Piclamilast (BioDeep_00000858841)
代谢物信息卡片
化学式: C18H18Cl2N2O3 (380.0694)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=C(C=C(C=C1)C(=O)NC2=C(C=NC=C2Cl)Cl)OC3CCCC3
InChI: InChI=1S/C18H18Cl2N2O3/c1-24-15-7-6-11(8-16(15)25-12-4-2-3-5-12)18(23)22-17-13(19)9-21-10-14(17)20/h6-10,12H,2-5H2,1H3,(H,21,22,23)
描述信息
D004791 - Enzyme Inhibitors > D010726 - Phosphodiesterase Inhibitors > D058988 - Phosphodiesterase 4 Inhibitors
C471 - Enzyme Inhibitor > C744 - Phosphodiesterase Inhibitor
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:47619
- KEGGdrug: D05474
- PubChem: 154575
- DrugBank: DB01791
- ChEMBL: CHEMBL42126
- CAS: 144035-83-6
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Thomas H Sisson, Paul J Christensen, Yo Muraki, Anthony J Dils, Lauren Chibucos, Natalya Subbotina, Kimio Tohyama, Jeffrey C Horowitz, Takanori Matsuo, Marc Bailie, Sham Nikam, Masatoshi Hazama. Phosphodiesterase 4 inhibition reduces lung fibrosis following targeted type II alveolar epithelial cell injury.
Physiological reports.
2018 06; 6(12):e13753. doi:
10.14814/phy2.13753
. [PMID: 29952109] - Thomas M Ehrman, David J Barlow, Peter J Hylands. In silico search for multi-target anti-inflammatories in Chinese herbs and formulas.
Bioorganic & medicinal chemistry.
2010 Mar; 18(6):2204-2218. doi:
10.1016/j.bmc.2010.01.070
. [PMID: 20188577] - Allen J Duplantier, Elizabeth L Bachert, John B Cheng, Victoria L Cohan, Teresa H Jenkinson, Kenneth G Kraus, Michael W McKechney, Joann D Pillar, John W Watson. SAR of a series of 5,6-dihydro-(9H)-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-alpha]pyridines as potent inhibitors of human eosinophil phosphodiesterase.
Journal of medicinal chemistry.
2007 Jan; 50(2):344-9. doi:
10.1021/jm060904g
. [PMID: 17228876] - Kerryn McCluskie, Uwe Klein, Chris Linnevers, Yu-Hua Ji, Alfred Yang, Craig Husfeld, G Roger Thomas. Phosphodiesterase type 4 inhibitors cause proinflammatory effects in vivo.
The Journal of pharmacology and experimental therapeutics.
2006 Oct; 319(1):468-76. doi:
10.1124/jpet.106.105080
. [PMID: 16861399] - E B Haddad, M Birrell, K McCluskie, A Ling, S E Webber, M L Foster, M G Belvisi. Role of p38 MAP kinase in LPS-induced airway inflammation in the rat.
British journal of pharmacology.
2001 Apr; 132(8):1715-24. doi:
10.1038/sj.bjp.0704022
. [PMID: 11309243] - D Argenti, S K Vaccaro, B Shah, Gillen, S Rohatagi, B K Jensen. Effect of food and gender on the pharmacokinetics of RP 73401, a phosphodiesterase IV inhibitor.
International journal of clinical pharmacology and therapeutics.
2000 Dec; 38(12):588-94. doi:
10.5414/cpp38588
. [PMID: 11125872] - K C Cassidy, M Muc, R Hsu, Z Jayyosi, M P Marietta. Quantitation of N-(3,5-dichloropyrid-4-yl)-3-cyclopentyloxy-4-methoxybenzamide and 4-amino-3,5-dichloropyridine in rat and mouse plasma by LC/MS/MS.
Journal of pharmaceutical and biomedical analysis.
2000 Jun; 22(5):869-77. doi:
10.1016/s0731-7085(00)00254-5
. [PMID: 10815728] - C Hulme, K Moriarty, B Miller, R Mathew, M Ramanjulu, P Cox, J Souness, K M Page, J Uhl, J Travis, F C Huang, R Labaudiniere, S W Djuric. The synthesis and biological evaluation of a novel series of indole PDE4 inhibitors I.
Bioorganic & medicinal chemistry letters.
1998 Jul; 8(14):1867-72. doi:
10.1016/s0960-894x(98)00324-2
. [PMID: 9873449] - J C Stevens, R B White, S H Hsu, M Martinet. Human liver CYP2B6-catalyzed hydroxylation of RP 73401.
The Journal of pharmacology and experimental therapeutics.
1997 Sep; 282(3):1389-95. doi:
. [PMID: 9316851]