pilsicainide (BioDeep_00000858740)

   


代谢物信息卡片


pilsicainide

化学式: C17H24N2O (272.18885339999997)
中文名称: 比西卡尼
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=C(C(=CC=C1)C)NC(=O)CC23CCCN2CCC3
InChI: InChI=1S/C17H24N2O/c1-13-6-3-7-14(2)16(13)18-15(20)12-17-8-4-10-19(17)11-5-9-17/h3,6-7H,4-5,8-12H2,1-2H3,(H,18,20)

描述信息

C78274 - Agent Affecting Cardiovascular System > C47793 - Antiarrhythmic Agent
D002317 - Cardiovascular Agents > D026941 - Sodium Channel Blockers
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D049990 - Membrane Transport Modulators

同义名列表

1 个代谢物同义名

pilsicainide



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Suchitra Matsukura, Yuji Nakamura, Xin Cao, Takeshi Wada, Hiroko Izumi-Nakaseko, Kentaro Ando, Hiroshi Yamazaki, Atsushi Sugiyama. Characterization of microminipigs as an in vivo experimental model for cardiac safety pharmacology. Journal of pharmacological sciences. 2017 Feb; 133(2):103-109. doi: 10.1016/j.jphs.2017.02.002. [PMID: 28245963]
  • Mikiko Shimizu, Masayuki Hashiguchi, Tsuyoshi Shiga, Koichi Nakamura, Hiro-omi Tamura, Mayumi Mochizuki. Quantitation of pilsicainide in microscale samples of human biological fluids using liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2015 Mar; 985(?):172-9. doi: 10.1016/j.jchromb.2015.01.013. [PMID: 25687803]
  • Shimpei Nakatani, Masayuki Taniike, Nobuhiko Makino, Yasuyuki Egami, Ryu Shutta, Jun Tanouchi, Masami Nishino. A Case of Sudden Cardiac Death due to Pilsicainide-Induced Torsades de Pointes. Korean circulation journal. 2014 Mar; 44(2):122-4. doi: 10.4070/kcj.2014.44.2.122. [PMID: 24653743]
  • Qi Qiu, Wenfang Liu, Jing Li, Yongxiang Wei, Kexu Yang, Wei Suo, Wei Wu, Haiyan Du, Yingchao Zhang, Guiping Zhao, Zijie Zhou, Yingming Zheng, Yang Lin. Pharmacokinetics of pilsicainide hydrochloride for injection in healthy Chinese volunteers: a randomized, parallel-group, open-label, single-dose study. Clinical therapeutics. 2014 Feb; 36(2):255-63. doi: 10.1016/j.clinthera.2013.12.015. [PMID: 24480637]
  • Ken Kitahara, Yuji Nakamura, Yayoi Tsuneoka, Satomi Adachi-Akahane, Hikaru Tanaka, Hiroshi Yamazaki, Akira Takahara, Junichi Yamazaki, Takanori Ikeda, Atsushi Sugiyama. Cardiohemodynamic and electrophysiological effects of anti-influenza drug oseltamivir in vivo and in vitro. Cardiovascular toxicology. 2013 Sep; 13(3):234-43. doi: 10.1007/s12012-013-9202-6. [PMID: 23420508]
  • Takeshi Ibata, Hiromi Hinokiyama, Chisako Nakashita, Saori Mito, Seiko Doi, Satomi Shiki, Akiko Hata, Miyuki Sato, Ryutaro Komuro, Hohei Iijima. [Two elderly case reports of renal excretion type drug poisoning caused by dehydration that was due to poor eating in home care]. Gan to kagaku ryoho. Cancer & chemotherapy. 2010 Dec; 37 Suppl 2(?):224-6. doi: NULL. [PMID: 21368531]
  • Masaru Yamaki, Nobuyuki Sato, Motoi Okada, Satoshi Fujita, Kazutomo Go, Naka Sakamoto, Yasuko Tanabe, Toshiharu Takeuchi, Yuichiro Kawamura, Naoyuki Hasebe. A case of Brugada syndrome in which diurnal ECG changes were associated with circadian rhythms of sex hormones. International heart journal. 2009 Sep; 50(5):669-76. doi: 10.1536/ihj.50.669. [PMID: 19809215]
  • Hiroshi Iwasaki, Akira Takahara, Yuji Nakamura, Yoshioki Satoh, Takeshi Nagai, Norihiro Shinkai, Atsushi Sugiyama. Simultaneous assessment of pharmacokinetics of pilsicainide transdermal patch and its electropharmacological effects on atria of chronic atrioventricular block dogs. Journal of pharmacological sciences. 2009 Jul; 110(3):410-4. doi: 10.1254/jphs.09061sc. [PMID: 19574726]
  • Bo-Hyung Kim, Jung-Ryul Kim, Kyoung Soo Lim, Jae Woo Kim, Kyu-pyo Kim, Jang-Hee Hong, In-Jin Jang, Sang-Goo Shin, Kyung-Sang Yu, Takanori Tanaka. An open-label, single-dose, parallel-group, dose-increasing study comparing the pharmacokinetics and tolerability of pilsicainide hydrochloride in healthy Korean and Japanese male subjects. Clinical therapeutics. 2009 Mar; 31(3):609-18. doi: 10.1016/j.clinthera.2009.03.015. [PMID: 19393851]
  • Takashi Komatsu, Hideaki Tachibana, Yoshihiro Sato, Mahito Ozawa, Kyoko Ohshima, Makoto Orii, Fusanori Kunigida, Motoyuki Nakamura. A randomized study on the efficacy of intravenous cibenzoline and pilsicainide administered prior to electrical cardioversion in patients with lone paroxysmal and persistent atrial fibrillation. Journal of cardiology. 2009 Feb; 53(1):35-42. doi: 10.1016/j.jjcc.2008.08.007. [PMID: 19167636]
  • Ryuta Imaki, Shinichi Niwano, Hiroe Niwano, Daisuke Satoh, Toru Yoshida, Yoshihiko Masaki, Tohru Izumi. Neutral endopeptidase inhibitor suppresses the early phase of atrial electrical remodeling in a canine rapid atrial pacing model. Indian pacing and electrophysiology journal. 2008 Apr; 8(2):102-13. doi: NULL. [PMID: 18379655]
  • Rhys Whomsley, Margherita Strolin-Benedetti, Eugène Baltes. Comment on severe arrhythmia as a result of the interaction of cetirizine and pilsicainide in a patient with renal insufficiency. Clinical pharmacology and therapeutics. 2006 Dec; 80(6):715-6; author reply 716. doi: 10.1016/j.clpt.2006.08.018. [PMID: 17178271]
  • Shuichi Tsuruoka, Takashi Ioka, Michi Wakaumi, Koh-ichi Sakamoto, Hitoshi Ookami, Akio Fujimura. Severe arrhythmia as a result of the interaction of cetirizine and pilsicainide in a patient with renal insufficiency: first case presentation showing competition for excretion via renal multidrug resistance protein 1 and organic cation transporter 2. Clinical pharmacology and therapeutics. 2006 Apr; 79(4):389-96. doi: 10.1016/j.clpt.2005.12.302. [PMID: 16580907]
  • Kazuyuki Nakata, Ryutaro Moriwaki, Atsushi Yamaguchi, Shin Takenouchi, Takashi Mato, Haruhiko Tsutsumi. [Case in which magnesium sulfate effectively treated ventricular tachycardia due to overdose of pilsicainide hydrochloride]. Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology. 2006 Jan; 19(1):49-53. doi: NULL. [PMID: 16491881]
  • Ryuichi Ogawa, Ryoji Kishi, Kiyoshi Mihara, Harumi Takahashi, Akihiko Takagi, Naoki Matsumoto, Keisou Masuhara, Kiyoshi Nakazawa, Fumihiko Miyake, Shinichi Kobayashi, Hirotoshi Echizen. Population pharmacokinetic and pharmacodynamic analysis of a class IC antiarrhythmic, pilsicainide, in patients with cardiac arrhythmias. Journal of clinical pharmacology. 2006 Jan; 46(1):59-68. doi: 10.1177/0091270005283281. [PMID: 16397285]
  • Kenzo Hirao, Kaoru Okishige, Naohito Yamamoto, Kenichiro Otomo, Kouji Azegami, Mitsuaki Isobe. Long-term efficacy of hybrid pharmacologic and ablation therapy in patients with pilsicainide-induced atrial flutter. Clinical cardiology. 2005 Jul; 28(7):338-42. doi: 10.1002/clc.4960280707. [PMID: 16075827]
  • Kyoko Fukumoto, Mamiko Tanemura, Yoshimasa Tsuchishita, Masaaki Kusumoto, Kana Matsumoto, Shiro Kamakura, Kazuyuki Ueno. Effect of protein binding of pilsicainide on the pharmacokinetics. Drug metabolism and pharmacokinetics. 2005 Jun; 20(3):183-6. doi: 10.2133/dmpk.20.183. [PMID: 15988120]
  • Go Hiasa, Hideki Okayama, Kazuhisa Nishimura, Takumi Sumimoto. Three elderly cases with Brugada-type electrocardiographic pattern unmasked by pilsicainide at the toxic level. Internal medicine (Tokyo, Japan). 2005 Jan; 44(1):55-9. doi: 10.2169/internalmedicine.44.55. [PMID: 15704664]
  • Yuhki Horita, Honin Kanaya, Yoshihide Uno, Tsukasa Yamazaki, Bunji Kaku, Akira Funada, Susumu Kitajima, Masami Matsumura, Takashi Satoh. A case of the toxicity of pilsicainide hydrochloride with comparison of the serial serum pilsicainide levels and electrocardiographic findings. Japanese heart journal. 2004 Nov; 45(6):1049-56. doi: 10.1536/jhj.45.1049. [PMID: 15655281]
  • Igor Sutovsky, Takao Katoh, Hideo Takayama, Tadaaki Ono, Teruo Takano. Therapeutic monitoring of class I antiarrhythmic agents using high-resolution electrocardiography instead of blood samples. Circulation journal : official journal of the Japanese Circulation Society. 2003 Mar; 67(3):195-8. doi: 10.1253/circj.67.195. [PMID: 12604865]
  • Akihiko Nogami, Motohiro Nakao, Shoichi Kubota, Aiko Sugiyasu, Hiroshi Doi, Ken Yokoyama, Kazuhiko Yumoto, Toshiyuki Tamaki, Ken-Ichi Kato, Noriyo Hosokawa, Hiroshi Sagai, Hiroyuki Nakamura, Jun-Ichi Nitta, Yasuteru Yamauchi, Kazutaka Aonuma. Enhancement of J-ST-segment elevation by the glucose and insulin test in Brugada syndrome. Pacing and clinical electrophysiology : PACE. 2003 Jan; 26(1P2):332-7. doi: 10.1046/j.1460-9592.2003.00044.x. [PMID: 12687840]
  • Toshihiro Kitahashi, Itaru Furuta. Quantification of pilsicainide in serum by capillary electrophoresis. Journal of pharmaceutical and biomedical analysis. 2002 Jul; 29(4):625-9. doi: 10.1016/s0731-7085(02)00077-8. [PMID: 12093491]
  • T Saita, H Fujito, M Mori. ELISA for the quantification of pilsicainide. Biological & pharmaceutical bulletin. 2001 Oct; 24(10):1113-6. doi: 10.1248/bpb.24.1113. [PMID: 11642313]
  • M Matsumoto, Z Fujii, Y Kawata, T Sakumura, M Minami, K Fujimoto, C Nawata, M Matsuzaki. Appropriate dosing of pilsicainide hydrochloride in patients on hemodialysis. Nephron. 2001 Jun; 88(2):134-7. doi: 10.1159/000045973. [PMID: 11399915]
  • T Numata, H Abe, T Nagatomo, K Kohshi, Y Nakashima. Effect of a single oral dose of pilsicainide on pacing thresholds in pacemaker patients with and without paroxysmal atrial fibrillation. Japanese circulation journal. 2000 Oct; 64(10):750-4. doi: 10.1253/jcj.64.750. [PMID: 11059614]
  • T Numata, H Abe, T Nagatomo, K Kohshi, Y Nakashima. Ventricular pacing failure after a single oral dose of pilsicainide in a patient with a permanent pacemaker and paroxysmal atrial fibrillation. Pacing and clinical electrophysiology : PACE. 2000 Sep; 23(9):1436-8. doi: 10.1111/j.1540-8159.2000.tb00977.x. [PMID: 11025904]
  • T Hidaka, T Inoue, K Komoriya, Y Hayashi, N Inomata. [Antiarrhythmic effects of pilsicainide hydrochloride and effects on cardiac function and ECG in dogs: comparison with disopyramide]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 2000 May; 115(5):295-308. doi: 10.1254/fpj.115.295. [PMID: 10872181]
  • T Toeda, R Susa, T Saigawa, T Abe, Y Yamaguchi, K Fuse, H Murooka. A case of sinus pause due to the proarrhythmia of pilsicainide. Japanese heart journal. 2000 May; 41(3):405-10. doi: 10.1536/jhj.41.405. [PMID: 10987357]
  • T Shiga, M Hashiguchi, A Urae, H Kasanuki, T Rikihisa. Effect of cimetidine and probenecid on pilsicainide renal clearance in humans. Clinical pharmacology and therapeutics. 2000 Mar; 67(3):222-8. doi: 10.1067/mcp.2000.104018. [PMID: 10741624]
  • S Ozeki, T Utsunomiya, S Matsuo, K Yano. Pilsicainide intoxication in a patient with dehydration. Japanese circulation journal. 1999 Mar; 63(3):219-22. doi: 10.1253/jcj.63.219. [PMID: 10201625]
  • T Ino, H Atarashi, A Kuruma, T Onodera, H Saitoh, H Hayakawa. Electrophysiologic and hemodynamic effects of a single oral dose of pilsicainide hydrochloride, a new class 1c antiarrhythmic agent. Journal of cardiovascular pharmacology. 1998 Jan; 31(1):157-64. doi: 10.1097/00005344-199801000-00021. [PMID: 9456290]
  • M Sakanashi, K Noguchi, T Matsuzaki, Y Ojiri, J Nakasone, T Itomine, M Higuchi, N Shiroma. Effects of pilsicainide on systemic hemodynamics and cardiac function of anesthetized dogs. Cardioscience. 1993 Dec; 4(4):241-50. doi: NULL. [PMID: 8298065]
  • T Takabatake, H Ohta, Y Yamamoto, Y Ishida, H Hara, Y Ushiogi, S Nakamura, N Hashimoto, T Sasaki, S Satoh. Pharmacokinetics of SUN 1165, a new antiarrhythmic agent, in renal dysfunction. European journal of clinical pharmacology. 1991; 40(4):411-4. doi: 10.1007/bf00265853. [PMID: 2050177]
  • K Aisaka, T Hidaka, Y Hattori, N Inomata, T Ishihara, F Satoh. General pharmacological studies on N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate. 3rd communication: effect on cardiovascular system. Arzneimittel-Forschung. 1988 Oct; 38(10):1417-25. doi: NULL. [PMID: 3196382]
  • K Hashimoto, M Ishii, S Komori, H Mitsuhashi. Canine digitalis arrhythmia as a model for detecting Na-channel blocking antiarrhythmic drugs: a comparative study using other canine arrhythmia models and the new antiarrhythmic drugs, propafenone, tocainide, and SUN 1165. Heart and vessels. 1985 Feb; 1(1):29-35. doi: 10.1007/bf02066484. [PMID: 2419304]
  • T Hidaka, S Hamasaki, K Aisaka, T Ishihara, M Morita, J Toyama, K Yamada. N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate (SUN 1165), a new antiarrhythmic agent: effects on cardiac conduction. Arzneimittel-Forschung. 1985; 35(9):1381-6. doi: NULL. [PMID: 4084339]