Fospropofol disodium (BioDeep_00000858794)
代谢物信息卡片
Fospropofol disodium
化学式: C13H19Na2O5P (332.07654540000004)
中文名称: [2,6-双(1-甲基乙基）苯氧基]甲醇磷酸二氢二钠盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)C1=C(C(=CC=C1)C(C)C)OCOP(=O)([O-])[O-].[Na+].[Na+]
InChI: /q
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent
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1 个代谢物同义名
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Liang-Quan Liu, Pei-Xi Hong, Xing-Hai Song, Chang-Cui Zhou, Rui Ling, Yi Kang, Qing-Rong Qi, Jun Yang. Design, Synthesis, and Activity Study of Water-Soluble, Rapid-Release Propofol Prodrugs.
Journal of medicinal chemistry.
2020 07; 63(14):7857-7866. doi:
10.1021/acs.jmedchem.0c00698. [PMID: 32588620] - Weiyi Zhang, Jun Yang, Jing Fan, Bin Wang, Yi Kang, Jin Liu, Wensheng Zhang, Tao Zhu. An improved water-soluble prodrug of propofol with high molecular utilization and rapid onset of action.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2019 Jan; 127(?):9-13. doi:
10.1016/j.ejps.2018.09.024. [PMID: 30290219] - Bing-Chen Lang, Jun Yang, Yu Wang, Yun Luo, Yi Kang, Jin Liu, Wen-Sheng Zhang. An improved design of water-soluble propofol prodrugs characterized by rapid onset of action.
Anesthesia and analgesia.
2014 Apr; 118(4):745-54. doi:
10.1213/ane.0000000000000124. [PMID: 24651228] - Y Zhou, J Yang, J Liu, Y Wang, W S Zhang. Efficacy comparison of the novel water-soluble propofol prodrug HX0969w and fospropofol in mice and rats.
British journal of anaesthesia.
2013 Nov; 111(5):825-32. doi:
10.1093/bja/aet218. [PMID: 23801745] - Jörg Fechner, Harald Ihmsen, Jürgen Schüttler, Christian Jeleazcov. A randomized open-label phase I pilot study of the safety and efficacy of total intravenous anesthesia with fospropofol for coronary artery bypass graft surgery.
Journal of cardiothoracic and vascular anesthesia.
2013 Oct; 27(5):908-15. doi:
10.1053/j.jvca.2013.01.029. [PMID: 24054187] - Michelle P McIntosh, Ken Iwasawa, Roger A Rajewski, Tatsuro Fujisawa, Hiroshi Goto. Hemodynamic profile in rabbits of fospropofol disodium injection relative to propofol emulsion following rapid bolus injection.
Journal of pharmaceutical sciences.
2012 Sep; 101(9):3518-25. doi:
10.1002/jps.23162. [PMID: 22529044] - Rui Li, Wen-sheng Zhang, Jin Liu, Min Tang, Ying-ying Yang, Nan-Fu Luo. Minimum infusion rates and recovery times from different durations of continuous infusion of fospropofol, a prodrug of propofol, in rabbits: a comparison with propofol emulsion.
Veterinary anaesthesia and analgesia.
2012 Jul; 39(4):373-84. doi:
10.1111/j.1467-2995.2012.00733.x. [PMID: 22642486] - Basem Abdelmalak, Ashish Khanna, John Tetzlaff. Fospropofol, a new sedative anesthetic, and its utility in the perioperative period.
Current pharmaceutical design.
2012; 18(38):6241-52. doi:
10.2174/138161212803832308. [PMID: 22762463] - Keith A Candiotti, Tong J Gan, Christopher Young, Alex Bekker, S T John Sum-Ping, Richard Kahn, Philip Lebowitz, Jeffrey J Littman. A randomized, open-label study of the safety and tolerability of fospropofol for patients requiring intubation and mechanical ventilation in the intensive care unit.
Anesthesia and analgesia.
2011 Sep; 113(3):550-6. doi:
10.1213/ane.0b013e31821d7faf. [PMID: 21596879] - Yu Liu, Chao-zhi Luo. [Protective effect of fospropofol disodium on in vivo liver ischemia-reperfusion injury in rats].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition.
2011 Mar; 42(2):231-3. doi:
NULL. [PMID: 21500560] - Gina D Moore, Alyssa M Walker, Robert MacLaren. Fospropofol: a new sedative-hypnotic agent for monitored anesthesia care.
The Annals of pharmacotherapy.
2009 Nov; 43(11):1802-8. doi:
10.1345/aph.1m290. [PMID: 19826098] - Jörg Fechner, Harald Ihmsen, Christian Jeleazcov, Jürgen Schüttler. Fospropofol disodium, a water-soluble prodrug of the intravenous anesthetic propofol (2,6-diisopropylphenol).
Expert opinion on investigational drugs.
2009 Oct; 18(10):1565-71. doi:
10.1517/13543780903193063. [PMID: 19758110] - Mark Welliver, Susan M Rugari. New drug, fospropofol disodium: a propofol prodrug.
AANA journal.
2009 Aug; 77(4):301-8. doi:
". [PMID: 19731849] - J Fechner, H Schwilden, J Schüttler. Pharmacokinetics and pharmacodynamics of GPI 15715 or fospropofol (Aquavan injection) - a water-soluble propofol prodrug.
Handbook of experimental pharmacology.
2008; ?(182):253-66. doi:
10.1007/978-3-540-74806-9_12. [PMID: 18175095] - Ekaterina Gibiansky, Michel M R F Struys, Leonid Gibiansky, Ann L G Vanluchene, James Vornov, Eric P Mortier, Eric Burak, Luc Van Bortel. AQUAVAN injection, a water-soluble prodrug of propofol, as a bolus injection: a phase I dose-escalation comparison with DIPRIVAN (part 1): pharmacokinetics.
Anesthesiology.
2005 Oct; 103(4):718-29. doi:
10.1097/00000542-200510000-00010. [PMID: 16192764] - Michel M R F Struys, Ann L G Vanluchene, Ekaterina Gibiansky, Leonid Gibiansky, James Vornov, Eric P Mortier, Luc Van Bortel. AQUAVAN injection, a water-soluble prodrug of propofol, as a bolus injection: a phase I dose-escalation comparison with DIPRIVAN (part 2): pharmacodynamics and safety.
Anesthesiology.
2005 Oct; 103(4):730-43. doi:
10.1097/00000542-200510000-00011. [PMID: 16192765] - Jörg Fechner, Harald Ihmsen, Christine Schiessl, Christian Jeleazcov, James J Vornov, Helmut Schwilden, Jürgen Schüttler. Sedation with GPI 15715, a water-soluble prodrug of propofol, using target-controlled infusion in volunteers.
Anesthesia and analgesia.
2005 Mar; 100(3):701-706. doi:
10.1213/01.ane.0000144772.13372.f4. [PMID: 15728055] - Jörg Fechner, Harald Ihmsen, Dirk Hatterscheid, Christian Jeleazcov, Christine Schiessl, James J Vornov, Helmut Schwilden, Jürgen Schüttler. Comparative pharmacokinetics and pharmacodynamics of the new propofol prodrug GPI 15715 and propofol emulsion.
Anesthesiology.
2004 Sep; 101(3):626-39. doi:
10.1097/00000542-200409000-00011. [PMID: 15329587] - Jörg Fechner, Harald Ihmsen, Dirk Hatterscheid, Christine Schiessl, James J Vornov, Eric Burak, Helmut Schwilden, Jürgen Schüttler. Pharmacokinetics and clinical pharmacodynamics of the new propofol prodrug GPI 15715 in volunteers.
Anesthesiology.
2003 Aug; 99(2):303-13. doi:
10.1097/00000542-200308000-00012. [PMID: 12883403] - M Schywalsky, H Ihmsen, A Tzabazis, J Fechner, E Burak, J Vornov, H Schwilden. Pharmacokinetics and pharmacodynamics of the new propofol prodrug GPI 15715 in rats.
European journal of anaesthesiology.
2003 Mar; 20(3):182-90. doi:
10.1017/s0265021503000322. [PMID: 12650488]