Ibuprofen Lysine (BioDeep_00000858789)
代谢物信息卡片
Ibuprofen Lysine
化学式: C19H32N2O4 (352.2362)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CC1=CC=C(C=C1)C(C)C(=O)O.C(CCN)CC(C(=O)O)N
InChI: 5-/m.0/s1
描述信息
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Thomas Weiser, Cornelia Schepers, Tobias Mück, Robert Lange. Pharmacokinetic Properties of Ibuprofen (IBU) From the Fixed-Dose Combination IBU/Caffeine (400/100 mg; FDC) in Comparison With 400 mg IBU as Acid or Lysinate Under Fasted and Fed Conditions-Data From 2 Single-Center, Single-Dose, Randomized Crossover Studies in Healthy Volunteers.
Clinical pharmacology in drug development.
2019 08; 8(6):742-753. doi:
10.1002/cpdd.672. [PMID: 30897305] - Lisa Miles, Jessica Hall, Bartosz Jenner, Richard Addis, Simon Hutchings. Predicting rapid analgesic onset of ibuprofen salts compared with ibuprofen acid: Tlag, Tlow, Tmed, and a novel parameter, TCmaxRef.
Current medical research and opinion.
2018 08; 34(8):1483-1490. doi:
10.1080/03007995.2018.1466697. [PMID: 29667449] - Karel J Hartlieb, Daniel P Ferris, James M Holcroft, Irawati Kandela, Charlotte L Stern, Majed S Nassar, Youssry Y Botros, J Fraser Stoddart. Encapsulation of Ibuprofen in CD-MOF and Related Bioavailability Studies.
Molecular pharmaceutics.
2017 05; 14(5):1831-1839. doi:
10.1021/acs.molpharmaceut.7b00168. [PMID: 28355489] - Alfredo García-Arieta, Juan Manuel Ferrero-Cafiero, Montse Puntes, Ignasi Gich, Susana Morales-Alcelay, Maite Tarré, Xavier Font, Rosa Maria Antonijoan. Impact of Chiral Bioanalytical Methods on the Bioequivalence of Ibuprofen Products Containing Ibuprofen Lysinate and Ibuprofen Base.
Chirality.
2016 05; 28(5):429-33. doi:
10.1002/chir.22598. [PMID: 27094918] - Aravind Krishna, Michael Rice, Tom Kester, Michael Waters, Terry Wilson. Particulate Study on NeoProfen, a Neonatal Injectable Product.
PDA journal of pharmaceutical science and technology.
2016 Jan; 70(1):76-92. doi:
10.5731/pdajpst.2015.005587. [PMID: 26889056] - Juan Manuel Ferrero-Cafiero, Ignasi Gich, Montse Puntes, Joan Martínez, Maria R Ballester, Jimena Coimbra, Yaira Mathison, Maite Tarré, Xavier Font, Rosa M Antonijoan. Ibuprofen lysinate, quicker and less variable: relative bioavailability compared to ibuprofen base in a pediatric suspension dosage form.
International journal of clinical pharmacology and therapeutics.
2015 Nov; 53(11):972-9. doi:
10.5414/cp202368. [PMID: 26249766] - Thomas J Legg, Aziz L Laurent, Rina Leyva, David Kellstein. Ibuprofen sodium is absorbed faster than standard Ibuprofen tablets: results of two open-label, randomized, crossover pharmacokinetic studies.
Drugs in R&D.
2014 Dec; 14(4):283-90. doi:
10.1007/s40268-014-0070-8. [PMID: 25395311] - Sanjiv B Amin, Nicholas Miravalle. Effect of ibuprofen on bilirubin-albumin binding affinity in premature infants.
Journal of perinatal medicine.
2011 01; 39(1):55-8. doi:
10.1515/jpm.2010.113. [PMID: 20954849] - Déborah Hirt, Bart Van Overmeire, Jean-Marc Treluyer, Jean-Paul Langhendries, Arnaud Marguglio, Mark J Eisinger, Paul Schepens, Saïk Urien. An optimized ibuprofen dosing scheme for preterm neonates with patent ductus arteriosus, based on a population pharmacokinetic and pharmacodynamic study.
British journal of clinical pharmacology.
2008 May; 65(5):629-36. doi:
10.1111/j.1365-2125.2008.03118.x. [PMID: 18307541] - M T C Ambat, E M Ostrea, J V Aranda. Effect of ibuprofen L-lysinate on bilirubin binding to albumin as measured by saturation index and horseradish peroxidase assays.
Journal of perinatology : official journal of the California Perinatal Association.
2008 Apr; 28(4):287-90. doi:
10.1038/sj.jp.7211925. [PMID: 18200021] - Karel Allegaert, Christine Vanhole, Jan de Hoon, Jean Pierre Guignard, Dick Tibboel, Hugo Devlieger, Bart Van Overmeire. Nonselective cyclo-oxygenase inhibitors and glomerular filtration rate in preterm neonates.
Pediatric nephrology (Berlin, Germany).
2005 Nov; 20(11):1557-61. doi:
10.1007/s00467-005-1998-2. [PMID: 16133061] - Bart Van Overmeire, Karel Allegaert, Alexandra Casaer, Christian Debauche, Wim Decaluwé, Ann Jespers, Joost Weyler, Inge Harrewijn, Jean-Paul Langhendries. Prophylactic ibuprofen in premature infants: a multicentre, randomised, double-blind, placebo-controlled trial.
Lancet (London, England).
2004 Nov; 364(9449):1945-9. doi:
10.1016/s0140-6736(04)17477-1. [PMID: 15567010] - F K Główka. Stereoselective pharmacokinetics of ibuprofen and its lysinate from suppositories in rabbits.
International journal of pharmaceutics.
2000 Apr; 199(2):159-66. doi:
10.1016/s0378-5173(00)00377-x. [PMID: 10802409] - T W Hermann, F K Gtówka, E R Garrett. Bioavailability of racemic ibuprofen and its lysinate from suppositories in rabbits.
Journal of pharmaceutical sciences.
1993 Nov; 82(11):1102-11. doi:
10.1002/jps.2600821108. [PMID: 8289122] - W Martin, G Koselowske, H Töberich, T Kerkmann, B Mangold, J Augustin. Pharmacokinetics and absolute bioavailability of ibuprofen after oral administration of ibuprofen lysine in man.
Biopharmaceutics & drug disposition.
1990 Apr; 11(3):265-78. doi:
10.1002/bdd.2510110311. [PMID: 2109643]
