11)19(35)31-9-18(34)32-10-21(25,26)27)17-8-20(36-33-17,22(28,29)30)13-5-14(23)7-15(24)6-13/h2-7H,8-10H2,1H3,(H,31,35)(H,32,34)
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kotaro Takano, Scott Carver, Yolandi Vermaak, Katja Fischer, Robert J Harvey, Kate E Mounsey. Assessment of the in vitro acaricidal activity of Bravecto® (fluralaner) and a proposed orange oil-based formulation vehicle for the treatment of Sarcoptes scabiei.
Parasites & vectors.
2024 Apr; 17(1):194. doi:
10.1186/s13071-024-06275-9. [PMID: 38664829] - Harish Kumar Shah, Vaishnavi Srinivasan, Shakila Venkatesan, Vijayakumar Balakrishnan, Sadanandane Candasamy, Nisha Mathew, Ashwani Kumar, Vijesh Sreedhar Kuttiatt. Evaluation of the mosquitocidal efficacy of fluralaner, a potential candidate for drug based vector control.
Scientific reports.
2024 03; 14(1):5628. doi:
10.1038/s41598-024-56053-x. [PMID: 38454095] - Leyi Shao, Wei Wang, Xin Gong, Yinghao Yu, Junao Xue, Xinnian Zeng, Jiali Liu. The Toxicity Differences of Fluralaner against the Red Imported Fire Ant (Solenopsis invicta) at Different Developmental Stages.
International journal of molecular sciences.
2023 Oct; 24(21):. doi:
10.3390/ijms242115627. [PMID: 37958611] - Maria A González-Morales, Andrea E Thomson, James Yeatts, Hiroko Enomoto, Ahmed Haija, Richard G Santangelo, Olivia A Petritz, Rocio Crespo, Coby Schal, Ronald Baynes. Pharmacokinetics of fluralaner as a systemic drug to control infestations of the common bed bug, Cimex lectularius, in poultry facilities.
Parasites & vectors.
2023 Sep; 16(1):333. doi:
10.1186/s13071-023-05962-3. [PMID: 37735689] - Blythe E Lawson, Emily G McDermott. Topical, contact, and oral susceptibility of adult Culicoides biting midges (Diptera: Ceratopogonidae) to fluralaner.
Parasites & vectors.
2023 Aug; 16(1):281. doi:
10.1186/s13071-023-05899-7. [PMID: 37580834] - Yichi Zhang, Qiutang Huang, Chengwang Sheng, Genyan Liu, Kexin Zhang, Zhongqiang Jia, Tao Tang, Xin Mao, Andrew K Jones, Zhaojun Han, Chunqing Zhao. G3'MTMD3 in the insect GABA receptor subunit, RDL, confers resistance to broflanilide and fluralaner.
PLoS genetics.
2023 Jun; 19(6):e1010814. doi:
10.1371/journal.pgen.1010814. [PMID: 37384781] - Rachel H Norris, Oshneil S Baker, Edwin R Burgess, Aaron Tarone, Alec Gerry, Rebecca T Trout Fryxell, Nancy C Hinkle, Cassandra Olds, David Boxler, Kenneth L Wise, Erika T Machtinger, Jeffrey G Scott. Selection for, and characterization of, fluralaner resistance in the house fly, Musca domestica.
Pesticide biochemistry and physiology.
2023 Apr; 191(?):105355. doi:
10.1016/j.pestbp.2023.105355. [PMID: 36963950] - María Salomé Gastaldi, Iván Felsztyna, Virginia Miguel, Mariela E Sánchez-Borzone, Daniel A García. Theoretical and Experimental Study of Molecular Interactions of Fluralaner with Lipid Membranes.
Journal of agricultural and food chemistry.
2023 Feb; 71(4):2134-2142. doi:
10.1021/acs.jafc.2c06811. [PMID: 36688903] - Ting Xiong, Si-Quan Ling, Jia-Li Liu, Xin-Nian Zeng. Insecticidal and P450 mediate metabolism of fluralaner against red imported fire ant, Solenopsis invicta (Hymenoptera: Formicidae).
Pesticide biochemistry and physiology.
2022 Oct; 187(?):105184. doi:
10.1016/j.pestbp.2022.105184. [PMID: 36127046] - Qiuhui Wang, Haocheng Wang, Yingxin Zhang, Jing Chen, Archana Upadhyay, Biswajit Bhowmick, Jiayu Hang, Shaoying Wu, Chenghong Liao, Qian Han. Functional analysis reveals ionotropic GABA receptor subunit RDL is a target site of ivermectin and fluralaner in the yellow fever mosquito, Aedes aegypti.
Pest management science.
2022 Oct; 78(10):4173-4182. doi:
10.1002/ps.7035. [PMID: 35690922] - Ivo Petersen, Katharina Johannhörster, Eric Pagot, Damian Escribano, Eva Zschiesche, Déborah Temple, Emmanuel Thomas. Assessment of fluralaner as a treatment in controlling Dermanyssus gallinae infestation on commercial layer farms and the potential for resulting benefits of improved bird welfare and productivity.
Parasites & vectors.
2021 Mar; 14(1):181. doi:
10.1186/s13071-021-04685-7. [PMID: 33789728] - Vicky Wilkinson, Kotaro Takano, David Nichols, Alynn Martin, Roz Holme, David Phalen, Kate Mounsey, Michael Charleston, Alexandre Kreiss, Ruth Pye, Elizabeth Browne, Christina Næsborg-Nielsen, Shane A Richards, Scott Carver. Fluralaner as a novel treatment for sarcoptic mange in the bare-nosed wombat (Vombatus ursinus): safety, pharmacokinetics, efficacy and practicable use.
Parasites & vectors.
2021 Jan; 14(1):18. doi:
10.1186/s13071-020-04500-9. [PMID: 33407820] - Peach Van Wick, Mark G Papich, Brie Hashem, Ernesto Dominguez-Villegas. PHARMACOKINETICS OF A SINGLE DOSE OF FLURALANER ADMINISTERED ORALLY TO AMERICAN BLACK BEARS (URSUS AMERICANUS).
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2020 Nov; 51(3):691-695. doi:
10.1638/2019-0200. [PMID: 33480547] - Zhaoxian Zhang, Liangliang Zhou, Yingying Gao, Jing Zhang, Beibei Gao, Haiyan Shi, Minghua Wang. Enantioselective Detection, Bioactivity, and Metabolism of the Novel Chiral Insecticide Fluralaner.
Journal of agricultural and food chemistry.
2020 Jun; 68(25):6802-6810. doi:
10.1021/acs.jafc.9b07907. [PMID: 32323985] - Kipchoge Leviticus, Li Cui, Han Ling, Zhong-Qiang Jia, Qiu-Tang Huang, Zhao-Jun Han, Chun-Qing Zhao, Lu Xu. Lethal and sublethal effects of fluralaner on the two-spotted spider mites, Tetranychus urticae Koch (Acari: Tetranychidae).
Pest management science.
2020 Mar; 76(3):888-893. doi:
10.1002/ps.5593. [PMID: 31429178] - Jérôme Pelletier, Jean-Philippe Rocheleau, Cécile Aenishaenslin, Francis Beaudry, Gabrielle Dimitri Masson, L Robbin Lindsay, Nicholas H Ogden, Catherine Bouchard, Patrick A Leighton. Evaluation of fluralaner as an oral acaricide to reduce tick infestation in a wild rodent reservoir of Lyme disease.
Parasites & vectors.
2020 Feb; 13(1):73. doi:
10.1186/s13071-020-3932-7. [PMID: 32054498] - Zhong-Qiang Jia, Di Liu, Ying-Chuan Peng, Zhao-Jun Han, Chun-Qing Zhao, Tao Tang. Identification of transcriptome and fluralaner responsive genes in the common cutworm Spodoptera litura Fabricius, based on RNA-seq.
BMC genomics.
2020 Feb; 21(1):120. doi:
10.1186/s12864-020-6533-0. [PMID: 32013879] - Cheng-Wang Sheng, Qiu-Tang Huang, Gen-Yan Liu, Xue-Xiang Ren, Jie Jiang, Zhong-Qiang Jia, Zhao-Jun Han, Chun-Qing Zhao. Neurotoxicity and mode of action of fluralaner on honeybee Apis mellifera L.
Pest management science.
2019 Nov; 75(11):2901-2909. doi:
10.1002/ps.5483. [PMID: 31081291] - Nadja Rohdich, Eva Zschiesche, Oliver Wolf, Wolfgang Loehlein, Zvezdelina Kirkova, Petar Iliev, Dhimitër Rapti, Rezart Postoli, Balázs Capári, Róbert Farkas, Rainer K A Roepke. A randomized, blinded, controlled, multi-centered field study assessing the treatment of gastrointestinal nematode infections in cats with fluralaner plus moxidectin spot-on solution (Bravecto® Plus).
Parasites & vectors.
2018 Nov; 11(1):589. doi:
10.1186/s13071-018-3169-x. [PMID: 30449275] - Di Liu, Zhong-Qiang Jia, Ying-Chuan Peng, Cheng-Wang Sheng, Tao Tang, Lu Xu, Zhao-Jun Han, Chun-Qing Zhao. Toxicity and sublethal effects of fluralaner on Spodoptera litura Fabricius (Lepidoptera: Noctuidae).
Pesticide biochemistry and physiology.
2018 Nov; 152(?):8-16. doi:
10.1016/j.pestbp.2018.08.004. [PMID: 30497715] - Zhong-Qiang Jia, Di Liu, Cheng-Wang Sheng, John E Casida, Chen Wang, Ping-Ping Song, Yu-Ming Chen, Zhao-Jun Han, Chun-Qing Zhao. Acute toxicity, bioconcentration, elimination and antioxidant effects of fluralaner in zebrafish, Danio rerio.
Environmental pollution (Barking, Essex : 1987).
2018 Jan; 232(?):183-190. doi:
10.1016/j.envpol.2017.09.032. [PMID: 28923341] - Susanne Kilp, Diana Ramirez, Mark J Allan, Rainer Ka Roepke. Comparative pharmacokinetics of fluralaner in dogs and cats following single topical or intravenous administration.
Parasites & vectors.
2016 05; 9(1):296. doi:
10.1186/s13071-016-1564-8. [PMID: 27241240] - Odile Crosaz, Elodie Chapelle, Noëlle Cochet-Faivre, Diane Ka, Céline Hubinois, Jacques Guillot. Open field study on the efficacy of oral fluralaner for long-term control of flea allergy dermatitis in client-owned dogs in Ile-de-France region.
Parasites & vectors.
2016 Mar; 9(?):174. doi:
10.1186/s13071-016-1463-z. [PMID: 27007494] - Feli M Walther, Mark J Allan, Rainer K A Roepke. Plasma pharmacokinetic profile of fluralaner (Bravecto™) and ivermectin following concurrent administration to dogs.
Parasites & vectors.
2015 Oct; 8(?):508. doi:
10.1186/s13071-015-1123-8. [PMID: 26438338] - Susanne Kilp, Diana Ramirez, Mark J Allan, Rainer K A Roepke, Martin C Nuernberger. Pharmacokinetics of fluralaner in dogs following a single oral or intravenous administration.
Parasites & vectors.
2014 Mar; 7(?):85. doi:
10.1186/1756-3305-7-85. [PMID: 24606874] - Feli M Walther, Mark J Allan, Rainer K A Roepke, Martin C Nuernberger. The effect of food on the pharmacokinetics of oral fluralaner in dogs.
Parasites & vectors.
2014 Mar; 7(?):84. doi:
10.1186/1756-3305-7-84. [PMID: 24598049] - S Kjelleberg, B Norkrans, H Löfgren, K Larsson. Surface balance study of the interaction between microorganisms and lipid monolayer at the air/water interface.
Applied and environmental microbiology.
1976 Apr; 31(4):609-11. doi:
10.1128/aem.31.4.609-611.1976. [PMID: 5058]