Imidafenacin (BioDeep_00000858829)
代谢物信息卡片
Imidafenacin
化学式: C20H21N3O (319.1684536)
中文名称: 咪达那新
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=NC=CN1CCC(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N
InChI: InChI=1S/C20H21N3O/c1-16-22-13-15-23(16)14-12-20(19(21)24,17-8-4-2-5-9-17)18-10-6-3-7-11-18/h2-11,13,15H,12,14H2,1H3,(H2,21,24)
描述信息
G - Genito urinary system and sex hormones > G04 - Urologicals > G04B - Urologicals > G04BD - Drugs for urinary frequency and incontinence
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent
Imidafenacin (KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors.
同义名列表
3 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:134720
- KEGGdrug: D06273
- PubChem: 6433090
- DrugBank: DB09262
- ChEMBL: CHEMBL53366
- CAS: 170105-16-5
- medchemexpress: HY-B0662
分类词条
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kentaro Machida, Tomotaka Kawayama, Masaharu Kinoshita, Masakazu Ichinose, Tohru Tsuda, Shohei Takata, Hiroshi Koto, Makoto Yoshida, Yoshinori Ashihara, Masaru Kawashima, Hideaki Suna, Hiromasa Inoue. Imidafenacin, An Orally Active Muscarinic Receptor Antagonist, Improves Pulmonary Function In Patients With Chronic Obstructive Pulmonary Disease: A Multicenter, Randomized, Double-Blind, Placebo-Controlled 3×3 Crossover Phase II Trial.
International journal of chronic obstructive pulmonary disease.
2019; 14(?):2175-2184. doi:
10.2147/copd.s223002. [PMID: 31571853] - Taek Hwan Shin, Sung Hyun Im, Min Su Goh, Eun Seok Lee, Myoung Jin Ho, Chang Hyun Kim, Myung Joo Kang, Young Wook Choi. Novel Extended-Release Multiple-Unit System of Imidafenacin Prepared by Fluid-Bed Coating Technique.
AAPS PharmSciTech.
2018 Aug; 19(6):2639-2645. doi:
10.1208/s12249-018-1100-6. [PMID: 29931609] - Yoshihiko Ito, Shiori Kuraoka, Soma Endo, Ayaka Takahashi, Satomi Onoue, Shizuo Yamada. Urinary Excretion Contributes to Long-Lasting Blockade of Bladder Muscarinic Receptors by Imidafenacin: Effect of Bilateral Ureteral Ligation.
The Journal of pharmacology and experimental therapeutics.
2017 Jan; 360(1):69-74. doi:
10.1124/jpet.116.236497. [PMID: 27831487] - Takanobu Yamazaki, Ayako Fukata, Yukiko Muraki. Imidafenacin exerts the antidiuretic effect by enhancing vasopressin-related responses in orally water-loaded rats.
European journal of pharmacology.
2016 Nov; 791(?):72-77. doi:
10.1016/j.ejphar.2016.08.021. [PMID: 27568834] - A Fukata, T Yamazaki. Comparative Influence of Imidafenacin and Oxybutynin on Voiding Function in Rats with Functional Urethral Obstruction.
Drug research.
2016 Jun; 66(6):306-11. doi:
10.1055/s-0035-1569410. [PMID: 26979753] - Masaki Ogoda, Yoshihiko Ito, Yusuke Fuchihata, Satomi Onoue, Shizuo Yamada. Characterization of muscarinic and P2X receptors in the urothelium and detrusor muscle of the rat bladder.
Journal of pharmacological sciences.
2016 May; 131(1):58-63. doi:
10.1016/j.jphs.2016.04.020. [PMID: 27174863] - Osamu Yokoyama, Akira Tsujimura, Hironobu Akino, Naoki Segawa, Satoshi Tamada, Naoki Oguchi, Yasuhide Kitagawa, Hidenori Tsuji, Akihiko Watanabe, Teruo Inamoto, Nobutaka Shimizu, Yasuyoshi Fujiuchi, Yoji Katsuoka, Haruhito Azuma, Tadashi Matsuda, Mikio Namiki, Hirotsugu Uemura, Akihiko Okuyama, Norio Nonomura, Hideki Fuse, Tatsuya Nakatani. Add-on anticholinergic therapy for residual nocturia in patients with lower urinary tract symptoms receiving α1-blocker treatment: a multi-centre, prospective, randomised study.
World journal of urology.
2015 May; 33(5):659-67. doi:
10.1007/s00345-014-1399-x. [PMID: 25224929] - Wei Huang, Huantao Zong, Xin Zhou, Yong Zhang. Efficacy and safety of imidafenacin for overactive bladder in adult: a systematic review and meta-analysis.
International urology and nephrology.
2015 Mar; 47(3):457-64. doi:
10.1007/s11255-015-0916-1. [PMID: 25636812] - C Park, J Park, M-S Choo, J C Kim, J G Lee, J Z Lee, K-S Lee, D Y Kim, S-J Lee, J T Seo. A randomised, prospective double-blind, propiverine-controlled trial of imidafenacin in patients with overactive bladder.
International journal of clinical practice.
2014 Feb; 68(2):188-96. doi:
10.1111/ijcp.12255. [PMID: 24373019] - K-S Lee, B Park, J H Kim, H G Kim, J T Seo, J G Lee, Y Jang, M-S Choo. A randomised, double-blind, parallel design, multi-institutional, non-inferiority phase IV trial of imidafenacin versus fesoterodine for overactive bladder.
International journal of clinical practice.
2013 Dec; 67(12):1317-26. doi:
10.1111/ijcp.12272. [PMID: 24246210] - Osamu Yokoyama, Yukio Homma, Osamu Yamaguchi. Imidafenacin, an antimuscarinic agent, improves nocturia and reduces nocturnal urine volume.
Urology.
2013 Sep; 82(3):515-20. doi:
10.1016/j.urology.2013.05.017. [PMID: 23876590] - Chihiro Hasegawa, Tomoya Ohno, Susumu Nakade, Kimio Shibakawa, Hiroyuki Miyabe, Takafumi Ouchi, Mikio Ogawa. Population pharmacokinetics and exposure-response relationship of a muscarinic receptor antagonist, imidafenacin.
Drug metabolism and pharmacokinetics.
2013; 28(3):203-12. doi:
10.2133/dmpk.dmpk-12-rg-062. [PMID: 23089801] - Naoki Wada, Masaki Watanabe, Masafumi Kita, Seiji Matsumoto, Hiroaki Osanai, Satoshi Yamaguchi, Atsushi Numata, Makoto Fujisawa, Yuji Saga, Kyokushin Hou, Hiromitsu Iuchi, Daisuke Niibori, Tatsuhiko Kura, Akihisa Taniguchi, Manabu Kunieda, Yasunobu Nakata, Hidehiro Kakizaki. Effect of imidafenacin on nocturia and sleep disorder in patients with overactive bladder.
Urologia internationalis.
2012; 89(2):215-21. doi:
10.1159/000339750. [PMID: 22832092] - Katsumi Inoue, Takahiro Shitamura, Toshiyuki Kamoto. [Investigation of pharmacokinetics of crushed imidafenacin 0.1-mg tablet after single oral administration in healthy men].
Hinyokika kiyo. Acta urologica Japonica.
2011 Dec; 57(12):677-81. doi:
NULL. [PMID: 22240300] - Shizuo Yamada, Masanao Seki, Masaki Ogoda, Ayako Fukata, Miho Nakamura, Yoshihiko Ito. Selective binding of bladder muscarinic receptors in relation to the pharmacokinetics of a novel antimuscarinic agent, imidafenacin, to treat overactive bladder.
The Journal of pharmacology and experimental therapeutics.
2011 Feb; 336(2):365-71. doi:
10.1124/jpet.110.172288. [PMID: 21047953] - Naoya Masumori, Shintaro Miyamoto, Taiji Tsukamoto, Seiji Furuya, Akihiko Iwasawa, Takashi Sato, Naoki Itoh, Akihiko Shibuya, Toshiro Oda. The efficacy and safety of propiverine hydrochloride in patients with overactive bladder symptoms who poorly responded to previous anticholinergic agents.
Advances in urology.
2011; 2011(?):714978. doi:
10.1155/2011/714978. [PMID: 21747845] - Naoya Masumori, Taiji Tsukamoto, Masahiro Yanase, Hiroki Horita, Masaharu Aoki. The add-on effect of solifenacin for patients with remaining overactive bladder after treatment with tamsulosin for lower urinary tract symptoms suggestive of benign prostatic obstruction.
Advances in urology.
2010; ?(?):205251. doi:
10.1155/2010/205251. [PMID: 20981257] - Saori Nishijima, Kimio Sugaya, Katsumi Kadekawa, Hidekatsu Naka, Minoru Miyazato. Comparison of the effect of anti-muscarinic agents on bladder activity, urinary ATP level, and autonomic nervous system in rats.
Biomedical research (Tokyo, Japan).
2009 Apr; 30(2):107-12. doi:
10.2220/biomedres.30.107. [PMID: 19420734] - Yukio Homma, Takuhiro Yamaguchi, Osamu Yamaguchi. A randomized, double-blind, placebo-controlled phase II dose-finding study of the novel anti-muscarinic agent imidafenacin in Japanese patients with overactive bladder.
International journal of urology : official journal of the Japanese Urological Association.
2008 Sep; 15(9):809-15. doi:
10.1111/j.1442-2042.2008.02104.x. [PMID: 18637156] - Yoshitaka Hashimoto, Kimio Shibakawa, Susumu Nakade, Yasuyuki Miyata. Validation and application of a 96-well format solid-phase extraction and liquid chromatography-tandem mass spectrometry method for the quantitation of digoxin in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Jun; 869(1-2):126-32. doi:
10.1016/j.jchromb.2008.05.026. [PMID: 18515196] - Tomoya Ohno, Kazuki Nakayama, Susumu Nakade, Junsaku Kitagawa, Shinya Ueda, Hiroyuki Miyabe, Yasuyuki Miyata, Akihiro Ohnishi. Effect of itraconazole on the pharmacokinetics of imidafenacin in healthy subjects.
Journal of clinical pharmacology.
2008 Mar; 48(3):330-4. doi:
10.1177/0091270007310386. [PMID: 18218784] - Tomoya Ohno, Susumu Nakade, Kazuki Nakayama, Junsaku Kitagawa, Shinya Ueda, Hiroyuki Miyabe, Yuichi Masuda, Yasuyuki Miyata. Absolute bioavailability of imidafenacin after oral administration to healthy subjects.
British journal of clinical pharmacology.
2008 Feb; 65(2):197-202. doi:
10.1111/j.1365-2125.2007.02999.x. [PMID: 18251758] - Susumu Nakade, Tomoya Ohno, Kazuki Nakayama, Junsaku Kitagawa, Yoshitaka Hashimoto, Akihiro Ohnishi, Yasuyuki Miyata. No effect of imidafenacin, a novel antimuscarinic drug, on digoxin pharmacokinetics in healthy subjects.
Drug metabolism and pharmacokinetics.
2008; 23(2):95-100. doi:
10.2133/dmpk.23.95. [PMID: 18445988] - Tomoya Ohno, Susumu Nakade, Kazuki Nakayama, Junsaku Kitagawa, Hiroyuki Miyabe, Toshihiko Konomi, Yasuyuki Miyata. Population pharmacokinetic analysis of a novel muscarinic receptor antagonist, imidafenacin, in healthy volunteers and overactive bladder patients.
Drug metabolism and pharmacokinetics.
2008; 23(6):456-63. doi:
10.2133/dmpk.23.456. [PMID: 19122340] - Satoshi Ohmori, Masahiro Miura, Chifuyu Toriumi, Yoshiaki Satoh, Tsuyoshi Ooie. Absorption, metabolism, and excretion of [14C]imidafenacin, a new compound for treatment of overactive bladder, after oral administration to healthy male subjects.
Drug metabolism and disposition: the biological fate of chemicals.
2007 Sep; 35(9):1624-33. doi:
10.1124/dmd.107.016030. [PMID: 17567733] - Yuichi Masuda, Norihiro Kanayama, Shigeru Manita, Satoshi Ohmori, Tsuyoshi Ooie. Development and validation of bioanalytical methods for imidafenacin (KRP-197/ONO-8025) and its metabolites in human urine by using liquid chromatography-tandem mass spectrometry.
Biomedical chromatography : BMC.
2007 Sep; 21(9):940-8. doi:
10.1002/bmc.837. [PMID: 17474137] - Yuichi Masuda, Norihiro Kanayama, Shigeru Manita, Satoshi Ohmori, Tsuyoshi Ooie. Development and validation of bioanalytical methods for Imidafenacin (KRP-197/ONO-8025) and its metabolites in human plasma by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Jun; 853(1-2):70-9. doi:
10.1016/j.jchromb.2007.02.047. [PMID: 17387045]