Eperisone (BioDeep_00000858745)
Volatile Flavor Compounds
代谢物信息卡片
化学式: C17H25NO (259.193604)
中文名称: 艾哌瑞松, 埃哌立松
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC1=CC=C(C=C1)C(=O)C(C)CN2CCCCC2
InChI: InChI=1S/C17H25NO/c1-3-15-7-9-16(10-8-15)17(19)14(2)13-18-11-5-4-6-12-18/h7-10,14H,3-6,11-13H2,1-2H3
描述信息
M - Musculo-skeletal system > M03 - Muscle relaxants > M03B - Muscle relaxants, centrally acting agents
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010276 - Parasympatholytics
D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:77070
- KEGGdrug: D07898
- PubChem: 3236
- DrugBank: DB08992
- ChEMBL: CHEMBL1902981
- CAS: 64840-90-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Junteng Zhu, Jiecheng Xiao, Jianxiong Hu, Jianlin Shen, Bai Chen, Chengfei Zhao. Muscle Strength Decline Caused by Eperisone Hydrochloride: A Case Report.
Clinical therapeutics.
2024 01; 46(1):74-78. doi:
10.1016/j.clinthera.2023.10.003
. [PMID: 37914584] - Satoru Mitsuboshi. Association Between Baclofen and Respiratory Depression in Patients With Chronic Kidney Disease.
Journal of clinical pharmacology.
2021 06; 61(6):836-837. doi:
10.1002/jcph.1843
. [PMID: 33629349] - Dongqing Cui, Yanxia Liu, Liang Jin, Liping Hu, Lili Cao. A novel compound heterozygous mutation in the arginase-1 gene identified in a Chinese patient with argininemia: A case report.
Medicine.
2020 Aug; 99(32):e21634. doi:
10.1097/md.0000000000021634
. [PMID: 32769929] - Kamran Ahmed, Muhammad Harris Shoaib, Rabia Ismail Yousuf, Fahad Siddiqui, Faaiza Qazi, Javeria Iftikhar, Farrukh Rafiq Ahmed, Muhammad Iqbal Nasiri. Comparative pharmacokinetics of osmotic-controlled and immediate-release Eperisone tablet formulation in healthy human subjects using a sensitive plasma LC-ESI-MS/MS method.
Scientific reports.
2020 02; 10(1):1867. doi:
10.1038/s41598-020-58801-1
. [PMID: 32024955] - Hyun-Ju Lee, Eun-Sol Ha, Yoonseo Lee, Dae-Chul Ha, Youn-Woong Choi, In-Hwan Baek, Min-Soo Kim. Pharmacokinetic and bioequivalence study of sugar-coated and film-coated eperisone tablets in healthy subjects: A randomized, open-label, three-way, reference-replicated crossover study
.
International journal of clinical pharmacology and therapeutics.
2019 Jan; 57(1):55-62. doi:
10.5414/cp203346
. [PMID: 30415650] - Gulam Rabbani, Mohammad Hassan Baig, Eun Ju Lee, Won-Kyung Cho, Jin Yeul Ma, Inho Choi. Biophysical Study on the Interaction between Eperisone Hydrochloride and Human Serum Albumin Using Spectroscopic, Calorimetric, and Molecular Docking Analyses.
Molecular pharmaceutics.
2017 05; 14(5):1656-1665. doi:
10.1021/acs.molpharmaceut.6b01124
. [PMID: 28380300] - Ju-Hee Ryu, Joo-Il Kim, Hyung Son Kim, Gyu-Jeong Noh, Kyung-Tae Lee, Eun Kyoung Chung. Pharmacokinetic Interactions Between Pelubiprofen and Eperisone Hydrochloride: A Randomized, Open-label, Crossover Study of Healthy Korean Men.
Clinical therapeutics.
2017 Jan; 39(1):138-149. doi:
10.1016/j.clinthera.2016.11.020
. [PMID: 27989618] - Marcello Locatelli, Roberta Cifelli, Cristina Di Legge, Renato Carmine Barbacane, Nicola Costa, Massimo Fresta, Christian Celia, Carlo Capolupo, Luisa Di Marzio. Simultaneous determination of eperisone hydrochloride and paracetamol in mouse plasma by high performance liquid chromatography-photodiode array detector.
Journal of chromatography. A.
2015 Apr; 1388(?):79-86. doi:
10.1016/j.chroma.2015.02.008
. [PMID: 25704771] - Naoya Miura, Takeshi Saito, Takayuki Taira, Takeshi Yamagiwa, Sein Morita, Sadaki Inokuchi. Rapid simultaneous determination of eperisone, tolperisone, and tizanidine in human serum by using a MonoSpin® C18 extraction column and liquid chromatography/tandem mass spectrometry.
Journal of AOAC International.
2014 Nov; 97(6):1546-51. doi:
10.5740/jaoacint.13-295
. [PMID: 25632432] - Takeshi Yamagiwa, Seiji Morita, Mari Amino, Naoya Miura, Takeshi Saito, Sadaki Inokuchi. Serum concentration of eperisone hydrochloride correlates with QT interval.
The American journal of emergency medicine.
2014 Jan; 32(1):75-7. doi:
10.1016/j.ajem.2013.09.006
. [PMID: 24135462] - R Nageswara Rao, S Satyanarayana Raju. Enantioselective separation and simultaneous determination of tolperisone and eperisone in rat plasma by LC-MS/MS.
Chirality.
2013 Oct; 25(10):622-7. doi:
10.1002/chir.22187
. [PMID: 23840024] - Mi Jo Kim, Hyeong-Seok Lim, Yook-Hwan Noh, Yo Han Kim, Hee Youn Choi, Kyung-Mi Park, Sei-Eun Kim, Kyun-Seop Bae. Pharmacokinetic interactions between eperisone hydrochloride and aceclofenac: a randomized, open-label, crossover study of healthy Korean men.
Clinical therapeutics.
2013 Oct; 35(10):1528-35. doi:
10.1016/j.clinthera.2013.08.012
. [PMID: 24050970] - Barbara Melilli, Cateno Piazza, Daniela Cristina Vitale, Maria Rosa Marano, Andrea Pecori, Paolo Mattana, Valentina Li Volsi, Carmelo Iuculano, Francesco Cardì, Filippo Drago. Human pharmacokinetics of the muscle relaxant, eperisone hydrochloride by liquid chromatography-electrospray tandem mass spectrometry.
European journal of drug metabolism and pharmacokinetics.
2011 Jun; 36(2):71-8. doi:
10.1007/s13318-011-0034-0
. [PMID: 21448778] - Takeshi Yamagiwa, Mari Amino, Seiji Morita, Rie Yamamoto, Takeshi Saito, Sadaki Inokuchi. A case of torsades de pointes induced by severe QT prolongation after an overdose of eperisone and triazolam in a patient receiving nifedipine.
Clinical toxicology (Philadelphia, Pa.).
2010 Feb; 48(2):149-52. doi:
10.3109/15563650903524126
. [PMID: 20199131] - Min Kyo Jeoung, Eun Sook Jeong, Nam Hee Kim, Chang-Soo Kim, Youn-Bok Chung, Yong-Moon Lee, Su-Youn Ahn, Hwang-Eui Cho, Yong Hwa Lee, Jin Tae Hong, Dong-Cheul Moon. Determination of eperisone in human plasma by liquid chromatography-ESI-tandem mass spectrometry.
Archives of pharmacal research.
2007 Sep; 30(9):1174-8. doi:
10.1007/bf02980255
. [PMID: 17958338] - Li Ding, Xin Wei, Shengqiang Zhang, Jianpin Sheng, Yindi Zhang. Rapid and sensitive liquid chromatography-electrospray ionization-mass spectrometry method for the determination of eperisone in human plasma: method and clinical applications.
Journal of chromatographic science.
2004 May; 42(5):254-8. doi:
10.1093/chromsci/42.5.254
. [PMID: 15189598] - Xin Wei, Li Ding, Jia-min Gao, Jun Li, Sheng-qiang Zhang, Jian-ping Shen, Yin-di Zhang. [Pharmacokinetics and bioequivalence of eperisone hydrochloride tablet in healthy subjects].
Yao xue xue bao = Acta pharmaceutica Sinica.
2004 Apr; 39(4):309-11. doi:
NULL
. [PMID: 15303666] - Masaru Kato, Kumiko Sakai-Kato, Nozomi Matsumoto, Toshimasa Toyo'oka. A protein-encapsulation technique by the sol-gel method for the preparation of monolithic columns for capillary electrochromatography.
Analytical chemistry.
2002 Apr; 74(8):1915-21. doi:
10.1021/ac0112162
. [PMID: 11985326] - M Matsunaga, Y Uemura, Y Yonemoto, K Kanai, H Etoh, S Tanaka, Y Atsuta, Y Nishizawa, Y Yamanishi. Long-lasting muscle relaxant activity of eperisone hydrochloride after percutaneous administration in rats.
Japanese journal of pharmacology.
1997 Mar; 73(3):215-20. doi:
10.1254/jjp.73.215
. [PMID: 9127816] - T Takamatsu, K Yamazaki, M Kayano, F Takenaka, M Hasui, T Ohkawa. Determination of eperisone in human plasma by gas chromatography-mass spectrometry.
Journal of chromatography.
1992 Dec; 584(2):261-6. doi:
10.1016/0378-4347(92)80584-d
. [PMID: 1484111] - Y Yamazaki, T Mano, S Iwase. [Effects of muscle relaxant E-0646 on human stretch reflex and responses].
No to shinkei = Brain and nerve.
1991 Apr; 43(4):369-75. doi:
NULL
. [PMID: 1888576] - K Murayama, T Katsumi, E Tajika, T Nakamura. [Clinical application of eperisone hydrochloride to neurogenic bladder].
Hinyokika kiyo. Acta urologica Japonica.
1984 Mar; 30(3):403-8. doi:
NULL
. [PMID: 6464913]