Vascor (BioDeep_00000858809)
代谢物信息卡片
Bepridil hydrochloride
化学式: C24H37ClN2O2 (420.2543412)
中文名称: 盐酸苄普地尔
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)COCC(CN(CC1=CC=CC=C1)C2=CC=CC=C2)N3CCCC3.O.Cl
InChI: 1H
描述信息
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker
同义名列表
2 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:52715
- KEGGdrug: D00631
- PubChem: 91725
- ChEMBL: CHEMBL1200382
- MeSH: Bepridil
- CAS: 74764-40-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Erol C Vatansever, Kai S Yang, Aleksandra K Drelich, Kaci C Kratch, Chia-Chuan Cho, Kempaiah Rayavara Kempaiah, Jason C Hsu, Drake M Mellott, Shiqing Xu, Chien-Te K Tseng, Wenshe Ray Liu. Bepridil is potent against SARS-CoV-2 in vitro.
Proceedings of the National Academy of Sciences of the United States of America.
2021 03; 118(10):. doi:
10.1073/pnas.2012201118. [PMID: 33597253] - Kazuki Matsui, Yutaro Mukai, Kota Sakakura, Kyoichi Wada, Tsutomu Nakamura, Atsufumi Kawabata, Nobue Terakawa, Naoki Hayakawa, Kengo Kusano, Kouichi Hosomi, Satoshi Yokoyama, Mitsutaka Takada. Relationship between serum bepridil concentration and corrected QT interval.
International journal of clinical pharmacology and therapeutics.
2021 Jan; 59(1):63-70. doi:
10.5414/cp203843. [PMID: 33026317] - Xin Cao, Yoshinobu Nagasawa, Chengshun Zhang, Hanxiao Zhang, Megumi Aimoto, Akira Takahara. Electropharmacological profile of an atrial-selective sodium channel blocker acehytisine assessed in the isoflurane-anesthetized guinea-pig model.
Journal of pharmacological sciences.
2019 Dec; 141(4):153-159. doi:
10.1016/j.jphs.2019.10.006. [PMID: 31757741] - Bhavesh D Patel, Nageswararao Palakundam, Rajesh Alamanda, Ajit R Gadekar, Amol A Raje, Rakshit Ameta. A simple and sensitive LC-MS/MS method for quantification of Bepridil in rat plasma and its application to pharmacokinetic studies.
Journal of pharmaceutical and biomedical analysis.
2019 Aug; 172(?):113-119. doi:
10.1016/j.jpba.2019.04.038. [PMID: 31029800] - Kjell De Vriese, Ellie Himschoot, Kai Dünser, Long Nguyen, Andrzej Drozdzecki, Alex Costa, Moritz K Nowack, Jürgen Kleine-Vehn, Dominique Audenaert, Tom Beeckman, Steffen Vanneste. Identification of Novel Inhibitors of Auxin-Induced Ca2+ Signaling via a Plant-Based Chemical Screen.
Plant physiology.
2019 05; 180(1):480-496. doi:
10.1104/pp.18.01393. [PMID: 30737267] - Chikako Shimizu, Yutaka Mitani, Youichi Tsuchiya, Toshitaka Nabeshima. Effects of Oral Calcium Dosage and Timing on Ethanol-Induced Sensitization of Locomotion in DBA/2 Mice.
Biological & pharmaceutical bulletin.
2018 Jul; 41(7):1049-1061. doi:
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Human & experimental toxicology.
2018 Jun; 37(6):636-646. doi:
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The European journal of neuroscience.
2017 Sep; 46(5):2108-2120. doi:
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Drug metabolism and pharmacokinetics.
2015 Aug; 30(4):257-62. doi:
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Therapeutic drug monitoring.
2013 Jun; 35(3):367-73. doi:
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Biochimica et biophysica acta.
2013 Jun; 1828(6):1494-502. doi:
10.1016/j.bbamem.2013.02.012. [PMID: 23473737] - Wei Cui, Jie Zhang, Chuan-Xin Zhang, Guang-Zhong Jiao, Min Zhang, Tian-Yang Wang, Ming-Jiu Luo, Jing-He Tan. Control of spontaneous activation of rat oocytes by regulating plasma membrane Na+/Ca2+ exchanger activities.
Biology of reproduction.
2013 Jun; 88(6):160. doi:
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Biological & pharmaceutical bulletin.
2012; 35(5):672-6. doi:
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Journal of chromatographic science.
2011 Aug; 49(7):519-23. doi:
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Circulation journal : official journal of the Japanese Circulation Society.
2011; 75(6):1334-42. doi:
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Journal of cardiovascular pharmacology.
2010 May; 55(5):511-7. doi:
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Orvosi hetilap.
2008 Feb; 149(7):305-15. doi:
10.1556/oh.2008.28212. [PMID: 18258561] - Akira Fujiki, Tamotsu Sakamoto, Kunihiro Nishida, Koichi Mizumaki, Hiroshi Inoue. Relation of interleukin-6 and C-reactive protein levels to sinus maintenance after pharmacological cardioversion in persistent atrial fibrillation.
Journal of cardiovascular pharmacology.
2007 Sep; 50(3):264-6. doi:
10.1097/fjc.0b013e318074f952. [PMID: 17878753] - Masato Taguchi, Akira Fujiki, Jotaro Iwamoto, Hiroshi Inoue, Katsutoshi Tahara, Katsuya Saigusa, Isao Horiuchi, Yukari Oshima, Yukiya Hashimoto. Nonlinear mixed effects model analysis of the pharmacokinetics of routinely administered bepridil in Japanese patients with arrhythmias.
Biological & pharmaceutical bulletin.
2006 Mar; 29(3):517-21. doi:
10.1248/bpb.29.517. [PMID: 16508157] - Toshiaki Sato, Alexandre D T Costa, Tomoaki Saito, Takehiko Ogura, Hideyuki Ishida, Keith D Garlid, Haruaki Nakaya. Bepridil, an antiarrhythmic drug, opens mitochondrial KATP channels, blocks sarcolemmal KATP channels, and confers cardioprotection.
The Journal of pharmacology and experimental therapeutics.
2006 Jan; 316(1):182-8. doi:
10.1124/jpet.105.094029. [PMID: 16174795] - Motohiro Shiotani, Takuma Harada, Junko Abe, Yasufusa Sawada, Keitaro Hashimoto, Yoshimasa Hamada, Ikuo Horii. Practical application of guinea pig telemetry system for QT evaluation.
The Journal of toxicological sciences.
2005 Aug; 30(3):239-47. doi:
10.2131/jts.30.239. [PMID: 16141657] - Tomoko Uchino, Tae-Seong Lee, Toshihiko Kaku, Noboru Yamashita, Takayuki Noguchi, Katsushige Ono. Voltage-dependent and frequency-independent inhibition of recombinant Cav3.2 T-type Ca2+ channel by bepridil.
Pharmacology.
2005 Jul; 74(4):174-81. doi:
10.1159/000085329. [PMID: 15855830] - Masaki Ohsawa, Fumitaka Tanaka, Fusanori Kunugita, Hidenori Saito, Motoyuki Nakamura, Takahiro Shiroto, Kazuhiko Hotta, Naoki Chiba, Katsuhiko Hiramori. A case of sick sinus syndrome that developed torsades de pointes, pacing failure and sensing failure during administration of bepridil.
Japanese heart journal.
2003 Sep; 44(5):783-8. doi:
10.1536/jhj.44.783. [PMID: 14587660] - Zoltán Macháty, Jagdeece J Ramsoondar, Aaron J Bonk, Randall S Prather, Kenneth R Bondioli. Na(+)/Ca(2+) exchanger in porcine oocytes.
Biology of reproduction.
2002 Oct; 67(4):1133-9. doi:
10.1095/biolreprod67.4.1133. [PMID: 12297528] - Ieva Stupans, Amra Kirlich, Kellie L Tuck, Peter J Hayball. Comparison of radical scavenging effect, inhibition of microsomal oxygen free radical generation, and serum lipoprotein oxidation of several natural antioxidants.
Journal of agricultural and food chemistry.
2002 Apr; 50(8):2464-9. doi:
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Journal of agricultural and food chemistry.
2002 Apr; 50(8):2454-8. doi:
10.1021/jf011369q. [PMID: 11929313] - K Indira Priyadarsini, Sujata M Khopde, S Santosh Kumar, Hari Mohan. Free radical studies of ellagic acid, a natural phenolic antioxidant.
Journal of agricultural and food chemistry.
2002 Mar; 50(7):2200-6. doi:
10.1021/jf011275g. [PMID: 11902978] - Hiroe Kikuzaki, Masashi Hisamoto, Kanae Hirose, Kayo Akiyama, Hisaji Taniguchi. Antioxidant properties of ferulic acid and its related compounds.
Journal of agricultural and food chemistry.
2002 Mar; 50(7):2161-8. doi:
10.1021/jf011348w. [PMID: 11902973] - Yoo K Kim, Qiong Guo, Lester Packer. Free radical scavenging activity of red ginseng aqueous extracts.
Toxicology.
2002 Mar; 172(2):149-56. doi:
10.1016/s0300-483x(01)00585-6. [PMID: 11882354] - Liangli Yu, Scott Haley, Jonathan Perret, Mary Harris, John Wilson, Ming Qian. Free radical scavenging properties of wheat extracts.
Journal of agricultural and food chemistry.
2002 Mar; 50(6):1619-24. doi:
10.1021/jf010964p. [PMID: 11879046] - Elin Mathisen, Drissa Diallo, Øyvind M Andersen, Karl Egil Malterud. Antioxidants from the bark of Burkea africana, an African medicinal plant.
Phytotherapy research : PTR.
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Phytotherapy research : PTR.
2002 Feb; 16(1):63-5. doi:
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Planta medica.
2002 Jan; 68(1):16-9. doi:
10.1055/s-2002-20050. [PMID: 11842320] - S Kobayashi, Y Reien, T Ogura, T Saito, Y Masuda, H Nakaya. Inhibitory effect of bepridil on hKv1.5 channel current: comparison with amiodarone and E-4031.
European journal of pharmacology.
2001 Nov; 430(2-3):149-57. doi:
10.1016/s0014-2999(01)01381-4. [PMID: 11711026] - V Weber, P Coudert, E Duroux, F Leal, J Couquelet, M Madesclaire. Synthesis and in vitro studies of pyrone derivatives as scavengers of active oxygen species.
Arzneimittel-Forschung.
2001 Nov; 51(11):877-84. doi:
10.1055/s-0031-1300131. [PMID: 11765588] - S S Kumar, T P Devasagayam, B Bhushan, N C Verma. Scavenging of reactive oxygen species by chlorophyllin: an ESR study.
Free radical research.
2001 Nov; 35(5):563-74. doi:
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Archives of pharmacal research.
2001 Oct; 24(5):427-30. doi:
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Journal of agricultural and food chemistry.
2001 Oct; 49(10):4956-60. doi:
10.1021/jf010606m. [PMID: 11600050] - M H Kweon, H J Hwang, H C Sung. Identification and antioxidant activity of novel chlorogenic acid derivatives from bamboo (Phyllostachys edulis).
Journal of agricultural and food chemistry.
2001 Oct; 49(10):4646-55. doi:
10.1021/jf010514x. [PMID: 11600002] - J J Chen, Y L Chang, C M Teng, I S Chen. Vasorelaxing and antioxidant constituents from Hernandia nymphaeifolia.
Planta medica.
2001 Oct; 67(7):593-8. doi:
10.1055/s-2001-17348. [PMID: 11582533] - T C J Munasinghe, C K Seneviratne, M I Thabrew, A M Abeysekera. Antiradical and antilipoperoxidative effects of some plant extracts used by Sri Lankan traditional medical practitioners for cardioprotection.
Phytotherapy research : PTR.
2001 Sep; 15(6):519-23. doi:
10.1002/ptr.994. [PMID: 11536382] - Y Narukawa, N Shimizu, K Shimotohno, T Takeda. Two new diterpenoids from Plectranthus nummularius Briq.
Chemical & pharmaceutical bulletin.
2001 Sep; 49(9):1182-4. doi:
10.1248/cpb.49.1182. [PMID: 11558608] - R Aquino, S Morelli, M R Lauro, S Abdo, A Saija, A Tomaino. Phenolic constituents and antioxidant activity of an extract of Anthuriumversicolor leaves.
Journal of natural products.
2001 Aug; 64(8):1019-23. doi:
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European journal of drug metabolism and pharmacokinetics.
2001 Jul; 26(3):155-66. doi:
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Acta poloniae pharmaceutica.
2001 Jul; 58(4):283-8. doi:
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Journal of natural products.
2001 Jul; 64(7):892-5. doi:
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Bioorganic & medicinal chemistry letters.
2001 Jun; 11(12):1565-8. doi:
10.1016/s0960-894x(01)00129-9. [PMID: 11412982] - H Lou, H Yuan, Y Yamazaki, T Sasaki, S Oka. Alkaloids and flavonoids from peanut skins.
Planta medica.
2001 Jun; 67(4):345-9. doi:
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Bioscience, biotechnology, and biochemistry.
2001 Jun; 65(6):1302-9. doi:
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Chemical & pharmaceutical bulletin.
2001 May; 49(5):563-71. doi:
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Biochemical pharmacology.
2001 Apr; 61(8):939-46. doi:
10.1016/s0006-2952(01)00543-3. [PMID: 11286985] - R Søgaard, T Ljungstrøm, K A Pedersen, S P Olesen, B S Jensen. KCNQ4 channels expressed in mammalian cells: functional characteristics and pharmacology.
American journal of physiology. Cell physiology.
2001 Apr; 280(4):C859-66. doi:
10.1152/ajpcell.2001.280.4.c859. [PMID: 11245603] - Y Watanabe, J Kimura. Blocking effect of bepridil on Na+/Ca2+ exchange current in guinea pig cardiac ventricular myocytes.
Japanese journal of pharmacology.
2001 Apr; 85(4):370-5. doi:
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Archives of pharmacal research.
2001 Apr; 24(2):105-8. doi:
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Journal of nutritional science and vitaminology.
2001 Apr; 47(2):167-71. doi:
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Biological & pharmaceutical bulletin.
2001 Mar; 24(3):209-13. doi:
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Phytotherapy research : PTR.
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Phytotherapy research : PTR.
2001 Mar; 15(2):127-30. doi:
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Life sciences.
2001 Feb; 68(12):1351-66. doi:
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Atherosclerosis.
2001 Jan; 154(1):87-96. doi:
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Journal of Asian natural products research.
2001; 3(1):63-75. doi:
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Journal of agricultural and food chemistry.
2000 Nov; 48(11):5710-4. doi:
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Journal of natural products.
2000 Oct; 63(10):1444-6. doi:
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Chemical & pharmaceutical bulletin.
2000 Sep; 48(9):1327-31. doi:
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Bioscience, biotechnology, and biochemistry.
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Journal of ethnopharmacology.
2000 Sep; 72(1-2):239-46. doi:
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Phytotherapy research : PTR.
2000 Aug; 14(5):323-8. doi:
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Biological & pharmaceutical bulletin.
2000 Aug; 23(8):989-94. doi:
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Free radical research.
2000 Jul; 33(1):105-14. doi:
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The Journal of pharmacy and pharmacology.
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