Nafronyl oxalate (BioDeep_00000858774)

   

Chemicals and Drugs


代谢物信息卡片


Naftidrofuryl (oxalate)

化学式: C26H35NO7 (473.2413)
中文名称: 草酸萘酯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCN(CC)CCOC(=O)C(CC1CCCO1)CC2=CC=CC3=CC=CC=C32.C(=O)(C(=O)O)O
InChI: (H,3,4)(H,5,6)

描述信息

D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
C78274 - Agent Affecting Cardiovascular System > C29707 - Vasodilating Agent
C78272 - Agent Affecting Nervous System > C66885 - Serotonin Antagonist
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
Naftidrofuryl oxalate (Nafronyl oxalate salt) is a drug used in the management of peripheral and cerebral vascular disorders as a vasodilator, enhance cellular oxidative capacity, and may also be a 5-HT2 receptor antagonist.

同义名列表

3 个代谢物同义名

Naftidrofuryl (oxalate); Nafronyl oxalate; Nafronyl oxalate salt



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

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Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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亚细胞结构定位 关联基因列表


文献列表

  • Ömer Faruk Gülaştı, Şadan Yavuz, Ali Ahmet Arıkan, Fatma Ceyla Eraldemir, Ersan Özbudak, Deniz Şahin, Hale Maral Kır. Comparison of Cilostazol and Naftidrofuryl in an Experimental Acute Ischemia-Reperfusion Model. Vascular and endovascular surgery. 2021 Jan; 55(1):11-17. doi: 10.1177/1538574420953944. [PMID: 32878581]
  • Suzy M Sabry, Tarek S Belal, Magda H Barary, Mohammed E A Ibrahim. A validated HPLC method for the simultaneous determination of naftidrofuryl oxalate and its degradation product (metabolite), naftidrofuryl acid: applications to pharmaceutical tablets and biological samples. Drug testing and analysis. 2013 Jun; 5(6):500-8. doi: 10.1002/dta.421. [PMID: 22374844]
  • Min Jee Kim, Ji Shin Lee, Soo Wan Kim. Acute kidney injury associated with nafronyl oxalate overdose. Clinical and experimental nephrology. 2013 Jun; 17(3):437-8. doi: 10.1007/s10157-012-0752-x. [PMID: 23254471]
  • Jörg Melzer, Reinhard Saller. [Clinical studies in peripheral arterial occlusive disease: update from the aspects of a meta-narrative review]. Forschende Komplementarmedizin (2006). 2013; 20 Suppl 2(?):17-21. doi: 10.1159/000351720. [PMID: 23860108]
  • Bruno Legallicier, Stephane Barbier, Laetitia Bolloni, Jean-Paul Fillastre, Michel Godin, Thomas Kuhn, Florence Porte, Pierre Chretien, Thibaut Dupain, Maguy Bromet-Petitd. Pharmacokinetics of naftidrofuryl in patients with renal impairment. Arzneimittel-Forschung. 2005; 55(7):370-5. doi: 10.1055/s-0031-1296874. [PMID: 16080275]
  • Luan D Truong, Ulkem Yakupoglu, Daniel Feig, John Hicks, Joiner Cartwight, David Sheikh-Hamad, Wadi N Suki. Calcium oxalate deposition in renal allografts: morphologic spectrum and clinical implications. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2004 Aug; 4(8):1338-44. doi: 10.1111/j.1600-6143.2004.00511.x. [PMID: 15268737]
  • Rainer Schindler, Tanja Fielenbach, Gerhard Rave, Anne Blömer, Richard Kellersmann. Vitamin A metabolism is altered in brown Norway and long-Evans rats infused with naftidrofuryl or erythromycin intravenously. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition. 2002 Jul; 72(4):210-20. doi: 10.1024/0300-9831.72.4.210. [PMID: 12214558]
  • Dierk Endemann, Frank Schweda, Mike Stubanus, Karl-Peter Ittner, Michael Fischereder, Martin C Kammerl, Bernhard K Krämer. Naftidrofuryl exerts antiserotonergic but no endothelin-receptor blocking effects in AS4.1 cells, juxtaglomerular cells and isolated perfused rat kidneys. Journal of cardiovascular pharmacology. 2002 Jan; 39(1):1-8. doi: 10.1097/00005344-200201000-00001. [PMID: 11743222]
  • I A Jagroop, D P Mikhailidis. Effect of endothelin-1 on human platelet shape change: reversal of activation by naftidrofuryl. Platelets. 2000 Aug; 11(5):272-7. doi: 10.1080/09537100050129288. [PMID: 11030461]
  • F Retornaz, M J Jean-Pastor, S Monestier, J M Durand, J Soubeyrand. Recurrent calcium oxalate nephrolithiasis induced by naftidrofuryl oxalate. Nephron. 2000 May; 85(1):92. doi: 10.1159/000045636. [PMID: 10773762]
  • K Lamm, W Arnold. The effect of blood flow promoting drugs on cochlear blood flow, perilymphatic pO(2) and auditory function in the normal and noise-damaged hypoxic and ischemic guinea pig inner ear. Hearing research. 2000 Mar; 141(1-2):199-219. doi: 10.1016/s0378-5955(00)00005-8. [PMID: 10713508]
  • C Le Dévéhat, T Khodabandehlou, M Mosnier. Effect of naftidrofuryl on platelet aggregation in plasma from aspirin treated patients: an in vitro study. Clinical hemorheology and microcirculation. 2000; 22(3):197-204. doi: NULL. [PMID: 10976713]
  • A A Kubatiev, T S Balashova, V Iu Smirnova, I A Strokov, T A Konstantinovskaia. [The effect of naftidrofuryl on peroxidation of serum and erythrocyte membrane lipids in patients with insulin-dependent diabetes mellitus]. Biulleten' eksperimental'noi biologii i meditsiny. 1996 Sep; 122(9):338-41. doi: NULL. [PMID: 8974495]
  • A Heidland, G Schindler, S Franke. Acute renal failure following high intravenous doses of naftidrofuryloxalate. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 1995 Dec; 10(12):2371. doi: 10.1093/ndt/10.12.2371a. [PMID: 8808247]
  • C Moesch, J P Charmes, F Bouthier, C Leroux-Robert. Calcium oxalate crystalluria in elderly patients and treatment with naftidrofuryl oxalate. Age and ageing. 1995 Nov; 24(6):464-7. doi: 10.1093/ageing/24.6.464. [PMID: 8588533]
  • R Kirsten, B Erdeg, D Moxter, K Hesse, M Breidert, K Nelson. Platelet aggregation after naftidrofuryl application in vitro and ex vivo. International journal of clinical pharmacology and therapeutics. 1995 Feb; 33(2):81-4. doi: NULL. [PMID: 7757315]
  • Y Le Meur, C Moesch, M Rincé, J C Aldigier, C Leroux-Robert. Potential nephrotoxicity of intravenous infusions of naftidrofuryl oxalate. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 1995; 10(9):1751-5. doi: 10.1093/ndt/10.9.1751. [PMID: 8559500]
  • C Cuvelier, E Goffin, J P Cosyns, N Claeys, J P Squifflet, Y Pirson, C V de Strihou. Acute renal failure due to naftidrofuryl oxalate Praxilène overdose in a kidney transplant recipient. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 1995; 10(9):1756-8. doi: NULL. [PMID: 8559501]
  • F Hoffmann, C Beck, A Schutz, P Offermann. [Ginkgo extract EGb 761 (tenobin)/HAES versus naftidrofuryl (Dusodril)/HAES. A randomized study of therapy of sudden deafness]. Laryngo- rhino- otologie. 1994 Mar; 73(3):149-52. doi: 10.1055/s-2007-997099. [PMID: 7513516]
  • V Meininger, E Chaineau, B Soudière. [Effect of naftidrofuryl (LS129) on axonal growth]. Revue neurologique. 1994; 150(2):115-22. doi: NULL. [PMID: 7863151]
  • M A Barradas, G Stansby, G Hamilton, D P Mikhailidis. Effect of naftidrofuryl and aspirin on platelet aggregation in peripheral vascular disease. In vivo (Athens, Greece). 1993 Nov; 7(6A):543-8. doi: NULL. [PMID: 8193274]
  • B L Zhang, K L Liu, J Sacquet, N Wiernsperger, D Benzoni, J Sassard. Effects of naftidrofuryl on isolated perfused kidneys of spontaneously hypertensive rats. Clinical and experimental pharmacology & physiology. 1993 Oct; 20(10):655-61. doi: 10.1111/j.1440-1681.1993.tb01648.x. [PMID: 8261661]
  • A A Weber, T Hohlfeld, H Strobach, K Schrör. Oral naftidrofuryl prevents platelet hyperreactivity ex vivo and inhibits functional desensitization to prostacyclin in hypercholesterolemic rabbits. Journal of cardiovascular pharmacology. 1993 Feb; 21(2):332-8. doi: 10.1097/00005344-199302000-00021. [PMID: 7679170]
  • D Beati, A Mermoud, R Faggioni. [Effect of naftidrofuryl (Praxilene) in primary open angle glaucoma: prospective double-blind study]. Klinische Monatsblatter fur Augenheilkunde. 1992 May; 200(5):407-8. doi: 10.1055/s-2008-1045778. [PMID: 1614112]
  • P Költringer, W Langsteger, F Reisecker, O Eber. [Effect of naftidrofuryl on viscoelasticity, thrombocyte aggregation and erythrocyte fluidity of blood]. VASA. Zeitschrift fur Gefasskrankheiten. 1992; 21(4):411-4. doi: NULL. [PMID: 1485477]
  • C Moesch, M Rince, M Daudon, J C Aldigier, C Leroux-Robert. Renal intratubular crystallisation of calcium oxalate and naftidrofuryl oxalate. Lancet (London, England). 1991 Nov; 338(8776):1219-20. doi: 10.1016/0140-6736(91)92093-h. [PMID: 1682637]
  • P Stehlík, H Houbová. [Determination of naphthidrofuryl and naphthidrofurylic acid in human plasma using RP-HPLC and fluorimetric detection]. Ceskoslovenska farmacie. 1990 Nov; 39(9):394-9. doi: NULL. [PMID: 2095982]
  • U Steinmann, R Braun, H Sippel, C J Estler. Effects of naftidrofuryl on the indocyanine green clearance and cardiovascular function of rats with liver cirrhosis. Arzneimittel-Forschung. 1990 Jun; 40(6):709-11. doi: NULL. [PMID: 2397008]
  • P Lehert, F E Riphagen, S Gamand. The effect of naftidrofuryl on intermittent claudication: a meta-analysis. Journal of cardiovascular pharmacology. 1990; 16 Suppl 3(?):S81-6. doi: 10.1097/00005344-199000163-00019. [PMID: 1369727]
  • K Roth, M Hildebrand, K H Beyer. Metabolism of nafronyl in man. European journal of drug metabolism and pharmacokinetics. 1989 Apr; 14(2):133-8. doi: 10.1007/bf03190853. [PMID: 2591417]
  • L M Walmsley, T Taylor, P A Wilkinson, R R Brodie, L F Chasseaud, V Alun-Jones, J O Hunter. Plasma concentrations and relative bioavailability of naftidrofuryl from different salt forms. Biopharmaceutics & drug disposition. 1986 Jul; 7(4):327-34. doi: 10.1002/bdd.2510070403. [PMID: 3768488]
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  • R Parussini, C Godinot. NADPH-induced microsomal lipid peroxidation as measured by malondialdehyde production in rat liver. Inhibitory effect of naftidrofuryl. Free radical research communications. 1986; 2(1-2):93-100. doi: 10.3109/10715768609088059. [PMID: 3505243]
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  • R R Brodie, L F Chasseaud, T Taylor, J O Hunter, P J Ciclitira. Determination of naftidrofuryl in the plasma of humans by high-performance liquid chromatography. Journal of chromatography. 1979 Dec; 164(4):534-40. doi: 10.1016/s0378-4347(00)81559-5. [PMID: 541432]
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