Pholedrine (BioDeep_00000858790)
代谢物信息卡片
Pholedrine
化学式: C10H15NO (165.1154)
中文名称: 甲羟苯丙胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(CC1=CC=C(C=C1)O)NC
InChI: InChI=1S/C10H15NO/c1-8(11-2)7-9-3-5-10(12)6-4-9/h3-6,8,11-12H,7H2,1-2H3
描述信息
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics
D002491 - Central Nervous System Agents > D000697 - Central Nervous System Stimulants
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent
同义名列表
1 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Kenji Kuwayama, Kenji Tsujikawa, Hajime Miyaguchi, Tatsuyuki Kanamori, Yuko T Iwata, Hiroyuki Inoue. Interaction of 3,4-methylenedioxymethamphetamine and methamphetamine during metabolism by in vitro human metabolic enzymes and in rats.
Journal of forensic sciences.
2012 Jul; 57(4):1008-13. doi:
10.1111/j.1556-4029.2011.02039.x. [PMID: 22211929] - Sunnassee Ananda, Zhu Shaohua, Yang Fan, Liu Liang. HIV-negative drug addict diagnosed with AIDS and tuberculosis at autopsy: a case report and brief review of literature.
Journal of forensic and legal medicine.
2011 Apr; 18(3):136-8. doi:
10.1016/j.jflm.2011.01.010. [PMID: 21420653] - Rika Nakajima, Muneo Morishita, Sadakazu Aiso, Takehiko Yajima. Direct determination of p-hydroxymethamphetamine glucuronide in human urine by high-performance liquid chromatography.
Chemical & pharmaceutical bulletin.
2006 Apr; 54(4):493-5. doi:
10.1248/cpb.54.493. [PMID: 16595951] - N Shima, H T Kamata, M Katagi, H Tsuchihashi. Urinary excretion of the main metabolites of methamphetamine, including p-hydroxymethamphetamine-sulfate and p-hydroxymethamphetamine-glucuronide, in humans and rats.
Xenobiotica; the fate of foreign compounds in biological systems.
2006 Feb; 36(2-3):259-67. doi:
10.1080/00498250600627475. [PMID: 16702115] - Noriaki Shima, Hiroe Tsutsumi, Tooru Kamata, Mayumi Nishikawa, Munehiro Katagi, Akihiro Miki, Hitoshi Tsuchihashi. Direct determination of glucuronide and sulfate of p-hydroxymethamphetamine in methamphetamine users' urine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Jan; 830(1):64-70. doi:
10.1016/j.jchromb.2005.10.014. [PMID: 16263342] - Noriyuki Kato, Hiroaki Kubo, Hiroshi Homma. Fluorescence analysis of p-hydroxymethamphetamine in urine by thin-layer chromatography.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2005 Sep; 21(9):1117-9. doi:
10.2116/analsci.21.1117. [PMID: 16363483] - W Römhild, D Krause, H Bartels, A Ghanem, R Schöning, H Wittig. LC-MS/MS analysis of pholedrine in a fatal intoxication case.
Forensic science international.
2003 Apr; 133(1-2):101-6. doi:
10.1016/s0379-0738(03)00055-0. [PMID: 12742695] - Manfred T Birchler, Klara Landau, Philip T Went, Sandro J Stoeckli. Paraganglioma of the cervical sympathetic trunk.
The Annals of otology, rhinology, and laryngology.
2002 Dec; 111(12 Pt 1):1087-91. doi:
10.1177/000348940211101205. [PMID: 12498369] - G P Peinhardt. High-performance liquid chromatographic determination of pholedrine in human serum using ion-pair extraction and amperometric detection.
Journal of chromatography. B, Biomedical sciences and applications.
1999 Apr; 726(1-2):309-12. doi:
10.1016/s0378-4347(99)00068-7. [PMID: 10348201] - O al-Dirbashi, N Kuroda, F Menichini, S Noda, M Minemoto, K Nakashima. Enantioselective high-performance liquid chromatography with fluorescence detection of methamphetamine and its metabolites in human urine.
The Analyst.
1998 Nov; 123(11):2333-7. doi:
10.1039/a804720k. [PMID: 10396810] - O Al-Dirbashi, J Qvarnstrom, K Irgum, K Nakashima. Simple and sensitive high-performance liquid chromatographic determination of methamphetamines in human urine as derivatives of 4-(4,5-diphenyl-1H-imidazol-2-yl) benzoyl chloride, a new fluorescence derivatization reagent.
Journal of chromatography. B, Biomedical sciences and applications.
1998 Aug; 712(1-2):105-12. doi:
10.1016/s0378-4347(98)00128-5. [PMID: 9698233] - N Kuroda, R Nomura, O al-Dirbashi, S Akiyama, K Nakashima. Determination of methamphetamine and related compounds by capillary electrophoresis with UV and laser-induced fluorescence detection.
Journal of chromatography. A.
1998 Mar; 798(1-2):325-34. doi:
10.1016/s0021-9673(97)00950-3. [PMID: 9542143] - H S Shin, B B Park, S N Choi, J J Oh, C P Hong, H Ryu. Identification of new urinary metabolites of famprofazone in humans.
Journal of analytical toxicology.
1998 Jan; 22(1):55-60. doi:
10.1093/jat/22.1.55. [PMID: 9491970] - G Peinhardt. Radioimmunoassay for the determination of pholedrine.
Die Pharmazie.
1997 Dec; 52(12):937-9. doi:
NULL. [PMID: 9442557] - A Hutchaleelaha, M Mayersohn. p-Hydroxymethamphetamine enantiomer pharmacokinetics and metabolism in rats: absence of N-demethylation.
Biopharmaceutics & drug disposition.
1997 Jul; 18(5):423-32. doi:
10.1002/(sici)1099-081x(199707)18:5<423::aid-bdd30>3.0.co;2-y. [PMID: 9210980] - K Hara, S Kashimura, Y Hieda, M Kageura. Simple extractive derivatization of methamphetamine and its metabolites in biological materials with Extrelut columns for their GC-MS determination.
Journal of analytical toxicology.
1997 Jan; 21(1):54-8. doi:
10.1093/jat/21.1.54. [PMID: 9013294] - M Katagi, H Nishioka, K Nakajima, H Tsuchihashi, H Fujima, H Wada, K Nakamura, K Makino. Direct high-performance liquid chromatographic and high-performance liquid chromatographic-thermospray-mass spectrometric determination of enantiomers of methamphetamine and its main metabolites amphetamine and p-hydroxymethamphetamine in human urine.
Journal of chromatography. B, Biomedical applications.
1996 Feb; 676(1):35-43. doi:
10.1016/0378-4347(95)00410-6. [PMID: 8852042] - K Hayakawa, Y Miyoshi, H Kurimoto, Y Matsushima, N Takayama, S Tanaka, M Miyazaki. Simultaneous determination of methamphetamine and its metabolites in the urine samples of abusers by high performance liquid chromatography with chemiluminescence detection.
Biological & pharmaceutical bulletin.
1993 Sep; 16(9):817-21. doi:
10.1248/bpb.16.817. [PMID: 7903574] - K S Nam, J W Kim, M J Choi, M Y Han, I S Choe, T W Chung. Production and characterization of monoclonal antibody that simultaneously recognizes methamphetamine and its major metabolite.
Biological & pharmaceutical bulletin.
1993 May; 16(5):490-2. doi:
10.1248/bpb.16.490. [PMID: 8103394] - T Nagai, S Kamiyama. Simultaneous HPLC analysis of optical isomers of methamphetamine and its metabolites, and stereoselective metabolism of racemic methamphetamine in rat urine.
Journal of analytical toxicology.
1991 Nov; 15(6):299-304. doi:
10.1093/jat/15.6.299. [PMID: 1685757] - R Neubert, S Fischer. Influence of lipophilic counter ions on the transport of ionizable hydrophilic drugs.
The Journal of pharmacy and pharmacology.
1991 Mar; 43(3):204-6. doi:
10.1111/j.2042-7158.1991.tb06667.x. [PMID: 1675280] - T Yamamoto, R Takano, T Egashira, Y Yamanaka, M Terada. Simultaneous determination of methamphetamine and its metabolites in monkey urine by gas chromatography/mass spectrometry with selected ion monitoring.
Journal of analytical toxicology.
1989 Mar; 13(2):117-9. doi:
10.1093/jat/13.2.117. [PMID: 2733390] - M Petzsche, W Fürst, A Fahr, W Sziegoleit. [Preparation, detection and pharmacokinetic behavior of pholedrine sulfuric acid ester. 6. Determination of pholedrine and pholedrine sulfuric acid esters in plasma after oral administration of pholedrine].
Die Pharmazie.
1988 Dec; 43(12):875. doi:
NULL. [PMID: 3247384] - M Petzsche, W Fürst. [Preparation, detection and pharmacokinetic behavior of pholedrine sulfuric acid ester. 5. Methods for determining pholedrine and pholedrine sulfuric acid esters in plasma].
Die Pharmazie.
1988 Dec; 43(12):867-8. doi:
NULL. [PMID: 3247382] - K Shimosato. Urinary excretion of p-hydroxylated methamphetamine metabolites in man. II. Effect of alcohol intake on methamphetamine metabolism.
Pharmacology, biochemistry, and behavior.
1988 Apr; 29(4):733-40. doi:
10.1016/0091-3057(88)90195-5. [PMID: 3413199] - M Petzsche, E Noll, S Hartung, W Fürst. [Preparation, detection and pharmacokinetic behavior of pholedrine sulfuric acid esters. 3. Determination of free and bound pholedrine in urine].
Die Pharmazie.
1988 Apr; 43(4):291. doi:
NULL. [PMID: 3413223] - M Petzsche, W Fürst. [Preparation, detection and pharmacokinetic behavior of pholedrine sulfuric acid esters. 4. Detection and determination of pholedrine sulfuric acid esters in urine].
Die Pharmazie.
1988 Apr; 43(4):291-2. doi:
NULL. [PMID: 3413224] - K Shimosato, H Oda, M Ohmae, M Tomita, Y Doi. Biphasic effects of alcohol drinking on methamphetamine metabolism in man.
Alcohol and alcoholism (Oxford, Oxfordshire).
1988; 23(5):351-7. doi:
10.1093/oxfordjournals.alcalc.a044828. [PMID: 3228456] - R Neubert, W Fürst, H Schleiermacher, P Bergmann, E Stolte. [Drug transport through artificial lipoid membranes. 21. Ion pair transport with alkyl salicylic acids].
Die Pharmazie.
1987 May; 42(5):309-11. doi:
". [PMID: 3671439] - K Shimosato, M Tomita, I Ijiri. Urinary excretion of p-hydroxylated methamphetamine metabolites in man. I. A method for determination by high-performance liquid chromatography-electrochemistry.
Archives of toxicology.
1986 Oct; 59(3):135-40. doi:
10.1007/bf00316321. [PMID: 3813878] - K Shimosato, M Tomita, I Ijiri. Rapid determination of p-hydroxylated methamphetamine metabolites by column liquid chromatography-electrochemistry.
Journal of chromatography.
1986 Apr; 377(?):279-86. doi:
10.1016/s0378-4347(00)80783-5. [PMID: 3711218] - H Yamada, K Oguri, H Yoshimura. Effects of several factors on urinary excretion of methamphetamine and its metabolites in rats.
Xenobiotica; the fate of foreign compounds in biological systems.
1986 Feb; 16(2):137-41. doi:
10.3109/00498258609043516. [PMID: 3962334] - R Neubert, W Fürst, H Schleiermacher. [Drug permeation through artificial lipoid membranes. 19. The mechanism of ion pair permeation--alkali ion countertransport].
Die Pharmazie.
1985 Jul; 40(7):497. doi:
". [PMID: 4048259] - M Terada. Determination of methamphetamine and its metabolites in rat tissues by gas chromatography with a nitrogen-phosphorus detector.
Journal of chromatography.
1985 Jan; 318(2):307-18. doi:
10.1016/s0021-9673(01)90691-0. [PMID: 3980624] - A C Buck. Disorders of micturition in bacterial prostatitis.
Proceedings of the Royal Society of Medicine.
1975 Aug; 68(8):508-11. doi:
NULL. [PMID: 681]
