Potassium canrenoate (BioDeep_00000858807)
代谢物信息卡片
Potassium canrenoate
化学式: C22H29KO4 (396.1702814)
中文名称: 坎利酸钾
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC12CCC(=O)C=C1C=CC3C2CCC4(C3CCC4(CCC(=O)[O-])O)C.[K+]
InChI: /q
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D000451 - Mineralocorticoid Receptor Antagonists
C - Cardiovascular system > C03 - Diuretics > C03D - Aldosterone antagonists and other potassium-sparing agents > C03DA - Aldosterone antagonists
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents
C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist
D045283 - Natriuretic Agents > D004232 - Diuretics
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D01943
- PubChem: 23671691
- ChEMBL: CHEMBL1371200
- MeSH: Canrenoic Acid
- CAS: 2181-04-6
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Rafał Dąbrowski, Paweł Syska, Justyna Mączyńska, Michał Farkowski, Stefan Sawicki, Agata Kubaszek-Kornatowska, Piotr Michałek, Ilona Kowalik, Hanna Szwed, Tomasz Hryniewiecki. Clinical efficacy of potassium canreonate-canrenone in sinus rhythm restoration among patients with atrial fibrillation - a protocol of a pilot, randomized, double -blind, placebo-controlled study (CANREN-AF trial).
Trials.
2020 May; 21(1):397. doi:
10.1186/s13063-020-04277-3. [PMID: 32398047] - Anne D Thuesen, Stine H Finsen, Louise L Rasmussen, Ditte C Andersen, Boye L Jensen, Pernille B L Hansen. Deficiency of T-type Ca2+ channels Cav3.1 and Cav3.2 has no effect on angiotensin II-induced hypertension but differential effect on plasma aldosterone in mice.
American journal of physiology. Renal physiology.
2019 08; 317(2):F254-F263. doi:
10.1152/ajprenal.00121.2018. [PMID: 31042060] - Misato Nakamura, Ayumi Eguchi, Mari Inohana, Rei Nagahara, Hirotada Murayama, Masashi Kawashima, Sayaka Mizukami, Mihoko Koyanagi, Shim-Mo Hayashi, Robert R Maronpot, Makoto Shibutani, Toshinori Yoshida. Differential impacts of mineralocorticoid receptor antagonist potassium canrenoate on liver and renal changes in high fat diet-mediated early hepatocarcinogenesis model rats.
The Journal of toxicological sciences.
2018; 43(10):611-621. doi:
10.2131/jts.43.611. [PMID: 30298849] - Giovanni Sansoè, Manuela Aragno, Raffaella Mastrocola, Maurizio Parola. Pathogenesis of solute-free water retention in experimental ascitic cirrhosis: is vasopressin the only culprit?.
Clinical science (London, England : 1979).
2016 Jan; 130(2):117-24. doi:
10.1042/cs20150479. [PMID: 26519424] - Javaid Iqbal, Ruth Andrew, Nicholas L Cruden, Christopher J Kenyon, Katherine A Hughes, David E Newby, Patrick W F Hadoke, Brian R Walker. Displacement of cortisol from human heart by acute administration of a mineralocorticoid receptor antagonist.
The Journal of clinical endocrinology and metabolism.
2014 Mar; 99(3):915-22. doi:
10.1210/jc.2013-2049. [PMID: 24423282] - Maysa Suyagh, Ahmed F Hawwa, Paul S Collier, Jeffrey S Millership, Prashant Kole, Muriel Millar, Mike D Shields, Henry L Halliday, James C McElnay. Potassium canrenoate treatment in paediatric patients: a population pharmacokinetic study using novel dried blood spot sampling.
Journal of hypertension.
2013 Sep; 31(9):1901-8. doi:
10.1097/hjh.0b013e3283626994. [PMID: 23846862] - Miriam T Rademaker, Christopher J Charles, M Gary Nicholls, A Mark Richards. Interactions of enhanced urocortin 2 and mineralocorticoid receptor antagonism in experimental heart failure.
Circulation. Heart failure.
2013 Jul; 6(4):825-32. doi:
10.1161/circheartfailure.112.000205. [PMID: 23753530] - Maysa Suyagh, Ahmed F Hawwa, Paul S Collier, Jeffrey S Millership, Prashant Kole, Muriel Millar, Mike D Shields, Henry L Halliday, James C McElnay. Population pharmacokinetic model of canrenone after intravenous administration of potassium canrenoate to paediatric patients.
British journal of clinical pharmacology.
2012 Nov; 74(5):864-72. doi:
10.1111/j.1365-2125.2012.04257.x. [PMID: 22376078] - Amitava Dasgupta, Myrtle J Johnson, Tamal K Sengupta. Clinically insignificant negative interferences of spironolactone, potassium canrenoate, and their common metabolite canrenone in new dimension vista LOCI digoxin immunoassay.
Journal of clinical laboratory analysis.
2012 May; 26(3):143-7. doi:
10.1002/jcla.21501. [PMID: 22628228] - Yasir H Siddique, Gulshan Ara, Tanveer Beg, Mohammad Afzal, Mohammad Faisal. Antigenotoxic effect of the Plumbago zeylanica extract against the genotoxic damage induced by potassium canrenoate in cultured human peripheral blood lymphocytes.
Drug and chemical toxicology.
2012 Apr; 35(2):119-26. doi:
10.3109/01480545.2011.589443. [PMID: 21995272] - Luminita H Pojoga, Patricia Coutinho, Alicia Rivera, Tham M Yao, Enrique R Maldonado, Rodeler Youte, Gail K Adler, Jonathan Williams, Alexander Turchin, Gordon H Williams, Jose R Romero. Activation of the mineralocorticoid receptor increases striatin levels.
American journal of hypertension.
2012 Feb; 25(2):243-9. doi:
10.1038/ajh.2011.197. [PMID: 22089104] - Melissa Lingis, Elaine M Richards, Maureen Keller-Wood. Differential effects of mineralocorticoid blockade on the hypothalamo-pituitary-adrenal axis in pregnant and nonpregnant ewes.
American journal of physiology. Endocrinology and metabolism.
2011 Mar; 300(3):E592-9. doi:
10.1152/ajpendo.00560.2010. [PMID: 21205934] - Andrea DeFrance, David Armbruster, Diana Petty, Kelley C Cooper, Amitava Dasgupta. Abbott ARCHITECT clinical chemistry and immunoassay systems: digoxin assays are free of interferences from spironolactone, potassium canrenoate, and their common metabolite canrenone.
Therapeutic drug monitoring.
2011 Feb; 33(1):128-31. doi:
10.1097/ftd.0b013e3181fd4c30. [PMID: 21079546] - Kathleen M Knights, Kushari Bowalgaha, John O Miners. Spironolactone and canrenone inhibit UGT2B7-catalyzed human liver and kidney microsomal aldosterone 18beta-glucuronidation: a potential drug interaction.
Drug metabolism and disposition: the biological fate of chemicals.
2010 Jul; 38(7):1011-4. doi:
10.1124/dmd.110.032870. [PMID: 20304966] - Wenxia Chai, Johannes Hofland, Pieter M Jansen, Ingrid M Garrelds, René de Vries, Antoon J van den Bogaerdt, Richard A Feelders, Frank H de Jong, A H Jan Danser. Steroidogenesis vs. steroid uptake in the heart: do corticosteroids mediate effects via cardiac mineralocorticoid receptors?.
Journal of hypertension.
2010 May; 28(5):1044-53. doi:
10.1097/hjh.0b013e328335c381. [PMID: 20179635] - Amitava Dasgupta, Myrtle J Johnson. Effect of spironolactone, potassium canrenoate, and their common metabolite canrenone on Dimension Vista Digoxin Assay.
Journal of clinical laboratory analysis.
2010; 24(6):413-7. doi:
10.1002/jcla.20421. [PMID: 21089173] - Amitava Dasgupta, Gertie Tso, Alice Wells. Effect of spironolactone, potassium canrenoate and their common metabolite canrenone on serum digoxin measurement by digoxin III, a new digoxin immunoassay.
Therapeutic drug monitoring.
2008 Dec; 30(6):744-7. doi:
10.1097/ftd.0b013e31818b0e6a. [PMID: 18824952] - Helen C Atkinson, Susan A Wood, Emma S Castrique, Yvonne M Kershaw, Crispin C R Wiles, Stafford L Lightman. Corticosteroids mediate fast feedback of the rat hypothalamic-pituitary-adrenal axis via the mineralocorticoid receptor.
American journal of physiology. Endocrinology and metabolism.
2008 Jun; 294(6):E1011-22. doi:
10.1152/ajpendo.00721.2007. [PMID: 18349112] - Caroline Rugale, Magali Cordaillat, Albert Mimran, Bernard Jover. Time-course reduction of renal function in rats on high sodium intake: acute reversal by potassium canrenoate.
Clinical and experimental pharmacology & physiology.
2008 Apr; 35(4):412-5. doi:
10.1111/j.1440-1681.2008.04888.x. [PMID: 18307731] - Monica Minnaard-Huiban, Judith M A Emmen, Luc Roumen, Ilona P E Beugels, Géraldine M S Cohuet, Helma van Essen, Eveline Ruijters, Koen Pieterse, Peter A J Hilbers, Harry C J Ottenheijm, Ralf Plate, Marcel E de Gooyer, Jos F M Smits, J J Rob Hermans. Fadrozole reverses cardiac fibrosis in spontaneously hypertensive heart failure rats: discordant enantioselectivity versus reduction of plasma aldosterone.
Endocrinology.
2008 Jan; 149(1):28-31. doi:
10.1210/en.2007-0584. [PMID: 17884944] - Helle C Thiesson, Boye L Jensen, Claus Bistrup, Peter D Ottosen, Alison D McNeilly, Ruth Andrew, Jonathan Seckl, Ole Skøtt. Renal sodium retention in cirrhotic rats depends on glucocorticoid-mediated activation of mineralocorticoid receptor due to decreased renal 11beta-HSD-2 activity.
American journal of physiology. Regulatory, integrative and comparative physiology.
2007 Jan; 292(1):R625-36. doi:
10.1152/ajpregu.00418.2005. [PMID: 16917017] - Luigi Bolondi, Fabio Piscaglia, Angelo Gatta, Francesco Salerno, Mauro Bernardi, Antonio Ascione, Oscar Ferraù, David Sacerdoti, Stefania Visentin, Franco Trevisani, Roberto Mazzanti, Gabriele Donati, Umberto Arena, Paolo Gentilini. Effect of potassium canrenoate, an anti-aldosterone agent, on incidence of ascites and variceal progression in cirrhosis.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.
2006 Nov; 4(11):1395-402. doi:
10.1016/j.cgh.2006.06.005. [PMID: 16931172] - Pietro Di Pasquale, Sergio Cannizzaro, Sebastiano Scalzo, Gaspare Parrinello, Sergio Fasullo, Francesco Giambanco, Antonio Fatta, Salvatore Paterna. Effects of canrenoate plus angiotensin-converting enzyme inhibitors versus angiotensin-converting enzyme inhibitors alone on systolic and diastolic function in patients with acute anterior myocardial infarction.
American heart journal.
2005 Nov; 150(5):919. doi:
10.1016/j.ahj.2005.03.032. [PMID: 16290961] - Ricardo Gómez, Lucía Núñez, Ricardo Caballero, Miguel Vaquero, Juan Tamargo, Eva Delpón. Spironolactone and its main metabolite canrenoic acid block hKv1.5, Kv4.3 and Kv7.1 + minK channels.
British journal of pharmacology.
2005 Sep; 146(1):146-61. doi:
10.1038/sj.bjp.0706302. [PMID: 15980874] - D Armanini, C Scaroni, M J Mattarello, C Fiore, N Albiger, P Sartorato. Idiopathic primary hyperaldosteronism: normalization of plasma aldosterone after one month withdrawal of long-term therapy with aldosterone-receptor antagonist potassium canrenoate.
Journal of endocrinological investigation.
2005 Mar; 28(3):236-40. doi:
10.1007/bf03345379. [PMID: 15952408] - Atsushi Sugiyama, Yoshioki Satoh, Akira Takahara, Kentaro Ando, Kai Wang, Sachiko Honsho, Yuji Nakamura, Keitaro Hashimoto. Electropharmacological effects of a spironolactone derivative, potassium canrenoate, assessed in the halothane-anesthetized canine model.
Journal of pharmacological sciences.
2004 Dec; 96(4):436-43. doi:
10.1254/jphs.fpj04025x. [PMID: 15599107] - F F Gudmundsson, A Viste, O L Myking, K Grong, K Svanes. Effects of the aldosterone receptor antagonist potassium canrenoate on renal blood flow and urinary output during prolonged increased intraabdominal pressure (IAP) in pigs.
Surgical endoscopy.
2004 Oct; 18(10):1528-34. doi:
10.1007/s00464-003-9295-2. [PMID: 15791383] - Janine Fletcher, Ashesh N Buch, Helen C Routledge, Saqib Chowdhary, John H Coote, Jonathan N Townend. Acute aldosterone antagonism improves cardiac vagal control in humans.
Journal of the American College of Cardiology.
2004 Apr; 43(7):1270-5. doi:
10.1016/j.jacc.2003.10.058. [PMID: 15063441] - Yoshiyuki Kagawa, Takuya Iwamoto, Hiroaki Matsuda, Rika Mukohara, Jun-ichi Sawada, Michio Kojima. Comparative evaluation of digoxin concentrations determined by three assay systems: TDx, IMx and OPUS.
Biopharmaceutics & drug disposition.
2004 Jan; 25(1):21-6. doi:
10.1002/bdd.382. [PMID: 14716749] - Pradip Datta, Amitava Dasgupta. A new turbidometric digoxin immunoassay on the ADVIA 1650 analyzer is free from interference by spironolactone, potassium canrenoate, and their common metabolite canrenone.
Therapeutic drug monitoring.
2003 Aug; 25(4):478-82. doi:
10.1097/00007691-200308000-00011. [PMID: 12883233] - Amitava Dasgupta, Helene Saffer, Alice Wells, Pradip Datta. Bidirectional (positive/negative) interference of spironolactone, canrenone, and potassium canrenoate on serum digoxin measurement: elimination of interference by measuring free digoxin or using a chemiluminescent assay for digoxin.
Journal of clinical laboratory analysis.
2002; 16(4):172-7. doi:
10.1002/jcla.10039. [PMID: 12112389] - P Di Pasquale, S Cannizzaro, A Scandurra, A Giubilato, S Scalzo, S Paterna. ACE-inhibition plus mineralocorticoid antagonism versus ACE-inhibition alone in patients with anterior myocardial infarction.
Cardiovascular drugs and therapy.
2001 Jul; 15(4):309-14. doi:
10.1023/a:1012754514127. [PMID: 11800414] - Georges Deschênes, Monika Wittner, Antonio DI Stefano, Sylvie Jounier, Alain Doucet. Collecting duct is a site of sodium retention in PAN nephrosis: a rationale for amiloride therapy.
Journal of the American Society of Nephrology : JASN.
2001 Mar; 12(3):598-601. doi:
10.1681/asn.v123598. [PMID: 11181809] - P Di Pasquale, S Cannizzaro, A Giubilato, M G Vitrano, A Scandurra, F Giambanco, G Saccone, F M Sarullo, S Paterna. Additional beneficial effects of canrenoate in patients with anterior myocardial infarction on ACE-inhibitor treatment. A pilot study.
Italian heart journal : official journal of the Italian Federation of Cardiology.
2001 Feb; 2(2):121-9. doi:
NULL. [PMID: 11256540] - P Di Pasquale, V Alessi, O Barberi, A Scandurra, V Bucca, G Maringhini, S Scalzo, S Paterna. The combination ace-inhibitors plus canreonate in patients with anterior myocardial infarction: safety and tolerability study.
International journal of cardiology.
2001 Feb; 77(2-3):119-27; discussion 128. doi:
10.1016/s0167-5273(00)00425-3. [PMID: 11182173] - M G Modena, P Aveta, A Menozzi, R Rossi. Aldosterone inhibition limits collagen synthesis and progressive left ventricular enlargement after anterior myocardial infarction.
American heart journal.
2001 Jan; 141(1):41-6. doi:
10.1067/mhj.2001.111258. [PMID: 11136485] - T Watanabe, R Ogawa. Suppression of surgical hyperaldosteronism by potassium canrenoate during gynecologic surgery under sevoflurane anesthesia.
Acta anaesthesiologica Scandinavica.
2000 Jul; 44(6):758-62. doi:
10.1034/j.1399-6576.2000.440616.x. [PMID: 10903022] - T E Jonassen, D Promeneur, S Christensen, J S Petersen, S Nielsen. Decreased vasopressin-mediated renal water reabsorption in rats with chronic aldosterone-receptor blockade.
American journal of physiology. Renal physiology.
2000 Feb; 278(2):F246-56. doi:
10.1152/ajprenal.2000.278.2.f246. [PMID: 10662729] - W Plihal, J Born. Memory consolidation in human sleep depends on inhibition of glucocorticoid release.
Neuroreport.
1999 Sep; 10(13):2741-7. doi:
10.1097/00001756-199909090-00009. [PMID: 10511433] - P Gentilini, V Casini-Raggi, G Di Fiore, R G Romanelli, G Buzzelli, M Pinzani, G La Villa, G Laffi. Albumin improves the response to diuretics in patients with cirrhosis and ascites: results of a randomized, controlled trial.
Journal of hepatology.
1999 Apr; 30(4):639-45. doi:
10.1016/s0168-8278(99)80194-9. [PMID: 10207805] - L Blendis, F Wong. Intravenous albumin with diuretics: protean lessons to be learnt?.
Journal of hepatology.
1999 Apr; 30(4):727-30. doi:
10.1016/s0168-8278(99)80207-4. [PMID: 10207818] - M Egfjord, H B Dahl, C Kayser, H Blaehr. Aldosterone metabolism in cultures of rat renal cortical and medullary cells.
Scandinavian journal of clinical and laboratory investigation.
1999 Apr; 59(2):107-13. doi:
10.1080/00365519950185832. [PMID: 10353324] - T E Jonassen, J S Petersen, A M Sørensen, F Andreasen, S Christensen. Aldosterone receptor blockade inhibits increased furosemide-sensitive sodium reabsorption in rats with liver cirrhosis.
The Journal of pharmacology and experimental therapeutics.
1998 Dec; 287(3):931-6. doi:
NULL. [PMID: 9864275] - H Kanauchi, Y Mimura. Inhibitory effect of aldosterone on the natriuretic response to atrial natriuretic peptide in hypocapnic rats.
Clinical and experimental pharmacology & physiology.
1998 Jul; 25(7-8):607-11. doi:
10.1111/j.1440-1681.1998.tb02259.x. [PMID: 9673436] - M Okazaki, Y Tanigawara, T Kita, F Komada, K Okumura. Cross-reactivity of TDX and OPUS immunoassay systems for serum digoxin determination.
Therapeutic drug monitoring.
1997 Dec; 19(6):657-62. doi:
10.1097/00007691-199712000-00009. [PMID: 9421107] - M Koda, Y Murawaki, H Kawasaki, S Ikawa. Effects of canrenoate potassium, an aldosterone antagonist on portal hemodynamics in patients with compensated liver cirrhosis.
Hepato-gastroenterology.
1996 Jul; 43(10):887-92. doi:
NULL. [PMID: 8884309] - N Glorioso, G Tonolo, C Troffa, A Soro, P Manunta, P Madeddu, G Sabino, P Pinna-Parpaglia, G Realdi. Recognition of markers of response to potassium-canrenoate in essential hypertension.
Steroids.
1995 Jan; 60(1):105-9. doi:
10.1016/0039-128x(94)00012-2. [PMID: 7792793] - A Takaya, H Fukui, M Matsumura, M Uemura, H Kojima, S Okamoto, T Tsujii. Stepped care medical treatment for cirrhotic ascites: analysis of factors influencing the response to treatment.
Journal of gastroenterology and hepatology.
1995 Jan; 10(1):30-5. doi:
10.1111/j.1440-1746.1995.tb01043.x. [PMID: 7620104] - C Emmeluth, C Drummer, R Gerzer, P Bie. Natriuresis in conscious dogs caused by increased carotid [Na+] during angiotensin II and aldosterone blockade.
Acta physiologica Scandinavica.
1994 Jul; 151(3):403-11. doi:
10.1111/j.1748-1716.1994.tb09760.x. [PMID: 7976412] - P Angeli, M Dalla Pria, E De Bei, G Albino, L Caregaro, C Merkel, G Ceolotto, A Gatta. Randomized clinical study of the efficacy of amiloride and potassium canrenoate in nonazotemic cirrhotic patients with ascites.
Hepatology (Baltimore, Md.).
1994 Jan; 19(1):72-9. doi:
10.1002/hep.1840190113. [PMID: 8276370] - C Dodt, W Kern, H L Fehm, J Born. Antimineralocorticoid canrenoate enhances secretory activity of the hypothalamus-pituitary-adrenocortical (HPA) axis in humans.
Neuroendocrinology.
1993 Nov; 58(5):570-4. doi:
10.1159/000126592. [PMID: 8115025] - M van Buren, P Boer, H A Koomans. Effects of acute mineralocorticoid and glucocorticoid receptor blockade on the excretion of an acute potassium load in healthy humans.
The Journal of clinical endocrinology and metabolism.
1993 Oct; 77(4):902-9. doi:
10.1210/jcem.77.4.8408463. [PMID: 8408463] - M Bernardi, G Laffi, M Salvagnini, G Azzena, S Bonato, F Marra, F Trevisani, G Gasbarrini, R Naccarato, P Gentilini. Efficacy and safety of the stepped care medical treatment of ascites in liver cirrhosis: a randomized controlled clinical trial comparing two diets with different sodium content.
Liver.
1993 Jun; 13(3):156-62. doi:
10.1111/j.1600-0676.1993.tb00624.x. [PMID: 8336527] - L L Woods, B E Smith, D R De Young. Regulation of renal hemodynamics after protein feeding: effects of proximal and distal diuretics.
The American journal of physiology.
1993 Feb; 264(2 Pt 2):R337-44. doi:
10.1152/ajpregu.1993.264.2.r337. [PMID: 8447489] - N Glorioso, M G Melis, P Manunta, C Troffa, G Tonolo, A Soro, P Madeddu, A Pazzola, F Pala, D Cusi. Different sensitivity to hydrochlorothiazide and to potassium-canrenoate among essential hypertensive patients.
Clinical and experimental hypertension (New York, N.Y. : 1993).
1993; 15 Suppl 1(?):187-96. doi:
NULL. [PMID: 8513309] - P Gentilini, G Laffi, G La Villa, V Carloni, M Foschi, R G Romanelli, F Marra. Torasemide in the treatment of patients with cirrhosis and ascites.
Cardiovascular drugs and therapy.
1993 Jan; 7 Suppl 1(?):81-5. doi:
10.1007/bf00877962. [PMID: 8435382] - G Rechkemmer. Effects of a low-sodium diet on electrolyte transport in the proximal and distal colon of the guinea pig (Cavia porcellus).
Comparative biochemistry and physiology. Comparative physiology.
1992 Nov; 103(3):501-5. doi:
10.1016/0300-9629(92)90279-y. [PMID: 1358506] - P Eiken, C Emmeluth, H J Schütten, P Bie. Vasopressin and angiotensin II in the conscious dog: synergistic effects on renal excretory parameters?.
Clinical science (London, England : 1979).
1992 Oct; 83(4):467-75. doi:
10.1042/cs0830467. [PMID: 1330410] - K Tsuji, S Nawa, K Kino, S Teramoto, K Hayashi. [Effect of potassium canrenoate on serum magnesium levels after extracorporeal circulation].
Kokyu to junkan. Respiration & circulation.
1992 Aug; 40(8):813-8. doi:
NULL. [PMID: 1529178] - S Morabito, M Fabiano, M Puliti, R Palumbo, R Marinelli, B M Simonetti, A Pierucci. [Potassium canrenoate and the combination of potassium canrenoate-butizide in the therapy of light to moderate arterial hypertension].
La Clinica terapeutica.
1992 Jul; 141(7):23-8. doi:
NULL. [PMID: 1505173] - E Niutta, D Cusi, R Colombo, M Pellizzoni, B Cesana, C Barlassina, L Soldati, G Bianchi. Predicting interindividual variations in antihypertensive therapy: the role of sodium transport systems and renin.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension.
1990 Sep; 8(4):S53-8. doi:
NULL. [PMID: 2175354] - S Asada, T Ohtawa, H Nakae. Reversible pharmacokinetic profiles of canrenoic acid and its biotransformed product. Canrenone in the rat.
Chemical & pharmaceutical bulletin.
1990 Apr; 38(4):1012-8. doi:
10.1248/cpb.38.1012. [PMID: 2379271] - S Laurent, P M Lacolley, J L Cuche, M E Safar. Influence of diuretics on brachial artery diameter and distensibility in hypertensive patients.
Fundamental & clinical pharmacology.
1990; 4(6):685-93. doi:
10.1111/j.1472-8206.1990.tb00048.x. [PMID: 2096107] - S Castellani, L Scarti, J L Chen, A Del Rosso, M Carnovali, G Masotti. The antihypertensive and renal activities of potassium canrenoate are associated with increased renal prostaglandin excretion.
Clinical science (London, England : 1979).
1989 Aug; 77(2):217-22. doi:
10.1042/cs0770217. [PMID: 2766661] - F Vargas, J M Haro, E Jodar, A Soler, C Garcia del Rio. Effects of K+-canrenoate on the development of DOCA-salt hypertension.
The Journal of pharmacy and pharmacology.
1989 May; 41(5):335-8. doi:
10.1111/j.2042-7158.1989.tb06467.x. [PMID: 2569521] - A Andriulli, A Arrigoni, T Gindro, I Karbowiak, G Buzzetti, D Armanini. Canrenone and androgen receptor-active materials in plasma of cirrhotic patients during long-term K-canrenoate or spironolactone therapy.
Digestion.
1989; 44(3):155-62. doi:
10.1159/000199905. [PMID: 2697627] - S Castellani, L Scarti, G Masotti, A Del Rosso, J I Chen, G G Neri Serneri. Selective stimulation of renal PGE2 by potassium canrenoate in essential hypertension.
Progress in clinical and biological research.
1989; 301(?):297-301. doi:
NULL. [PMID: 2678128] - E Niutta, D Cusi, R Colombo, G Tripodi, M Pellizzoni, P Pati, B Cesana, E Alberghini, C Barlassina, G Bianchi. Antihypertensive effect of captopril, canrenoate potassium, and atenolol. Relations with red blood cell sodium transport and renin.
American journal of hypertension.
1988 Oct; 1(4 Pt 1):364-71. doi:
10.1093/ajh/1.4.364. [PMID: 3063286] - M Emili, R Cuppone, G L Ricci. Comparative clinical study of spironolactone and potassium canrenoate. A randomized evaluation with double cross-over.
Arzneimittel-Forschung.
1988 Oct; 38(10):1492-5. doi:
NULL. [PMID: 3058132] - M Yamakado, M Nagano, M Umezu, H Tagawa, H Kiyose, S Tanaka. Extrarenal role of aldosterone in the regulation of blood pressure.
American journal of hypertension.
1988 Jul; 1(3 Pt 1):276-9. doi:
10.1093/ajh/1.3.276. [PMID: 3390321] - C S Cook, C L Hauswald, G L Schoenhard, C E Piper, A Patel, F M Radzialowski, J D Hribar, W Aksamit, P Finnegan, R H Bible. Difference in metabolic profile of potassium canrenoate and spironolactone in the rat: mutagenic metabolites unique to potassium canrenoate.
Archives of toxicology.
1988 Jan; 61(3):201-12. doi:
10.1007/bf00316635. [PMID: 3355365] - V Lahera, V Cachofeiro, F Duran, F J Cañizo, F J Rodriguez, J A Tresguerres. Acute effect of potassium canrenoate administration on renin-angiotensin, kallikrein-kinin and prostaglandin systems.
General pharmacology.
1988; 19(6):835-9. doi:
10.1016/s0306-3623(88)80015-6. [PMID: 3068096] - A Francavilla, A Di Leo, P K Eagon, L Polimeno, F Guglielmi, G Fanizza, M Barone, T E Starzl. Effect of spironolactone and potassium canrenoate on cytosolic and nuclear androgen and estrogen receptors of rat liver.
Gastroenterology.
1987 Oct; 93(4):681-6. doi:
10.1016/0016-5085(87)90428-8. [PMID: 3623016] - R J Hené, H A Koomans, P Boer, E J Dorhout Mees. Adaptation to chronic potassium loading in normal man.
Mineral and electrolyte metabolism.
1986; 12(3):165-72. doi:
NULL. [PMID: 3523191] - D J Morris, M J McDermott, M Freiberger, S A Latif, M Pacholski, A S Brem. The effects of antimineralocorticoids on synthesis of aldosterone metabolites in target tissues.
Journal of steroid biochemistry.
1986 Jan; 24(1):341-4. doi:
10.1016/0022-4731(86)90077-4. [PMID: 3702416] - P Gardiner. Spironolactone and potassium canrenoate metabolism.
Lancet (London, England).
1985 Dec; 2(8469-70):1432. doi:
10.1016/s0140-6736(85)92603-0. [PMID: 2867429] - L Rabinowitz, R L Sarason, H Yamauchi. Effect of aldosterone on potassium excretion during potassium chloride infusion in sheep.
The American journal of physiology.
1985 Oct; 249(4 Pt 2):R455-61. doi:
10.1152/ajpregu.1985.249.4.r455. [PMID: 4051031] - M J McDermott, M Freiberger, S A Latif, D J Morris. The synthesis of reduced metabolites of aldosterone by subcellular fractions of rat kidney: effects of antimineralocorticoids.
Journal of steroid biochemistry.
1985 Oct; 23(4):503-9. doi:
10.1016/0022-4731(85)90199-2. [PMID: 4068711] - D Armanini, I Karbowiak, A Goi, F Mantero, J W Funder. In-vivo metabolites of spironolactone and potassium canrenoate: determination of potential anti-androgenic activity by a mouse kidney cytosol receptor assay.
Clinical endocrinology.
1985 Oct; 23(4):341-7. doi:
10.1111/j.1365-2265.1985.tb01090.x. [PMID: 4064345] - S Suzuki, S Takamura, J Yoshida, N Ozaki. Effect of aldosterone antagonists on aldosterone-induced activation of Mg2+ -HCO3- -ATPase and carbonic anhydrase in rat intestinal mucosa.
Journal of steroid biochemistry.
1985 Jul; 23(1):57-66. doi:
10.1016/0022-4731(85)90260-2. [PMID: 3160893] - K Kojima, K Yamamoto, H Fujioka, H Kaneko. Pharmacokinetics of spironolactone and potassium canrenoate in humans.
Journal of pharmacobio-dynamics.
1985 Mar; 8(3):161-6. doi:
10.1248/bpb1978.8.161. [PMID: 4009408] - A Lant. Diuretics. Clinical pharmacology and therapeutic use (Part II).
Drugs.
1985 Feb; 29(2):162-88. doi:
10.2165/00003495-198529020-00003. [PMID: 3884320] - B Kaissling, M LeHir. [Adaptation of distal tubular segments to changes in electrolyte metabolism].
Acta histochemica. Supplementband.
1985; 31(?):185-91. doi:
NULL. [PMID: 2991983] - W Losert, J Casals-Stenzel, M Buse. Progestogens with antimineralocorticoid activity.
Arzneimittel-Forschung.
1985; 35(2):459-71. doi:
NULL. [PMID: 4039568] - L Rabinowitz, R L Sarason, H Yamauchi. Sheep renal potassium excretion: efferent kaliuretic regulatory factors.
The American journal of physiology.
1984 Sep; 247(3 Pt 2):F520-6. doi:
10.1152/ajprenal.1984.247.3.f520. [PMID: 6476127] - A N Lasaridis, A Tourkantonis, P Spanos, K Apostolopoulou, A Pharmakiotis. The effects of canrenoate K on corticosteroid biosynthesis in nephrectomized dogs.
Journal of steroid biochemistry.
1984 Apr; 20(4A):923-9. doi:
10.1016/0022-4731(84)90407-2. [PMID: 6323885] - B Denis, R Dimitriou, J Machecourt, J E Wolf, E Page, J P Reboud. [Hyperaldosteronism in the acute phase of myocardial infarction. Effects of its treatment on the prevention of ventricular fibrillation].
Archives des maladies du coeur et des vaisseaux.
1984 Apr; 77 Spec No(?):35-40. doi:
NULL. [PMID: 6428361] - L Ceremuzyński, A Budaj, B Michorowski. Single-dose i.v. Aldactone for congestive heart failure: a preliminary observation.
International journal of clinical pharmacology, therapy, and toxicology.
1983 Aug; 21(8):417-21. doi:
NULL. [PMID: 6629545] - H Osore, T A Harrow. Cardiovascular and renal properties of potassium-sparing diuretics of the spirolactone group--I: Effects of SC-14266/371 (potassium canrenoate) on renal transport Na+, K+-ATPase activity.
Biochemical pharmacology.
1982 Dec; 31(24):4068-71. doi:
10.1016/0006-2952(82)90658-x. [PMID: 6130770] - P Finotti, A Antonello. Canrenoate reversal of inhibitory effects of digoxin on basal and furosemide-stimulated renin secretion.
Clinical pharmacology and therapeutics.
1982 Jul; 32(1):1-6. doi:
10.1038/clpt.1982.118. [PMID: 6282524] - J Casals-Stenzel, M Buse, W Losert. Detection and comparative evaluation of aldosterone antagonists in glucocorticoid-treated, adrenalectomized rats.
European journal of pharmacology.
1982 May; 80(1):37-45. doi:
10.1016/0014-2999(82)90175-3. [PMID: 7095004] - M Le Hir, B Kaissling, U C Dubach. Distal tubular segments of the rabbit kidney after adaptation to altered Na- and K-intake. II. Changes in Na-K-ATPase activity.
Cell and tissue research.
1982; 224(3):493-504. doi:
10.1007/bf00213747. [PMID: 6288247] - P Corvol, M Claire, M E Oblin, K Geering, B Rossier. Mechanism of the antimineralocorticoid effects of spirolactones.
Kidney international.
1981 Jul; 20(1):1-6. doi:
10.1038/ki.1981.97. [PMID: 7029118] - R Tufano, M Scopa, G Brando, D Leone. [Use of potassium canrenoate in cardiosurgery].
Minerva anestesiologica.
1981 Apr; 47(4):149-54. doi:
NULL. [PMID: 7242963] - F Haschke, M Wimmer, K Parth. Hyperaldosteronism after heart surgery in children. Part I: Treatment with aldosterone antagonists.
Padiatrie und Padologie.
1981; 16(3):317-26. doi:
NULL. [PMID: 7254888] - T Muraki, T Nakadate, K Kubota, Y Tokunaga, R Kato. Effects of repeated administration of potassium canrenoate (SC-14266) on serum gonadotrophin, prolactin, testosterone and progesterone in male rats.
Experientia.
1980 Jun; 36(6):668-9. doi:
10.1007/bf01970128. [PMID: 6774884] - R Ruggerini, F Mazzocchi, G Albini, M Cifalinò. [Plasma hyperosmolarity aspects in intensive care and its treatment with potassium canreonate].
Minerva anestesiologica.
1979 Sep; 45(9):687-90. doi:
NULL. [PMID: 117400] - B Denis, J Machecourt, M C Denis, H Morena, J Pellet, B Rossignol, P Martin-Noël. [Value of potassium canrenoate in the prevention of arrhythmia during the acute phase of myocardial infarction].
Archives des maladies du coeur et des vaisseaux.
1979 Sep; 72(9):1014-22. doi:
NULL. [PMID: 116612] - K E Karlmar. Assay and properties of 18-hydroxylation of endogenous and exogenous corticosterone in rat adrenals. Evidence for heterogeneity of 18-hydroxylase activity.
Journal of lipid research.
1979 Aug; 20(6):729-39. doi:
. [PMID: 114599]