Sombrevin (BioDeep_00000858753)
代谢物信息卡片
Propanidid
化学式: C18H27NO5 (337.1889132)
中文名称: 普尔安
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCOC(=O)CC1=CC(=C(C=C1)OCC(=O)N(CC)CC)OC
InChI: InChI=1S/C18H27NO5/c1-5-10-23-18(21)12-14-8-9-15(16(11-14)22-4)24-13-17(20)19(6-2)7-3/h8-9,11H,5-7,10,12-13H2,1-4H3
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
N - Nervous system > N01 - Anesthetics > N01A - Anesthetics, general
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent
同义名列表
2 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:135432
- KEGGdrug: D05626
- PubChem: 15004
- DrugBank: DB13234
- ChEMBL: CHEMBL2105345
- MeSH: Propanidid
- CAS: 1421-14-3
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Alessia Cenani, Robert J Brosnan, Heather K Knych. In vitro and in vivo GABAA Receptor Interaction of the Propanidid Metabolite 4-(2-[Diethylamino]-2-Oxoethoxy)-3-Methoxy-Benzeneacetic Acid.
Pharmacology.
2019; 103(1-2):10-16. doi:
10.1159/000493753. [PMID: 30332672] - A Klockgether-Radke, J Kersten, T Schröder, D Stafforst, D Kettler, G Hellige. [Anesthesia with propanidid in a liposomal preparation. An experimental study in swine].
Der Anaesthesist.
1995 Aug; 44(8):573-80. doi:
10.1007/s001010050191. [PMID: 7573906] - H Habazettl, B Vollmar, F Röhrich, P Conzen, A Doenicke, A Baethmann. [Anesthesiologic efficacy of propanidid as a liposome dispersion. An experimental study with rats].
Der Anaesthesist.
1992 Aug; 41(8):448-56. doi:
NULL. [PMID: 1524155] - P Zawisza, L Przyborowski. [High-performance liquid chromatographic determination of propanidid and etomidate].
Acta poloniae pharmaceutica.
1992; 49(5-6):11-3. doi:
NULL. [PMID: 16092192] - P Zawisza, L Przyborowski. [Propanidid and etomidate identification from the blood by thin-layer chromatography].
Acta poloniae pharmaceutica.
1992; 49(5-6):15-7. doi:
NULL. [PMID: 16092193] - M Ennis, W Lorenz, W Gerland, J Heise. Isolation of mast cells from rabbit lung and liver: comparison of histamine release induced by the hypnotics Althesin and propanidid.
Agents and actions.
1987 Apr; 20(3-4):219-22. doi:
10.1007/bf02074674. [PMID: 2440276] - A Kertész, G Falkay, M Boros. Comparative study of intravenous anaesthetic techniques administered during short-term gynecological operations.
Acta medica Hungarica.
1985; 42(1-2):41-9. doi:
NULL. [PMID: 4034336] - U Nousiainen, O Raatikainen. High-performance liquid chromatography of propanidid in rat plasma.
Journal of chromatography.
1984 Jun; 308(?):376-81. doi:
10.1016/0378-4347(84)80234-0. [PMID: 6746830] - D Christmas. Immune reaction to propanidid.
Anaesthesia.
1984 May; 39(5):470-3. doi:
10.1111/j.1365-2044.1984.tb07318.x. [PMID: 6731777] - U Nousiainen. The effects of phenobarbital, bis-p-nitrophenyl phosphate and disulfiram on the hydrolysis of propanidid in Wistar rats.
General pharmacology.
1984; 15(5):397-402. doi:
10.1016/0306-3623(84)90037-5. [PMID: 6510675] - K I Bender, G A Seliverstov. [Effect of sombrevin and sodium oxybutyrate on the excitable membranes of a frog neuromuscular preparation].
Farmakologiia i toksikologiia.
1982 Jul; 45(4):30-4. doi:
". [PMID: 7128782] - K M Salah, K K Hampton, J B Findlay. The effects of general anaesthetics on glucose and phosphate transport across the membrane of the human erythrocyte.
Biochimica et biophysica acta.
1982 May; 688(1):163-8. doi:
10.1016/0005-2736(82)90591-0. [PMID: 7093272] - J Kienlen, P Chardon. [Pharmacokinetics of intravenous non-steroidal anesthetics].
Annales de l'anesthesiologie francaise.
1981; 22(2):129-41. doi:
NULL. [PMID: 6115600] - L Szegedi, A Dobjanschi, J Novak, L Szilagyi, E Wersching, T Kanyadi. [Comparative study of induction with propanidid plus succinylcholine and thiopental plus succinylcholine].
Revista de chirurgie, oncologie, radiologie, o.r.l., oftalmologie, stomatologie. Chirurgie.
1980 Nov; 29(6):469-72. doi:
NULL. [PMID: 6454186] - O T Pesando, L Piazza, G Berruti, G Sciandra. [Propanidid as an antagonist: competitive inhibitor of neuromuscular plaque acetylcholinesterase].
Minerva anestesiologica.
1980 Jun; 46(6):665-70. doi:
NULL. [PMID: 7465080] - K A El-Hawary, H M El-Kateb, S M Hussein, M D Atallah. Propanidid--suxamethonium apnea in bilharzial patients.
Middle East journal of anaesthesiology.
1980 Feb; 5(6):417-21. doi:
NULL. [PMID: 7402093] - L Gramstad, J Stovner. Plasma viscosity and cremophor-containing anaesthetics.
British journal of anaesthesia.
1979 Dec; 51(12):1175-9. doi:
10.1093/bja/51.12.1175. [PMID: 526386] - P E Taussig, H E Stojak, N R Bennett. In vitro interaction of propanidid and suxamethonium with pooled human plasma cholinesterase. A kinetic study.
British journal of anaesthesia.
1979 Mar; 51(3):181-6. doi:
10.1093/bja/51.3.181. [PMID: 435340] - H D Taube. [Pharmacology of injection anesthetics].
Intensivmedizinische Praxis.
1979; ?(2):65-73. doi:
NULL. [PMID: 553878] - E N Fry. Use of propanidid and lignocaine to modify the increase in serum potassium concentration following injection of suxamethonium.
British journal of anaesthesia.
1978 Aug; 50(8):841-3. doi:
10.1093/bja/50.8.841. [PMID: 678373] - W Lorenz, A Doenicke. Histamine release in clinical conditions.
The Mount Sinai journal of medicine, New York.
1978 May; 45(3):357-86. doi:
NULL. [PMID: 79135] - A Gismondi, F Micalella, R Caione. [Mixed anesthesia with ethrane in operations of long duration].
Minerva anestesiologica.
1978 Jan; 44(1):11-4. doi:
NULL. [PMID: 643187] - A A Antonov, V R Trushliakov, I G Antonova. [Anesthesia in semiopen puncture biopsy of the kidneys].
Anesteziologiia i reanimatologiia.
1977 Nov; ?(6):69-71. doi:
NULL. [PMID: 603092] - M M Ghoneim, K Korttila. Pharmacokinetics of intravenous anaesthetics: implications for clinical use.
Clinical pharmacokinetics.
1977 Sep; 2(5):344-72. doi:
10.2165/00003088-197702050-00003. [PMID: 21053] - L Stella, C L Castiglioni. [Variation in the brain level of anesthetic in relation to the modification of renal functional activity and renal distribution of anesthetics].
Anesthesie, analgesie, reanimation.
1977 Sep; 34(5):857-67. doi:
NULL. [PMID: 613861] - G Baur, H Kurz, H Trunk. Alteration of protein-binding during storage of human plasma preparations.
Der Anaesthesist.
1977 Mar; 26(3):148-50. doi:
NULL. [PMID: 857693] - J R Boyce, F J Wright, F W Cervenko, S P Pietak, S Faulkner. Prolongation of anesthetic action by BNPP (bis-[p-nitrophenyl] phosphate).
Anesthesiology.
1976 Dec; 45(6):629-34. doi:
10.1097/00000542-197612000-00006. [PMID: 984479] - I Pulay. Plasma potassium and inducation agents.
British journal of anaesthesia.
1976 Oct; 48(10):1029. doi:
10.1093/bja/48.10.1029. [PMID: 990143] - A Doenicke, W Lorenz. [In vivo blood histamine during anesthesia].
Annales de l'anesthesiologie francaise.
1976; 17(2):219-24. doi:
NULL. [PMID: 62535] - C Meyer-Burgdorff, G Seidel, I Wolf. [Liberation of histamine by anaesthetics (author's transl)].
Der Anaesthesist.
1976 Jan; 25(1):1-5. doi:
NULL. [PMID: 56908] - A Doenicke, W Lorenz. [Interference between histamine liberation and drugs used in anesthesiology. Prevention and treatment of the complications of histamine liberation].
Annales de l'anesthesiologie francaise.
1976; 17(3):355-64. doi:
NULL. [PMID: 62543] - A J Porsius, P A van Zwieten. Metabolic degradation of propanidid by various tissues. Short communication.
Arzneimittel-Forschung.
1976; 26(11):1999-2001. doi:
NULL. [PMID: 1037232] - A J Porsius, P A Van Zwieten. The negative inotropic action of propanidid. influence on calcium movements in atrial tissue.
European journal of pharmacology.
1975 Dec; 34(2):283-92. doi:
10.1016/0014-2999(75)90253-8. [PMID: 1234548] - D J McCleave, W B Blakemore. Anaesthesia for electroconvulsive therapy.
Anaesthesia and intensive care.
1975 Aug; 3(3):250-6. doi:
10.1177/0310057x7500300313. [PMID: 1166948] - S Szabo, S Komblos, Z Ignjatovic. Effect of pregnenolone-16alpha-carbonitrile (PCN) on drug response in man.
The Journal of pharmacy and pharmacology.
1975 Feb; 27(2):113-8. doi:
10.1111/j.2042-7158.1975.tb09418.x. [PMID: 237070] - R S Clarke, I M Bali, M Issac, J W Dundee, B Sheridan. Plasma cortisol and blood sugar following minor surgery under intravenous anaesthetics.
Anaesthesia.
1974 Sep; 29(5):545-50. doi:
10.1111/j.1365-2044.1974.tb00717.x. [PMID: 4433013] - R S Clarke. Biotransformation of the eugenols.
International anesthesiology clinics.
1974; 12(2):135-8. doi:
10.1097/00004311-197412020-00015. [PMID: 4846713] - I M Bali, W Dundee, R A Assaf. Proceedings: Immediate changes in plasma potassium induced by intravenous induction agents.
British journal of anaesthesia.
1973 Dec; 45(12):1238. doi:
10.1093/bja/45.12.1238. [PMID: 4787030] - P Lübke, H Dannemann, K Bihler, E Schindler. [Studies in mongrel dogs about the influence of propanidid on regional renal blood flow (author's transl)].
Zeitschrift fur praktische Anasthesie, Wiederbelebung und Intensivtherapie.
1973 Aug; 8(4):206-13. doi:
NULL. [PMID: 4765571] - V A Tomilets, V D Topolianskiĭ, M M Kolosov, S P Kilina, V M Shchelokova. [Blood serum histamine following anesthesia in patients with pulmonary tuberculosis].
Problemy tuberkuleza.
1973; 51(11):30-3. doi:
NULL. [PMID: 4129978] - S Takki, T Tammisto, P Nikki, A Jäättelä. Effect of laryngoscopy and intubation on plasma catecholamine levels during intravenous induction of anaesthesia.
British journal of anaesthesia.
1972 Dec; 44(12):1323-8. doi:
10.1093/bja/44.12.1323. [PMID: 4650351] - W Lorenz, A Doenicke, R Meyer, H J Reimann, J Kusche, H Barth, H Geesing, M Hutzel, B Weissenbacher. Histamine release in man by propanidid and thiopentone: pharmacological effects and clinical consequences.
British journal of anaesthesia.
1972 Apr; 44(4):355-69. doi:
10.1093/bja/44.4.355. [PMID: 4113349] - T H Spreadbury, H R Marrett. Cardiovascular collapse after propanidid.
British journal of anaesthesia.
1971 Oct; 43(10):925. doi:
10.1093/bja/43.10.925. [PMID: 5115030] - J Stovner, I Lund. The muscle relaxants and their antagonists.
British journal of anaesthesia.
1970 Mar; 42(3):235-48. doi:
10.1093/bja/42.3.235. [PMID: 4193499] - V Kamphues, R Ammon. [Characteristics and substrate specificity of dolantin esterase from rabbit liver].
Enzymologia.
1969 Dec; 37(5):356-77. doi:
NULL. [PMID: 5365561] - K Bihler. [Anesthesia induced renal changes and electrolyte excretion].
Der Anaesthesist.
1969 Dec; 18(12):396-400. doi:
NULL. [PMID: 5374288] - K Bihler, G Gundlach, G F Hoppe-Seyler, P May, C Planz. [Effect of propanidid on renal hemodynamics and excretion of electrolytes].
Der Anaesthesist.
1969 Feb; 18(2):43-6. doi:
NULL. [PMID: 5359861] - H L Zauder, R J Nichols. Intravenous anesthesia.
Clinical anesthesia.
1969; 3(?):317-57. doi:
NULL. [PMID: 5001180] - R S CLARKE, M J KIRWAN, J W DUNDEE, D W NEILL, E S MITCHELL. CLINICAL STUDIES OF INDUCTION AGENTS. 13. LIVER FUNCTION AFTER PROPANIDID AND THIOPENTONE ANAESTHESIA.
British journal of anaesthesia.
1965 Jun; 37(?):415-21. doi:
10.1093/bja/37.6.415. [PMID: 14328273]