Apafant (BioDeep_00000858741)
代谢物信息卡片
Apafant
化学式: C22H22ClN5O2S (455.11826620000005)
中文名称: 阿帕泛
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=NN=C2N1C3=C(C=C(S3)CCC(=O)N4CCOCC4)C(=NC2)C5=CC=CC=C5Cl
InChI: InChI=1S/C22H22ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12H,6-11,13H2,1H3
描述信息
C78275 - Agent Affecting Blood or Body Fluid > C1327 - Antiplatelet Agent
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
D006401 - Hematologic Agents > D005343 - Fibrinolytic Agents
D050299 - Fibrin Modulating Agents
D002317 - Cardiovascular Agents
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:92490
- KEGGdrug: D01652
- PubChem: 65889
- ChEMBL: CHEMBL280164
- CAS: 105219-56-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Toshiko Tanaka, Shiomi Yoshizumi, Kentaro Kasai, Kosho Yoshida, Hiroaki Sato. Efficacy of DRIVEN-FLOW® M7-II, a new on-site drug screening kit in postmortem urine compared with Triage DOA®.
Legal medicine (Tokyo, Japan).
2021 Feb; 48(?):101804. doi:
10.1016/j.legalmed.2020.101804. [PMID: 33152676] - Vyala Hanumanthareddy Chaithra, Shancy Petsel Jacob, Chikkamenahalli Lakshminarayana Lakshmikanth, Mosale Seetharam Sumanth, Kandahalli Venkataranganayaka Abhilasha, Chu-Huang Chen, Anita Thyagarajan, Ravi P Sahu, Jeffery Bryant Travers, Thomas M McIntyre, Kempaiah Kemparaju, Gopal Kedihithlu Marathe. Modulation of inflammatory platelet-activating factor (PAF) receptor by the acyl analogue of PAF.
Journal of lipid research.
2018 11; 59(11):2063-2074. doi:
10.1194/jlr.m085704. [PMID: 30139761] - R Munoz-Cano, E Ainsua-Enrich, I Torres-Atencio, M Martin, J Sánchez-Lopez, J Bartra, C Picado, J Mullol, A Valero. Effects of Rupatadine on Platelet- Activating Factor-Induced Human Mast Cell Degranulation Compared With Desloratadine and Levocetirizine (The MASPAF Study).
Journal of investigational allergology & clinical immunology.
2017 ; 27(3):161-168. doi:
10.18176/jiaci.0117. [PMID: 27758758] - Holger Fuchs, Wataru Kishimoto, Dietmar Gansser, Paul Tanswell, Naoki Ishiguro. Brain penetration of WEB 2086 (Apafant) and dantrolene in Mdr1a (P-glycoprotein) and Bcrp knockout rats.
Drug metabolism and disposition: the biological fate of chemicals.
2014 Oct; 42(10):1761-5. doi:
10.1124/dmd.114.058545. [PMID: 25053619] - Felipe Gazos-Lopes, Mauricio M Oliveira, Lucas V B Hoelz, Danielle P Vieira, Alexandre F Marques, Ernesto S Nakayasu, Marta T Gomes, Nasim G Salloum, Pedro G Pascutti, Thaïs Souto-Padrón, Robson Q Monteiro, Angela H Lopes, Igor C Almeida. Structural and functional analysis of a platelet-activating lysophosphatidylcholine of Trypanosoma cruzi.
PLoS neglected tropical diseases.
2014 Aug; 8(8):e3077. doi:
10.1371/journal.pntd.0003077. [PMID: 25101628] - Claudia S Bitencourt, Valérie L Bessi, David N Huynh, Liliane Ménard, Julie S Lefebvre, Tania Lévesque, Leila Hamdan, Fanny Sohouhenou, Lucia H Faccioli, Pierre Borgeat, Sylvie Marleau. Cooperative role of endogenous leucotrienes and platelet-activating factor in ischaemia-reperfusion-mediated tissue injury.
Journal of cellular and molecular medicine.
2013 Dec; 17(12):1554-65. doi:
10.1111/jcmm.12118. [PMID: 24373549] - Huamei Forsman, Karin Önnheim, Emil Andréasson, Karin Christenson, Anna Karlsson, Johan Bylund, Claes Dahlgren. Reactivation of desensitized formyl peptide receptors by platelet activating factor: a novel receptor cross talk mechanism regulating neutrophil superoxide anion production.
PloS one.
2013; 8(3):e60169. doi:
10.1371/journal.pone.0060169. [PMID: 23555913] - Masamichi Okubo, Hiroki Yamanaka, Kimiko Kobayashi, Hirosato Kanda, Yi Dai, Koichi Noguchi. Up-regulation of platelet-activating factor synthases and its receptor in spinal cord contribute to development of neuropathic pain following peripheral nerve injury.
Molecular pain.
2012 Feb; 8(?):8. doi:
10.1186/1744-8069-8-8. [PMID: 22296727] - Ana Claudia Onuchic, Camila M L Machado, Renata F Saito, Francisco J Rios, Sônia Jancar, Roger Chammas. Expression of PAFR as part of a prosurvival response to chemotherapy: a novel target for combination therapy in melanoma.
Mediators of inflammation.
2012; 2012(?):175408. doi:
10.1155/2012/175408. [PMID: 22570511] - Oliver Mann, Wolf-Jonas Tiefenbacher, Jussuf Kaifi, Claus Schneider, Dirk Kluth, Christian Bloechle, Emre Yekebas, Jakob R Izbicki, Tim Strate. Effect of platelet-activating factor antagonist WEB 2086 on microcirculatory disorders in acute experimental pancreatitis of graded severity.
Pancreas.
2009 Jan; 38(1):58-64. doi:
10.1097/mpa.0b013e3181841845. [PMID: 18695628] - Marcos Adriano Lessa, Cláudia Valéria Araújo, Maria Auxiliadora Kaplan, Daniel Pimenta, Maria Raquel Figueiredo, Eduardo Tibiriçá. Antihypertensive effects of crude extracts from leaves of Echinodorus grandiflorus.
Fundamental & clinical pharmacology.
2008 Apr; 22(2):161-8. doi:
10.1111/j.1472-8206.2008.00565.x. [PMID: 18353111] - Nicola J Menzies-Gow, M Fernanda Sepulveda, Simon R Bailey, Fiona M Cunningham, Jonathan Elliott. Roles of thromboxane A2 and 5-hydroxytryptamine in endotoxin-induced digital vasoconstriction in horses.
American journal of veterinary research.
2008 Feb; 69(2):199-207. doi:
10.2460/ajvr.69.2.199. [PMID: 18241016] - Shuang Wang, Ya-ling Tang, Yong-zong Yang, Zeng-xiang Xu, Kuang Peng. Opposite effects of WEB2086 on angiogenesis in atheromas and ischemic hindlimb of apoE gene deficient mice.
Chinese medical journal.
2007 May; 120(10):886-92. doi:
10.1097/00029330-200705020-00007. [PMID: 17543178] - Eduardo Tibiriçá, Andressa Almeida, Solange Caillleaux, Daniel Pimenta, Maria Auxiliadora Kaplan, Marcos Adriano Lessa, Maria Raquel Figueiredo. Pharmacological mechanisms involved in the vasodilator effects of extracts from Echinodorus grandiflorus.
Journal of ethnopharmacology.
2007 Apr; 111(1):50-5. doi:
10.1016/j.jep.2006.10.030. [PMID: 17150321] - Anna Fallani, Lido Calorini, Antonella Mannini, Silvia Gabellieri, Gabriele Mugnai, Salvatore Ruggieri. Platelet-activating factor (PAF) is the effector of IFN gamma-stimulated invasiveness and motility in a B16 melanoma line.
Prostaglandins & other lipid mediators.
2006 Dec; 81(3-4):171-7. doi:
10.1016/j.prostaglandins.2006.09.004. [PMID: 17085325] - C Cellai, A Laurenzana, A M Vannucchi, R Caporale, M Paglierani, S Di Lollo, A Pancrazzi, F Paoletti. Growth inhibition and differentiation of human breast cancer cells by the PAFR antagonist WEB-2086.
British journal of cancer.
2006 Jun; 94(11):1637-42. doi:
10.1038/sj.bjc.6603156. [PMID: 16721373] - W Sean Madorin, Tao Rui, Naohito Sugimoto, Osamu Handa, Gediminas Cepinskas, Peter R Kvietys. Cardiac myocytes activated by septic plasma promote neutrophil transendothelial migration: role of platelet-activating factor and the chemokines LIX and KC.
Circulation research.
2004 Apr; 94(7):944-51. doi:
10.1161/01.res.0000124395.20249.ae. [PMID: 14988231] - Alfred J Casillan, Norberto C Gonzalez, Jennifer S Johnson, Dawn R S Steiner, John G Wood. Mesenteric microvascular inflammatory responses to systemic hypoxia are mediated by PAF and LTB4.
Journal of applied physiology (Bethesda, Md. : 1985).
2003 Jun; 94(6):2313-22. doi:
10.1152/japplphysiol.00047.2002. [PMID: 12598480] - Rosita Gabbianelli, Giancarlo Falcioni, Crawford S Dow, Frank P Vince, Ben Swoboda. A new method to evaluate spontaneous platelet aggregation in type 2 diabetes by Cellfacts.
Clinica chimica acta; international journal of clinical chemistry.
2003 Mar; 329(1-2):95-102. doi:
10.1016/s0009-8981(03)00012-3. [PMID: 12589971] - Ulf Sibelius, Katja Hattar, Sabine Hoffmann, Konstantin Mayer, Ulrich Grandel, Angelika Schenkel, Werner Seeger, Friedrich Grimminger. Distinct pathways of lipopolysaccharide priming of human neutrophil respiratory burst: role of lipid mediator synthesis and sensitivity to interleukin-10.
Critical care medicine.
2002 Oct; 30(10):2306-12. doi:
10.1097/00003246-200210000-00020. [PMID: 12394960] - K L Ryan, J R Jauchem, M R Tehrany, H L Boyle. Platelet-activating factor does not mediate circulatory failure induced by 35-GHz microwave heating.
Methods and findings in experimental and clinical pharmacology.
2002 Jun; 24(5):279-86. doi:
10.1358/mf.2002.24.5.802305. [PMID: 12168504] - Monique Lenoir, Eric Pedruzzi, Samira Rais, Katy Drieu, Axel Perianin. Sensitization of human neutrophil defense activities through activation of platelet-activating factor receptors by ginkgolide B, a bioactive component of the Ginkgo biloba extract EGB 761.
Biochemical pharmacology.
2002 Apr; 63(7):1241-9. doi:
10.1016/s0006-2952(01)00866-8. [PMID: 11960600] - E Benito, M A Bosch. Role of platelet-activating factor in phosphatidylcholine secretion in primary cultures of rat type II pneumocytes.
Prostaglandins & other lipid mediators.
2002 Apr; 67(3-4):197-208. doi:
10.1016/s0090-6980(02)00004-7. [PMID: 12013527] - A Havt, M C Fonteles, H S Monteiro. The renal effects of Bothrops jararacussu venom and the role of PLA(2) and PAF blockers.
Toxicon : official journal of the International Society on Toxinology.
2001 Dec; 39(12):1841-6. doi:
10.1016/s0041-0101(01)00146-5. [PMID: 11600146] - E Carceller, J Salas, M Merlos, M Giral, R Ferrando, I Escamilla, J Ramis, J García-Rafanell, J Forn. Novel azo derivatives as prodrugs of 5-aminosalicylic acid and amino derivatives with potent platelet activating factor antagonist activity.
Journal of medicinal chemistry.
2001 Aug; 44(18):3001-13. doi:
10.1021/jm010852p. [PMID: 11520209] - P Y Chang, S Luo, T Jiang, Y T Lee, S C Lu, P D Henry, C H Chen. Oxidized low-density lipoprotein downregulates endothelial basic fibroblast growth factor through a pertussis toxin-sensitive G-protein pathway: mediator role of platelet-activating factor-like phospholipids.
Circulation.
2001 Jul; 104(5):588-93. doi:
10.1161/hc3101.092213. [PMID: 11479258] - C V Araújo, J M Barbosa-Filho, R S Cordeiro, E Tibiriçá. Protective effects of yangambin on cardiovascular hyporeactivity to catecholamines in rats with endotoxin-induced shock.
Naunyn-Schmiedeberg's archives of pharmacology.
2001 Mar; 363(3):267-75. doi:
10.1007/s002100000350. [PMID: 11284440] - S R Bailey, F M Cunningham, J Elliott. Endotoxin and dietary amines may increase plasma 5-hydroxytryptamine in the horse.
Equine veterinary journal.
2000 Nov; 32(6):497-504. doi:
10.2746/042516400777584730. [PMID: 11093623] - B K Oktar, T Coşkun, A Bozkurt, B C Yegen, M Yüksel, G Haklar, S Bilsel, F B Aksungar, U Cetinel, D N Granger, H Kurtel. Endothelin-1-induced PMN infiltration and mucosal dysfunction in the rat small intestine.
American journal of physiology. Gastrointestinal and liver physiology.
2000 Sep; 279(3):G483-91. doi:
10.1152/ajpgi.2000.279.3.g483. [PMID: 10960346] - C M Jesus-Morais, E F Assis, R S Cordeiro, J M Barbosa-Filho, W T Lima, Z L Silva, P T Bozza, H C Castro-Faria-Neto. Yangambin, a lignan obtained from Ocotea duckei, differentiates putative PAF receptor subtypes in the gastrointestinal tract of rats.
Planta medica.
2000 Apr; 66(3):211-6. doi:
10.1055/s-2000-8556. [PMID: 10821044] - J V Quinn, G J Slotman. Platelet-activating factor and arachidonic acid metabolites mediate tumor necrosis factor and eicosanoid kinetics and cardiopulmonary dysfunction during bacteremic shock.
Critical care medicine.
1999 Nov; 27(11):2485-94. doi:
10.1097/00003246-199911000-00027. [PMID: 10579269] - H Serra, A Monteiro, M C Fonteles. The effect of Bothrops jararaca venom on rat kidney after short-term exposure: preliminary results.
Pharmacology & toxicology.
1999 Oct; 85(4):198-200. doi:
10.1111/j.1600-0773.1999.tb00092.x. [PMID: 10563520] - L C Dy, Y Pei, J B Travers. Augmentation of ultraviolet B radiation-induced tumor necrosis factor production by the epidermal platelet-activating factor receptor.
The Journal of biological chemistry.
1999 Sep; 274(38):26917-21. doi:
10.1074/jbc.274.38.26917. [PMID: 10480902] - H S Monteiro, A A Lima, M C Fonteles. Glomerular effects of cholera toxin in isolated perfused rat kidney: a potential role for platelet activating factor.
Pharmacology & toxicology.
1999 Sep; 85(3):105-10. doi:
10.1111/j.1600-0773.1999.tb00075.x. [PMID: 10522748] - G Subbanagounder, N Leitinger, P T Shih, K F Faull, J A Berliner. Evidence that phospholipid oxidation products and/or platelet-activating factor play an important role in early atherogenesis : in vitro and In vivo inhibition by WEB 2086.
Circulation research.
1999 Aug; 85(4):311-8. doi:
10.1161/01.res.85.4.311. [PMID: 10455059] - T Nakasaki, K Masuyama, H Fukui, S Ogino, M Eura, Y Samejima, T Ishikawa, E Yumoto. Effects of PAF on histamine H1 receptor mRNA expression in rat trigeminal ganglia.
Prostaglandins & other lipid mediators.
1999 Aug; 58(1):29-41. doi:
10.1016/s0090-6980(99)00021-0. [PMID: 10482285] - S Cailleaux, R A Lopes-Martins, F Aimbire, R S Cordeiro, E Tibiriçá. Involvement of platelet-activating factor in the modulation of vascular tone in the isolated perfused rabbit kidney.
Naunyn-Schmiedeberg's archives of pharmacology.
1999 Jun; 359(6):505-11. doi:
10.1007/pl00005383. [PMID: 10431763] - A Gómez-Muñoz, L O'Brien, R Hundal, U P Steinbrecher. Lysophosphatidylcholine stimulates phospholipase D activity in mouse peritoneal macrophages.
Journal of lipid research.
1999 Jun; 40(6):988-93. doi:
10.1016/s0022-2275(20)33502-1. [PMID: 10357830] - S E Crawford, L Huang, W Hsueh, H Takami, F Gonzalez-Crussi, C L Backer, Y Mu, H Liu, C Mavroudis. Captopril and platelet-activating factor (PAF) antagonist prevent cardiac allograft vasculopathy in rats: role of endogenous PAF and PAF-like compounds.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.
1999 May; 18(5):470-7. doi:
10.1016/s1053-2498(98)00073-4. [PMID: 10363692] - J P de la Cruz, A Moreno, M I Ruiz-Ruiz, J García-Campos, F Sánchez de la Cuesta. Effect of WEB 2086-BS, an antagonist of platelet-activating factor receptors, on retinal vascularity in diabetic rats.
European journal of pharmacology.
1998 Oct; 360(1):37-42. doi:
10.1016/s0014-2999(98)00664-5. [PMID: 9845270] - G D Withers, P Kubes, G Ibbotson, R B Scott. Anaphylaxis-induced mesenteric vascular permeability, granulocyte adhesion, and platelet aggregates in rat.
The American journal of physiology.
1998 07; 275(1):H274-84. doi:
10.1152/ajpheart.1998.275.1.h274. [PMID: 9688924] - K Masuyama, T Toriya, R Minoda, M Eura, Y Samejima, T Ishikawa. PAF- and histamine-receptor antagonists lessen allergen-induced hearing impairment in guinea pigs.
Prostaglandins & other lipid mediators.
1998 Jul; 56(4):239-44. doi:
10.1016/s0090-6980(98)00055-0. [PMID: 9777655] - L Kotelevets, V Noë, E Bruyneel, E Myssiakine, E Chastre, M Mareel, C Gespach. Inhibition by platelet-activating factor of Src- and hepatocyte growth factor-dependent invasiveness of intestinal and kidney epithelial cells. Phosphatidylinositol 3'-kinase is a critical mediator of tumor invasion.
The Journal of biological chemistry.
1998 Jun; 273(23):14138-45. doi:
10.1074/jbc.273.23.14138. [PMID: 9603913] - A Shimada, Y Ota, Y Sugiyama, S Sato, K Kume, T Shimizu, S Inoue. In situ expression of platelet-activating factor (PAF)-receptor gene in rat skin and effects of PAF on proliferation and differentiation of cultured human keratinocytes.
The Journal of investigative dermatology.
1998 Jun; 110(6):889-93. doi:
10.1046/j.1523-1747.1998.00202.x. [PMID: 9620295] - R A Lopes-Martins, V Estato, C V Araújo, M Catelli, R S Cordeiro, E Tibiriçá. The acute increases in vasomotor tone and blood pressure induced by carotid artery occlusion are modulated by platelet-activating factor (PAF) independently of nitric oxide release.
Journal of lipid mediators and cell signalling.
1997 Dec; 17(3):151-65. doi:
10.1016/s0929-7855(97)00025-4. [PMID: 9524924] - J M Pearson, M B Bailie, G D Fink, R A Roth. Neither platelet activating factor nor leukotrienes are critical mediators of liver injury after lipopolysaccharide administration.
Toxicology.
1997 Sep; 121(3):181-9. doi:
10.1016/s0300-483x(97)03660-3. [PMID: 9231696] - N Perico, R Lapinski, K Konopka, S Aiello, M Noris, G Remuzzi. Platelet-activating factor mediates angiotensin II-induced proteinuria in isolated perfused rat kidney.
Journal of the American Society of Nephrology : JASN.
1997 Sep; 8(9):1391-8. doi:
10.1681/asn.v891391. [PMID: 9294830] - J Chen, N Giris. Species differences in PAF receptor binding in the lungs between hamster and guinea pig.
Journal of lipid mediators and cell signalling.
1997 Jun; 16(2):63-74. doi:
10.1016/s0929-7855(97)00573-7. [PMID: 9172049] - H E Bazan, Y Tao. PAF antagonists as possible inhibitors of corneal epithelial defects and ulceration.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.
1997 Jun; 13(3):277-85. doi:
10.1089/jop.1997.13.277. [PMID: 9185044] - H A Lehr, A S Weyrich, R K Saetzler, A Jurek, K E Arfors, G A Zimmerman, S M Prescott, T M McIntyre. Vitamin C blocks inflammatory platelet-activating factor mimetics created by cigarette smoking.
The Journal of clinical investigation.
1997 May; 99(10):2358-64. doi:
10.1172/jci119417. [PMID: 9153277] - M Bastos da Silva, F Herion, R Raskinet, J L David, P Gustin, P Lekeux. Combined effect of Web 2086 (Paf antagonist) and ketoprofen (Nsaid) on Paf-induced ex vivo platelet aggregation in bovine.
Zentralblatt fur Veterinarmedizin. Reihe A.
1997 Apr; 44(2):65-71. doi:
10.1111/j.1439-0442.1997.tb01087.x. [PMID: 9284631] - M Merlos, M Giral, D Balsa, R Ferrando, M Queralt, A Puigdemont, J García-Rafanell, J Forn. Rupatadine, a new potent, orally active dual antagonist of histamine and platelet-activating factor (PAF).
The Journal of pharmacology and experimental therapeutics.
1997 Jan; 280(1):114-21. doi:
NULL. [PMID: 8996188] - Y Iwahisa, S Yamaguchi, M Kagoshima, M Terasawa. Effect of Y-24180, a platelet-activating factor-receptor antagonist, on the antigen-induced airway microvascular leakage in guinea pigs.
Japanese journal of pharmacology.
1996 Nov; 72(3):209-15. doi:
10.1254/jjp.72.209. [PMID: 8957681] - M B da Silva, F Herion, R Raskinet, J L David, P Gustin, C Dessy, P Lekeux. Inhibition of PAF-induced platelet aggregation by WEB 2086 'in-vitro', an antagonist to the receptor for platelet-activating factor, in bovine.
Zentralblatt fur Veterinarmedizin. Reihe A.
1996 Sep; 43(7):399-413. doi:
10.1111/j.1439-0442.1996.tb00468.x. [PMID: 8921726] - M Giral, D Balsa, R Ferrando, M Merlos, J Garcia-Rafanell, J Forn. Effects of UR-12633, a new antagonist of platelet-activating factor, in rodent models of endotoxic shock.
British journal of pharmacology.
1996 Jul; 118(5):1223-31. doi:
10.1111/j.1476-5381.1996.tb15527.x. [PMID: 8818347] - Y Komatsu, Y Shiratori, Y Hikiba, N Hashimoto, K Han, T Kawase, H Yoshida, K Okano, M Omata. Role of platelet-activating factor in pathogenesis of galactosamine-lipopolysaccharide-induced liver injury.
Digestive diseases and sciences.
1996 May; 41(5):1030-7. doi:
10.1007/bf02091548. [PMID: 8625746] - P T Bozza, J L Payne, J L Goulet, P F Weller. Mechanisms of platelet-activating factor-induced lipid body formation: requisite roles for 5-lipoxygenase and de novo protein synthesis in the compartmentalization of neutrophil lipids.
The Journal of experimental medicine.
1996 Apr; 183(4):1515-25. doi:
10.1084/jem.183.4.1515. [PMID: 8666909] - G E Jarvis, R J Evans. Platelet-activating factor and not thromboxane A2 is an important mediator of endotoxin-induced platelet aggregation in equine heparinised whole blood in vitro.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.
1996 Mar; 7(2):194-8. doi:
10.1097/00001721-199603000-00021. [PMID: 8735817] - S Ishii, Y Matsuda, M Nakamura, I Waga, K Kume, T Izumi, T Shimizu. A murine platelet-activating factor receptor gene: cloning, chromosomal localization and up-regulation of expression by lipopolysaccharide in peritoneal resident macrophages.
The Biochemical journal.
1996 Mar; 314 ( Pt 2)(?):671-8. doi:
10.1042/bj3140671. [PMID: 8670084] - P Renesto, P Vicart, D Paulin, M Chignard. Protective effect of platelet activating factor antagonists on cultured endothelial cell lysis induced by elastase or activated neutrophils.
British journal of pharmacology.
1996 Mar; 117(5):902-6. doi:
10.1111/j.1476-5381.1996.tb15278.x. [PMID: 8851508] - M B Bailie, J M Pearson, G D Fink, R A Roth. Platelet activating factor receptor blockade alone or in combination with leukotriene synthesis inhibition does not ameliorate alpha-naphthylisothiocyanate-induced hepatotoxicity.
Toxicology letters.
1996 Feb; 84(2):89-95. doi:
10.1016/0378-4274(95)03620-2. [PMID: 8614909] - J A González-Fajardo, L Fernandez, T Alvarez, B Aguirre, G Ramos, C Vaquero. Protective effect of a platelet-activating factor antagonist (WEB-2086) in postischemic renal failure.
Annals of vascular surgery.
1996 Jan; 10(1):16-21. doi:
10.1007/bf02002336. [PMID: 8688291] - S J De Kimpe, C Thiemermann, J R Vane. Role for intracellular platelet-activating factor in the circulatory failure in a model of gram-positive shock.
British journal of pharmacology.
1995 Dec; 116(8):3191-8. doi:
10.1111/j.1476-5381.1995.tb15123.x. [PMID: 8719795] - H Thorlacius, J Raud, X Xie, P Hedqvist, L Lindbom. Microvascular mechanisms of histamine-induced potentiation of leukocyte adhesion evoked by chemoattractants.
British journal of pharmacology.
1995 Dec; 116(8):3175-80. doi:
10.1111/j.1476-5381.1995.tb15121.x. [PMID: 8719793] - Y M Dambisya, T L Lee, I M Hussaini. Effects of the platelet-activating factor receptor antagonist WEB 2086 on whole blood coagulation and fibrinolysis in a thromboelastography assay.
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The American journal of physiology.
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Clinical and experimental pharmacology & physiology.
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1994 Nov; 37(5):745-51. doi:
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1994 Sep; 10(3):251-68. doi:
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Clinical and experimental pharmacology & physiology.
1994 May; 21(5):413-6. doi:
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American journal of veterinary research.
1994 May; 55(5):681-8. doi:
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Immunology.
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The American review of respiratory disease.
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Prostaglandins, leukotrienes, and essential fatty acids.
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The American journal of physiology.
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Transplant international : official journal of the European Society for Organ Transplantation.
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1992 Sep; 220(1):55-61. doi:
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British journal of pharmacology.
1992 Sep; 107(1):44-9. doi:
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